Review
Oncology
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Summary: Several adjuvant treatments have been evaluated for preventing HCC recurrence after curative liver resection, with antiviral therapy and postoperative adjuvant transarterial chemoembolization showing promising results. However, further large-scale randomized controlled trials are needed to confirm their efficacy in different patient populations.
FRONTIERS OF MEDICINE
(2021)
Review
Oncology
Stepan M. Esagian, Christos D. Kakos, Emmanouil Giorgakis, Lyle Burdine, J. Camilo Barreto, Michail N. Mavros
Summary: The role of postoperative TACE after liver resection for HCC is still unclear, with existing evidence suggesting potential benefits but limited to Eastern Asian populations. High-quality randomized clinical trials are needed to confirm the oncologic benefits and applicability of adjuvant TACE.
Article
Chemistry, Multidisciplinary
Wei Zhao, Jiabin Xu, Yuanyuan You, Zhenhu Guo, Yun Xiang, Kenan Hao, Xiaofeng He, Peng Zhao
Summary: Transarterial chemoembolization (TACE) is a common treatment used for hepatocellular carcinoma (HCC), but the instability of emulsified chemotherapy drugs in iodinated oil often results in serious systemic cytotoxicity. In this study, a composite hydrogel Epi/Etpoil@MC/XG was developed by stably distributing ethiodized poppyseed oil (Etpoil) and epirubicin (Epi) in a blend hydrogel of methylcellulose (MC) and xanthan gum (XG). Due to its adjustable thermo-responsive and injectable properties, Epi/Etpoil@MC/XG has been successfully applied in embolization of the feeding artery in a VX2 tumor model.
CHEMICAL COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Ming-Feng Li, Huei-Lung Liang, Chia-Ling Chiang, Wei-Lun Tsai, Wen-Chi Chen, Cheng-Chung Tsai, I-Shu Chen
Summary: The new HAIC regimen is effective in treating Vp4 HCC patients, but additional sorafenib use does not provide any survival benefit.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Instruments & Instrumentation
Frederic Deschamps, Lambros Tselikas, Masako Tasaki, Shinji Motoyama, Thomas Isoardo, Michel Ducreux, Dragica Paunovic, Laurence Moine, Thierry de Baere
Summary: Utilizing sustained-HAI of oxaliplatin improves drug exposure in liver tumor compared to HAI, leading to a higher therapeutic index.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Oncology
Qiao Ke, Lei Wang, Weimin Wu, Xinhui Huang, Ling Li, Jingfeng Liu, Wuhua Guo
Summary: Postoperative adjuvant hepatic artery infusion chemotherapy (HAIC) can improve the long-term prognosis of hepatocellular carcinoma (HCC) patients, especially those with microvascular or macrovascular invasion. Patients would benefit from SR+HAIC regardless of chemotherapy regimens and courses, and further validation is needed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xuqi Peng, Yating Zheng, Yi Xue, Xiaoliu Liang, Pan He, Hu Chen, Peng He, Yisheng Peng, Zhenwen Zhao, Yulun Chen, Xiran Gui, Lei Yang, Yongfu Xiong, Juan Lin, Yesi Shi, Chengchao Chu, Yang Zhang, Gang Liu
Summary: Transcatheter arterial ionic-embolization (TAIE) is a promising approach that disrupts intracellular ionic balance to inhibit tumor activity and invasion in treating hepatocellular carcinoma (HCC). The super-stable homogeneous embolic formulation lipiodol-sodium chloride (LSC) selectively deposits in HCC lesions and disrupts the cell's ionic balance, causing cell death without drug resistance. LSC treatment significantly hinders tumor cell migration and invasion by inducing cell swelling and remodeling the cytoskeleton.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, General & Internal
Hamzah Adwan, Lars Hammann, Thomas J. Vogl
Summary: This study evaluated the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial surgical resection. The results showed that MWA treatment is effective and safe for recurrent HCC lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Yanyan Ye, Ying Wang, Haoqian Xu, Fengming Yi
Summary: This study conducted a network meta-analysis to compare the efficacy of different treatments for preventing recurrence and prolonging survival in hepatocellular carcinoma patients. The results showed that transarterial chemoembolization (TACE) + portal vein chemotherapy (PVC) and internal radiotherapy (IRT) were effective in reducing recurrence rate, while TACE, IRT, and dendritic cell (DC) treatments showed benefits in extending the patients' survival time.
BMC GASTROENTEROLOGY
(2023)
Article
Clinical Neurology
William C. Chen, Matthieu Lafreniere, Christina Phuong, S. John Liu, Joe D. Baal, Michael Lometti, Olivier Morin, Benjamin Ziemer, Harish N. Vasudevan, Calixto-Hope G. Lucas, Shawn L. Hervey-Jumper, Philip Theodosopoulos, Stephen T. Magill, Shannon Fogh, Jean L. Nakamura, Lauren Boreta, Penny K. Sneed, Michael W. McDermott, David R. Raleigh, Steve E. Braunstein
Summary: The study examined the safety and efficacy of salvage intracranial cesium-131 brachytherapy with resection of recurrent brain tumors. The results showed that the treatment achieved good local control with acceptable rates of complications in heavily pretreated patients.
JOURNAL OF NEUROSURGERY
(2022)
Review
Oncology
Bin Guo, Qian Chen, Zhicheng Liu, Xiaoping Chen, Peng Zhu
Summary: Curative surgical treatments, such as liver resection, are still optimal options for hepatocellular carcinoma patients. However, the high recurrence rate within 5 years after surgery, especially in high-risk patients who experience early recurrence, calls for effective adjuvant therapy. Adjuvant transarterial chemoembolization, antiviral treatment, and traditional Chinese medicine have shown potential in preventing recurrence, but standardized postoperative management protocols are lacking.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Chao An, Mengxuan Zuo, Wang Li, Qifeng Chen, Peihong Wu
Summary: This study compared the effectiveness of hepatic arterial infusion chemotherapy (HAIC) and transarterial chemoembolization (TACE) in patients with infiltrative hepatocellular carcinoma (HCC) and found that HAIC significantly improved overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR) compared to TACE. A nomogram model including various factors showed good predictive accuracy and outperformed other staging systems and conventional indices.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shao-Hua Li, Jie Mei, Yuan Cheng, Qiang Li, Qiao-Xuan Wang, Chong-Kai Fang, Qiu-Cheng Lei, Hua-Kun Huang, Ming-Rong Cao, Rui Luo, Jing-Duo Deng, Yu-Chuan Jiang, Rong-Ce Zhao, Liang-He Lu, Jing-Wen Zou, Min Deng, Wen-Ping Lin, Ren-Guo Guan, Yu-Hua Wen, Ji-Bin Li, Lie Zheng, Zhi-Xing Guo, Yi-Hong Ling, Huan-Wei Chen, Chong Zhong, Wei Wei, Rong-Ping Guo
Summary: This study investigated the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) with 5-fluorouracil and oxaliplatin (FOLFOX) in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). The results showed that HAIC significantly improved disease-free survival (DFS) and had acceptable toxicities compared to routine follow-up.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Surgery
Dexiang Zhu, Jianguo Xia, Yan Gu, Jianjiang Lin, Kefeng Ding, Bo Zhou, Fei Liang, Tianshu Liu, Chunzhi Qin, Ye Wei, Li Ren, Yunshi Zhong, Jianhua Wang, Zhiping Yan, Jiemin Cheng, Jingwen Chen, Wenju Chang, Shaokang Zhan, Yongbin Ding, Haizhong Huo, Fanlong Liu, Junhui Sun, Xinyu Qin, Jianmin Xu
Summary: The study demonstrated that the addition of preoperative hepatic and regional arterial chemotherapy (PHRAC) could improve disease-free survival (DFS), reduce the incidence of liver metastasis (LM), and enhance overall survival (OS) in patients with stage II and III colorectal cancer (CRC). Furthermore, it did not increase treatment-related morbidity or mortality, indicating that PHRAC is a safe and effective treatment option for these patients.
Article
Oncology
Lingbo Hu, Yu Zheng, Jiangyin Lin, Xingpeng Shi, Aidong Wang
Summary: This meta-analysis showed that postoperative adjuvant hepatic artery infusion chemotherapy (HAIC) is beneficial to HCC patients with portal vein invasion (PVI) and microvascular invasion (MVI). However, it remains uncertain whether HAIC can improve the survival outcome in all HCC patients after hepatic resection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, Valerie Chew
Summary: The study reveals significant immune intratumoural heterogeneity in hepatocellular carcinomas, which is closely associated with tumor evolution and poor clinical outcomes. Tumors with high immune heterogeneity demonstrate an immune suppressive microenvironment, indicating a complex interplay between tumor and immune system during disease progression.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Daniel Q. Huang, Mark D. Muthiah, Lei Zhou, Halisah Jumat, Wan Xin Tan, Guan Huei Lee, Seng Gee Lim, Alfred Kow, Glenn Bonney, Iyer Shridhar, Yi Ting Lim, Aileen Wee, Yin Huei Pang, Gwyneth Soon, Pierce Chow, Yock Young Dan
Summary: This study introduces a novel mouse cirrhotic model of xenotransplant that better predicts treatment response in HCC and allows for personalized therapy. The cirrhotic PDX model accurately predicts response to multikinase inhibitors, serving as an effective tool for drug testing.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Yvette Chong, Ye-Xin Koh, Jin-Yao Teo, Peng-Chung Cheow, Pierce K. Chow, Alexander Y. Chung, Chung-Yip Chan, Brian K. P. Goh
Summary: The study found that patients with previous non-liver-related abdominal surgery undergoing MILR did not have inferior outcomes compared to patients without previous abdominal surgery. Measures of operative difficulty and complication rates were comparable between the two groups and subgroups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Yun Le Linn, Yuxin Guo, Ye-Xin Koh, Pierce K. H. Chow, Chung-Yip Chan, Alexander Y. F. Chung, London L. P. J. Ooi, Brian K. P. Goh
Summary: This study retrospectively reviewed 25 patients who underwent metastasectomy for intraabdominal EHM from 2003 to 2016. The findings showed that hepatitis B positivity and high tumor grade were significant preoperative predictors of futile surgery. All 7 patients who had both hepatitis B and high tumor grade experienced early recurrence post-metastasectomy.
WORLD JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Justine Jia Wen Seow, Rhea Pai, Archita Mishra, Edwin Shepherdson, Tony Kiat Hon Lim, Brian K. P. Goh, Jerry K. Y. Chan, Pierce K. H. Chow, Florent Ginhoux, Ramanuj DasGupta, Ankur Sharma
Summary: The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 has been reported globally, with patients showing respiratory symptoms and liver comorbidities. A study found that a specific liver cell type, TROP2(+) liver progenitors, may be significantly impacted by viral ingress, affecting liver regeneration, particularly in cirrhotic patients.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
George Lau, Ming-Lung Yu, Grace Wong, Alexander Thompson, Hasmik Ghazinian, Jin-Lin Hou, Teerha Piratvisuth, Ji-Dong Jia, Masashi Mizokami, Gregory Cheng, Guo-Feng Chen, Zhen-Wen Liu, Oidov Baatarkhuu, Ann Lii Cheng, Woon Leung Ng, Patrick Lau, Tony Mok, Jer-Ming Chang, Saeed Hamid, A. Kadir Dokmeci, Rino A. Gani, Diana A. Payawal, Pierce Chow, Joong-Won Park, Simone Strasser, Rosmawaiti Mohamed, Khin Maung Win, Tanwandee Tawesak, Shiv Kumar Sarin, Masao Omata
Summary: The clinical practice guidelines aim to assist clinicians in effectively preventing and managing hepatitis B reactivation related to the use of immunosuppressive therapy. Recommendations include screening all patients for hepatitis B before starting immunosuppressive therapy and administering pre-emptive nucleos(t)ide analogues to those at substantial risk of hepatitis-induced acute-on-chronic liver failure.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Immunology
Yang Cheng, Bavani Gunasegaran, Harsimran D. Singh, Charles-Antoine Dutertre, Chiew Yee Loh, Jia Qi Lim, Jeremy Chase Crawford, Hong Kai Lee, Xiaomeng Zhang, Bernett Lee, Etienne Becht, Wan Jun Lim, Joe Yeong, Chung Yip Chan, Alexander Chung, Brian K. P. Goh, Pierce K. H. Chow, Jerry K. Y. Chan, Florent Ginhoux, David Tai, Jinmiao Chen, Seng Gee Lim, Weiwei Zhai, Su Pin Choo, Evan W. Newell
Summary: The study revealed that hepatocellular carcinoma patients have multiple antigen-specific T cells, with HBV-specific CD8(+) Trm cells potentially playing a crucial role in tumor control. These non-terminally exhausted cells exhibit characteristics of active involvement and effective antitumor response.
Article
Immunology
Kevin Mulder, Amit Ashok Patel, Wan Ting Kong, Cecile Piot, Evelyn Halitzki, Garett Dunsmore, Shabnam Khalilnezhad, Sergio Erdal Irac, Agathe Dubuisson, Marion Chevrier, Xiao Meng Zhang, John Kit Chung Tam, Tony Kiat Hon Lim, Regina Men Men Wong, Rhea Pai, Ahmed Ibrahim Samir Khalil, Pierce Kah Hoe Chow, Suny Z. Wu, Ghamdan Al-Eryani, Daniel Roden, Alexander Swarbrick, Jerry Kok Yen Chan, Salvatore Albani, Lisa Derosa, Laurence Zitvogel, Ankur Sharma, Jinmiao Chen, Aymeric Silvin, Antonio Bertoletti, Camille Bleriot, Charles-Antoine Dutertre, Florent Ginhoux
Summary: This study integrated a large number of mononuclear phagocytes from 13 tissues to generate a MNP single-cell RNA compendium, revealing conserved gene signatures and specialized cell subsets across multiple tissues. Specific macrophage populations were found to be expanded in cancer and inflammation, with tumor-associated macrophage populations present in all neoplastic tissues.
Article
Oncology
Brian K. P. Goh, Nicholas Syn, Ye-Xin Koh, Jin-Yao Teo, Peng-Chung Cheow, Prema R. Jeyaraj, Pierce K. H. Chow, London L. P. J. Ooi, Alexander Y. F. Chung, Chung-Yip Chan
Summary: MILR is associated with superior short-term postoperative outcomes compared to OLR, with no significant difference in overall survival and recurrence-free survival. In terms of long-term oncological outcomes, MILR is at least equivalent to OLR for HCC.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sang-Yun Lee, Yvonne Teng, Miseol Son, Bosung Ku, Hyun Ju Hwang, Vinay Tergaonkar, Pierce Kah-Hoe Chow, Dong Woo Lee, Do-Hyun Nam
Summary: The ASM creates large single spheroids by aggregating cells in Matrigel attached to the surface of 96-pillar plates, addressing the lack of cell-to-cell interaction issue in traditional 3D cell cultures. In drug screening assays, the ASM demonstrated higher drug resistance and greater expression of cancer markers associated with proliferation, tight junction formation, and epithelial cell identity compared to CSM and 2D cell culture model. The ASM also exhibited limited drug penetration in tissues in vivo, providing more instructive data for in vitro drug screening assays of tumor cells and improved prediction of efficacious drugs in HCC patients.
Article
Oncology
Brian K. P. Goh, Darren W. Chua, Ye-Xin Koh, Ek-Khoon Tan, Juinn-Huar Kam, Jin-Yao Teo, Peng-Chung Cheow, Prema Raj Jeyaraj, Pierce K. H. Chow, Chung-Yip Chan, Alexander Y. F. Chung, London L. P. J. Ooi
Summary: A retrospective study of 1300 patients who underwent partial hepatectomy for hepatocellular carcinoma in the 21st century showed that there were significant changes in patient demographics, surgical procedures, and outcomes over time, leading to improved postoperative mortality and long-term survival.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Oncology
Jian Han, Thomas Thurnherr, Alexander Y. F. Chung, Brian K. P. Goh, Pierce K. H. Chow, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Tony K. H. Lim, Samuel S. Chong, London L. P. J. Ooi, Caroline G. Lee
Summary: This study presents a novel strategy to identify key circRNA signatures in clinically relevant networks, which modulate the prognosis of HCC patients. Through integration with miRNA profiles, ceRNA networks were constructed. Five master circRNAs were identified, with circGPC3 playing a significant role in cell-cycle regulation and cell transformation. These circRNAs have potential as prognostic biomarkers for HCC patients, with circGPC3 showing promise as a non-invasive prognostic biomarker for early HCC. The identified deregulated key circRNAs play important roles in HCC and may be targeted for better prognosis.
Article
Multidisciplinary Sciences
Weiwei Zhai, Hannah Lai, Neslihan Arife Kaya, Jianbin Chen, Hechuan Yang, Bingxin Lu, Jia Qi Lim, Siming Ma, Sin Chi Chew, Khi Pin Chua, Jacob Josiah Santiago Alvarez, Pauline Jieqi Chen, Mei Mei Chang, Lingyan Wu, Brian K. P. Goh, Alexander Yaw-Fui Chung, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Juinn Huar Kam, Alfred Wei-Chieh Kow, Iyer Shridhar Ganpathi, Rawisak Chanwat, Jidapa Thammasiri, Boon Koon Yoong, Diana Bee-Lan Ong, Vanessa H. de Villa, Rouchelle D. Dela Cruz, Tracy Jiezhen Loh, Wei Keat Wan, Zeng Zeng, Anders Jacobsen Skanderup, Yin Huei Pang, Krishnakumar Madhavan, Tony Kiat-Hon Lim, Glenn Bonney, Wei Qiang Leow, Valerie Chew, Yock Young Dan, Wai Leong Tam, Han Chong Toh, Roger Sik-Yin Foo, Pierce Kah-Hoe Chow
Summary: This study investigated intra-tumor heterogeneity in hepatocellular carcinoma (HCC) using a large prospective surgical cohort. The results showed that phenotypic heterogeneity had a different trajectory across stages and diversified rapidly in some patients. Interestingly, phenotypic heterogeneity was found to be more informative in predicting patient survival than genomic heterogeneity, highlighting the importance of studying phenotypic evolution in cancer types.
NATIONAL SCIENCE REVIEW
(2022)
Article
Oncology
Kennedy Yao Yi Ng, Edwin Wei Xiang Chow, Bochao Jiang, Cindy Lim, Brian Kim Poh Goh, Ser Yee Lee, Jin Yao Teo, Damien Meng Yew Tan, Peng Chung Cheow, London Lucien Peng Jin Ooi, Pierce Kah Hoe Chow, Joycelyn Jie Xin Lee, Juinn Huar Kam, Ye Xin Koh, Prema Raj Jeyaraj, Ek Khoon Tan, Su Pin Choo, Chung Yip Chan, Alexander Yaw Fui Chung, David Tai
Summary: The study retrospectively analyzed the clinical outcomes of 165 Asian patients with resected pancreatic adenocarcinoma, showing that patients receiving adjuvant chemotherapy had comparable survival to reported Western randomized trials. Lymph node ratio and perineural invasion status were identified as prognostic factors affecting survival.
Article
Oncology
Lee Jin Lim, Lay Hiang Ling, Yu Pei Neo, Alexander Y. F. Chung, Brian K. P. Goh, Pierce K. H. Chow, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Tony K. H. Lim, Samuel S. Chong, London L. P. J. Ooi, Caroline G. Lee
Summary: This study introduces a novel strategy to identify deregulated IncRNAs in HCC patients associated with clinical characteristics impacting prognosis. Experimental manipulation of LOC101926913 revealed its potential as an onco-IncRNA affecting cell functions. These findings suggest LOC may serve as a therapeutic target modulating prognosis in HCC patients.