Article
Oncology
C. Villard, M. Habib, C. Nordenvall, P. J. Nilsson, C. Jorns, E. Sparrelid
Summary: Conversion therapy can offer a survival benefit in selected patients, but the majority of patients still cannot undergo liver resection treatment.
Article
Gastroenterology & Hepatology
Alexander M. Fagenson, Elizabeth M. Gleeson, Fatima Nabi, Kwan N. Lau, Henry A. Pitt
Summary: The study found that patients undergoing partial hepatectomy or with metastatic disease had increased postoperative complications when a Pringle Maneuver was performed, along with a significant increase in operative time.
Review
Oncology
Lingbo Hu, Aidong Wang, Yingli Qiao, Xiandan Huang
Summary: Intermittent Pringle maneuver (IPM) is effective in controlling blood loss during liver resection and does not affect the long-term survival of patients with hepatocellular carcinoma (HCC).
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Piotr Krawczyk, Marcin Morawski, Maciej Krasnodebski, Damian Sienko, Michal Grat, Philipp Kron, Peter Lodge
Summary: The study aimed to investigate the impact of the Pringle maneuver (PM) on patient outcomes during major liver resections. Results showed that the use of PM was associated with significantly improved 5-year overall survival compared to no PM, particularly in the subgroup of patients at intermediate risk of recurrence.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Meredith C. Mason, Maciej Krasnodebski, Caitlin A. Hester, Anai N. Kothari, Caeli Barker, Yujiro Nishioka, Yi-Ju Chiang, Timothy E. Newhook, Ching-Wei D. Tzeng, Yun Shin Chun, Jean-Nicolas Vauthey, Hop S. Tran Cao
Summary: In patients with colorectal liver metastases, mixed pathologic response is possible in multiple metastases. Patients with mixed response have higher survival rates compared to other pathologic responses, suggesting that the greatest response achieved in any metastasis is the best predictor of survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Colin S. Wood, Kathryn A. F. Pennel, Holly Leslie, Assya Legrini, Andrew J. Cameron, Lydia Melissourgou-Syka, Jean A. Quinn, Hester C. van Wyk, Jennifer Hay, Antonia K. Roseweir, Colin Nixon, Campbell S. D. Roxburgh, Donald C. McMillan, Andrew V. Biankin, Owen J. Sansom, Paul G. Horgan, Joanne Edwards, Colin W. Steele, Nigel B. Jamieson
Summary: Strong immune responses in primary colorectal cancer are associated with better patient survival. However, identifying patients with good prognosis after surgery for colorectal cancer liver metastases remains challenging. This study aims to determine the practical application of immune cell infiltration and stromal content in predicting outcome and investigate the underlying functional biology.
Article
Oncology
Koichiro Yoshino, Hiroki Osumi, Hiromichi Ito, Daisaku Kamiimabeppu, Akira Ooki, Takeru Wakatsuki, Keitaro Shimozaki, Izuma Nakayama, Mariko Ogura, Daisuke Takahari, Keisho Chin, Atsushi Oba, Yoshihiro Ono, Takafumi Sato, Yosuke Inoue, Yu Takahashi, Kensei Yamaguchi, Eiji Shinozaki
Summary: Postoperative and post-adjuvant chemotherapy CEA levels > 5 ng/ml may serve as predictors of recurrence-free survival (RFS) and overall survival (OS) in patients with colorectal cancer and liver metastasis (CLM).
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Svein Dueland, Tor M. Smedman, Bard Rosok, Harald Grut, Trygve Syversveen, Lars H. Jorgensen, Pal-Dag Line
Summary: Liver transplantation in selected colorectal cancer patients with nonresectable liver-only metastases can result in a 5-year overall survival of up to about 70-100%. However, the majority will experience disease recurrence. Nine out of the 44 patients had no evidence of disease at the end of follow-up, with a median overall survival of 8.4 years. Systematic long-term follow-up should be conducted for these patients due to the high incidence of recurrent disease.
TRANSPLANT INTERNATIONAL
(2021)
Article
Oncology
M. S. Schuurman, M. A. G. Elferink, C. Verhoef, I. H. J. T. de Hingh, V. E. P. P. Lemmens
Summary: In the treatment of elderly patients with synchronous peritoneal metastases colorectal cancer, the number of patients receiving treatment decreases with age, the postoperative mortality decreases in different age groups, but the overall survival rate remains stable.
Article
Oncology
Sven Jacob, Florian Boesch, Markus B. Schoenberg, Elise Pretzsch, Christopher Lampert, Ren Haoyu, Bernhard W. Renz, Marlies Michl, Jorg Kumbrink, Thomas Kirchner, Jens Werner, Martin K. Angele, Jens Neumann
Summary: This study identified CIB1 as significantly overexpressed in CRC leading to liver metastases compared to M0 and PER. The findings suggest that CIB1 may play a crucial role in hematogenous spread to the liver but not for peritoneal carcinomatosis. Consequently, CIB1 seems to be a promising prognostic marker and a potential tool for future targeted therapies as well as early diagnostics and follow-up.
Article
Oncology
Christina Villard, Ahmed Abdelrafee, Miriam Habib, Nelson Ndegwa, Carl Jorns, Ernesto Sparrelid, Marc-Antoine Allard
Summary: This study aimed to construct a predictive model for overall survival (OS) in patients with colorectal liver metastases (CRLM) and to identify factors that significantly impact patients' survival. The model was validated using patient data from Sweden and France. The findings provide a valuable tool for predicting individualized survival and facilitating treatment recommendations for all CRLM patients.
Article
Oncology
Michelle. R. de Graaff, Joost M. Klaase, Ronald M. van Dam, Koert F. D. Kuhlmann, Geert Kazemier, Rutger-Jan Swijnenburg, Arthur K. E. Elfrink, Cees Verhoef, J. Sven Mieog, Peter B. van den Boezem, Paul Gobardhan, Arjen M. Rijken, Daan J. Lips, Wouter G. K. Leclercq, Hendrik A. Marsman, Peter van Duijvendijk, Joost A. B. van der Hoeven, Marteb Vermas, Marcel den Dulk, Dirk J. Grunhagen, Niels F. M. Kok
Summary: The effectiveness of preoperative chemotherapy in patients with colorectal liver metastases remains controversial. This study found that preoperative chemotherapy does not provide an overall survival benefit compared to surgery alone in patients eligible for surgical resection.
Article
Gastroenterology & Hepatology
Hassaan Bari, Umasankar M. Thiyagarajan, Rachel Brown, Keith J. Roberts, Nikolaos Chatzizacharias, Ravi Marudanayagam, Paolo Muiesan, John Isaac, Darius F. Mirza, Robert P. Sutcliffe, Bobby V. M. Dasari
Summary: The study evaluated the correlation between margin status on the specimen side and patient side in colorectal liver metastases patients. The poor correlation between Rs and Rp suggests that tumor biology may be more relevant than margin status in predicting local recurrence rates in multifocal CRLM patients.
Editorial Material
Oncology
Kazunari Sasaki, Luis I. Ruffolo, Michelle H. Kim, Masato Fujiki, Koji Hashimoto, Yuki Imaoka, Marc L. Melcher, Federico N. Aucejo, Koji Tomiyama, Roberto Hernandez-Alejandro
Summary: This study summarizes the characteristics and outcomes of liver transplantation for nonresectable colorectal liver metastases (CRLM) in 46 patients. It suggests a growing interest in high-volume U.S. transplant centers for this indication.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Sven H. Loosen, Christoph Roderburg, Patrick H. Alizai, Anjali A. Roeth, Sophia M. Schmitz, Mihael Vucur, Mark Luedde, David Schoeler, Pia Paffenholz, Frank Tacke, Christian Trautwein, Tom Luedde, Ulf P. Neumann, Tom F. Ulmer
Summary: Surgical tumor resection is potentially curative for patients with resectable colorectal liver metastases, but disease recurrence is common. Elevated levels of CEA, CA19-9, and CRP are associated with unfavorable prognosis after CRLM resection, with CEA being an independent prognostic marker.
Article
Surgery
Nadia Russolillo, Alessandro Borello, Serena Langella, Michele Casella, Roberto Lo Tesoriere, Alessandro Ferrero
Summary: The study showed that preoperative MRI in CRLMs patients undergoing LLR can predict liver metastases, while LUS can additionally detect new nodules, helping adjust surgical strategy and improve accuracy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Critical Care Medicine
Jacopo Guerrini, Daniela Zugna, Dario Poretti, Laura Sama, Guido Costa, Simona Mei, Martina Ceolin, Alan Biloslavo, Mauro Zago, Luca Vigano, Hayato Kurihara
Summary: This study aimed to build a predictive model based on CT data to discriminate between ASBO caused by single adhesive bands or matted adhesions. Findings suggest that the presence of complete obstruction and fat notch sign can increase the odds of single band ASBO, with the predictive model achieving 86% accuracy in predicting single band ASBO.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Oncology
Antonella Leonetti, Guglielmo Puglisi, Marco Rossi, Luca Vigano, Marco Conti Nibali, Lorenzo Gay, Tommaso Sciortino, Henrietta Howells, Luca Fornia, Marco Riva, Gabriella Cerri, Lorenzo Bello
Summary: The prevalence of Mood Disorders (MD) and decline in Health Related Quality of Life (HRQoL) in glioma patients may be associated with tumor features or treatment-related symptoms. Factors associated with MD and low HRQoL vary in lower-grade gliomas (LGGs) and higher-grade gliomas (HGGs) over the course of the disease.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Luca Vigano, Jacopo Galvanin, Dario Poretti, Daniele Del Fabbro, Damiano Gentile, Vittorio Pedicini, Luigi Solbiati, Guido Torzilli
Summary: Ablation without chemotherapy for early liver-only recurrence proves to be a reliable approach that minimizes invasiveness, shows good effectiveness, and has high salvageability in case of local treatment failure.
UPDATES IN SURGERY
(2021)
Article
Oncology
Felice Giuliante, Luca Vigano, Agostino M. De Rose, Darius F. Mirza, Real Lapointe, Gernot Kaiser, Eduardo Barroso, Alessandro Ferrero, Helena Isoniemi, Santiago Lopez-Ben, Irinel Popescu, Jean-Francois Ouellet, Catherine Hubert, Jean-Marc Regimbeau, Jen-Kou Lin, Oleg G. Skipenko, Francesco Ardito, Rene Adam
Summary: In patients with synchronous CRLM, the liver-first approach should be considered for those with multiple bilobar metastases, as it has been associated with longer survival compared to alternative approaches. The surgical strategy should be tailored based on the hepatic tumor burden.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Felice Giuliante, Luca Vigano, Agostino M. De Rose, Rene Adam
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Luca Vigano, Damiano Gentile, Jacopo Galvanin, Pio Corleone, Guido Costa, Matteo Cimino, Fabio Procopio, Guido Torzilli
Summary: Approximately 12% of patients undergoing aggressive surgery for colorectal liver metastases experience very early recurrence, especially those with numerous metastases or extrahepatic disease. Patients with very early recurrence have a very poor prognosis, similar to that of unresected patients, with a low chance of effective repeated treatment.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Marco Rossi, Luca Vigano, Gugliemo Puglisi, Marco Conti Nibali, Antonella Leonetti, Lorenzo Gay, Tommaso Sciortino, Luca Fornia, Vincenzo Callipo, Marta Lamperti, Marco Riva, Gabriella Cerri, Lorenzo Bello
Summary: The study highlights the novel technique for on-line identification of two functional components in the Primary-Motor-Cortex (M1) during tumor resection, showing the potential plasticity reorganization of M1 and its impact on tumor resection and patient motor performance. By detecting and targeting these components, complete tumor removal rate can be increased while maintaining motor function, suggesting M1 plasticity potentials.
Article
Oncology
Guido Costa, Lara Cavinato, Chiara Masci, Francesco Fiz, Martina Sollini, Letterio Salvatore Politi, Arturo Chiti, Luca Balzarini, Alessio Aghemo, Luca di Tommaso, Francesca Ieva, Guido Torzilli, Luca Vigano
Summary: The study demonstrated that radiomic analysis of liver parenchyma combined with clinical and laboratory data improves the non-invasive diagnosis of chemotherapy-related liver injuries. Radiomic features independently predicted sinusoidal dilatation (SinDil), nodular regenerative hyperplasia (NRH), and non-alcoholic steatohepatitis (NASH), with high accuracy, sensitivity, and specificity. The radiomic analysis may provide a signature that enhances the diagnosis of CALI when combined with clinical and laboratory data.
Article
Medicine, General & Internal
Francesco Fiz, Guido Costa, Nicolo Gennaro, Ludovico la Bella, Alexandra Boichuk, Martina Sollini, Letterio S. Politi, Luca Balzarini, Guido Torzilli, Arturo Chiti, Luca Vigano
Summary: The study found that contrast enhancement can impact the radiomic textural features of colorectal liver metastases and peritumoral tissue, but has minimal effect on the liver parenchyma. Different volumes of interest show varying changes in textural features before and after contrast administration, indicating a gradient distribution.
Article
Surgery
Luca Vigano, Jacopo Galvanin, Matteo Cimino, Guido Torzilli
Summary: The hooking technique is an advanced adjunctive maneuver for laparoscopic liver surgery, ensuring the safety of the procedure and successful tumor resection with negative margins. Despite being technically challenging, this technique is crucial for advancing the standardization of parenchyma-sparing liver surgery and minimally invasive approaches.
UPDATES IN SURGERY
(2022)
Review
Medicine, General & Internal
Francesco Fiz, Visala S. Jayakody Arachchige, Matteo Gionso, Ilaria Pecorella, Apoorva Selvam, Dakota Russell Wheeler, Martina Sollini, Luca Vigano
Summary: Radiomics plays an important role in the management of biliary tumors, providing prediction of pathology data, survival, and differential diagnosis. Texture features can accurately differentiate different types of biliary tumors. Predictive/prognostic models combining radiomic and clinical data outperform standard clinical models. However, further studies are needed for implementation in clinical practice.
Article
Gastroenterology & Hepatology
Roberto Lo Tesoriere, Fabio Forchino, Mariasole Fracasso, Nadia Russolillo, Serena Langella, Alessandro Ferrero
Summary: This study demonstrates the feasibility of using CD-IOUS in laparoscopic liver resections for tumors involving the hepatic veins. The evaluation of the veno-occlusive area with CD-IOUS can increase the success rate of parenchyma-sparing surgery.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Medicine, General & Internal
Luca Vigano, Egesta Lopci, Luca Di Tommaso, Annarita Destro, Alessio Aghemo, Lorenza Rimassa, Luigi Solbiati, Arturo Chiti, Guido Torzilli, Francesco Fiz
Summary: Intra-tumoural heterogeneity is a major factor affecting the response to therapy and outcomes in intrahepatic cholangiocarcinoma (ICC). This study proposed an innovative technique that combines preoperative PET-CT and intraoperative ultrasonography to assess the functional tumour heterogeneity of ICC. The results suggest that PET-CT can guide biopsy to sample the most informative areas of ICC and potentially provide a non-invasive evaluation of intra-tumoural heterogeneity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Francesco Fiz, Noemi Rossi, Serena Langella, Andrea Ruzzenente, Matteo Serenari, Francesco Ardito, Alessandro Cucchetti, Teresa Gallo, Giulia Zamboni, Cristina Mosconi, Luca Boldrini, Mariateresa Mirarchi, Stefano Cirillo, Mario De Bellis, Ilaria Pecorella, Nadia Russolillo, Martina Borzi, Giulio Vara, Caterina Mele, Giorgio Ercolani, Felice Giuliante, Matteo Ravaioli, Alfredo Guglielmi, Alessandro Ferrero, Martina Sollini, Arturo Chiti, Guido Torzilli, Francesca Ieva, Luca Vigano
Summary: This multicenter study demonstrates that radiomic data extracted from preoperative computed tomography scans have a strong association with tumor grading and microscopic vascular invasion in patients with intrahepatic cholangiocarcinoma. The combination of radiomic and clinical data improves the accuracy of prediction, marking a step towards precision medicine in intrahepatic cholangiocarcinoma patients.
