Review
Biochemistry & Molecular Biology
Hsiang-Ying Lee, Chien-Sheng Wang, Yung-Shun Juan
Summary: This article focuses on detrusor underactivity (DU) with bladder outlet obstruction (BOO) in male patients, discussing the pathophysiology, evaluation, treatment and predictors for successful BOO surgery. The article highlights the lack of understanding and research on DU from BOO, as well as the need for effective and safe medication to restore bladder contractility. Further research to explore the unknown aspects of DU is deemed valuable.
Article
Health Care Sciences & Services
Guy Verhovsky, Ilia Baberashvili, Yishai H. Rappaport, Dorit E. Zilberman, Amos Neheman, Jonathan Gal, Amnon Zisman, Kobi Stav
Summary: The objective of this study was to assess the objective association between bladder outlet obstruction (BOO) and abnormal sensation parameters during filling cystometry in men. The results indicated a strong association between bladder oversensitivity and BOO in men. Men with first desire to void (FDV) <140 mL had a significantly increased probability of being obstructed.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Ye Gao, Peilin Liu, Fan He, Xingliang Yang, Ronghua Wu, Wei Chen, Longkun Li, Zhenxing Yang
Summary: Non-invasive biomarkers are still needed to identify patients with bladder outlet obstruction (BOO)-related dysfunction. In a study involving rats and BPH patients, it was found that FGF2 is involved in the development of bladder hypertrophy in partial BOO and is positively correlated with prostate volume in BPH patients. BDNF, on the other hand, showed no correlation with prostate volume, age, or BMI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ning Wang, Lu Lu, Qi Feng Cao, Subo Qian, Jie Ding, Chen Wang, Huangqi Duan, Haibo Shen, Jun Qi
Summary: The research revealed that ALK4 may alleviate bladder fibrosis in a mouse model of partial bladder outlet obstruction, possibly by suppressing Smad2/3 activity.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Oxana Yu Kytikova, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Denis E. Naumov, Tatyana A. Gvozdenko, Juliy M. Perelman
Summary: Asthma is a chronic disease with a complex etiology, influenced by both natural-climatic and anthropogenic factors. Studies have shown that temperature plays a significant role in airway inflammation, and thermosensory TRP channels are crucial in the pathogenesis of asthma. New treatment methods for asthma exacerbations caused by temperature and humidity should focus on regulating channel activity.
Review
Urology & Nephrology
Christopher R. Chapple, Nadir Osman
Summary: It is not possible to diagnose the cause of voiding difficulty based on medical history alone. Different urinary problems may have overlapping symptoms. To differentiate between underactive bladder and bladder outlet obstruction as the underlying cause of lower urinary tract symptoms, invasive urodynamic study of the bladder is often required.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Physiology
Francis M. Hughes, Shelby N. Harper, Brent D. Nose, Armand Allkanjari, Michael T. Zheng, Huixia Jin, J. Todd Purves
Summary: Inflammation is a key factor in bladder outlet obstruction pathology, and understanding the various specialized proresolving mediators (SPMs) and their receptors in the bladder holds promise for developing new ways to address inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Jingyu Liu, Liuhua Zhou, Feng Zhao, Changcheng Zhou, Tianli Yang, Zhongle Xu, Xinning Wang, Luwei Xu, Zheng Xu, Yuzheng Ge, Ran Wu, Ruipeng Jia
Summary: Treatment with ad-SVF spheroids can significantly improve bladder function and symptoms in patients with underactive bladder (UAB), promoting angiogenesis, suppressing cell apoptosis, and stimulating cell proliferation.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Food Science & Technology
Hsiang-Ying Lee, Hann-Chorng Kuo
Summary: This article reviewed the use of botulinum toxin type A (BTX-A) injections into the bladder wall for men with small prostates without bladder outlet obstruction (BOO). The results showed that BTX-A injections were effective and safe for treating overactive bladders (OAB) in men, particularly in those without prior prostate surgery. Patients with prior radical prostatectomy (RP) also had better efficacy and lower risk of side effects. However, the pathophysiology mechanism of OAB in men may differ from that in women, which could affect the efficacy of BTX-A injection.
Article
Multidisciplinary Sciences
Jingyi Huang, Hongliang Li, Yao Zhang, Jiaye Liu, Hongying Cao, Yongling Long
Summary: Overactive bladder (OAB) is a common chronic symptom complex with a high prevalence in women worldwide and has caused a social burden. The pathogenesis of OAB remains unclear. In this study, a rat model of OAB was established and it was found that the rats in the model group had significantly increased urine volume, urodynamic parameters, contractile responses of detrusor muscles, bladder wall thickness, muscle-to-collagen ratio, as well as the gene and protein expression levels of choline acetyltransferase (ChAT) and solute carrier family 17 member 9 (SLC17A9). These findings suggest that OAB may be associated with increased excitatory purinergic and cholinergic expression.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Wei Wang, Jianzhong Ai, Banghua Liao, Kaiwen Xiao, Lede Lin, Huiling Chen, Liang Zhou
Summary: The study demonstrates that M1 macrophages are predominantly observed at the inflammatory stage while M2 macrophages are mainly found during the fibrosis stage in bladder outlet obstruction. Furthermore, M2 macrophages promote BOO-induced fibrosis through the secretion of TGF-beta and transformation into collagen-producing myofibroblasts. Targeting the MCP-1/CCR2 signaling pathway may be a potential therapeutic strategy for bladder fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao-Yu Cheng, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Chao Lu, Ren-Peng Zhou
Summary: TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Jae Heon Kim, Hee Jo Yang, Hong J. Lee, Yun Seob Song
Summary: This study found that chronic bladder outlet obstruction in rats lead to bladder hypoxia which resulted in the upregulation and downregulation of certain genes involved in hypoxia response, indicating the important role of hypoxia in decompensated bladder in bladder outlet obstruction.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Review
Medicine, Research & Experimental
Suwen Bai, Yuan Wei, Rong Liu, Yuhua Chen, Wanling Ma, Minghua Wang, Li Chen, Yumei Luo, Juan Du
Summary: Metastasis, the spread of cancer cells to other parts of the body, is a major factor in tumor treatment failure and death. Transient receptor potential (TRP) channels play a crucial role in various stages of metastasis, including promoting cell migration, angiogenesis, immune regulation, and gene expression changes. This review examines the mechanisms of TRP channels, their involvement in tumor metastasis, inhibitors of TRP channels, and challenges in studying TRP channels in tumor metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Urology & Nephrology
Jonathan J. Aning, Robert C. Calvert, Chris Harding, Sarah Fowler, Tharani Nitkunan, Su-Min Lee, John S. McGrath, Joanne Cresswell, Patricia Hagan, Louisa Hermans, Andrew J. Dickinson
Summary: A retrospective cohort study was conducted in 105 UK hospitals to determine the preoperative assessment and perioperative outcomes of men undergoing bladder outlet obstruction (BOO) surgery. The study found that completion rates of frequency-volume charts and urinary symptom questionnaires were low, with 5% of men experiencing complications within 30 days of surgery. Overall, the study concluded that BOO surgery treatments are safe and effective, but there is room for improvement in adherence to preoperative assessment guidelines.
