Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

(2011) J. Chad Brenner et al.   CANCER CELL

Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival

(2011) Emma Hörnberg et al.   PLoS One

The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study

(2011) Jayaprakash Karkera et al.   PROSTATE

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling

(2011) Vinagolu K. Rajasekhar et al.   Nature Communications

Androgen receptor signaling and mutations in prostate cancer

(2010) Shahriar Koochekpour   ASIAN JOURNAL OF ANDROLOGY

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

(2010) Jindan Yu et al.   CANCER CELL

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Androgen-Induced TMPRSS2:ERG Fusion in Nonmalignant Prostate Epithelial Cells

(2010) N. C. Bastus et al.   CANCER RESEARCH

Activation of NF-κB by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4

(2010) Jianghua Wang et al.   CANCER RESEARCH

Aberrant Activation of the Androgen Receptor by NF- B2/p52 in Prostate Cancer Cells

(2010) N. Nadiminty et al.   CANCER RESEARCH

Evidence of Limited Contributions for Intratumoral Steroidogenesis in Prostate Cancer

(2010) J. Hofland et al.   CANCER RESEARCH

Clinical and Correlative Results of SWOG S0354: A Phase II Trial of CNTO328 (Siltuximab), a Monoclonal Antibody against Interleukin-6, in Chemotherapy-Pretreated Patients with Castration-Resistant Prostate Cancer

(2010) T. B. Dorff et al.   CLINICAL CANCER RESEARCH

Detection of Androgen Receptor Mutations in Circulating Tumor Cells in Castration-Resistant Prostate Cancer

(2010) Y. Jiang et al.   CLINICAL CHEMISTRY

TMPRSS2–ERG gene fusion is associated with low Gleason scores and not with high-grade morphological features

(2010) Samson W Fine et al.   MODERN PATHOLOGY

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

NF-κB Regulates Androgen Receptor Expression and Prostate Cancer Growth

(2009) Liying Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy

(2009) M. P. Steinkamp et al.   CANCER RESEARCH

Characterization of ERG, AR and PTEN Gene Status in Circulating Tumor Cells from Patients with Castration-Resistant Prostate Cancer

(2009) G. Attard et al.   CANCER RESEARCH

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion-Resistant Growth

(2009) Z. Guo et al.   CANCER RESEARCH

Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer

(2009) Qianben Wang et al.   CELL

Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells

(2009) J. Y. Chun et al.   CLINICAL CANCER RESEARCH

The Role of Androgen Receptor Mutations in Prostate Cancer Progression

(2009) G. Brooke et al.   CURRENT GENOMICS

Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells

(2009) Frédéric R Santer et al.   ENDOCRINE-RELATED CANCER

ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical Practice

(2009) Scott A. Tomlins et al.   EUROPEAN UROLOGY

Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs

(2009) Rajendra K Singh et al.   Molecular Cancer

Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2

(2009) S. Feng et al.   MOLECULAR CANCER THERAPEUTICS

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

(2009) Brett S Carver et al.   NATURE GENETICS

aPKC /  promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6

(2009) H. Ishiguro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Castration-resistant prostate cancer: Targeting androgen metabolic pathways in recurrent disease

(2009) Elahe A. Mostaghel et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications

(2008) Elahe A. Mostaghel et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The discovery and application of gene fusions in prostate cancer

(2008) David S. Morris et al.   BJU INTERNATIONAL

Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

(2008) S. M. Dehm et al.   CANCER RESEARCH

The Nuclear Factor- B Pathway Controls the Progression of Prostate Cancer to Androgen-Independent Growth

(2008) R. J. Jin et al.   CANCER RESEARCH

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

(2008) R. Hu et al.   CANCER RESEARCH

Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation

(2008) A. Seaton et al.   CARCINOGENESIS

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Chemotherapy-Induced CXC-Chemokine/CXC-Chemokine Receptor Signaling in Metastatic Prostate Cancer Cells Confers Resistance to Oxaliplatin through Potentiation of Nuclear Factor- B Transcription and Evasion of Apoptosis

(2008) C. Wilson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome

(2008) Maisa Yoshimoto et al.   MODERN PATHOLOGY

Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol

(2008) Paulette R. Dillard et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells

(2008) C. Wilson et al.   MOLECULAR CANCER THERAPEUTICS

A causal role for ERG in neoplastic transformation of prostate epithelium

(2008) O. Klezovitch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation

(2008) Nagalakshmi Nadiminty et al.   PROSTATE

Interleukin-4 activates androgen receptor through CBP/p300

(2008) Soo Ok Lee et al.   PROSTATE