Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Review
Nutrition & Dietetics
Letizia Baldini, Katia Librandi, Chiara D'Eusebio, Antonella Lezo
Summary: This review aims to analyze the role of an adequate form of nutritional support in patients with Fontan circulation throughout different stages of their lives and provide a practical approach to appropriate nutritional management.
Article
Cardiac & Cardiovascular Systems
Parag N. Jain, Katherine B. Salciccioli, Danielle Guffey, Jinyoung Byun, Timothy B. Cotts, Peter Ermis, Michael Gaies, Nancy Ghanayem, Francis Kim, Javier J. Lasa, Andrew Smith, Stephanie Fuller
Summary: This study analyzed the postoperative care of adults with congenital heart disease in pediatric cardiac intensive care units, finding that high complexity operations, previous sternotomies, preoperative arrhythmias, renal dysfunction, and respiratory failure are independent risk factors for prolonged length of stay and/or major complications.
ANNALS OF THORACIC SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Xiao Jin, Wei Ni, Guolan Wang, Qin Wu, Jun Zhang, Guoju Li, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Quansheng Xing
Summary: This study conducted in Qingdao, China, found that congenital heart disease (CHD) is a serious health issue with a prevalence similar to existing research. The positive rate of prenatal CHD screening was higher than the incidence of neonatal CHD. Risk factors for CHD were identified in the study, which could have significant implications for developing CHD intervention strategies.
Article
Engineering, Biomedical
Yinyu Yang, Xindi Yu, Zheng Guo, Wei Zhang, Jia Shen, Wei Wang
Summary: An analysis of risk factors for intracranial hemorrhage (ICH) in congenital heart disease patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO) revealed that neonates, use of ECPR, and maximum procalcitonin values were independent risk factors for ICH. The incidence of ICH remains high in children supported with VA-ECMO after cardiac surgery.
Review
Cardiac & Cardiovascular Systems
Patryk Leczycki, Maciej Banach, Marek Maciejewski, Agata Bielecka-Dabrowa
Summary: In recent decades, there has been a significant increase in the number of adults with congenital heart diseases (ACHD), necessitating thorough evaluation of their current condition. There is currently a lack of universal parameters or scales to easily assess the deterioration of ACHD patients' condition, emphasizing the need to identify widely available, cost-effective, and user-friendly factors. Studies have shown potential prognostic factors including echocardiography and magnetic resonance imaging, cardiopulmonary exercise testing, and biomarkers. However, further research is needed to create a specific assessment panel for patients with specific congenital heart diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Li Sun, Qianlan Wu, Huiying Wang, Juning Liu, Yan Shao, Rong Xu, Tian Gong, Xiaoju Peng, Baoli Zhang
Summary: This study investigates the association between maternal exposure to air pollutants and the risk of congenital heart defects in Suzhou, China. The results suggest that exposure to PM2.5 and NO2 is associated with an increased risk of CHDs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Stephanie Ibrahim, Benedicte Gaborit, Marien Lenoir, Gwenaelle Collod-Beroud, Sonia Stefanovic
Summary: Congenital heart defects (CHDs), the most common form of birth defects in humans, are complex and difficult to understand. While genetic factors can explain only a minority of cases, environmental risk factors also contribute to the development of CHDs. Maternal pregestational diabetes is associated with an increased risk, but the specific molecular mechanisms remain unclear. This review summarizes key findings on the molecular mechanisms altered in cardiac development under hyperglycemic conditions, presents experimental modeling techniques, and suggests new approaches for understanding and prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Markus Schwerzmann, Francisco Javier Ruperti-Repilado, Helmut Baumgartner, Berto Bouma, Judith Bouchardy, Werner Budts, Laurence Campens, Massimo Chessa, Maria Jesus del Cerro Marin, Harald Gabriel, Pastora Gallego, Rocio Garcia-Orta, Ana Elvira Gonzalez, Annette Schophuus Jensen, Magalie Ladouceur, Berta Miranda-Barrio, Marielle Morissens, Agnes Pasquet, Joaquin Rueda, Annemien E. van den Bosch, Heleen Berdina van der Zwaan, Daniel Tobler, Matthias Greutmann
Summary: This study aimed to collect clinical outcome data and identify risk factors for a complicated course of COVID-19 in patients with adult congenital heart disease (ACHD). Risk factors such as age, obesity, and multiple comorbidities were associated with an increased risk of a complicated COVID-19 course in ACHD patients. Cyanotic heart disease, including unrepaired cyanotic defects or Eisenmenger syndrome, were identified as particularly high-risk congenital cardiac defects in ACHD patients.
Article
Cardiac & Cardiovascular Systems
Gerhard-Paul Diller, Astrid Elisabeth Lammers, Alicia Fischer, Stefan Orwat, Klara Nienhaus, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Johannes Roth, Joachim Gerss, Eike Bormann, Helmut Baumgartner
Summary: The study aims to provide population-based data on the prevalence and clinical significance of immune deficiency syndromes (IDS) associated with congenital heart disease (CHD). By utilizing administrative German Health System data, the prevalence of increased susceptibility to infection (ISI) or confirmed IDS was assessed in CHD patients and compared with an age-matched non-congenital control group. The study found that 27.5% of CHD patients had ISI and 5.6% had a documented IDS, higher than the general population.
EUROPEAN HEART JOURNAL
(2023)
Article
Immunology
Yoshihiro Takahashi, Kentaro Ueno, Koji Nakae, Junpei Kawamura, Tomoyuki Matsuba, Yasuhiro Okamoto
Summary: A retrospective study found that low preoperative serum protein and albumin levels are risk factors for surgical site infection in pediatric cardiac surgeries, possibly due to malnutrition.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Theodora Fteropoulli, Manavi Tyagi, Shashivadan P. Hirani, Fiona Kennedy, Nathalie Picaut, Shay Cullen, John E. Deanfield, Stanton P. Newman
Summary: This study compared the health-related quality of life (HRQoL) of people with adult congenital heart disease (ACHD) with the general population and among 4 diagnostic groups. Risk factors for poor HRQoL in ACHD were identified, including younger age, perception of more severe symptoms, depression, and anxiety.
JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Biology
Antonio Amodeo, Milena Stojanovic, Tugba Erdil, Hitendu Dave, Robert Cesnjevar, Sebastian Paal, Oliver Kretschmar, Martin Schweiger
Summary: This retrospective single-center study aimed to investigate the outcomes of children with congenital heart defects on extracorporeal membrane oxygenation (ECMO), focusing on various risk factors. Among the 88 patients, 36 had a single-ventricle defect, while 52 had a biventricular defect. Overall, 28% of patients survived, with no significant difference in survival rates between the two groups. Children with biventricular hearts had shorter ECMO durations but longer stays in the intensive care unit. The occurrence of complications and the need for a second ECMO run were higher in children with a single ventricle.
Review
Obstetrics & Gynecology
Xiaolu Nie, Xiaohang Liu, Chen Wang, Zehao Wu, Zimo Sun, Jian Su, Ruohua Yan, Yaguang Peng, Yuxuan Yang, Chengrong Wang, Siyu Cai, Yali Liu, Huanling Yu, Qingqing Wu, Xiaoxia Peng, Chenghong Yin
Summary: This umbrella review comprehensively summarized the evidence on non-genetic risk factors of congenital heart defect (CHD) and found various factors, including family genetic history, maternal obesity, harmful chemicals, related to CHD. Sensitivity analysis based on cohort studies showed changes in evidence levels, indicating the importance of future research focusing on this aspect.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Cell Biology
Yuwen Chen, Deyong Xiao, Lu Zhang, Chen-Leng Cai, Bai-Yan Li, Ying Liu
Summary: Tbx20, a member of the T-box gene family, plays crucial roles in cardiovascular development and homeostasis, as well as cardiac remodeling in response to pathophysiological stresses. Mutations and genetic variants in TBX20 are associated with a wide spectrum of congenital heart defects and heart diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)