Article
Cardiac & Cardiovascular Systems
Sourbha S. Dani, Ahmad N. Lone, Zulqarnain Javed, Muhammad S. Khan, Muhammad Zia Khan, Edo Kaluski, Salim S. Virani, Michael D. Shapiro, Miguel Cainzos-Achirica, Khurram Nasir, Safi U. Khan
Summary: In the United States, the rate of decline in premature AMI mortality has slowed down since 2011, with significant variations across different demographic groups, states, and urbanicity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Jeppe K. Petersen, Abdulrahman N. Shams-Eldin, Emil L. Fosbol, Rasmus Rorth, Rikke Sorensen, Reza Jabbari, Thomas Engstrom, Lene Holmvang, Frants Pedersen, Amna Alhakak, Johanna Kroll, Christian Torp-Pedersen, Lars Kober, Jawad H. Butt
Summary: Employment status prior to acute myocardial infarction is associated with long-term risk of mortality and recurrent MI. Patients who were not part of the workforce had a higher risk of death and new heart attacks following discharge compared to those who were part of the workforce.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Kamal Awad, Maged Mohammed, Mahmoud Mohamed Zaki, Abdelrahman I. Abushouk, Gregory Y. H. Lip, Michael J. Blaha, Carl J. Lavie, Peter P. Toth, J. Wouter Jukema, Naveed Sattar, Maciej Banach
Summary: Statin therapy in older people for primary prevention of cardiovascular disease is associated with significantly lower risks of all-cause mortality, CVD death, and stroke, but not with myocardial infarction. The observational findings support the need for further trials to test the benefits of statins in individuals above 75 years of age.
Article
Cardiac & Cardiovascular Systems
Maria Bergami, Edina Cenko, Jinsung Yoon, Guiomar Mendieta, Sasko Kedev, Marija Zdravkovic, Zorana Vasiljevic, Davor Milicic, Olivia Manfrini, Mihaela van der Schaar, Chris P. Gale, Lina Badimon, Raffaele Bugiardini
Summary: Preventive statin therapy in the elderly reduces the risk of ST-segment elevation myocardial infarction (STEMI) and has benefits in mortality, regardless of the presence of hypercholesterolemia history. This effect persists after the age of 76 years, but the benefits are less pronounced in women.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Lidia Alcoberro, Pedro Moliner, Joan Vime, Santiago Jimenez-Marrero, Alberto Garay, Sergi Yun, Alexandra Pons-Riverola, Raul Ramos-Polo, Mar Ras-Jimenez, Marta Tajes, Encarna Hidalgo, Esther Calero, Marta Ruiz, Nuria Jose-Bazan, Carles Ferre, Cristina Delso, Laia Alcober, Cristina Enjuanes, Josep Comin-Colet
Summary: A new nurse-led coordinated transitional program for heart failure patients reduces the composite endpoint of death and hospitalization both at 90 and 180 days after discharge. This decrease is mainly driven by a reduction in cardiovascular and heart failure hospitalizations. A more exhaustive discharge planning process further reduces all-cause mortality.
Article
Cardiac & Cardiovascular Systems
Phoebe Tran, Lam Tran, Liem Tran
Summary: A study found that 1.1 million MI survivors in the US (8.7%) are binge drinkers. Factors associated with binge drinking in MI survivors include being young, male, Hispanic, having higher income, and having lower educational attainment.
Article
Medicine, General & Internal
Dougho Park, Mun-Chul Kim, Daeyoung Hong, Yong-Suk Jeong, Hyoung Seop Kim, Jong Hun Kim
Summary: This study aimed to explore the long-term risk of recurrence and mortality in patients with acute ischemic stroke (AIS), acute myocardial infarction (AMI), or acute hemorrhagic stroke (AHS). The results showed that the risk of developing secondary AIS was significantly lower in the AMI and AHS groups compared to the AIS group. The risk of developing secondary AMI was also significantly lower in the AMI and AHS groups compared to the AIS group. Initial AHS was a decisive risk factor for developing secondary AHS. Furthermore, AMI and AHS were more closely related to long-term mortality than AIS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Laila A. Hopstock, Bente Morseth, Sarah Cook, Anne Elise Eggen, Sameline Grimsgaard, Marie W. Lundblad, Maja-Lisa Lochen, Ellisiv Mathiesen, Amalie Nilsen, Inger Njolstad
Summary: This study investigated the achievement of European guideline treatment targets for cardiovascular risk factors in Norwegian women and men after myocardial infarction (MI) or ischemic stroke. The study found that secondary prevention of cardiovascular disease was suboptimal, with only a negligible proportion of participants achieving all treatment targets for cardiovascular risk factors.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Rock Bum Kim, Jang-Rak Kim, Jin Yong Hwang
Summary: This review provides a comprehensive analysis of the epidemiological indicators of myocardial infarction in Korea, comparing them with other high-income countries. The results indicate that although there is an increasing trend, the hospitalization incidence, prevalence, and mortality rate of myocardial infarction are lower in Korea than in other countries. The study emphasizes the need for comprehensive national-level support and surveillance systems to collect accurate epidemiological indicators.
EPIDEMIOLOGY AND HEALTH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Josephine Harrington, Stefan Anker, Javed Butler
Summary: This editorial summarizes the article 'Empagliflozin in acute myocardial infarction: the EMMY trial' by D. von Lewinski et al., which discusses the use of Empagliflozin in the treatment of myocardial infarction in diabetic patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Rosemary Brown, Jim Lewsey, Sarah Wild, Jennifer Logue, Paul Welsh
Summary: This study found that non-achievement of lipid and statin adherence targets in myocardial infarction survivors is associated with increased risks of all-cause and cardiovascular disease mortality, but not with recurrent myocardial infarctions. Further research is needed to optimize their use in clinical practice to improve outcomes.
Article
Medicine, General & Internal
Temur Mamadjanov, Konstantinos Volaklis, Margit Heier, Dennis Freuer, Ute Amann, Annette Peters, B. Kuch, Christian Thilo, Jakob Linseisen, Christa Meisinger
Summary: The study found a significant association between admission blood glucose levels and 28-day mortality in patients aged 65-74 with AMI, but not in those aged 75-84. However, higher admission blood glucose was linked to major cardiac complications in both age groups.
Article
Cardiac & Cardiovascular Systems
Francisco Jose de Abajo, Sara Rodriguez-Martin, Diana Barreira, Antonio Rodriguez-Miguel, Encarnacion Fernandez-Anton, Miguel Gil, Alberto Garcia-Lledo
Summary: The study suggests a moderate protective effect of influenza vaccination on AMI in the general population, primarily in primary prevention. The reduced risk of AMI was observed shortly after vaccination and persisted over time, with no significant association found with pneumococcal vaccine.
Article
Cardiac & Cardiovascular Systems
Jessica Schubert, Bertil Lindahl, Hakan Melhus, Henrik Renlund, Margret Leosdottir, Ali Yari, Peter Ueda, Stefan James, Stephanie R. Reading, Paul J. Dluzniewski, Andrew W. Hamer, Tomas Jernberg, Emil Hagstrom
Summary: Clinical trials have shown that reducing LDL-C can decrease cardiovascular events, and a study found that larger reductions in LDL-C and more intensive statin therapy after myocardial infarction were associated with lower risks of cardiovascular outcomes and all-cause mortality.
EUROPEAN HEART JOURNAL
(2021)
Editorial Material
Medicine, General & Internal
Lynne W. Stevenson, Andrew P. DeFilippis
Summary: The evolution of the fight-or-flight response system is to help humans deal with acute physiological threats, which are now less common than chronic cardiovascular stress. The study shows that pharmacologic inhibition of RAAS improves chronic heart failure and the natriuretic peptide system provides a counterbalance to RAAS. Neprilysin, a key neutral endopeptidase, degrades a variety of peptides including natriuretic peptides and angiotensin II.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Article
Public, Environmental & Occupational Health
Maria-Pia Hergens, Max Bell, Per Haglund, Johan Sundstrom, Erik Lampa, Joanna Nederby-Ohd, Maria Rotzen Ostlund, Thomas Cars
Summary: This observational study based on the real-time Covid-19 monitoring framework provides insights into the risk factors associated with mortality, hospitalization, and ICU admission in Covid-19 infections. Kidney failure, diabetes, obesity, heart failure, and ischemic heart disease increase the risk of mortality and hospitalization, while atrial fibrillation and hypertension do not. The study also suggests that triage processes affect the ICU admission risk, as certain comorbid conditions are associated with lower ICU admission.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dexter Canoy, Emma Copland, Milad Nazarzadeh, Rema Ramakrishnan, Ana-Catarina Pinho-Gomes, Abdul Salam, Jamie P. Dwyer, Farshad Farzadfar, Johan Sundstrom, Mark Woodward, Barry R. Davis, Kazem Rahimi
Summary: This study conducted a meta-analysis of individual patient-level data from randomized clinical trials to investigate the long-term effects of antihypertensive drugs on blood pressure. The results showed that antihypertensive drugs were effective in lowering blood pressure, with maximal effect observed after 12 months and gradual attenuation over time. The findings suggest the need for appropriate treatment strategies to sustain long-term blood pressure reductions.
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Koen F. Dekkers, Sergi Sayols-Baixeras, Gabriel Baldanzi, Christoph Nowak, Ulf Hammar, Diem Nguyen, Georgios Varotsis, Louise Brunkwall, Nynne Nielsen, Aron C. Eklund, Jacob Bak Holm, H. Bjorn Nielsen, Filip Ottosson, Yi-Ting Lin, Shafqat Ahmad, Lars Lind, Johan Sundstrom, Gunnar Engstrom, J. Gustav Smith, Johan Arnlov, Marju Orho-Melander, Tove Fall
Summary: In this study, the gut microbiota was found to explain up to 58% of the variance of individual plasma metabolites. This research sheds light on the close connection between the gut microbiome and individual health, providing a basis for targeted studies on perturbation of specific metabolites and identification of potential plasma biomarkers.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P. Wilson, Anne H. Moxley, Swarooparani Vadlamudi, Arushi Varshney, Anne U. Jackson, Vasudha Ahuja, Stefan R. Bornstein, Laura J. Corbin, Graciela E. Delgado, Om P. Dwivedi, Lilian Fernandes Silva, Timothy M. Frayling, Harald Grallert, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Christian Herder, Sandra Herrmann, Kurt Hojlund, David A. Hughes, Marcus E. Kleber, Cecilia M. Lindgren, Ching-Ti Liu, Jian'an Luan, Anni Malmberg, Angela P. Moissl, Andrew P. Morris, Nikolaos Perakakis, Annette Peters, John R. Petrie, Michael Roden, Peter E. H. Schwarz, Sapna Sharma, Angela Silveira, Rona J. Strawbridge, Tiinamaija Tuomi, Andrew R. Wood, Peitao Wu, Bjorn Zethelius, Damiano Baldassarre, Johan G. Eriksson, Tove Fall, Jose C. Florez, Andreas Fritsche, Bruna Gigante, Anders Hamsten, Eero Kajantie, Markku Laakso, Jari Lahti, Deborah A. Lawlor, Lars Lind, Winfried Maerz, James B. Meigs, Johan Sundstrom, Nicholas J. Timpson, Robert Wagner, Mark Walker, Nicholas J. Wareham, Hugh Watkins, Ines Barroso, Stephen O'Rahilly, Niels Grarup, Stephen CJ. Parker, Michael Boehnke, Claudia Langenberg, Eleanor Wheeler, Karen L. Mohlke
Summary: Insufficient insulin secretion and increased proinsulin levels indicate beta-cell stress and insulin resistance. A meta-analysis of European-ancestry individuals identified 36 independent signals at 30 loci associated with fasting proinsulin. These loci are involved in various mechanisms that affect insulin processing and beta-cell function. Colocalization analysis provided potential candidate genes and regulatory mechanisms for proinsulin production and glucose regulation. This study highlights the importance of genetic studies for understanding disease predisposition.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Tracey G. Simon, Bjorn Roelstraete, Naim Alkhouri, Hannes Hagstrom, Johan Sundstrom, Jonas F. Ludvigsson
Summary: This study found that children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure, compared to matched population controls.
Article
Public, Environmental & Occupational Health
Sara Higueras-Fresnillo, Angel Herraiz-Adillo, Viktor H. Ahlqvist, Daniel Berglind, Cecilia Lenander, Bledar Daka, Maria Braennholm Syrjala, Johan Sundstrom, Carl Johan Ostgren, Karin Radholm, Pontus Henriksson
Summary: The aim of this study was to examine the prevalence of ideal cardiovascular health (iCVH) in the middle-aged population of Sweden. Data from a large population-based study were analyzed and a total iCVH score was calculated based on seven components. Results showed that only 18.2% of the population reached ideal status, while 51.9% were classified as intermediate status and 29.9% as poor status of iCVH. Women had a higher prevalence of iCVH status and a lower prevalence of poor iCVH status. These findings can be used as benchmarks for future comparisons and efforts to promote cardiovascular health.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Stefan Gustafsson, Daniel Gedon, Erik Lampa, Antonio H. Ribeiro, Martin J. Holzmann, Thomas B. Schon, Johan Sundstrom
Summary: The study aimed to develop and validate a deep learning model using electrocardiograms (ECGs) to predict myocardial infarction in emergency department patients. The model showed excellent performance in discriminating between myocardial infarction and control group, indicating its potential value in ECG decision support in the emergency department.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Lars Lind, Tove Fall, Johan Arnlov, Solve Elmstahl, Johan Sundstrom
Summary: This study explored the relationship between a wide range of circulating metabolites and future cardiovascular disease (CVD) as well as subclinical markers of CVD in the general population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson, Jocelyne Benatar, Lisa Brandin, David Erlinge, Urban Haaga, Claes Held, Pelle Johansson, Patric Karlstrom, Thomas Kellerth, Toomas Marandi, Katarina Mars, Annica Ravn-Fischer, Johan Sundstrom, Ollie Ostlund, Robin Hofmann, Tomas Jernberg
Summary: This article introduces a trial called REDUCE-AMI, which aims to evaluate the effect of long-term beta-blocker treatment on death and recurrent myocardial infarction in patients with acute MI. The study will involve 5000 patients and observe both primary and secondary endpoints. The results will have important implications for guidelines and clinical practice.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Norhammar, Johan Bodegard, Marc Vanderheyden, Navdeep Tangri, Avraham Karasik, Aldo Pietro Maggioni, Kari Anne Sveen, Tiago Taveira-Gomes, Manuel Botana, Lukas Hunziker, Marcus Thuresson, Amitava Banerjee, Johan Sundstrom, Andreas Bollmann
Summary: The CaReMe HF study collected individual level data from digital healthcare systems in 11 countries to estimate the prevalence, clinical outcomes, and costs of HF. The study found that 1-2% of the contemporary adult population has HF, and these individuals are at significant risk of adverse outcomes and associated costs.
Article
Cardiac & Cardiovascular Systems
Joel Ohm, Ralf Kuja-Halkola, Anna Warnqvist, Henrike Haebel, Per H. Skoglund, Johan Sundstroem, Kristina Hambraeus, Tomas Jernberg, Per Svensson
Summary: Low socioeconomic status is associated with worse prognosis after myocardial infarction. This study identified nonparticipation in cardiac rehabilitation, cardiometabolic risk profile, and persistent smoking as mediating factors in the relationship between low income and post-MI recurrent atherosclerotic cardiovascular disease events.
Article
Psychiatry
Eric Clapham, Johan Reutfors, Marie Linder, Lena Brandt, Johan Sundstrom, Robert Boden
Summary: The risk of cardiac adverse events following the use of clozapine is debated; however, its risk for chemically related antipsychotics olanzapine and quetiapine is unknown. A Swedish study used registers to analyze the risk of perimyocarditis and heart failure in patients receiving these antipsychotics. The study found that clozapine use was associated with a significantly increased short-term risk of perimyocarditis and an increased long-term risk of heart failure. Olanzapine and quetiapine use did not show an increased risk compared to no antipsychotic treatment.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.