Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 20, Issue 34, Pages 12346-12349Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v20.i34.12346
Keywords
BRAF; Colorectal carcinoma; MicroRNA-31; MLH1; microsatellite instability; Serrated pathway
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Funding
- Japan Society for the Promotion of Science (JSPS) [23790800]
- A-STEP (Adaptable and Seamless Technology Transfer Program)
- Grants-in-Aid for Scientific Research [23790800] Funding Source: KAKEN
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MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC). We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. Moreover, high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps (HPs). These results suggest that miR-31 may contribute to the progression of serrated lesions. At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features. Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component. Higher miR-31 expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa, suggesting that miR-31 may be one of the key molecules in serrated pathway progression. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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