Review
Oncology
Jingkai Zhou, Matthieu Corvaisier, Darina Malycheva, Maria Alvarado-Kristensson
Summary: Oncogenic transformation leads to adaptive changes in tumor cells, affecting their cellular organization and functions. These changes can be used as diagnostic markers in clinical settings. This review summarizes the roles of actin, microtubules, and the gamma-tubulin meshwork in regulating cell metabolism and functional cellular asymmetry.
Article
Multidisciplinary Sciences
Song Gao, Shuaibin Wang, Zhiying Zhao, Chao Zhang, Zhicao Liu, Ping Ye, Zhifang Xu, Baozhu Yi, Kai Jiao, Gurudatta A. Naik, Shi Wei, Soroush Rais-Bahrami, Sejong Bae, Wei-Hsiung Yang, Guru Sonpavde, Runhua Liu, Lizhong Wang
Summary: The expression of TUBB4A is found to be significantly higher in prostate cancer, particularly in aggressive cancer cases, and is associated with poor patient survival. TUBB4A plays a role in protecting the cell nucleus from genomic instability during migration, and its overexpression contributes to cancer progression.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Takashi Hotta, Sarah E. Haynes, Teresa L. Blasius, Margo Gebbie, Emily L. Eberhardt, David Sept, Michael Cianfrocco, Kristen J. Verhey, Alexey Nesvizhskii, Ryoma Ohi
Summary: The translation discusses the importance of detyrosination as a post-translational modification of microtubules and the use of parthenolide to block this process. It also highlights the efficacy of epoY as an alternative inhibitor of microtubule detyrosination.
Article
Oncology
Qinglin Wang, Hao Wu, Jian Hu, Haijuan Fu, Yanghui Qu, Yijun Yang, Kathy Q. Cai, Andrey Efimov, Minghua Wu, Tim Yen, Yuan Wang, Zeng-Jie Yang
Summary: Nestin is significantly upregulated in human GBM compared to other types of glioma and its deficiency leads to apoptosis in tumor cells, interacts with beta II-tubulin, and sensitizes GBM cells to microtubule-destabilizing drugs.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Review
Cell Biology
Shih-Chieh Ti
Summary: This article provides an overview of the importance of tubulin in cellular structures and functions, and highlights the characteristics of purified α/β-tubulin heterodimers through in vitro experiments, revealing the regulatory mechanisms of microtubule dynamics and stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katrina B. Velle, Andrew S. Kennard, Monika Trupini, Arian Ivec, Andrew J. M. Swafford, Emily Nolton, Luke M. Rice, Iva M. Tolic, Lillian K. Fritz-Laylin, Patricia Wadsworth
Summary: Naegleria gruberi is a unicellular eukaryote that is useful for studying the last common eukaryotic ancestor. Its mitotic spindle is a distinctive barrel-like structure with unique properties.
Article
Biology
Andrea E. Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Muhlethaler, Federico Gago, Maria A. Oliva, Michel O. Steinmetz, Wei-Shuo Fang, J. Fernando Diaz
Summary: This study provides atomic-level details of the interaction between paclitaxel and tubulin, shedding light on the mechanism of action and binding determinants.
Article
Immunology
Victoria Lucia Alonso, Mara Emilia Carloni, Camila Silva Goncalves, Gonzalo Martinez Peralta, Maria Eugenia Chesta, Alejandro Pezza, Luis Emilio Tavernelli, Maria Cristina M. Motta, Esteban Serra
Summary: Trypanosomatids have a simpler cytoskeleton arrangement with stable microtubules, extensively acetylated in Trypanosoma cruzi. The identification of T. cruzi ATAT as a tubulin acetyltransferase sheds light on the role of alpha-tubulin acetylation in regulating cell cycle progression and parasite biology. Over-expression of TcATAT leads to morphological defects, kinetoplast division impairment, and increased resistance to microtubule depolymerizing drugs in T. cruzi, emphasizing the importance of finely regulated alpha-tubulin acetylation levels for normal cell cycle progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Oncology
Daniela Trisciuoglio, Francesca Degrassi
Summary: This review focuses on the significant role of tubulin modifications in determining different cancer characteristics, including metastatic cell migration, therapy resistance, and autophagy. It highlights the potential of inducing microtubule modifications as a means to kill cancer cells and the influence of modulating tubulin-modifying enzymes on cancer cell survival and aggressiveness. It suggests that targeting tubulin post-translational modifications can be a promising avenue in cancer therapy.
Article
Biology
Yean Ming Chew, Robert A. Cross
Summary: Taxol has different effects on different single-isotype microtubule lattices. It stabilizes and expands α1β4 GDP-tubulin lattices, but only stabilizes α1β3 GDP-tubulin lattices. This isotype-specific action of taxol drives the gliding of segmented-isotype GDP-taxol microtubules along convoluted paths.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Torben Johann Hausrat, Philipp C. Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister-Ullerich, Irm Hermans-Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel
Summary: The loss of tubulin a4 polyglutamylation reverses tau hyperphosphorylation, oligomerization, and microglia activation in a tauopathy mouse model, highlighting tubulin polyglutamylation as a potential therapeutic strategy in fighting tauopathies.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kirstine Lavrsen, Girish Rajendraprasad, Marcin Leda, Susana Eibes, Elisa Vitiello, Vasileios Katopodis, Andrew B. Goryachev, Marin Barisic
Summary: Cell polarization and symmetry breaking are crucial for directed cell migration. The study reveals that microtubule detyrosination drives cell polarization by transporting APC protein to cortical sites through kinesin-1-based transport, supporting the formation of leading edge and directed cell migration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Yu-Ming Lu, Chaogu Zheng
Summary: This review summarizes the current understanding of the expression patterns and cellular functions of nine alpha-tubulin and six beta-tubulin isotypes in Caenorhabditis elegans. The studies have identified region-specific expression patterns of tubulin isotypes and revealed their functional redundancy and specificity. Tubulin posttranslational modifications, such as polyglutamylation, are shown to regulate microtubule organization and properties.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Markus Hopfler, Eva Absmeier, Sew-Yeu Peak-Chew, Evangelia Vartholomaiou, Lori A. Passmore, Ivana Gasic, Ramanujan S. Hegde
Summary: Microtubules are crucial for cellular architecture, intracellular transport, and mitosis. Excess free tubulin triggers the degradation of tubulin mRNAs through the recognition of nascent polypeptides by the tubulin-specific ribosome-binding factor TTC5. Our study reveals that TTC5 recruits the protein SCAPER to the ribosome, which in turn associates with the CCR4-NOT complex to initiate tubulin mRNA decay. Mutations in SCAPER impair CCR4-NOT recruitment, tubulin mRNA degradation, and microtubule-dependent chromosome segregation, leading to intellectual disability and retinitis pigmentosa in humans. This research provides insights into the specificity of cytoplasmic gene regulation through protein-protein interactions.
Review
Medicine, General & Internal
Arne Gruen, Thomas Kuhnt, Thorsten Schlomm, Heidi Olze, Volker Budach, Carmen Stromberger
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Jan K. Hennigs, Sarah Minner, Pierre Tennstedt, Rolf Loeser, Hartwig Huland, Hans Klose, Markus Graefen, Thorsten Schlomm, Guido Sauter, Carsten Bokemeyer, Friedemann Honecker
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Franziska Buescheck, Mariam Sulimankhil, Nathaniel Melling, Doris Hoeflmayer, Claudia Hube-Magg, Ronald Simon, Cosima Goebel, Andrea Hinsch, Soeren Weidemann, Jacob R. Izbicki, Frank Jacobsen, Tim Mandelkow, Niclas C. Blessin, Christina Moeller-Koop, Florian Lutz, Florian Viehweger, Katharina Moeller, Guido Sauter, Maximillian Lennartz, Eike Burandt, Patrick Lebok, Sarah Minner, Sarah Bonk, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Christoph Fraune
Article
Oncology
Sarah Katharina Charlotte Holtfrerich, Sophie Knipper, Janna Purwins, Jasmin Castens, Burkhard Beyer, Thorsten Schlomm, Esther Kristina Diekhof
Article
Urology & Nephrology
Laura Wiemer, Markus Hollenbach, Robin Heckmann, Beatrice Kittner, Henning Plage, Max Reimann, Patrick Asbach, Frank Friedersdorff, Thorsten Schlomm, Sebastian Hofbauer, Hannes Cash
Summary: The study evaluated micro-ultrasound of the prostate with real-time targeting of suspicious regions in patients suspected to have prostate cancer and found potential benefits in detecting cancer and clinically significant cancer. Micro-ultrasound appears to be a valuable addition and alternative to traditional ultrasound methods.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Oncology
Paulina Nastaly, Sara Stoupiec, Marta Popeda, Julia Smentoch, Thorsten Schlomm, Colm Morrissey, Anna Joanna Zaczek, Burkhard Beyer, Pierre Tennstedt, Markus Graefen, Elke Eltze, Paolo Maiuri, Axel Semjonow, Klaus Pantel, Burkhard Brandt, Natalia Bednarz-Knoll
BRITISH JOURNAL OF CANCER
(2020)
Article
Oncology
Tobias Lange, Timur R. Samatov, Vladimir V. Galatenko, Pascal Steffen, Helge von Kriegstein, Tanja Spethmann, Daniel Wicklein, Hanna Maar, Kristine Kupfernagel, Vera Labitzky, Sandra Hanika, Sarah Starzonek, Ann-Kristin Ahlers, Kristoffer Riecken, Ronald Simon, Adam Polonski, Guido Sauter, Thorsten Schlomm, Hartwig Huland, Steven A. Johnsen, Hartmut Schlueter, Alexander G. Tonevitsky, Udo Schumacher
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Oncology
Katharina Moller, Martina Kluth, Malik Ahmed, Lia Burkhardt, Christina Moller-Koop, Franziska Buscheck, Soren Weidemann, Maria-Christina Tsourlakis, Sarah Minner, Hans Heinzer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm, David Dum, Ronald Simon
Summary: Deletion of chromosome 5q is common in prostate cancer, with separate deletions at 5q13 and 5q21 leading to aggressive disease. Cancers with co-deletion of 5q13 and 5q21 have worse prognosis compared to those with isolated deletions at either locus. 5q21 deletions are associated with ERG negativity, while 5q13 deletions are not related to ERG status.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Thorsten H. Ecke, Adisch Kiani, Thorsten Schlomm, Frank Friedersdorff, Anja Rabien, Klaus Jung, Ergin Kilic, Peter Bostrom, Minna Tervahartiala, Pekka Taimen, Jan Gleichenhagen, Georg Johnen, Thomas Bruening, Stefan Koch, Jenny Roggisch, Ralph M. Wirtz
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Jonathan D. Tward, Thorsten Schlomm, Stephen Bardot, Daniel J. Canter, Troy Scroggins, Stephen J. Freedland, Lauren Lenz, Darl D. Flake, Todd Cohen, Michael K. Brawer, Steven Stone, Jay Bishoff
Summary: The study evaluated a score combining a genomic expression classifier and clinical information to predict progression to metastatic disease in men with prostate cancer. It found that some patients could safely forgo multimodal therapy, and validated the effectiveness of the combined clinical cell-cycle risk score in assessing disease progression risk in patients.
CLINICAL GENITOURINARY CANCER
(2021)
Editorial Material
Urology & Nephrology
Arkadiusz Miernik, Thorsten Schlomm, Christian Bolenz
Article
Urology & Nephrology
T. Schlomm, T. Roediger, J. Graalmann
Summary: Medicine is becoming increasingly precise, particularly in oncology. The shift from a one-drug-fits-all model to an individualized biomarker-driven approach facilitates the transition from efficacy to effectiveness. Ensuring end-to-end precision from diagnostics to real-world evidence is crucial in achieving high-quality, affordable precision medicine for all in the future.
Article
Urology & Nephrology
M. Schoenthaler, T. Schlomm
Summary: The aim of projects like the Medical Informatics Funding Scheme is to facilitate the exchange of patient data between institutions by integrating data from various sources into a data warehouse. This will open access to high-performance and precision medicine for more patients, establish a translational link between basic research and patient care, and facilitate a detailed analysis of healthcare and treatment quality using digitally integrated patient data.
Article
Anatomy & Morphology
Doris Hoeflmayer, Christoph Fraune, Claudia Hube-Magg, Ronald Simon, Cornelia Schroeder, Franziska Buescheck, Katharina Moeller, David Dum, Soeren Weidemann, Corinna Wittmer, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Guido Sauter, Eike Burandt, Till S. Clauditz, Stefan Steurer, Sarah Minner, Waldemar Wilczak, Adam Polonski
Summary: TRIM24 upregulation in prostate cancer is associated with poor prognosis and provides additional prognostic information, independent of clinicopathologic parameters. This suggests promising potential for TRIM24 in the routine diagnostic work-up of patients with low Gleason grade tumors.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2021)
Article
Oncology
Andreas Marx, Lena Koopmann, Doris Haflmayer, Franziska Buescheck, Claudia Hube-Magg, Stefan Steurer, Till Eichenauer, Till S. Clauditz, Waldemar Wilczak, Ronald Simon, Guido Sauter, Jakob R. Izbicki, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Thorsten Schlomm, Christian Bernreuther, Patrick Lebok, Sarah Bonk
Summary: ANO7 protein expression is strongly associated with prostate epithelial cells and its reduced expression is closely linked to adverse tumor features, serving as a strong and independent predictor of poor prognosis in prostate cancer.
CANCER BIOLOGY & MEDICINE
(2021)