Article
Biotechnology & Applied Microbiology
Jiang Hu, Jun Pan, Zhiguo Luo, Qiwen Duan, Dan Wang
Summary: Emerging evidence suggests that lncRNA FOXD3-AS1 may promote the development of NPC by upregulating FOXD3 expression through binding with miR-185-3p. This study found that lncRNA FOXD3-AS1 plays a significant role in NPC and is correlated with tumor node metastasis stage and pathological type.
CANCER GENE THERAPY
(2021)
Article
Multidisciplinary Sciences
Laura Wiggins, Alice Lord, Killian L. Murphy, Stuart E. Lacy, Peter J. O'Toole, William J. Brackenbury, Julie Wilson
Summary: CellPhe is a pattern recognition toolkit that enables unbiased characterization of cellular phenotypes within time-lapse videos. It imports tracking information from multiple algorithms and provides automated recognition and removal of erroneous cell boundaries. It also offers a variety of feature selection and classification algorithms.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Li, Mengxia Chen, Biru Liu, Peifen Lu, Xiang Lv, Xiang Zhao, Shuaiying Cui, Peipei Xu, Yukio Nakamura, Ryo Kurita, Bing Chen, David C. S. Huang, De-Pei Liu, Ming Liu, Quan Zhao
Summary: This study identified NonO as a novel transcriptional repressor of gamma-globin gene expression in human erythroid cells, through direct binding to the promoter. Depletion of NonO led to significant activation of gamma-globin expression. Further research also revealed a conserved role for NonO during mammalian evolution.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Li, Mengxia Chen, Biru Liu, Peifen Lu, Xiang Lv, Xiang Zhao, Shuaiying Cui, Peipei Xu, Yukio Nakamura, Ryo Kurita, Bing Chen, David C. S. Huang, De-Pei Liu, Ming Liu, Quan Zhao
Summary: The study demonstrates that NonO interacts with SOX6 to repress gamma-globin gene expression in human erythroid cells, and depletion of NonO results in significant activation of gamma-globin expression. In vivo experiments using mice also confirm the role of NonO in reactivating globin gene expression, suggesting a conserved function of NonO during mammalian evolution.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, General & Internal
Erica B. Esrick, Leslie E. Lehmann, Alessandra Biffi, Maureen Achebe, Christian Brendel, Marioara F. Ciuculescu, Heather Daley, Brenda MacKinnon, Emily Morris, Amy Federico, Daniela Abriss, Kari Boardman, Radia Khelladi, Kit Shaw, Helene Negre, Olivier Negre, Sarah Nikiforow, Jerome Ritz, Sung-Yun Pai, Wendy B. London, Colleen Dansereau, Matthew M. Heeney, Myriam Armant, John P. Manis, David A. Williams
Summary: This study confirms BCL11A inhibition as an effective approach for inducing HbF in sickle cell disease. Preliminary evidence suggests that shmik-based gene knockdown offers a favorable risk-benefit profile in treating sickle cell disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Daniel Rojo, Alejandro Madrid, Sebastian San Martin, Mario Parraga, Maria Aparecida Silva Pinhal, Joan Villena, Manuel Valenzuela-Valderrama
Summary: Resveratrol inhibits the invasion potential of gastric cancer cells by increasing SOD activity and decreasing NF-kappa B transcriptional activity and heparanase enzymatic activity.
Article
Biology
Heesun Kim, Yue-He Ding, Gangming Zhang, Yong-Hong Yan, Darryl Conte, Meng-Qiu Dong, Craig C. Mello
Summary: In eukaryotic cells, guided search is used to coordinate the control of dispersed genetic elements. SUMOylation of the type 1 histone deacetylase HDA-1 has been shown to be essential for Argonaute-directed transcriptional silencing in Caenorhabditis elegans by promoting the association of HDAC1 with chromatin remodeling factors and nuclear Argonaute.
Article
Biochemistry & Molecular Biology
Shaozheng Wang, Hejiang Guo, Jin Jia, Wen Zhang, Shanshan Gao, Hua Guan, Huan He, Pingkun Zhou
Summary: TAB182 is overexpressed in cancerous tissues and correlated with poor overall survival in lung cancer patients. It participates in DNA damage repair and endows tumour cells with radio- and chemoresistance. Its role in non-small cell lung cancer (NSCLC) remains unclear.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Shun Yao, Feifei Shi, Ning Mu, Xiaopeng Li, Guilin Ma, Yingying Wang, Xiaoyang Sun, Xiangguo Liu, Ling Su
Summary: AAMP, considered a pro-tumor protein, is upregulated in non-small cell lung carcinoma and promotes migration and invasion in NSCLC cells. It interacts with CDC42 to activate it, leading to the formation of cellular protrusions. AAMP enhances CDC42 activation by impairing the combination of ARHGAP1 and CDC42.
Article
Genetics & Heredity
Cigdem Donmez, Ece Konac
Summary: FOXD1 is highly expressed in prostate cancer and its silencing can suppress the proliferation, migration, and invasion of 22Rv1 cells through downregulation of the Wnt/β-catenin signaling pathway. The expression status of FOXD1 may serve as a new prognostic factor and potential therapeutic target in prostate cancer treatment.
Article
Biochemistry & Molecular Biology
Kikyo Watanabe, Masashi Ugaki
Summary: The study demonstrated that the replication-associated protein (Rep) and RepA encoded by Tobacco yellow dwarf virus (TYDV) have TGS suppressor activity, leading to decreased accumulation of 24-nt siRNAs, suggesting that Rep and RepA can block the steps before the loading of siRNAs into Argonaute (AGO) proteins. This is the first report of TGS suppressors in the genus Mastrevirus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Miriam Gross-Cohen, Sari Feld, Gil Arvatz, Neta Ilan, Israel Vlodavsky
Summary: Hpa2, a close homolog of heparanase, plays a role in a rare genetic disease called urofacial syndrome, indicating its importance in protein coding; despite lacking HS-degrading activity, it shows a high affinity to HS; experimental evidence shows that Hpa2 affects cell adhesion, migration, and colony morphology.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Akhmanova, Shamsi Emtenani, Daniel Krueger, Attila Gyoergy, Mariana Guarda, Mikhail Vlasov, Fedor Vlasov, Andrei Akopian, Aparna Ratheesh, Stefano De Renzis, Daria E. Siekhaus
Summary: This study reveals that cellular infiltration in densely packed tissues requires cell division and tissue dynamics regulation.
Article
Biotechnology & Applied Microbiology
Qi-Qi Zhan, Qian-Yu Liu, Xin Yang, Yu-Hui Ge, Lei Xu, Guan-Yi Ding, Shang Guo, Bing Zhu, Wei-Guo Xu
Summary: The silencing of neuropilin-2 (NRP-2) was found to significantly inhibit the proliferation, migration, and invasion abilities of colorectal cancer HT-29 cells.