Article
Plant Sciences
Anthony Guihur, Bruno Fauvet, Andrija Finka, Manfredo Quadroni, Pierre Goloubinoff
Summary: In the scorching summer dawn, land plants establish molecular defenses to prepare for extreme midday temperatures, inducing heat-shock proteins for acquired thermotolerance. Despite high protein crowding, heat priming did not accumulate HSP chaperones in chloroplasts, while HSP20s accumulated in the cytosol, suggesting their role in preventing heat-labile protein aggregation.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Neurosciences
Feilin Liu, Dmytro Morderer, Melissa C. Wren, Sara A. Vettleson-Trutza, Yanzhe Wang, Benjamin E. Rabichow, Michelle R. Salemi, Brett S. Phinney, Bjorn Oskarsson, Dennis W. Dickson, Wilfried Rossoll
Summary: The most common inherited cause of ALS and FTD is the expansion of GGGGCC repeats in the C9orf72 gene. In addition to haploinsufficiency and toxic RNA foci, other disease mechanisms are involved. Through the use of the BioID approach, it was found that DPR aggregates are associated with specific proteins that play important roles in protein folding and degradation. Heat shock proteins and co-chaperones were found to be closely associated with one of the DPRs, poly-GA, and may play a significant role in reducing its aggregation.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Microbiology
Felix Gruenberger, Georg Schmid, Zubeir El Ahmad, Martin Fenk, Katharina Vogl, Robert Reichelt, Winfried Hausner, Henning Urlaub, Christof Lenz, Dina Grohmann
Summary: This study investigated the transcriptomic and proteomic responses of hyperthermophilic archaea Pyrococcus furiosus to heat and cold shock stress. The results showed rapid and dynamic changes in gene and protein expression following these stress responses. The study also identified distinct short- and long-term responses at both the RNA and protein levels to cold shock. The findings contribute to our understanding of stress response mechanisms in extremophiles.
Article
Physiology
Jiayue Zhou, Jing Wu, Sifan Zheng, Xiangjun Chen, Daizhan Zhou, Xingchao Shentu
Summary: Cold cataract refers to the reversible opacification of the lens as temperature decreases, but prolonged exposure to low temperature can lead to irreversible opacification. Transcriptomic analysis showed up-regulation of genes related to lens structure and development, with small heat shock proteins identified as hub genes. Proteomic analysis revealed up-regulation of the apoptotic process, and integrated analysis suggested down-regulation of specific signaling pathways as part of the regulatory mechanism in the irreversible opacification process.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Plant Sciences
Farhad Masoomi-Aladizgeh, Ullah Najeeb, Sara Hamzelou, Dana Pascovici, Ardeshir Amirkhani, Daniel K. Y. Tan, Mehdi Mirzaei, Paul A. Haynes, Brian J. Atwell
Summary: The development of plant gametes is highly sensitive to heatwaves, even lasting for just a few days, adversely affecting pollen maturation and reproductive success. Exposure to heat at 40 degrees Celsius can significantly reduce pollen size after the tetrad stage and decrease cotton boll production by 65%. Interestingly, levels of sugar in pollen grains increase after exposure to heat, ruling out carbohydrate deficits as a likely cause of poor reproductive capacity.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Biochemical Research Methods
Weili Miao, Yen-Yu Yang, Yinsheng Wang
Summary: The study utilized SILAC and LC-MS/MS techniques to identify significant alterations in protein expression levels in human cells in response to heat shock, resulting in both decreased and increased protein expressions. Using targeted proteomics, the research further examined changes in kinase proteins, revealing that several kinases showed significant changes after heat shock.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Habibpourmehraban, Yunqi Wu, Jemma X. Wu, Sara Hamzelou, Farhad Masoomi-Aladizgeh, Karthik Shantharam Kamath, Ardeshir Amirkhani, Brian J. Atwell, Paul A. Haynes
Summary: Rice crops are affected by multiple abiotic stresses, with different genotypes exhibiting varied physiological and proteomic responses. Under combined drought, salt, and extreme temperature stress, rice stomata close, ABA levels increase, and proteins like heat shock proteins show consistent responsiveness in two rice genotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Review
Food Science & Technology
Pavan Kumar, Muideen Adewale Ahmed, Abubakar Ahmed Abubakar, Muhammad Nizam Hayat, Ubedullah Kaka, Mokrish Ajat, Yong Meng Goh, Awis Qurni Sazili
Summary: Stress biomarkers such as blood profiles, serum hormones, and physiological conditions can be used to assess the stress status of animals. Factors including previous exposure, genetics, stress adaptation, intensity, duration, and rearing practices contribute to variations in the expression of stress biomarkers. Meat proteomics, specifically the analysis of muscle protein expression, can predict meat quality and stress in animals before slaughter. Finding non-invasive, rapid, and accurate stress biomarkers is essential for objectively assessing stress in animals.
Article
Plant Sciences
Tonny I. Selinga, Sipho T. Maseko, Hawwa Gabier, Mohammed S. Rafudeen, A. Muthama Muasya, Olivier Crespo, John B. O. Ogola, Alex J. Valentine, Carl-Otto Ottosen, Eva Rosenqvist, Samson B. M. Chimphango
Summary: The expression of heat shock proteins and other stress-protective proteins in cowpea genotypes under different environmental conditions were investigated in this study. The results showed that different genotypes had different responses to heat stress, with more proteins being expressed in the field. Moreover, IT-96D-610 exhibited a strong ability to respond to heat stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Maike Schuldt, Larissa M. Dorsch, Jaco C. Knol, Thang V. Pham, Tim Schelfhorst, Sander R. Piersma, Cris dos Remedios, Michelle Michels, Connie R. Jimenez, Diederik W. D. Kuster, Jolanda van der Velden
Summary: Proteomic analysis revealed higher levels of tubulin and heat shock proteins in female HCM patients compared to males, while proteins involved in carbohydrate metabolism were significantly lower in females. This suggests that tubulin may partly contribute to the more severe diastolic dysfunction in women with HCM. Additionally, heat shock proteins in females and reduced protein turnover in males may play a role in disease progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ahmed Barakat, Even Birkeland, Melissa D. Jorstad, Magalie El Hajj, Msafiri Marijani, Anne Doskeland, Olav Mjaavatten, Frode S. Berven, Tehmina Mustafa
Summary: This study investigated the proteomic profile of PBMCs in pulmonary tuberculosis (PTB) patients to predict treatment response. Blood samples were collected from 8 adult PTB patients in Tanzania at baseline, 2 months of treatment, and treatment completion. Proteins extracted from PBMCs were quantified and analyzed using LC-MS/MS. The results identified differentially expressed proteins involved in cellular processes, metabolic processes, binding, and catalytic activity, suggesting that proteome analysis of PBMCs can be used as a novel technique to monitor anti-tuberculosis treatment response and gain insights into PTB.
Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Article
Multidisciplinary Sciences
Shivam Yadav, Martin Centola, Mathilda Glaesmann, Denys Pogoryelov, Roman Ladig, Mike Heilemann, L. C. Rai, Ozkan Yildiz, Enrico Schleiff
Summary: This study reveals the role of a cyanobacterial cyclophilin in stress responses and assembly of photosynthetic complexes, and presents its unique structural features.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Hao Chen, Xiao-Hui Min, Qi-Yi Wang, Felix W. Leung, Liu Shi, Yu Zhou, Tao Yu, Chuan-Ming Wang, Geng An, Wei-Hong Sha, Qi-Kui Chen
SCIENTIFIC REPORTS
(2015)
Article
Medicine, Research & Experimental
Zefeng Zhang, Xiaoling Bu, Hao Chen, Qiyi Wang, Weihong Sha
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2016)
Article
Oncology
Yuliang Xiao, Xiaojing Yang, Yinglei Miao, Xikun He, Ming Wang, Weihong Sha
Article
Oncology
Zefeng Zhang, Qiyi Wang, Xiaoling Bu, Chuangqiang Zhang, Hao Chen, Weihong Sha, Wanwei Liu
MOLECULAR MEDICINE REPORTS
(2017)
Article
Gastroenterology & Hepatology
Shi-xue Dai, Hong-xiang Gu, Qian-yi Lin, Shao-zhuo Huang, Tiao-si Xing, Qing-fang Zhang, Gang Wu, Min-hua Chen, Wan-er Tan, Hong-jian Jian, Zhong-wen Zheng, Tao Zhong, Min-hai Zhang, Xing-fang Cheng, Peng Huang, Guang-jie Liao, Wei-hong Sha
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2017)
Review
Medicine, General & Internal
Ze-Feng Zhang, Yu-Jun Luo, Quan Lu, Shi-Xue Dai, Wei-Hong Sha
WORLD JOURNAL OF CLINICAL CASES
(2018)
Article
Medicine, Research & Experimental
Zhanrong Qiang, Lingyu Meng, Caixia Yi, Lianying Yu, Wenxia Chen, Weihong Sha
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Ning-Li Chai, Hui-Kai Li, En-Qiang Linghu, Zhao-Shen Li, Shu-Tian Zhang, Yu Bao, Wei-Gang Chen, Philip W. Y. Chiu, Tong Dang, Wei Gong, Shu-Tang Han, Jian-Yu Hao, Shui-Xiang He, Bing Hu, Bing Hu, Xiao-Jun Huang, Yong-Hui Huang, Zhen-Dong Jin, Mouen A. Khashab, James Lau, Peng Li, Rui Li, De-Liang Liu, Hai-Feng Liu, Jun Liu, Xiao-Gang Liu, Zhi-Guo Liu, Ying-Cai Ma, Gui-Yong Peng, Long Rong, Wei-Hong Sha, Pateek Sharma, Jian-Qiu Sheng, Shui-Sheng Shi, Dong Wan Seo, Si-Yu Sun, Gui-Qi Wang, Wen Wang, Qi Wu, Hong Xu, Mei-Dong Xu, Ai-Ming Yang, Fang Yao, Hong-Gang Yu, Ping-Hong Zhou, Bin Zhang, Xiao-Feng Zhang, Ya-Qi Zhai
WORLD JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Oncology
Juan Ma, Ling-Ling Xia, Xue-Qing Yao, Shi-Min Zheng, Shi Li, Li-Shu Xu, Wei-Hong Sha, Ze-Song Li
Article
Gastroenterology & Hepatology
Shi-Min Zheng, Hao Chen, Wei-Hong Sha, Xiao-Fen Chen, Jian-Bin Yin, Xiao-Bo Zhu, Zhong-Wen Zheng, Juan Ma
Summary: ox-LDL stimulates CD206+ macrophages to upregulate CD44 and CD133 expression in HFD related CRC, suggesting a potential role of ox-LDL in the development of HFD associated CRC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Psychiatry
Xiaokai Feng, Chenlu Yang, Huanjuan Yang, Kai Wang, Yuanyuan Xu, Xiaoxia Zhang, Qiang Zhang, Juan Ma
Summary: This study investigated the mental health of healthcare workers (HCWs) exposed to the Omicron variant of SARS-CoV-2 at high altitude in Xining, Qinghai province, China. The results showed a high prevalence of mental health disorders, particularly among HCWs with chronic diseases, loans, longer working hours, and engaged in nucleic acid collection. Physical exercise was found to have a beneficial effect on anxiety and physical disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Hematology
Xiao-Kai Feng, Xiao-Fen Chen, Bei-Bei Wang, Zhi-Gang Zeng, Chao Liu, Wei-Hong Sha, Juan Ma
Summary: This article reports a rare case of Cronkhite-Canada syndrome (CCS) complicated with deep vein thrombosis (DVT). The patient's clinical details, endoscopic findings, safety, and efficacy of treatment are reported. After 24 months of treatment, the patient's clinical manifestations and endoscopic findings reached complete remission two years after the diagnosis.
THROMBOSIS JOURNAL
(2023)
Article
Oncology
Ling Zhang, Shengtao Zhu, Xuesen Shi, Weihong Sha
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2015)