Article
Surgery
Marianna Maspero, Camillo Leonardo Bertoglio, Lorenzo Morini, Bruno Alampi, Michele Mazzola, Valerio Girardi, Andrea Zironda, Gisella Barone, Carmelo Magistro, Giovanni Ferrari
Summary: A study of 322 obese patients undergoing laparoscopic ventral hernia repair found that class III obesity was associated with a longer hospital stay, but showed no significant differences in postoperative complications and long-term outcomes compared to class I and II obesity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Rachel Whittaker, Zachary Lewis, Margaret A. Plymale, Michael Nisiewicz, Ajadi Ebunoluwa, Daniel L. Davenport, Jessica K. Reynolds, John Scott Roth
Summary: This study evaluated the outcomes of emergent ventral hernia repair with and without mesh. It found that repairs without mesh were associated with a higher hernia recurrence rate, but no difference in the risk of infectious complications was observed. Efforts to understand the rationale for suture-based repair compared to mesh repair are needed to reduce hernia recurrences in the emergent population.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Mariana Toffolo Pasquini, Pablo Medina, Ramiro Arrechea Antelo, Roberto Cerutti, Eduardo Agustin Porto, Daniel Enrique Pirchi
Summary: This study analyzed the long-term recurrence rate and compared the IPOM and IPOM plus techniques for laparoscopic ventral hernia repair (LVHR). The results showed that the IPOM plus technique had a higher cut-off point for ring size and a lower recurrence risk. These findings have implications for expanding the indication for LVHR and selecting the appropriate surgical technique.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Fabio Cesare Campanile, Mauro Podda, Francesca Pecchini, Marco Inama, Sarah Molfino, Marco Augusto Bonino, Monica Ortenzi, Gianfranco Silecchia, Ferdinando Agresta, Michela Cinquini
Summary: The Italian Society for Endoscopic Surgery (SICE) developed new guidelines on laparoscopic treatment of ventral hernias, which were accepted by the government agency and published on the SNLG website. The guidelines are based on extensive literature review and the rigorous GRADE method. However, they have limitations due to the rapidly evolving nature of the topic and their focus on minimally invasive techniques.
UPDATES IN SURGERY
(2023)
Article
Surgery
Jason Joe Baker, Stina Oberg, Jacob Rosenberg
Summary: This study aimed to compare the reoperation rate for recurrence in laparoscopic ventral hernia repair using different mesh types. The nationwide cohort study analyzed data from the Danish Ventral Hernia Database. The results showed that Physiomesh and Proceed Surgical Mesh had a significantly higher risk of reoperation for recurrence in primary hernias; for incisional hernias, Physiomesh, Parietex Composite, Ventralex Hernia Patch, and Proceed Surgical Mesh all had a significantly higher risk compared with Ventralight ST Mesh.
Article
Surgery
Mette W. Christoffersen, Lars N. Jorgensen, Kristian K. Jensen
Summary: This study compared the outcomes of patients with small- to medium-sized ventral hernia who underwent robotic-assisted laparoscopic transabdominal repair with retrorectus mesh placement (rRetrorectus) or laparoscopic intraperitoneal onlay mesh repair (IPOM). The results showed that rRetrorectus was associated with a lower postoperative need for TAP block or epidural analgesia and a shorter length of stay compared to IPOM.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Melissa LaPinska, Kyle Kleppe, Lars Webb, Thomas G. Stewart, Molly Olson
Summary: The study compared outcomes of robotic-assisted ventral hernia repair (RVHR) and laparoscopic ventral hernia repair (LVHR) procedures without myofascial release, showing generally comparable results between the two approaches.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, General & Internal
Chirag Pereira, Rakesh Rai
Summary: LVHR has advantages over open hernia repair in terms of longer operative time, less postoperative pain, shorter hospital stay, and faster return to normal activity.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Surgery
Naila H. H. Dhanani, Nicole B. B. Lyons, Oscar A. A. Olavarria, Karla Bernardi, Julie L. L. Holihan, Shinil K. K. Shah, Todd D. D. Wilson, Michele M. M. Loor, Lillian S. S. Kao, Mike K. K. Liang
Summary: This study reports the 2-year outcomes of a multicenter randomized controlled trial comparing robotic and laparoscopic ventral hernia repair. The results suggest that robotic repair may offer similar or improved outcomes compared to laparoscopy at the 2-year follow-up.
Article
Surgery
Alexandra Hernandez, Rebecca Petersen
Summary: In recent years, there has been a significant growth in the surgical management of abdominal wall hernias, with advances in minimally invasive techniques leading to improved success rates and reduced complications. The objectives of hernia repair remain the same, with a focus on symptom relief and preventing recurrence. Minimally invasive approaches offer advantages such as decreased wound complications and faster recovery, but there is currently no superior procedure for ventral hernia repair. Patient characteristics, hernia type, defect size, surgeon experience, and technical aspects play important roles in decision-making for optimal approach. Other factors such as socioeconomics, perioperative nutrition and conditioning, anatomic characteristics, closure techniques, and implications for surrounding organs also contribute to the optimization of abdominal wall surgery. Aligning patient and surgeon goals and expectations before surgery can improve patient satisfaction. Attention to these details will enhance patient outcomes and ongoing research will continue to optimize treatment strategies and outcomes.
SURGICAL CLINICS OF NORTH AMERICA
(2023)
Article
Surgery
Philippe Ngo, Jean-Pierre Cossa, Sylvie Gueroult, Edouard Pelissier
Summary: According to EHS guidelines, mesh repair is recommended for concomitant diastasis recti (DR) and ventral hernia more than 1 cm. A bilayer suture technique is effective for hernias up to 3 cm, but may result in flawed skin appearance. Patients generally rated the operation results as excellent or good.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Per Lindstrom, Goran Rietz, Asa Hallqvist Everhov, Gabriel Sandblom
Summary: Robot-assisted laparoscopic ventral hernia repair is shown to be feasible and safe in the present study. There were no postoperative infections and no recurrences at 1 year. At the 30-day follow-up, 75% of patients rated their pain as zero or easily ignored, and after 1 year no one had pain that was not easily ignored. More randomized controlled trials are needed to assess the potential benefits of shorter operation times, earlier discharge, and less postoperative pain associated with the robot technique.
FRONTIERS IN SURGERY
(2021)
Article
Surgery
C. K. Gentle, J. D. Thomas, K. C. Montelione, C. Tu, A. S. Prabhu, D. M. Krpata, L. R. Beffa, S. Rosenblatt, M. J. Rosen, E. Lo Menzo, D. Alaedeen, S. Szomstein, C. G. Massier, C. C. Petro
Summary: Most patients use fewer opioid tablets than prescribed after laparoscopic inguinal hernia repair (LIHR). Requests for additional opioid supply are rare and associated with higher initial opioid prescribing.
Article
Surgery
Nicholas Bell-Allen, Kate Swift, Nis-Julius Sontag, Nicholas O'Rourke
Summary: This study reports a hybrid technique for the repair of medium to large-sized ventral hernias, combining laparoscopic and open techniques. It provides an alternative method for the management of medium-sized ventral hernias.
ANZ JOURNAL OF SURGERY
(2022)
Article
Surgery
Barbara Perez-Kohler, Selma Benito-Martinez, Francisca Garcia-Moreno, Marta Rodriguez, Gemma Pascual, Juan Manuel Bellon
Summary: The study investigated the use of cyanoacrylate tissue adhesive to improve mesh behavior at fixation zones. Results showed that cyanoacrylate prevented bacterial adhesion, reducing infections and optimizing the efficacy of antibacterial meshes compared to those fixed with sutures.
Article
Biochemical Research Methods
Stephanie C. Hicks, Ruoxi Liu, Yuwei Ni, Elizabeth Purdom, Davide Risso
Summary: Single-cell RNA-Sequencing (scRNA-seq) is a widely used technology for measuring gene expression at the single-cell level, with analyses often detecting distinct cell subpopulations through clustering algorithms. The development of the mbkmeans package offers a solution for handling large datasets without requiring full data loading into memory. This package provides efficient computation and performance comparisons with other clustering methods.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Pediatrics
Seyed A. Arshad, Gabrielle E. Hatton, Dalya M. Fergusona, Linda T. Li, Mary T. Austin, KuoJen Tsao
Summary: In children undergoing minimally invasive repair of pectus excavatum, cryoanalgesia is associated with a reduction in length of stay without an increase in operative time or complication rates. This suggests that cryoanalgesia may be a promising adjunct for enhancing recovery strategies in pediatric patients undergoing MIRPE.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Linda T. Li, Nutan B. Hebballi, Eric W. Reynolds, Seyed A. Arshad, Gabrielle E. Hatton, Dalya M. Ferguson, Mary T. Austin, Kevin P. Lally, Kuojen Tsao
Summary: This study retrospectively reviewed the opioid utilization in 30 neonates with gastroschisis and found significant variations primarily prior to fascial closure. Multivariate regression analysis showed that the type of surgery was associated with opioid use after adjusting for weight, gestational age, and gender, with p = 0.02.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Editorial Material
Biochemical Research Methods
Benjamin J. Heil, Michael M. Hoffman, Florian Markowetz, Su-In Lee, Casey S. Greene, Stephanie C. Hicks
Summary: By adhering to standards based on data, model and code publication, programming best practices and workflow automation, researchers in the life sciences can enhance the computational reproducibility of machine-learning analyses and ensure their trustworthiness.
Article
Biochemical Research Methods
Ariel A. Hippen, Matias M. Falco, Lukas M. Weber, Erdogan Pekcan Erkan, Kaiyang Zhang, Jennifer Anne Doherty, Anna Vaharautio, Casey S. Greene, Stephanie C. Hicks
Summary: The miQC package was developed to predict low-quality cells in a given scRNA-seq dataset by jointly modeling the proportion of reads mapping to mitochondrial DNA (mtDNA) genes and the number of detected genes using mixture models in a probabilistic framework. The QC metric easily adapts to different types of single-cell datasets to remove low-quality cells while preserving high-quality cells for downstream analyses.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Biology
Lukas M. Weber, Ariel A. Hippen, Peter F. Hickey, Kristofer C. Berrett, Jason Gertz, Jennifer Anne Doherty, Casey S. Greene, Stephanie C. Hicks
Summary: The study evaluated the feasibility of using genetic demultiplexing tools in cancer tissue with a pooled experimental design, showing significant cost savings and performance effectiveness. However, caution should be taken regarding the impact of ambient RNA from cell debris.
Article
Medicine, General & Internal
Linda T. Li, Tongtong Huang, Elmer Bernstam, Xiaoqian Jiang
Summary: This study externally validated a machine learning algorithm for identifying unnecessary laboratory tests, demonstrating similar performance in a different institution. The model showed good accuracy in predicting abnormality and transitions, but performed poorly in predicting laboratory values in clinical applications.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Biochemical Research Methods
Dario Righelli, Lukas M. Weber, Helena L. Crowell, Brenda Pardo, Leonardo Collado-Torres, Shila Ghazanfar, Aaron T. L. Lun, Stephanie C. Hicks, Davide Risso
Summary: SpatialExperiment is a new data infrastructure for storing and accessing spatially-resolved transcriptomics data, implemented in the R/Bioconductor framework. It offers advantages such as modularity, interoperability, standardized operations, and comprehensive documentation. The project provides example datasets and visualization tools for users.
Article
Pediatrics
Seyed A. Arshad, Dalya M. Ferguson, Elisa Garcia, Nutan B. Hebballi, Linda T. Li, Mary T. Austin, Akemi L. Kawaguchi, Kevin P. Lally, KuoJen Tsao
Summary: Significant variability exists in opioid prescribing practices, knowledge, and beliefs among providers who care for pediatric surgical patients. Effective opioid stewardship requires comprehensive policies, pediatric specific guidelines, and education for all providers caring for children to align provider proficiency and optimize prescribing patterns.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Biochemical Research Methods
Yi Wang, Stephanie C. Hicks, Kasper D. Hansen
Summary: Estimates of correlation between genes in co-expression analysis are commonly used to construct gene networks. However, the distribution of these correlations depends on the observed expression level, resulting in a higher correlation for highly expressed genes. This relationship is not observed in protein-protein interaction data, indicating that it is not biologically relevant. To address this issue, we propose a method called spatial quantile normalization (SpQN) that normalizes local distributions in a correlation matrix, removing the mean-correlation relationship and correcting expression bias in network reconstruction.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Statistics & Probability
Lucy D'Agostino McGowan, Roger D. Peng, Stephanie C. Hicks
Summary: The data revolution has sparked interest in data analysis practices, and design thinking serves as a complementary form of thinking in the field. The choices made by data analysts and producers in constructing and designing data analyses can significantly impact the resulting products and consumer experience. This study introduces design principles for data analysis and explores their variations among producers, providing guidance for characterizing the data analytic process.
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS
(2023)
Article
Mathematical & Computational Biology
Albert Kuo, Kasper D. Hansen, Stephanie C. Hicks
Summary: In complex tissues, single-nucleus RNA-sequencing (snRNA-seq) is preferred over single-cell RNA-sequencing (scRNA-seq) to measure gene expression. We show that droplet-based snRNA-seq data follow a negative binomial distribution and that quantification choices in adapting scRNA-seq to snRNA-seq can impact downstream analyses. Additionally, we confirm the presence of a gene length bias in snRNA-seq data and explore potential causes for the bias.
Article
Neurosciences
Erik D. Nelson, Kristen R. Maynard, Kyndall R. Nicholas, Matthew N. Tran, Heena R. Divecha, Leonardo Collado-Torres, Stephanie C. Hicks, Keri Martinowich
Summary: This study used single-nucleus RNA sequencing to identify cell type-specific molecular signatures associated with induced activity in hippocampal neurons in a mouse model. The results provide valuable insights into the activity-regulated transcriptional responses in hippocampal neurons.
Article
Multidisciplinary Sciences
Lukas M. Weber, Arkajyoti Saha, Abhirup Datta, Kasper D. Hansen, Stephanie C. Hicks
Summary: nnSVG is a scalable approach based on nearest-neighbor Gaussian processes for identifying spatially variable genes. It can identify genes that show continuous variation in expression across the entire tissue or within specific spatial domains, and it scales linearly with the number of spatial locations. We demonstrate its performance using experimental data and simulations.
NATURE COMMUNICATIONS
(2023)
Article
Education, Scientific Disciplines
Roger D. Peng, Athena Chen, Eric Bridgeford, Jeffrey T. Leek, Stephanie C. Hicks
Summary: This article discusses the importance of teaching data analysis skills by using real-world problems and datasets, and the challenges and methods students face in diagnosing data analytic problems.
JOURNAL OF STATISTICS AND DATA SCIENCE EDUCATION
(2021)
