Article
Oncology
V. T. Hoek, S. Buettner, C. L. Sparreboom, R. Detering, A. G. Menon, G. J. Kleinrensink, M. W. J. M. Wouters, J. F. Lange, J. K. Wiggers
Summary: This study aimed to develop a robust preoperative prediction model for anastomotic leakage after surgical resection for rectal cancer. Significant risk factors were identified and included in the prediction model, which can be used for patient counselling and risk-stratification before undergoing rectal resection for cancer.
Article
Surgery
Zhao-liang Yu, Xuan-hui Liu, Hua-shan Liu, Jia Ke, Yi-feng Zou, Wu-teng Cao, Jian Xiao, Zhi-yang Zhou, Ping Lan, Xiao-jian Wu, Xian-rui Wu
Summary: The study evaluated the impact of pelvic dimensions on the risk of anastomotic leak in rectal cancer patients. The results showed that pelvic inlet and intertuberous distance were independent predictors for postoperative anastomotic leak. The incorporation of pelvic dimensions with other factors in the nomogram may provide a clinical tool for predicting anastomotic leak.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Kai Chen, Akio Shiomi, Hiroyasu Kagawa, Hitoshi Hino, Shoichi Manabe, Yusuke Yamaoka, Shunichiro Kato, Marie Hanaoka, Kentaro Saito, Chikara Maeda, Tadahiro Kojima, Ikuma Shioi, Kenji Nanishi, Yusuke Tanaka, Shunsuke Kasai
Summary: This study found that the use of robotic staplers in robotic low anterior resection is associated with a lower rate of anastomotic leakage, with manual staplers and anastomosis <4 cm from the anal verge identified as independent risk factors for symptomatic leakage.
Article
Surgery
E. Back, J. Haggstrom, K. Holmgren, M. M. Haapamaki, P. Matthiessen, J. Rutegard, M. Rutegard
Summary: Using preoperative data, the risk of permanent stoma after anterior resection for rectal cancer at 2 years can be predicted fairly accurately. Factors such as age, tumor metastasis, and preoperative treatment all play a role in influencing the stoma outcome.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui, Xiangqian Su
Summary: Prolonged duration of operation increased the risk of symptomatic AL after laparoscopic LAR for rectal cancer. No impact of symptomatic AL on long-term survival was observed in this study. Further studies are required for a conclusive result.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Jung Cheol Kuk, Dae Ro Lim, Eung Jin Shin
Summary: This study retrospectively analyzed data from 556 patients with rectal cancer and found that the placement of a transanal drainage tube (TDT) can reduce the occurrence of anastomotic leakage (AL) following low anterior resection (LAR). Logistic analysis identified the non-use of a TDT as a risk factor for AL.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Medicine, Research & Experimental
Xiang-nan Yu, Lu-ming Xu, Ya-wen Bin, Ye Yuan, Shao-bo Tian, Bo Cai, Kai-xiong Tao, Lin Wang, Guo-bin Wang, Zheng Wang
Summary: This study retrospectively analyzed data of rectal cancer patients undergoing anterior resection and found that being male and having T3-T4 stage were independent risk factors for anastomotic leakage (AL). Additionally, defunctioning stoma (DS) was found to reduce the occurrence of symptomatic AL.
CURRENT MEDICAL SCIENCE
(2022)
Article
Health Care Sciences & Services
Fei Tan, Kai Xu, Xinyu Qi, Pin Gao, Maoxing Liu, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui, Xiangqian Su
Summary: This study aimed to explore the role of postoperative neutrophil-to-lymphocyte ratio in predicting symptomatic anastomotic leakage in patients who underwent laparoscopic low anterior resection for rectal cancer. The study found that patients with symptomatic anastomotic leakage had significantly higher neutrophil-to-lymphocyte levels on postoperative day 5 compared to those without leakage. In conclusion, neutrophil-to-lymphocyte ratio can serve as a predictive biomarker for symptomatic anastomotic leakage, helping to increase the clinical suspicion of this complication.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Surgery
Kevin Talboom, Nynke G. Greijdanus, Cyriel Y. Ponsioen, Pieter J. Tanis, Wilhelmus A. Bemelman, Roel Hompes
Summary: Early initiation of EVASC for anastomotic leakage after rectal cancer resection yields high rates of healed and functional anastomosis. EVASC shows increasing success with the implementation of highly selective diversion and early diagnosis of the leak.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Henrik Jutesten, Pamela L. Buchwald, Eva Angenete, Martin Rutegard, Marie-Louise Lydrup
Summary: This retrospective observational cohort study found a significant association between anastomotic leakage and the occurrence of major low anterior resection syndrome.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Gastroenterology & Hepatology
Chenchen Guo, Zhiwen Fu, Xin Qing, Mengen Deng
Summary: The study aimed to evaluate the efficacy of transanal drainage tube (TDT) placement for preventing anastomotic leakage after low anterior resection for rectal cancer. The results showed that in randomized controlled trials, TDT was not associated with a significant difference in anastomotic leakage but increased the risk of anastomotic bleeding. In observational studies, TDT was significantly associated with a reduction in anastomotic leakage and no significant difference in anastomotic bleeding. Both types of studies demonstrated a comparable reduction in reoperation rate with TDT. These findings suggest that TDTs may not have superiority and highlight the differences between randomized controlled trials and observational data.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Frans van Workum, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Borja F. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo Oliva Perez, Tsuyoshi Konishi, Yves Panis, Camiel Rosman, Roel Hompes, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: This study aims to investigate the factors contributing to the severity of anastomotic leakage after low anterior resection for rectal cancer, create a severity score, and evaluate the effects of different treatment approaches on outcome parameters. The international multicentre retrospective cohort study, TENTACLE-Rectum, will provide valuable evidence-based recommendations for improving outcomes in patients with severe treatment-related morbidity.
COLORECTAL DISEASE
(2021)
Article
Surgery
Vladimir Bencurik, Matej Skrovina, Lubomir Martinek, Jiri Bartos, Maria Machackova, Michal Dosoudil, Erika Stepanova, Lenka Pribylova, Radim Bris, Katherine Vomackova
Summary: The study showed that using ICG to visualize tissue perfusion in low rectal resections for cancer can significantly reduce the incidence of AL. Diabetes and the application of a transanal drain (NoCoil) were identified as additional risk factors for AL.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Ruiqi Li, Jiajie Zhou, Shuai Zhao, Qiannan Sun, Daorong Wang
Summary: This study established a reliable model to predict the occurrence probability of anastomotic leakage after anterior resection for rectal cancer using retrospective data analysis.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Oncology
Rongbo Wen, Kuo Zheng, Qihang Zhang, Leqi Zhou, Qizhi Liu, Guanyu Yu, Xianhua Gao, Liqiang Hao, Zheng Lou, Wei Zhang
Summary: This study identified eight factors that may affect the incidence of anastomotic leakage (AL) after rectal cancer surgery. By creating a predictive random forest classifier based on these factors, the model demonstrated satisfactory prediction efficacy, with a higher efficiency compared to the traditional nomogram. The findings provide valuable insight for clinicians in risk assessment and decision-making regarding the use of temporary stoma to reduce complications.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)