Journal
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
Volume 24, Issue 10, Pages 2277-2282Publisher
SPRINGER
DOI: 10.1007/s11274-008-9752-0
Keywords
surfactin C; Mycoplasma hyopneumoniae; MIC; FIC; killing rate curve
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Funding
- Ministry of Commerce, Industry and Energy (MOCIE)
- Center for Traditional Microorganism Resources (TMR)
- Keimyung University and the Regional Industry Technology
- Korea Institute of Industrial Technology(KITECH) [B0008871] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study evaluated the killing rate as well as the antimycoplasmal effect of surfactins isolated from Bacillus subtilis complex BC1212, either alone or in combination with various antibacterials against Mycoplasma hyopneumoniae. Prior to the killing rate and the combination effect studies of surfactins, the minimal inhibitory concentrations (MICs) of various antibacterials and surfactins (consisting of surfactins A, B, C, and D) against M. hyopneumoniae were investigated. The MIC of all surfactins was found to be 64 mu g/ml. The MICs of colistin (COL), norfloxacin (NFX), oxytetracycline (OTC), streptomycin (SM) and tiamulin (TIA) were > 256, 0.063, 0.025, 4, and 0.015 mu g/ml, respectively. In the killing rate curve studies, surfactin C at 2x MIC and 4x MIC concentrations was found to reduce viability by > 3 log(10) c.c.u./ml within 2-4 h of incubation. Combination of surfactin C with other antibacterials showed additive interaction from the viewpoint of fractional inhibitory concentration (FIC) index of > 0.5 but <= 2 as a borderline. Taking all results into consideration, surfactin C may be useful as a preventive or therapeutic adjuvant in the pathogenesis of mycoplasmal infection.
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