Review
Health Care Sciences & Services
Elke Boxhammer, Alexander E. Berezin, Vera Paar, Nina Bacher, Albert Topf, Sergii Pavlov, Uta C. Hoppe, Michael Lichtenauer
Summary: The current scientific data situation regarding cardiovascular biomarkers as non-invasive diagnostic tools for the determination of pulmonary hypertension in patients with severe aortic valve stenosis is poor. There is a great potential to combine different biomarkers in a non-invasive way to determine the presence or absence of pulmonary hypertension.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Leon Kanwischer, Xingbo Xu, Afifa Binta Saifuddin, Sabine Maamari, Xiaoying Tan, Fouzi Alnour, Bjoern Tampe, Thomas Meyer, Michael Zeisberg, Gerd Hasenfuss, Miriam Puls, Elisabeth M. Zeisberg
Summary: Aortic stenosis (AS) is a common cardiac disease, and transcatheter aortic valve implantation (TAVI) reduces mortality in these patients. However, some patients still die within two years after TAVI. This study investigated the association between circulating methylated DNA of the IRX3 gene and cardiac fibrosis and/or mortality in AS patients undergoing TAVI. The results suggest that high levels of IRX3 methylation are associated with better overall survival and reflect myocardial IRX3 expression.
CLINICAL EPIGENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Shan-shan Wang, Jia-min Li, Po Hu, Yu-chao Guo, Xian-bao Liu, Jian-an Wang, Han Chen
Summary: This study found that high plasma irisin levels are independently associated with pure aortic stenosis (PAS), and irisin levels can predict the occurrence of PAS. Furthermore, the severity of aortic valve calcification is negatively associated with plasma irisin levels.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Badder Kattih, Daniel C. Carstens, Felicitas Boeckling, Tina Rasper, Graziella Pergola, Stefanie Dimmeler, Mariuca Vasa-Nicotera, Andreas M. Zeiher, Silvia Mas-Peiro
Summary: This study assessed the prognostic value of circulating musclin as a novel biomarker in identifying high-risk patients undergoing transcatheter aortic valve implantation (TAVI). The results showed that circulating musclin is an independent predictor of 1-year overall survival in TAVI patients, and when combined with EuroSCORE II, it can improve the prediction of mortality in low to intermediate clinical risk TAVI patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Chemistry, Multidisciplinary
Elke Boxhammer, Lukas Schmidbauer, Moritz Mirna, Vera Paar, Matthias Hammerer, Uta C. Hoppe, Michael Lichtenauer
Summary: This study aimed to evaluate the role of cardiovascular biomarkers in patients with severe aortic valve stenosis. The results showed that certain cardiovascular biomarkers have potential in the detection of pulmonary hypertension using echocardiography.
APPLIED SCIENCES-BASEL
(2022)
Article
Surgery
Michael P. Rogers, Haroon Janjua, Emanuel Eguia, Lucian Lozonschi, Paul C. Kuo
Summary: This study evaluated the adoption of transcatheter aortic valve replacement technology in surgical aortic valve procedures in Florida. The findings showed that the introduction of transcatheter aortic valve replacement significantly increased the overall surgical volume and may be associated with lower hospital charges.
Article
Cardiac & Cardiovascular Systems
Lawrence M. Wei, Chris C. Cook, J. W. Awori Hayanga, J. Scott Rankin, Christopher E. Mascio, Vinay Badhwar
Summary: Fully robotic-assisted aortic valve replacement (RAVR) shows promising procedural safety and short-term outcomes, with the potential for safely performing concomitant procedures.
ANNALS OF THORACIC SURGERY
(2022)
Review
Medicine, General & Internal
Lola Gutierrez, Mauro Boiago, Chiara De Biase, Omar Oliva, Pietro Laforgia, Souheib Feliachi, Alessandro Beneduce, Nicolas Dumonteil, Didier Tchetche
Summary: Bicuspid aortic valve disease is the most common congenital heart disease, associated with unique morphological features and lack of consensus in sizing measurement. Multi-slice computed tomography plays a crucial role in TAVI procedure planning, and advancements in devices and procedure planning have improved clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Samir R. R. Kapadia, Raj Makkar, Martin Leon, Mohamed Abdel-Wahab, Thomas Waggoner, Steffen Massberg, Wolfgang Rottbauer, Samuel Horr, Lars Sondergaard, Juhana Karha, Robert Gooley, Lowell Satler, Robert C. Stoler, Steven R. Messe, Suzanne J. Baron, Julia Seeger, Susheel Kodali, Amar Krishnaswamy, Vinod H. Thourani, Katherine Harrington, Stuart Pocock, Rodrigo Modolo, Dominic J. Allocco, Ian T. Meredith, Axel Linke, PROTECTED TAVR Investigators
Summary: Among patients with aortic stenosis undergoing transfemoral TAVR, the use of CEP did not have a significant effect on the incidence of periprocedural stroke, but on the basis of the 95% confidence interval around this outcome, the results may not rule out a benefit of CEP during TAVR.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Geriatrics & Gerontology
Wieneke Vlastra, Astrid C. van Nieuwkerk, Anne-Sophie G. T. Bronzwaer, Adriaan Versteeg, Esther E. Bron, Wiro J. Niessen, Henk J. M. M. Mutsaerts, Bjorn J. P. van Der Ster, Charles B. L. M. Majoie, Geert J. Biessels, Aart J. Nederveen, Mat J. A. P. Daemen, Matthias J. P. van Osch, Jan Baan, Jan J. Piek, Johannes J. Van Lieshout, Ronak Delewi
Summary: Following TAVI, an increase in cardiac output was associated with an increase in cerebral blood flow, but the extent of increase in cerebral blood flow varied among patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cardiac & Cardiovascular Systems
Tadeja Kolar, Nikola Lakic, Alesa Kotnik, David Stubljar, Zlatko Fras, Matjaz Bunc
Summary: This study compared the outcomes of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) in octogenarians. The results showed similar clinical outcomes in terms of clinical endpoints in low- and medium-risk groups, but differences were observed in certain indicators such as paravalvular leak, acute kidney injury, and new onset atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Virginia Nguyen, Nadav Willner, Helene Eltchaninoff, Ian G. Burwash, Morgane Michel, Eric Durand, Martine Gilard, Christel Dindorf, Bernard Iung, Alain Cribier, Alec Vahanian, Karine Chevreul, David Messika-Zeitoun
Summary: The number of aortic valve replacements has doubled in a decade and TAVR became the dominant form of AVR in 2018. The improvement in patient profiles seems to have anticipated the demonstrated benefit of TAVR in intermediate and low-risk patients. For patients 75 years or older, TAVR should be considered as the first option.
EUROPEAN HEART JOURNAL
(2022)
Article
Health Care Sciences & Services
Stefan Hecht, Elke Boxhammer, Reinhard Kaufmann, Bernhard Scharinger, Christian Reiter, Juergen Kammler, Joerg Kellermair, Matthias Hammerer, Hermann Blessberger, Clemens Steinwender, Uta C. Hoppe, Klaus Hergan, Michael Lichtenauer
Summary: This study compared the expression of cardiovascular biomarkers in patients with CT-diagnosed sarcopenia and found that there were no significant differences in biomarker expression between patients with muscle degradation and those without it.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Marko Banovic, Svetozar Putnik, Martin Penicka, Gheorghe Doros, Marek A. Deja, Radka Kockova, Martin Kotrc, Sigita Glaveckaite, Hrvoje Gasparovic, Nikola Pavlovic, Lazar Velicki, Stefano Salizzoni, Wojtek Wojakowski, Guy Van Camp, Serge D. Nikolic, Bernard Iung, Jozef Bartunek
Summary: This international randomized controlled trial evaluated the safety and efficacy of early surgical treatment in asymptomatic patients with severe aortic stenosis. The results showed that early surgery reduced the primary composite end point of all-cause death, acute myocardial infarction, stroke, or unplanned hospitalization for heart failure compared with conservative treatment.
Article
Biochemistry & Molecular Biology
Dhananjie N. K. Chandrasekera, Joshua P. H. Neale, Isabelle van Hout, Shruti Rawal, Sean Coffey, Gregory T. Jones, Richard Bunton, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Patrick Manning, Michael J. A. Williams, Rajesh Katare
Article
Biochemistry & Molecular Biology
Gregory T. Jones, Judith Marsman, Basharat Bhat, Victoria L. Phillips, Aniruddha Chatterjee, Euan J. Rodger, Michael J. A. Williams, Andre M. van Rij, Sally P. A. McCormick
Article
Endocrinology & Metabolism
Hamish M. Aitken-Buck, Aram A. Babakr, Ingrid C. Fomison-Nurse, Isabelle van Hout, Philip J. Davis, Richard W. Bunton, Michael J. A. Williams, Sean Coffey, Peter P. Jones, Regis R. Lamberts
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Anesthesiology
B. H. Roxburgh, H. A. Campbell, J. D. Cotter, U. Reymann, M. J. A. Williams, D. Gwynne-Jones, K. N. Thomas
Summary: This study compared cardiopulmonary exercise testing variables and subjective responses in four different exercise modalities. The results showed that exercise modalities utilizing the lower limbs affected by osteoarthritis elicited higher peak oxygen consumption and anaerobic threshold values compared with arm ergometry.
Article
Surgery
Gregory T. Jones, Ben Drinkwater, Ashton Blake-Barlow, Geraldine B. Hill, Michael J. A. Williams, Jolanta Krysa, Andre M. van Rij, Sean Coffey
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2020)
Article
Endocrinology & Metabolism
Nima Purvis, Sweta Kumari, Dhananjie Chandrasekera, Jayanthi Bellae Papannarao, Sophie Gandhi, Isabelle van Hout, Sean Coffey, Richard Bunton, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Michael J. A. Williams, Andrew Bahn, Rajesh Katare
Summary: Diabetes mellitus leads to dysregulation of miRNAs in cardiac progenitor cells, and therapeutic overexpression of miR-30c-5p helps reduce diabetes-induced cell death and maintain MMP levels in CPCs.
Article
Cardiac & Cardiovascular Systems
Eng Leng Saw, James T. Pearson, Daryl O. Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J. A. Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare
Summary: This study identified dysregulation of cardiac NNCS in diabetic heart disease (DHD) and demonstrated that increased cardiac ACh is beneficial for maintaining cardiac and vascular function in diabetic hearts. Activation of cardiac NNCS could potentially serve as a new therapeutic strategy to prevent or delay the development of DHD.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hamish M. Aitken-Buck, Julia Krause, Isabelle van Hout, Philip J. Davis, Richard W. Bunton, Dominic J. Parry, Michael J. A. Williams, Sean Coffey, Tanja Zeller, Peter P. Jones, Regis R. Lamberts
Summary: This study is the first to demonstrate that LCAC 18:1 directly and acutely alters human myocardial function and in vitro Ca2+ handling. The metabolite promotes proarrhythmic muscle contractions and increases contractility. The exploratory findings in vitro suggest that LCAC 18:1 increases proarrhythmic RyR2-mediated spontaneous Ca2+ release propensity.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Sivabaskari Pasupathy, Bertil Lindahl, Peter Litwin, Rosanna Tavella, Michael J. A. Williams, Tracy Air, Christopher Zeitz, Nathaniel R. Smilowitz, Harmony R. Reynolds, Kai M. Eggers, Anna M. Nordenskjold, Peter Barr, Tomas Jernberg, Raffaele Marfella, Kevin Bainey, Karam Sodoon Alzuhairi, Nina Johnston, Andrew Kerr, John F. Beltrame
Summary: This study systematically reviewed the 12-month all-cause mortality of patients with MINOCA and found that MINOCA patients had a lower mortality rate compared to MI-CAD patients, but there was a statistically non-significant trend towards worse outcomes compared to patients without a known history of MI.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2021)
Article
Cardiac & Cardiovascular Systems
Michael J. A. Williams, Mildred Lee, Mesfer Alfadhel, Andrew J. Kerr
Summary: In patients with acute coronary syndrome, moderate and severe obesity are associated with worse survival rates, with higher non-CVD mortality in moderate/severe obesity and higher CVD mortality in severe obesity being contributing factors.
HEART LUNG AND CIRCULATION
(2021)
Article
Cardiac & Cardiovascular Systems
Sean Coffey, Parul Dixit, Eng Leng Saw, Aram A. Babakr, Isabelle van Hout, Ivor F. Galvin, Pankaj Saxena, Richard W. Bunton, Philip J. Davis, Regis R. Lamberts, Rajesh Katare, Michael J. A. Williams
Summary: The study examined whether thiamine would improve Cardiac Progenitor Cell (CPC) function in humans, but found that it did not improve CPC proliferation ability in patients undergoing coronary artery bypass surgery (CABG). However, thiamine did increase the proportion of CD34(-)/CD105(+) cells in isolated CPCs.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Peter McLeod, Sean Coffey, Katherine Sneddon, Michael Williams, Andrew Kerr, James Pemberton
Summary: This study aimed to determine the usefulness of routinely collected cardiac troponin in predicting significant left ventricular impairment. The results showed that cardiac troponins had poor discriminative ability to predict or exclude LV impairment and were not suitable for clinical use in prioritizing patients for cardiac imaging.
HEART LUNG AND CIRCULATION
(2022)
Article
Medicine, Research & Experimental
Nilanjan Ghosh, Sonya Fenton, Isabelle van Hout, Gregory T. Jones, Sean Coffey, Michael J. A. Williams, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Daryl O. Schwenke, Anirudha Chatterjee, Rajesh Katare
Summary: The study demonstrates that miR-320 plays a pathological role in diabetic heart disease by promoting apoptosis and cardiac dysfunction, and therapeutic knockdown of miR-320 can partially restore cardiac function.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Psychiatry
Ashleigh Barrett-Young, Antony Ambler, Kirsten Cheyne, Hayley Guiney, Jesse Kokaua, Yih Chung Tham, Michael J. A. Williams, Graham A. A. Wilson, Tien Yin Wong, Richie Poulton
Summary: The study examined the association between childhood social isolation and retinal neural layer changes in adulthood, independent of other childhood or adulthood risk factors. Data from a longitudinal study of over 1000 participants in New Zealand revealed that childhood social isolation was associated with thinner retinal nerve fiber layers in middle age, and this association was not explained by other psychosocial or physical health factors.
PSYCHOSOMATIC MEDICINE
(2023)
Article
Health Care Sciences & Services
Daniel Z. L. Chan, Ralph A. H. Stewart, Andrew J. Kerr, Bridget Dicker, Campbell Kyle, Philip D. Adamson, Gerry Devlin, John Edmond, Seif El-Jack, John M. Elliott, Nick Fisher, Charmaine Flynn, Mildred Lee, Yi-Wen (Becky) Liao, Maxine Rhodes, Tony Scott, Tony Smith, Martin K. Stiles, Andrew H. Swain, Verity F. Todd, Mark W. Webster, Michael J. A. Williams, Harvey D. White, Jithendra B. Somaratne
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2020)