Article
Oncology
Alexander C. Mertens, Marianne C. Kalff, Wietse J. Eshuis, Thomas M. Van Gulik, Mark I. Van Berge Henegouwen, Suzanne S. Gisbertz
Summary: In a propensity score-matched cohort, transthoracic esophagectomy showed a better lymph node dissection with higher yield, but also resulted in increased morbidity and short-term mortality.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Jinzhi You, Hailing Zhang, Wei Li, Ninghuang Dai, Bo Lu, Zhonghua Ji, Huaiqian Zhuang, Zhongfeng Zheng
Summary: A comparison study of intrathoracic anastomosis and cervical anastomosis in esophagectomy showed that the intrathoracic anastomosis group had a lower risk of anastomotic leak and recurrent laryngeal nerve injury.
Article
Cardiac & Cardiovascular Systems
Ehsan Soltani, Habibollah Mahmoodzadeh, Azadeh Jabbari Nooghabi, Mehdi Jabbari Nooghabi, Khosrow Ravankhah Moghaddam, Ehsan Hassanzadeh Haddad
Summary: This study compared the post-operative complications and outcomes of transthoracic esophagectomy (TTE) and transhiatal esophagectomy (THE) in patients with esophageal cancer. The study found that the two groups had similar characteristics and rates of complications, but the THE group had a lower operative mortality.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
Chengcheng Christine Zhang, Lukas Liesenfeld, Rosa Klotz, Ronald Koschny, Christian Rupp, Thomas Schmidt, Markus K. Diener, Beat P. Mueller-Stich, Thilo Hackert, Peter Sauer, Markus W. Buechler, Anja Schaible
Summary: The study found that endoscopic vacuum therapy is a safe and effective treatment for intrathoracic anastomotic leakage following abdomino-thoracic esophageal resections, offering a high closure rate and potential to lower mortality rates related to leakage.
BMC GASTROENTEROLOGY
(2021)
Article
Surgery
Robert Cubas, Robert Andres, Shravan Chintalapani, Estefania Roldan, Andrea Marcadis, Valerie Wu Chao Ying, Robert Bowles, Jose Martinez
Summary: The study reviewed one surgeon's experience with esophageal dilations after transhiatal esophagectomy, showing that early aggressive endoscopic management of esophageal anastomotic strictures after THE can be safely performed.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Nihanth Palivela, Bryan M. Burt
Summary: Neurogenic thoracic outlet syndrome (TOS) is a musculoskeletal condition characterized by compression of the brachial plexus in the scalene triangle. Traditional surgical approaches to first rib resection and scalenectomy have limitations, but a novel transthoracic robotic approach shows promising outcomes with improved safety and decreased morbidity.
Article
Surgery
Noel E. Donlon, Anitha Kammili, Ryan Roopnarinesingh, Maria Davern, Robert Power, Sinead King, Jakub Chmelo, Alexander W. Phillips, Claire L. Donohoe, Narayanasamy Ravi, Maeve Lowery, Carmen L. Mueller, Jonathan Cools-Lartigue, Lorenzo E. Ferri, John Reynolds
Summary: The study explored the outcomes of FLOT and TIE treatment for gastric, junctional, and esophageal adenocarcinoma, finding significant toxicities and varied pathological responses post-surgery, but an overall survival rate of 60%.
Editorial Material
Cardiac & Cardiovascular Systems
Velda L. Y. Chow, Valerie W. Y. Ho, Ian Y. H. Wong, Fion S. Y. Chan, Simon Y. K. Law, Jimmy Y. W. Chan
Summary: This study introduced an anterior transcervical transtracheal approach for resecting smooth muscle tumors in the cervical esophagus, aiming to avoid risks of injuries and improve surgical outcomes.
ANNALS OF THORACIC SURGERY
(2021)
Review
Surgery
Qi-Yue Ge, Yu-Heng Wu, Zhuang-Zhuang Cong, Yong Qiang, Yan-Qing Wang, Chao Zheng, Yi Shen
Summary: This study compared the clinical outcomes of intrathoracic anastomosis (IA) and cervical anastomosis (CA) for the treatment of esophageal cancer. The results showed that IA had a lower incidence of anastomotic leakage and a lower 90-day mortality rate compared to CA. However, the reliability of the results may be limited by significant heterogeneity and publication bias, and more high-quality studies are needed to confirm these findings.
Article
Gastroenterology & Hepatology
C. G. S. Huscher, F. Cobellis, G. Lazzarin
Summary: This study investigated the feasibility, clinical utility, and safety of intrathoracic robotic-sewn esophageal anastomosis (IrEA) during Ivor Lewis esophagectomy for adenocarcinoma and type I tumors at the gastro-esophageal junction. The results showed that IrEA was associated with better surgical outcomes and comparable oncological outcomes compared to the current standard of care, highlighting the need for further validation and implementation in clinical practice.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Frans van Workum, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan A. W. Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Suzanne S. Gisbertz, Gerjon Hannink, Jan Willem Haveman, Joos Heisterkamp, Walther Jansen, Ewout A. Kouwenhoven, Jan J. B. van Lanschot, Grard A. P. Nieuwenhuijzen, Donald L. van der Peet, Fatih Polat, Sander Ubels, Bas P. L. Wijnhoven, Maroeska M. Rovers, Camiel Rosman
Summary: In this randomized clinical trial, intrathoracic anastomosis resulted in better outcomes for patients undergoing transthoracic MIE for midesophageal to distal esophageal or gastroesophageal junction cancer.
Article
Gastroenterology & Hepatology
Kelly R. Haisley, Walaa F. Abdelmoaty, Christy M. Dunst
Summary: This study reviewed the modern experience with laparoscopic transhiatal esophagectomy for distal esophageal adenocarcinoma in 82 patients. The success rate of the surgery was high, with an overall 5-year survival rate of 52%, although postoperative complications were common. Most patients were clinical stage III, and 68.3% received neoadjuvant chemoradiation.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Oncology
Anas Dabsha, Ismail A. M. H. Elkharbotly, Mohammad Yaghmour, Amr Badr, Fady Badie, Sherif Khairallah, Yomna M. Esmail, Shon Shmushkevich, Mohamed Hossny, Amr Rizk, Amgad Ishak, Jessica Wright, Abdelrahman Mohamed, Mohamed Rahouma
Summary: Minimally invasive surgery is a growing field that has replaced many open surgical techniques. Mediastinoscope-assisted esophagectomy is a promising technique that aims to decrease the surgical burden and enhance recovery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
E. Jezerskyte, L. M. Saadeh, E. R. C. Hagens, M. A. G. Sprangers, L. Noteboom, H. W. M. van Laarhoven, W. J. Eshuis, M. C. C. M. Hulshof, M. I. van Berge Henegouwen, S. S. Gisbertz
Summary: The study found that long-term health-related quality of life (HR-QoL) in disease-free patients following transthoracic esophagectomy (TTE) or transhiatal esophagectomy (THE) for distal esophageal or GEJ cancer is largely comparable, with any differences favoring TTE.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park
Summary: Intersphincteric resection (ISR) for low-lying rectal cancer aims to avoid abdominoperineal resection (APR). This study compared open and minimally invasive ISR, finding similar 5-year disease-free survival rates. Minimally invasive ISR showed advantages in postoperative outcomes like reduced surgical site infection and shorter hospital stay.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Ralf-Dieter Hilgers, Martin Manolov, Nicole Heussen, William F. Rosenberger
STATISTICAL METHODS IN MEDICAL RESEARCH
(2020)
Article
Urology & Nephrology
Thomas Rauen, Stephanie Wied, Christina Fitzner, Frank Eitner, Claudia Sommerer, Martin Zeier, Britta Otte, Ulf Panzer, Klemens Budde, Urs Benck, Peter R. Mertens, Uwe Kuhlmann, Oliver Witzke, Oliver Gross, Volker Vielhauer, Johannes F. E. Mann, Ralf-Dieter Hilgers, Juergen Floege
KIDNEY INTERNATIONAL
(2020)
Article
Urology & Nephrology
David Paul Lennartz, Claudia Seikrit, Stephanie Wied, Christina Fitzner, Frank Eitner, Ralf-Dieter Hilgers, Thomas Rauen, Juergen Floege
JOURNAL OF NEPHROLOGY
(2020)
Article
Clinical Neurology
Andreas Traschutz, Andrea Cortese, Selina Reich, Natalia Dominik, Jennifer Faber, Heike Jacobi, Annette M. Hartmann, Dan Rujescu, Solveig Montaut, Andoni Echaniz-Laguna, Sevda Erer, Valerie Cornelia Schutz, Alexander A. Tarnutzer, Marc Sturm, Tobias B. Haack, Nadege Vaucamps-Diedhiou, Helene Puccio, Ludger Schols, Thomas Klockgether, Bart P. van de Warrenburg, Martin Paucar, Dagmar Timmann, Ralf-Dieter Hilgers, Jose Gazulla, Michael Strupp, German Moris, Alessandro Filla, Henry Houlden, Mathieu Anheim, Jon Infante, A. Nazli Basak, Matthis Synofzik
Summary: The study found that RFC1 disease is common across different populations, with CANVAS and ACC as highly diagnostic features, but the phenotype is variable and overlapping, spanning a spectrum of multisystem diseases. Treatment trials require a large number of patients to detect reduced progression.
Article
Clinical Neurology
Kathrin Reetz, Imis Dogan, Ralf-Dieter Hilgers, Paola Giunti, Michael H. Parkinson, Caterina Mariotti, Lorenzo Nanetti, Alexandra Durr, Claire Ewenczyk, Sylvia Boesch, Wolfgang Nachbauer, Thomas Klopstock, Claudia Stendel, Francisco Javier Rodriguez de Rivera Garrido, Christian Rummey, Ludger Schoels, Stefanie N. Hayer, Thomas Klockgether, Ilaria Giordano, Claire Didszun, Myriam Rai, Massimo Pandolfo, Jorg B. Schulz
Summary: The EFACTS study aimed to assess progression characteristics and identify patient groups with differential progression rates in Friedreich's ataxia using 4-year longitudinal data. Results showed significant differences in disease progression based on age of onset and ambulatory abilities.
Article
Health Care Sciences & Services
Vance W. Berger, Louis Joseph Bour, Kerstine Carter, Jonathan J. Chipman, Colin C. Everett, Nicole Heussen, Catherine Hewitt, Ralf-Dieter Hilgers, Yuqun Abigail Luo, Jone Renteria, Yevgen Ryeznik, Oleksandr Sverdlov, Diane Uschner
Summary: Restricted randomization procedures play a crucial role in clinical trials by promoting balance between treatment groups and enhancing the validity of statistical tests. This paper provides a systematic roadmap for selecting and applying these procedures, including exploration of statistical properties and considerations for when common model assumptions are violated. Randomization-based tests are highlighted as robust and valid alternatives to likelihood-based tests, with covariate-adjusted analysis recommended for ensuring validity of results, especially in cases with small sample sizes.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Gastroenterology & Hepatology
Peter Ott, Aftab Ala, Frederick K. Askari, Anna Czlonkowska, Ralf-Dieter Hilgers, Aurelia Poujois, Eve A. Roberts, Thomas Damgaard Sandahl, Karl Heinz Weiss, Peter Ferenci, Michael L. Schilsky
Summary: Improving the design and standardization of clinical trials for Wilson's disease is essential for better treatment comparisons and reducing the number of patients needed per trial in the future.
Article
Engineering, Biomedical
Vamsi Lavu, Norbert Gutknecht, Amrutha Vasudevan, S. K. Balaji, Ralf-Dieter Hilgers, Rene Franzen
Summary: This study aimed to investigate the efficacy of adjunctive photobiomodulation in improving outcomes following the use of laterally closed tunnel technique for isolated gingival recession. The results showed that photobiomodulation did not have a significant impact on recession depth, but appeared to accelerate wound healing and improve patient comfort. Further evaluation is needed to assess the long-term effects and overcome the limitations in sample size.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Mathematical & Computational Biology
Marcia Viviane Rueckbeil, Martin Manolov, Ralf-Dieter Hilgers
Summary: The susceptibility of a clinical trial to allocation bias is related to the randomization procedure used to allocate patients to treatments. Choice of a suitable randomization procedure is crucial in trial design. Weighted versions of the log-rank test and combination tests have been suggested to increase statistical power when proportional hazards assumption is not fulfilled.
STATISTICS IN BIOPHARMACEUTICAL RESEARCH
(2023)
Article
Oncology
Tristan Roemer, Sabrina Franzen, Hanna Kravets, Ahmed Farrag, Anna Makowska, Hans Christiansen, Michael J. Eble, Beate Timmermann, Gundula Staatz, Felix M. Mottaghy, Martina Buehrlen, Ulrich Hagenah, Alexander Puzik, Pablo Hernaiz Driever, Jeanette Greiner, Norbert Jorch, Stephan Tippelt, Dominik T. Schneider, Gabriele Kropshofer, Tobias R. Overbeck, Holger Christiansen, Triantafyllia Brozou, Gabriele Escherich, Martina Becker, Waltraud Friesenbichler, Tobias Feuchtinger, Wolfram Puppe, Nicole Heussen, Ralf D. Hilgers, Udo Kontny
Summary: The study shows that multimodal treatment is highly effective in children and young adults with nasopharyngeal carcinoma. High survival rates are maintained after extended follow-up and in a larger cohort, and reducing radiation doses may reduce treatment-related late effects.
Article
Urology & Nephrology
Turgay Saritas, Sebastian Reinartz, Thilo Krueger, Markus Ketteler, Orfeas Liangos, Laura Labriola, Peter Stenvinkel, Christoph Kopp, Ralf Westenfeld, Pieter Evenepoel, Robert Siepmann, Stephanie Wied, Ralf-Dieter Hilgers, Leon Schurgers, Juergen Floege
Summary: Vitamin K1 intervention is a safe, potent, and cost-effective approach to reduce cardiovascular calcification in chronic dialysis patients.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Surgery
Andreas Kroh, Markus Zufacher, Roman Eickhoff, Daniel Heise, Marius Helmedag, Florian Ulmer, Ulf P. Neumann, Joachim Conze, Ralf-Dieter Hilgers, Marcel Binneboesel
Summary: This study compared the effectiveness of two different pore sizes of polypropylene meshes in retromuscular incisional hernia repair. The results showed no significant differences in foreign body sensation, recurrence rate, and other side effects between the two meshes within 24 months postoperatively.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Riman Nasher, Ralf-Dieter Hilgers, Norbert Gutknecht
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2020)
Article
Surgery
Darya Alhaidary, Rene Franzen, Ralf-Dieter Hilgers, Norbert Gutknecht
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2019)
Meeting Abstract
Medicine, General & Internal
Thomas Rauen, Stephanie Wied Supsup, Christina Fitzner, Frank Eitner, Claudia Sommerer, Martin Zeier, Britta Otte, Ulf Panzer, Klemens Budde, Urs Benck, Peter R. Mertens, Uwe Kuhlmann, Oliver Witzke, Oliver Gross, Volker Vielhauer, Johannes Mann, Ralf-Dieter Hilgers, Juergen Floege