Article
Medicine, General & Internal
Eugenia Claudia Zarnescu, Narcis Octavian Zarnescu, Radu Costea
Summary: Anastomotic leakage is a severe complication following colorectal surgery, with multiple risk factors identified. There are both nonmodifiable and modifiable risk factors associated with this complication. Different preoperative and postoperative approaches may not necessarily reduce the occurrence of anastomotic leakage.
Article
Surgery
Daitlin E. Huisman, Muriel Reudink, Stefanus J. van Rooijen, Boukje T. Bootsma, Tim van de Brug, Jurre Stens, Wim Bleeker, Laurents P. S. Stassen, Audrey Jongen, Carlo Feo, Simone Targa, Niels Komen, Hidde M. Kroon, Tarik Sammour, Emmanuel A. G. L. Lagae, Aalbert K. Talsma, Johannes A. Wegdam, Tammo S. de Vries Reilingh, Bob van Wely, Marie J. van Hoogstraten, Dirk J. A. Sonneveld, Sanne C. Veltkamp, Emiel G. G. Verdaasdonk, Rudi M. H. Roumen, Gerrit D. Slooter, Freek Daams
Summary: This study aimed to assess the impact of potentially modifiable perioperative risk factors on anastomotic leakage in adult patients undergoing colorectal surgery.
Article
Oncology
Liliana Mereu, Francesca Dalpra, Valeria Berlanda, Riccardo Pertile, Daniela Coser, Basilio Pecorino, Maria Gabriella D'Agate, Francesco Ciarleglio, Alberto Brolese, Saverio Tateo
Summary: This study evaluated the incidence, risk factors, and utility of drainage and stoma in patients undergoing intestinal surgery for ovarian cancer. The results showed that rectosigmoid resection for ovarian cancer is a standardized procedure with comparable results for anastomotic leakage (AL), and risk factors for AL are discretely homogeneous. The use of stomas and/or drains, however, was not standardized according to the literature. Therefore, further exploration is needed to verify the preventive role of protective stoma and/or intra-abdominal drains in selected and standardized situations.
Article
Oncology
Zhongyuan He, Hongda Liu, Ling Zhou, Qingya Li, Linjun Wang, Diancai Zhang, Hao Xu, Zekuan Xu
Summary: This study aimed to explore the risk factors and efficacy of conservative treatment for Anastomotic leakage (AL) after gastrectomy in patients with gastric cancer. The results showed that low albumin concentration, diabetes, laparoscopic method, total gastrectomy, and proximal gastrectomy were predicting factors for AL. Conservative treatment was relatively safe and effective for AL management.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Felice Borghi, Marco Migliore, Desiree Cianflocca, Giacomo Ruffo, Alberto Patriti, Paolo Delrio, Marco Scatizzi, Stefano Mancini, Gianluca Garulli, Andrea Lucchi, Alessandro Carrara, Felice Pirozzi, Stefano Scabini, Andrea Liverani, Gianluca Baiocchi, Roberto Campagnacci, Andrea Muratore, Graziano Longo, Marco Caricato, Raffaele Macarone Palmieri, Nereo Vettoretto, Paolo Ciano, Michele Benedetti, Elisa Bertocchi, Marcello Ceccaroni, Ugo Pace, Lorenzo Pandolfini, Andrea Sagnotta, Basilio Pirrera, Vincenzo Alagna, Giacomo Martorelli, Giuseppe Tirone, Michele Motter, Antonio Sciuto, Antonio Martino, Andrea Scarinci, Sarah Molfino, Angela Maurizi, Patrizia Marsanic, Federico Tomassini, Simone Santoni, Gabriella Teresa Capolupo, Pietro Amodio, Elisa Arici, Simone Cicconi, Irene Marziali, Gianluca Guercioni, Marco Catarci
Summary: Anastomotic leakage after elective colorectal surgery can lead to higher mortality and/or unplanned ICU admission rates, and affect length of stay, persistent stoma rate, and return to intended oncologic therapy rate.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Oncology
Yongqing Zhao, Bo Li, Yao Sun, Qi Liu, Qian Cao, Tao Li, Jiannan Li
Summary: Anastomotic leak is a detrimental complication after colorectal surgery and its prevention and treatment still face challenges. This review discusses the identified risk factors for anastomotic leak and proposes preventive measures related to patients, surgery, and gut microbiota. The manipulation of gut microbiota and advancements in laboratory examinations and blood perfusion assessment methods may offer new strategies in preventing and treating anastomotic leak.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Surgery
Jae-Woo Ju, Ho-Jin Lee, Min Jung Kim, Seung-Bum Ryoo, Won Ho Kim, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park
Summary: This study aimed to investigate the association between early postoperative NSAID use and anastomotic leakage (AL) in patients who underwent colorectal cancer surgery. The findings showed a significant association between early postoperative NSAID use and AL.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Christos Tsalikidis, Athanasia Mitsala, Vasileios I. Mentonis, Konstantinos Romanidis, George Pappas-Gogos, Alexandra K. Tsaroucha, Michail Pitiakoudis
Summary: This study aims to identify specific preoperative, intraoperative and perioperative factors that lead to anastomotic leakage (AL) following colorectal cancer surgery, and investigate the role of biomarkers in predicting AL.
Article
Surgery
Thomas W. A. Koedam, Boukje T. Bootsma, Charlotte L. Deijen, Tim van de Brug, Geert Kazemier, Miguel A. Cuesta, Alois Furst, Antonio M. Lacy, Eva Haglind, Jurriaan B. Tuynman, Freek Daams, Hendrik J. Bonjer
Summary: Anastomotic leakage after rectal cancer surgery negatively affects long-term oncological outcomes, leading to increased local recurrences and decreased disease-free survival. However, its impact on outcomes after colon cancer surgery remains inconclusive.
Article
Surgery
Xiumin Liu, Yuting Tang, Zhiming Li, Jie Tan, Jixiang Zheng, Mingyuan Feng, Jinliang Wan, Shijie Wang, Kemao Qiu, Hongli Ji, Jun Yan
Summary: The study evaluated anastomotic microcirculation in different perfusion models using CLE, finding that poor perfusion led to reduced capillaries, lower blood cell flow, and more severe intestinal adhesion and ischemia, with a higher incidence of anastomotic leakage and abdominal infection. This suggests that CLE is a feasible technique for real-time imaging and intraoperative evaluation in various anastomotic perfusion situations, laying the groundwork for future in vivo research in humans.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Oncology
Maria Michela Chiarello, Pietro Fransvea, Maria Cariati, Neill James Adams, Valentina Bianchi, Giuseppe Brisinda
Summary: Anastomotic leakage is a feared complication in colorectal surgery for oncological disease, with significant impact on surgery outcome and prognosis. Early predictors like C-reactive protein and procalcitonin, along with abdominal-pelvic computed tomography scan for diagnosis are commonly used. Individualized management is recommended based on patient's condition and anastomotic defect size, with non-operative treatment preferred for patients with proximal faecal diversion at the initial operation.
SURGICAL ONCOLOGY-OXFORD
(2022)
Article
Oncology
Tim Michael Feenstra, Charlotte Julia Verberne, Niels F. M. Kok, Arend Geert Johan Aalbers
Summary: The study investigates anastomotic leakage after colorectal surgery and the effects of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) after Cytoreductive Surgery (CRS). Assessing the risk factors in these patients can aid surgeons in making perioperative decisions.
Article
Gastroenterology & Hepatology
Melissa N. N. Arron, Nynke G. Greijdanus, Richard P. G. ten Broek, Jan Willem T. Dekker, Frans van Workum, Harry van Goor, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: This study compared and analyzed the changes in the incidence, risk factors, and mortality of anastomotic leakage (AL) after colon cancer and rectal cancer surgery over the past nine years. There was a decrease in AL incidence after colon cancer surgery but an increase after rectal cancer surgery. Risk factors for AL also changed over time, with rectal cancer surgery having a lower mortality rate compared to colon cancer surgery.
COLORECTAL DISEASE
(2021)
Letter
Gastroenterology & Hepatology
Maria Michela Chiarello, Valentina Bianchi, Pietro Fransvea, Giuseppe Brisinda
Summary: Anastomotic leakage is a serious complication with varying treatment options depending on the patient's symptoms and timing of the leak. There is a recent trend towards more conservative management, considering surgery as a last resort.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Simran Grewal, J. Reinder D. Reuvers, Gabor S. A. Abis, Rene H. J. Otten, Geert Kazemier, Hein B. A. C. Stockmann, Marjolein van Egmond, Steven J. Oosterling
Summary: Prophylactic oral antibiotics combined with mechanical bowel preparation can reduce the rates of surgical-site infection and anastomotic leakage in patients undergoing elective colorectal carcinoma surgery, with selective decontamination of the digestive tract showing greater effectiveness in reducing anastomotic leakage compared to broad-spectrum antibiotics.
Letter
Surgery
Yi Xie, Ishith Seth, David J. Hunter-Smith, Warren M. Rozen, Richard J. Ross, Mathew Lee
AESTHETIC PLASTIC SURGERY
(2023)
Article
Surgery
Yi Xie, Ishith Seth, David J. Hunter-Smith, Warren M. Rozen, Richard Ross, Matthew Lee
Summary: This observational study evaluates the performance of ChatGPT in rhinoplasty consultations. The results show that it can provide coherent and easily understandable answers, emphasizing the importance of individualized approach. However, it has limitations in providing detailed or personalized advice.
AESTHETIC PLASTIC SURGERY
(2023)
Letter
Surgery
Ishith Seth, Yi Xie, Warren M. Rozen
AESTHETIC PLASTIC SURGERY
(2023)
Article
Orthopedics
Ishith Seth, Bryan Lim, Yi Xie, David J. Hunter-Smith, Warren M. Rozen
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2023)
Article
Surgery
Alisha Fong, Hye-Sung Park, David A. Ross, Warren M. Rozen
Summary: This study compared patients undergoing breast reconstruction with pedicled TRAM flaps with and without preoperative CTA. The results showed no significant difference in operative times or outcomes between the two groups, but preoperative CTA can guide surgical technique and provide greater confidence intraoperatively.
Article
Surgery
Ishith Seth, Peter Sinkjaer Kenney, Gabriella Bulloch, David J. Hunter-Smith, Jorn Bo Thomsen, Warren M. Rozen
Summary: ChatGPT is an open AI chat box that has the potential to revolutionize academia and enhance research writing. This study evaluated ChatGPT's contributions to an article on base of thumb arthritis, finding that while the information provided was accurate, it lacked depth and analytical ability. Furthermore, ChatGPT failed to provide relevant references, highlighting the need for caution when using it as an AI generator for medical publishing.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)
Letter
Surgery
Yi Xie, Ishith Seth, David J. Hunter-Smith, Marc A. Seifman, Warren M. Rozen
ANZ JOURNAL OF SURGERY
(2023)
Article
Surgery
Yi Xie, Ishith Seth, David J. Hunter-Smith, Warren M. Rozen, Marc A. Seifman
Summary: This study evaluated the effectiveness of three popular large language models (LLMs) as clinical decision-making support tools for junior doctors. ChatGPT showed superior readability and reliability, providing medical advice that aligned well with clinical guidelines. In summary, LLMs have the potential utility in fostering self-directed and personalized learning, as well as bolstering clinical decision-making support for junior doctors.
ANZ JOURNAL OF SURGERY
(2023)
Article
Dermatology
Aditya Sathe, Ishith Seth, Gabriella Bulloch, Yi Xie, David J. Hunter-Smith, Warren M. Rozen
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Review
Surgery
Ishith Seth, Gabriella Bulloch, Matthew Jennings, Nimish Seth, Dylan Gracias, David J. Hunter-Smith, Warren M. Rozen
Summary: This meta-analysis investigates the impact of chemotherapy on complication rates in breast reconstruction surgery (BRS). The results show that there is no significant association between chemotherapy and the overall complication rate. However, the rate of wound dehiscence is slightly higher in the neoadjuvant systemic therapy (NST) group compared to the BRS only group, while the rate of infection is lower in the NST group.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Medicine, General & Internal
Bryan Lim, Ishith Seth, Skyler Kah, Foti Sofiadellis, Richard J. Ross, Warren M. Rozen, Roberto Cuomo
Summary: Artificial intelligence, especially Generative Adversarial Networks, has the potential to transform medical and patient education, particularly in the field of cosmetic surgery. However, the generated images show bias in terms of gender, age, and skin tone, highlighting the importance of comprehensive representation and adherence to medical standards.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Ishith Seth, Gabriella Bulloch, Konrad Joseph, David J. Hunter-Smith, Warren Matthew Rozen
Summary: This narrative review explores the role of artificial intelligence (AI) in breast reconstruction and highlights its potential in improving surgical procedures and decision making. However, challenges related to data quality, privacy, and ethical considerations hinder the seamless integration of AI in the medical field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Jevan Cevik, Ishith Seth, David J. Hunter-Smith, Warren M. Rozen
Summary: Breast reconstruction is a crucial part of the treatment for breast cancer patients, and preoperative planning has played a vital role in assisting surgeons. Advancements in 3D imaging and the development of adjuncts have improved the accuracy of preoperative planning. The future holds immense promise, with the potential for artificial intelligence algorithms to automate and enhance the process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
Warren M. Rozen, Vachara Niumsawatt, Luke D. Gibson, Ishith Seth, David J. Hunter-Smith, Edmund W. Ek
Summary: This study aimed to quantify the level I lymph nodes of the neck and describe the regional anatomy. The results showed an average of 5.2 lymph nodes in the level I region, further subcategorized into IA and IB with averages of 3.7 and 4.7 lymph nodes, respectively. Current literature supports the effectiveness of vascularized lymph node transfer for lymphedema treatment.
Review
Surgery
Ojochonu D. Anthony, David J. Hunter-Smith, Warren M. Rozen
Summary: This review examines the utility and safety of scalp bone burring technique and finds limited evidence for its oncological efficacy. Further investigation is needed to evaluate its effectiveness and drawbacks. Comparisons to alternative methods and more detailed reporting of outcomes are recommended.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)