Article
Gastroenterology & Hepatology
Ann-Lii Cheng, Shukui Qin, Masafumi Ikeda, Peter R. Galle, Michel Ducreux, Tae-You Kim, Ho Yeong Lim, Masatoshi Kudo, Valeriy Breder, Philippe Merle, Ahmed O. Kaseb, Daneng Li, Wendy Verret, Ning Ma, Alan Nicholas, Yifan Wang, Lindong Li, Andrew X. Zhu, Richard S. Finn
Summary: The study demonstrated that atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma patients led to improved survival outcomes. After updated analysis, atezolizumab plus bevacizumab maintained its position as the first-line treatment option for advanced hepatocellular carcinoma.
JOURNAL OF HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Guilherme Nader Marta, Leonardo G. da Fonseca, Maria Ignez Braghiroli, Fernando Moura, Paulo M. Hoff, Jorge Sabbaga
Summary: This study evaluated the efficacy and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma, showing no significant differences in outcomes between younger and older patients. Age alone should not restrict clinical decision-making for patients with advanced HCC.
Review
Oncology
Shenglan Huang, Dan Li, LingLing Zhuang, Liying Sun, Jianbing Wu
Summary: This meta-analysis explored the efficacy and safety of sorafenib in hepatocellular carcinoma patients after radical surgery, revealing that sorafenib can improve overall survival, recurrence-free survival, and reduce recurrence rates without intolerable side effects. More evidence is needed for a definitive conclusion.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Jia Luo, Benjian Gao, Zhiyu Lin, Hua Fan, Wen Ma, Danfei Yu, Qian Yang, Jing Tian, Xiaoli Yang, Bo Li
Summary: This meta-analysis compares the efficacy and safety of lenvatinib and sorafenib in patients with advanced hepatocellular carcinoma (HCC). The results showed that lenvatinib had significantly better progression-free survival and disease control rate compared to sorafenib, with similar incidences of adverse events. Lenvatinib is a promising alternative to sorafenib as a first-line therapy for advanced HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yoshimichi Haruna, Takayuki Yakushijin, Seiichi Kawamoto
Summary: The study confirmed that dosing vitamin K alongside sorafenib can significantly enhance its anticancer effects against hepatocellular carcinoma, leading to improved objective response rate and progression-free survival time. Patients who received vitamin K in addition to sorafenib also showed significantly extended overall survival time, especially those who achieved complete or partial response.
Article
Gastroenterology & Hepatology
Takeshi Terashima, Tatsuya Yamashita, Noboru Takata, Yasuhito Takeda, Hidenori Kido, Noriho Iida, Masaaki Kitahara, Tetsuro Shimakami, Hajime Takatori, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
Summary: Sequential administration of sorafenib followed by regorafenib or lenvatinib is effective against advanced hepatocellular carcinoma, with similar safety profiles observed between sorafenib and regorafenib but differences in adverse events and anti-tumor effects between sorafenib and lenvatinib. The results provide insights for selecting sequential therapy for patients with advanced HCC.
HEPATOLOGY RESEARCH
(2021)
Article
Immunology
Tzu-Rong Peng, Chao-Chuan Wu, Sou-Yi Chang, Yen-Chih Chen, Ta-Wei Wu, Ching-Sheng Hsu
Summary: This study investigated the therapeutic efficacy of nivolumab plus sorafenib therapy in patients with unresectable HCC. The findings showed that the combination therapy resulted in better overall survival outcomes compared to sorafenib alone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mengdi Jin, Qiong Yu, Yahui Liu, Weiling Xu, Xueqi Fu, Bai Ji
Summary: This study compared the efficacy and safety of physical thermal ablation combined with sorafenib versus physical thermal ablation alone for the treatment of hepatocellular carcinoma (HCC). The combination therapy showed better overall survival and efficacy, but also led to increased incidences of adverse reactions.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Oncology
Yiran Chen, Deliang Guo, Xinyi Li, Chang Xu, Qian Zhu
Summary: Hypertension, liver cirrhosis, higher total bilirubin levels, tumor size > 5cm, and ascites are significant predictors of spontaneous tumor rupture in hepatocellular carcinoma. Patients in the ruptured group had a higher recurrence rate and lower survival rate, but there was no difference in postoperative complications and mortality.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Gong Zhang, Yufeng Wang, Bryan C. Fuchs, Wei Guo, David L. Drum, Derek J. Erstad, Baomin Shi, Albert B. DeLeo, Hui Zheng, Lei Cai, Liyuan Zhang, Kenneth K. Tanabe, Xinhui Wang
Summary: The combination of DSF/Cu and sorafenib can effectively treat HCC by targeting HCSCs both in vitro and in vivo. DSF/Cu enhances the sensitivity of HCC cells to sorafenib, inhibits proliferation of HCC cells, and decreases the stemness of HCC cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mahzeiar Samadaei, Daniel Senfter, Sibylle Madlener, Karolina Uranowska, Christine Hafner, Michael Trauner, Nataliya Rohr-Udilova, Matthias Pinter
Summary: The combination of the RAD51 inhibitor B02 and sorafenib has a significant effect on reducing cell viability, colony formation ability, and invasion capacity of HCC cells. The in silico approach shows that higher expression of RAD51 is associated with shorter overall survival in HCC patients.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Jialiang Luo, Lei Li, Zhengyumeng Zhu, Bo Chang, Fan Deng, Di Wang, Xiao Lu, Daming Zuo, Qingyun Chen, Jia Zhou
Summary: This study demonstrated that the combination of fucoidan and sorafenib could overcome sorafenib resistance in hepatocellular carcinoma cells by interacting with cell membrane EGFR and suppressing EGFR redistribution and downstream signaling. The simultaneous treatment of fucoidan and sorafenib might serve as a potential therapeutic strategy against sorafenib-resistant HCC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Pang-Shuo Perng, Yu-Hsuan Lai, Po-Hsuan Lee, Chi-Chen Huang, Hao-Hsiang Hsu, Jung-Shun Lee
Summary: Surgery or whole-brain radiotherapy (WBRT) can improve survival in patients with brain metastasis of hepatocellular carcinoma (HCC). This study aimed to investigate the safety and efficacy of multi-tyrosine kinase inhibitors (TKIs) in these patients. The results showed that TKIs were associated with better survival outcomes without increasing the risk of intracranial bleeding.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Limin An, Haotian Liao, Kefei Yuan
Summary: This study evaluated the efficacy and safety of second-line therapies followed by sorafenib in patients with advanced HCC, finding potential improvements in disease control rate and survival period, with regorafenib appearing to be more effective than other second-line therapies.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Chemistry, Medicinal
Mundanattu Swetha, Chenicheri K. Keerthana, Tennyson P. Rayginia, Lekshmi R. Nath, Nair Hariprasad Haritha, Anwar Shabna, Kalishwaralal Kalimuthu, Arun K. Thangarasu, Sreekumar U. Aiswarya, Somaraj Jannet, Sreekumar Pillai, Kuzhuvelil B. Harikumar, Sankar Sundaram, Nikhil Ponnoor Anto, Dee H. Wu, Ravi S. Lankalapalli, Rheal Towner, Noah Isakov, Sathyaseelan S. Deepa, Ruby John Anto
Summary: This study validates the superior anti-HCC efficacy of uttroside B (Utt-B) over sorafenib and demonstrates that Utt-B is a pharmacologically safer molecule. Clinical studies utilizing Utt-B in HCC patients are a key step to promote this drug to the clinic.