Review
Dermatology
Yukie Kataoka, Mao Kunimitsu, Gojiro Nakagami, Sofoklis Koudounas, Carolina D. Weller, Hiromi Sanada
Summary: Chronic wounds are difficult to heal wounds caused by disrupted wound healing mechanisms, which have a high risk of infection and biofilm formation. Ultrasonic debridement has been introduced as a new method to decrease infection and promote healing of chronic wounds. Studies indicate that both non-contact and direct contact ultrasonic debridement devices have positive effects on wound healing by reducing biofilm formation or bacterial load. Further research on ultrasonic debridement in chronic wounds is needed to establish optimal settings and improve outcomes.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Medicine, General & Internal
Yen-Hsi Lin, Yen-Chin Chen, Kuo-Sheng Cheng, Po-Jui Yu, Jiun-Ling Wang, Nai-Ying Ko
Summary: This study found a positive correlation between higher periwound temperatures and better wound healing, as well as a link between higher malnutrition scores and poor wound healing. Multivariate analysis showed that changes in periwound temperature can be a useful indicator for predicting pressure ulcer healing outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Pinar Avsar, Zena Moore, Declan Patton
Summary: Research suggests that utilizing dressings made from low-friction materials on the outer surface can help reduce frictional forces transmitted to the patient's skin. The ability of dressings to absorb and redistribute shear forces, as well as reduce pressure on the patient's tissues through cushioning of bony prominences, is important in reducing the incidence of pressure ulcers. Additionally, dressings that reduce humidity at the skin/dressing interface may also play a role in preventing pressure ulcers.
JOURNAL OF WOUND CARE
(2021)
Review
Biochemistry & Molecular Biology
Stephen M. Niemiec, Amanda E. Louiselle, Kenneth W. Liechty, Carlos Zgheib
Summary: Pressure ulcers, like other chronic wounds, are preventable yet common conditions that cause significant patient morbidity and high healthcare costs. Impaired wound healing is mainly due to dysregulated immune processes. This review focuses on describing key biochemical pathways in the pathogenesis of pressure ulcers and miRNA regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Kazuko Ugai, Didier Y. Koffi, Kouame Kouadio, Aubin Yao, Rie R. Yotsu
Summary: This study investigates the impact of nutritional status on wound healing in patients with Buruli ulcer, and highlights the importance of integrating nutritional interventions into wound management protocols and properly assessing and controlling wound pain.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Review
Endocrinology & Metabolism
Pingnan Jiang, Qianhang Li, Yanhong Luo, Feng Luo, Qingya Che, Zhaoyu Lu, Shuxiang Yang, Yan Yang, Xia Chen, Yulan Cai
Summary: Diabetic foot ulcer (DFU) is a serious complication of diabetes that can lead to amputation and death. Proper management includes surgical treatment, topical dressings, vascular assessment, and glycemic control. Among these, dressings play a crucial role in protecting the wound and promoting healing.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Gisele Abreu Coelho, Philippe-Henri Secretan, Lionel Tortolano, Loic Charvet, Najet Yagoubi
Summary: This review aims to identify and discuss the different stages of chronic wound progression, focusing on the changes in the biochemical composition of the wound microenvironment, particularly in venous leg ulcers (VLUs). It provides detailed information about the pathophysiology of venous ulcers and reviews the known changes in the VLU microenvironment as the VLU evolves. Additionally, it discusses simulating conditions for VLU and highlights potentially relevant simulating media to assess the biological safety of medical devices intended to be in contact with these wounds.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Mari van de Vyver, Kiara Boodhoo, Trivia Frazier, Katie Hamel, Marta Kopcewicz, Benjamin Levi, Michelle Maartens, Sylwia Machcinska, Johanna Nunez, Chase Pagani, Emma Rogers, Katarzyna Walendzik, Joanna Wisniewska, Barbara Gawronska-Kozak, Jeffrey M. Gimble
Summary: This study aims to develop and validate a scoring system based on healing parameters in each phase, which can be easily and accurately assessed using H&E or MT staining. The study compares parameters assessed using different staining methods and reports high sensitivity for each parameter, ranging between 80% and 95%. The validated scoring system defines minimum criteria for assessing wound healing dynamics and is associated with academic and scientific institutions involved in its development.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Clinical Neurology
Hanna Tufvesson, Viktor Hamrefors, Bodil Roth, Artur Fedorowski, Bodil Ohlsson
Summary: Postural orthostatic tachycardia syndrome (POTS) is associated with sociodemographic and lifestyle factors, but not with malnutrition. Patients with POTS have lower education levels, lower alcohol intake, lower physical activity levels, and higher heart rate. Higher CRP levels, lower albumin levels, and higher sodium levels are observed in POTS patients.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Article
Dermatology
Ze Xu, Ke Zhang, Kai Cheng, Guangwei Sun, Yaning Zhang, Jian Jia
Summary: A meta-analysis was conducted to evaluate the effects of cemented and uncemented prostheses on postoperative surgical site wound infection and pain in patients with femoral neck fractures. The results showed that cemented prostheses significantly reduced the incidence of surgical site wound infections and relieved surgical site wound pain, but did not reduce the incidence of pressure ulcers after surgery.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Nursing
Ye-Na Lee, Sung Ok Chang
Summary: This study aims to explore and describe the way wound care nurses experience and perceive pressure injury management. A qualitative, phenomenographic approach was used, and semi-structured interviews were conducted with twenty wound care nurses. The analysis resulted in an assessment domain and an intervention domain, each containing three descriptive categories based on five identified conceptions. The study provides a framework for understanding pressure injury management based on practical knowledge and emphasizes the importance of a harmonious approach to patients and wounds.
Review
Dermatology
JiannWen Yap, Samantha Holloway
Summary: The review examined the evidence supporting the use of nutritional supplements in pressure ulcer prevention strategies. Most of the reviewed studies were of low-to-moderate quality, but showed a reduction in pressure ulcer incidence after nutritional supplement use.
INTERNATIONAL WOUND JOURNAL
(2021)
Editorial Material
Otorhinolaryngology
Sydney T. Jiang, Christina H. Fang, Jen-Ting Chen, Richard V. Smith
Summary: During the COVID-19 pandemic, some critically ill patients receiving oxygen therapy may require prolonged prone positioning, leading to facial pressure wounds and ear necrosis.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Maelys Teng, Djamel Bensmail, Mouna Hanachi, Rebecca Haddad, Caroline Hugeron, Thibaud Lansaman, Jonathan Levy
Summary: This study aims to describe the nutritional status of patients with advanced-stage multiple sclerosis (MS). The study found that malnutrition is common in these patients and is associated with disease severity, MS subtype, and swallowing disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Emergency Medicine
Xuerong Wei, Minxiong Li, Zijun Zheng, Jun Ma, Yanbin Gao, Lianglong Chen, Yujie Peng, Shengxiang Yu, Lei Yang
Summary: Cellular senescence plays a crucial role in chronic wounds, and novel strategies targeting senescence can be applied for their treatment.
Article
Clinical Neurology
Nao Tamai, Takeo Minematsu, Tomonori Maeda, Koichi Yabunaka, Hiromi Sanada
Article
Dermatology
Dianis Wulan Sari, Takeo Minematsu, Mikako Yoshida, Maiko Noguchi-Watanabe, Sanai Tomida, Aya Kitamura, Masatoshi Abe, Hiromi Sanada
Summary: This study validated biomarkers in skin blotting to identify and measure itching sensation as well as conventional methods to measure skin barrier function, revealing associations between itching symptoms and various skin measurements such as SC hydration and pH, providing insights into itchy skin issues among older adults.
JOURNAL OF TISSUE VIABILITY
(2021)
Article
Nursing
Satsuki Shimizu, Kaori Yonezawa, Megumi Haruna, Emi Sasagawa, Naoko Hikita, Hiromi Sanada, Takeo Minematsu
Summary: The study found that infantile facial skin problems were related to changes in sebum secretion and hydration before and after bathing. The ability to recover well after bathing is crucial in preventing facial skin problems.
JAPAN JOURNAL OF NURSING SCIENCE
(2021)
Article
Dermatology
Takeo Minematsu, Misako Dai, Nao Tamai, Gojiro Nakagami, Tamae Urai, Ayano Nakai, Shiori Nitta, Yukie Kataoka, Weijie Kuang, Mao Kunimitsu, Toshihiro Tsukatani, Hajime Oyama, Tomohiro Yoshikawa, Chika Takada, Miyoko Kuwata, Hiromi Sanada
Summary: The study aimed to propose a risk scoring tool for skin tears in Japanese older adults, identifying risk factors such as senile purpura, pseudoscar, contracture, and dry skin. The tool showed high accuracy but low specificity in predicting forearm skin tears in older adults in Japan.
JOURNAL OF TISSUE VIABILITY
(2021)
Article
Cell Biology
Toshihiro Tsukatani, Takeo Minematsu, Misako Dai, Nao Tamai, Gojiro Nakagami, Junko Sugama, Chika Takada, Hiromi Sanada
Summary: The study revealed significant associations between certain SNPs and different types of PI history, indicating that targeted investigations on individual PI susceptibilities may provide valuable insights for preventive care options.
WOUND REPAIR AND REGENERATION
(2021)
Article
Dermatology
Wei-Jhen Hsu, Takeo Minematsu, Gojiro Nakagami, Sofoklis Koudounas, Sanai Tomida, Ayano Nakai, Mao Kunimitsu, Shiori Nitta, Hiromi Sanada
Summary: This study aimed to distinguish the effects of pressure and shear loading on skin injuries through the study of miRs. The results indicate that miR-92b and miR-877 are promising biomarkers for intervention and prevention of PIs.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Multidisciplinary Sciences
Daijiro Haba, Gojiro Nakagami, Takeo Minematsu, Hiromi Sanada
Summary: The study found that a LFV of 50 Hz, 1000 mVpp, 40 min/d, over 5 days was optimal for accelerating AMPK-mediated GLUT4 translocation and glucose uptake in adipocytes.
Article
Dermatology
Mao Kunimitsu, Gojiro Nakagami, Takeo Minematsu, Sofoklis Koudounas, Hiromi Sanada
Summary: In critically colonized wounds, signs of infection are often absent and delayed healing is the main clinical manifestation. This study developed a novel animal model by transplanting dysbiotic microbiota to investigate the pathogenesis of critical colonisation in wounds. The results show that the dysbiosis group had a higher degree of change in microbial similarity and larger wound area, as well as significant neutrophil infiltration. Additionally, there were significantly fewer regulatory T cells in the wounds of the dysbiosis group.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Sofoklis Koudounas, Takeo Minematsu, Yuko Mugita, Ayano Nakai, Hiromi Tobe, Chihiro Takizawa, Mao Kunimitsu, Gojiro Nakagami, Hiromi Sanada
Summary: Incontinence-associated dermatitis (IAD) is a common and often painful skin condition caused by prolonged exposure to urine/liquid stool. We developed an animal model of IAD using urine and bacteria to guide the development of prevention strategies.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Chihiro Takizawa, Takeo Minematsu, Gojiro Nakagami, Aya Kitamura, Sofoklis Koudounas, Mao Kunimitsu, Hiromi Sanada
Summary: This study aimed to evaluate the validity of mRNAs and proteins as fresh exudate markers for critical colonisation. The results suggest that Itgb6 mRNA in fresh exudates is a promising biomarker for critical colonisation.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Mao Kunimitsu, Gojiro Nakagami, Aya Kitamura, Takeo Minematsu, Sofoklis Koudounas, Kazuhiro Ogai, Junko Sugama, Chika Takada, SeonAe Yeo, Hiromi Sanada
Summary: This study aimed to investigate the relationship between microbial dissimilarity and healing status in wound and peri-wound skin. The analysis of microbial composition in deep and superficial wounds showed that healing wounds had the same predominant bacteria as the peri-wound skin, while hard-to-heal wounds had different bacteria. This study provides a new perspective for assessing wound bioburden.
JOURNAL OF TISSUE VIABILITY
(2023)
Article
Dermatology
Ayano Nakai, Takeo Minematsu, Shiori Nitta, Wei-Jhen Hsu, Hiromi Tobe, Hiromi Sanada
Summary: This study investigated whether PI-related biomarkers can distinguish persistent and blanchable redness (PBR) from transient redness (TR) and non-blanchable redness (NBR) using skin blotting. The results suggest that HSP90 alpha and IL-1 beta may be potential markers to distinguish PBR from TR and NBR.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Qi Qin, Daijiro Haba, Chihiro Takizawa, Sanai Tomida, Mao Kunimitsu, Takeo Minematsu, Hiromi Sanada, Gojiro Nakagami
Summary: The study aims to establish a method for collecting viable cells from discarded wound dressings. A protocol was designed to wash out nonadherent cells and detach adherent cells from silicone-faced foam wound dressings using trypsin-EDTA. The optimal concentration and incubation time of trypsin-EDTA for collecting equivalent proportions of different cell types to the original cell population were determined through in vitro and ex vivo studies.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Daijiro Haba, Qi Qin, Chihiro Takizawa, Sanai Tomida, Takeo Minematsu, Hiromi Sanada, Gojiro Nakagami
Summary: This study aimed to investigate the effect of low-frequency vibration (LLFV) on wound healing in hyperglycemic rats, focusing on glycometabolism, inflammation, vasodilation, and angiogenesis. The results showed that LLFV at 600-1,000 mVpp could promote the healing of full-thickness wounds in hyperglycemic rats, improve glycometabolism and inflammation, and enhance vasodilation and angiogenesis.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Dermatology
Sachi Higuchi, Seiichi Yoshida, Takeo Minematsu, Yutaka Hatano, Akifumi Notsu, Takamichi Ichinose
Summary: The purpose of this study was to determine whether bathing or the dry technique of cleaning is better for maintaining skin health in the early neonatal period. The results suggest that the dry technique may maintain skin health better than bathing.
ANNALS OF DERMATOLOGY
(2023)