Article
Pharmacology & Pharmacy
Fangfang Xu, Pan Wang, Xiuli Zhang, Tao Hou, Lala Qu, Chaoran Wang, Jixia Wang, Yanfang Liu, Xinmiao Liang
Summary: FFA4 is an emerging therapeutic target for metabolic diseases like type II diabetes, with shikonin identified as a potent agonist through HPLC-CAD and DMR methods. The study elucidated multiple signaling pathways downstream of FFA4 in HT-29 cells, providing insights for drug design and understanding of FFA4 pharmacology. Shikonin showed anti-diabetes effects in db/db mice, reducing plasma glucose levels and demonstrating potential for type II diabetes treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Yuqi Tan, Danmei Tian, Cong Li, Yanhui Chen, Yiran Shen, Jia Li, Jinshan Tang
Summary: A new pentacyclic triterpenoid and a new benzoxepin-5-one, along with 26 known compounds, were isolated from the roots of Arnebia euchroma. These compounds showed potential cytotoxicity towards human lung adenocarcinoma cells and inhibitory effects on key enzymes regulating glucose and lipid metabolism. Among them, three compounds displayed moderate inhibitory effects on the enzymes and no obvious cytotoxicity, suggesting their potential for the development of new agents for the treatment of metabolic diseases.
Article
Plant Sciences
Lian Zhu, Sheng-jun Ma, Ming-juan Liu, Kai-lin Li, E. Shuai, Zi-ming Wang, Sha-ni Li, Sheng-lan Zhang, Wei Cai
Summary: An analytical method based on affinity ultrafiltration coupled with UHPLC-Q-Exactive Orbitrap mass spectrometry was established to rapidly screen and identify estrogen receptor ligands from Arnebiae Radix extract. Molecular docking and surface plasmon resonance experiments were conducted to investigate the bindings and affinities of the ligands with estrogen receptor alpha and estrogen receptor beta. The study demonstrated the potential bioactive components and possible mechanisms of action of Arnebiae Radix, as well as providing a basis for quality control of this traditional Chinese medicine.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
Zhen-Peng Zhang, Yan Liu, Hai-Dan Zou, Juan Pan, Zhi-Chao Hao, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang, Bing-You Yang
Summary: Six new naphthoquinones and nine known naphthoquinones were isolated from the roots of Arnebia euchroma (Royle) Johnst. The structures of the new compounds were confirmed through extensive spectroscopic analyses. The study demonstrated that compounds 2 and 4 exhibited strong anti-proliferative activities at higher concentrations.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Plant Sciences
Yuheng Huang, Xiaoxin Guo, Zhen Wang, Cong Yin, Mu Chen, Jiaming Xie, Ning Li, Zhengchao Tu, Juan Li, Jiaqing Cao, Zhengjin Jiang, Weihuan Huang, Haiyan Tian
Summary: Arnebia euchroma, a traditional Chinese medicine, has potential inhibitory activities on bacterial and viral neuraminidases, making it a promising candidate for anti-infectious drugs. Through high-resolution bioassay profiling, potential active ingredients in A. euchroma were identified and their inhibitory activities on neuraminidases were determined.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nuramatjan Ablat, Mihray Ablimit, Abudoureheman Abudoukadier, Buhaiqiemu Kadeer, Lei Yang
Summary: The ethyl acetate extract of Arnebia euchroma showed potential hemostatic effects in mice by shortening bleeding and clotting time, increasing platelet count, inducing platelet aggregation, adhesion, and PF-4 secretion, as well as increasing fibrinogen levels while shortening TT.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Nuramatjan Ablat, Mihray Ablimit, Abudoureheman Abudoukadier, Buhaiqiemu Kadeer, Abulaitijiang Maihemuti, Alibati Bakewaiyi, Atike Tuerxun, Adilijiang Aihemaiti
Summary: This study aimed to investigate the hepatoprotective and hemostatic effects of the ethyl acetate extract of Arnebia euchroma in rats with CCl4-induced liver injury. The results showed that the extract affected platelet production and blood coagulation, improving liver function-damaging modifications. A dosage of 3.5 g/kg/day resulted in the most optimal effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zixia Chen, Long Yi, Yanni Pan, Xingyao Long, Jianfei Mu, Ruokun Yi, Xin Zhao
Summary: The study showed that ZS40 could have positive effects on ulcerative colitis by regulating oxidative indicators, cytokine levels, NF-kappa B, MAPK pathways, etc.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hao Li, Lindsey M. Christman, Yavuz Yagiz, Taylor L. Washington, Gary P. Wang, Liwei Gu
Summary: This study compares the effects of dealcoholized muscadine wine (DMW) on DSS-induced colitis in mice in terms of prevention, treatment, and combined activity. It finds that DMW can alleviate inflammation and improve the gut microbiome, with better results observed when used for both prevention and treatment.
Article
Chemistry, Analytical
Z. H. I. B. I. N. Wang, M. I. N. G. Y. U. Zhang, W. E. N. B. O. Zhu, C. H. U. N. J. U. A. N. Yang, H. A. I. X. U. E. Kuang
Summary: A rapid and efficient UPLC-ESI-MS/MS method was established for the simultaneous determination of shikonin and its derivatives in beagle plasma, using esculetin as an internal standard. The method showed good selectivity, linearity, precision, accuracy, and stability.
ACTA CHROMATOGRAPHICA
(2022)
Article
Medicine, Research & Experimental
Mona H. Zohny, Mohammed Alrouji, Sharif Alhajlah, Othman AlOmeir, Mohamed Gamal El-Din Ewees, Dalia M. Abdel Ghaffar, Noura El Adle Khalaf, Osama A. Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Waleed Barakat El-Bahouty, Amr Elrabat, Sahar Zakaria, Zeinab M. Abdel-Nasser, Amira A. Haleem, Doaa M. El-Gharbawy, Rasha Abdelhady, Mohamed M. Y. Kaddah, Ahmed Shata, Sameh Saber
Summary: Diacetylrhein has significant antioxidant and anti-inflammatory potential for the treatment of acute ulcerative colitis (UC) and may represent a promising agent in the management of the disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Maonan Wang, Bo Xu, Lintao Liu, Dawei Wang
Summary: Oridonin (Ori) has a regulatory role in ulcerative colitis (UC) by improving pathological damage, protecting colonic mucosal barrier integrity, reducing inflammation and oxidative stress levels, and inhibiting intestinal mucosal cell apoptosis in mice.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Mohammed Gamah, Murad Alahdal, Yu Zhang, Yiling Zhou, Qiaorong Ji, Zhouyang Yuan, Ying Han, Xiangqun Shen, Yanming Ren, Wei Zhang
Summary: This study found that high altitude hypoxia exacerbates the severity of ulcerative colitis in mice by activating the increase of inflammatory Th1 and Th17 lymphocytes.
Article
Food Science & Technology
Weidong Dou, Hao Xu, Shuo Feng, Tao Liu, Lin Xiao, Yingchao Wu, Shanwen Chen, Yisheng Pan, Xin Wang
Summary: This study investigates the protective effects of betaine on intestinal barrier function in a mouse model of ulcerative colitis and reveals its mechanism of action. The results show that betaine protects the intestinal barrier function of mice with ulcerative colitis by inhibiting the activation of the NF-kappa B-mediated signaling pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)