Article
Nutrition & Dietetics
Mia Bendix, Anders Dige, Soren Peter Jorgensen, Jens Frederik Dahlerup, Bo Martin Bibby, Bent Deleuran, Jorgen Agnholt
Summary: Seven-week high-dose vitamin D treatment reduces the need for later infliximab dose escalation and decreases inflammatory markers in patients with active Crohn's disease.
Article
Gastroenterology & Hepatology
Jacob E. Ollech, Inessa Normatov, Noam Peleg, Jingzhou Wang, Shivani A. Patel, Victoria Rai, Yangtian Yi, Jorie Singer, Sushila R. Dalal, Atsushi Sakuraba, Russell D. Cohen, David T. Rubin, Joel Pekow
Summary: Shortening the ustekinumab dose interval to 4 weeks improved clinical and biological indices of disease activity in patients with Crohn's disease who did not respond to the standard dose every 8 weeks. This approach could be effective and safe for patients who lose response to the standard dose of ustekinumab.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hiroshi Nakase, Motohiro Esaki, Fumihito Hirai, Taku Kobayashi, Katsuyoshi Matsuoka, Minoru Matsuura, Makoto Naganuma, Masayuki Saruta, Kiichiro Tsuchiya, Motoi Uchino, Kenji Watanabe, Tadakazu Hisamatsu, TRADE Consensus Grp
Summary: The study aimed to develop specific treatment guidelines for patients with different types of Crohn's disease (CD), including luminal CD, CD with perianal disease or fistula, CD with small bowel stenosis, postoperative CD, and patients who need to reduce or discontinue treatment. The study reviewed relevant studies and utilized a modified Delphi process to reach consensus among specialists. The resulting statements provide guidance on treatment intensification and de-intensification for CD patients.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Gloria S. Z. Tun, Kerry Robinson, Laura Marshall, Alison Wright, Laura Thompson, Graeme Wild, Ravishankar Sargur, Alenka J. Brooks, Melissa F. Hale, Thean S. Chew, Alan J. Lobo
Summary: DE strategy in selected patients receiving infliximab is associated with increased drug levels and reduced ATI positivity, and approximately 70% of patients achieve clinical remission within 6 months.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ruben J. Colman, Ye Xiong, Tomoyuki Mizuno, Jeffrey S. Hyams, Joshua D. Noe, Brendan Boyle, Geert R. D'Haens, Johan van Limbergen, Kelly Chun, Jane Yang, Michael J. Rosen, Lee A. Denson, Alexander A. Vinks, Phillip Minar
Summary: This study evaluated the impact of ATI on infliximab clearance and loss of response, finding that even low levels of ATI can affect drug clearance. The data suggest that dose optimization for low-level ATI can improve infliximab clearance and prevent loss of response.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chen Yueying, Feng Jing, Feng Qi, Shen Jun
Summary: A magnetic resonance enterography-based model was constructed in this study to predict the risk of loss of response to infliximab (IFX) in bio-naive patients with Crohn's disease (CD), providing an effective tool for the early estimation of treatment response before biological intervention.
EUROPEAN RADIOLOGY
(2023)
Review
Medicine, Research & Experimental
Remo Panaccione, Wan-Ju Lee, Ryan Clark, Kristina Kligys, Rhiannon I. Campden, Stacy Grieve, Tim Raine
Summary: This study aimed to identify and characterize the dosing escalation patterns of advanced therapies in Crohn's disease (CD) and ulcerative colitis (UC). The study found that most studies aligned with regulatory recommendations, but there were also some studies indicating more diverse or aggressive dose escalation.
ADVANCES IN THERAPY
(2023)
Article
Oncology
Jessica P. Harris, Michael A. Postow, David M. Faleck
Summary: Immune checkpoint inhibitor-related colitis is a common complication of immunotherapy in cancer patients. Current guidelines suggest using standard dose infliximab for corticosteroid-refractory colitis, but this case series suggests that dose escalation of infliximab may be a viable treatment option for refractory cases.
Article
Gastroenterology & Hepatology
Neeraj Narula, Emily C. L. Wong, Parambir S. Dulai, Neil K. Sengupta, John K. Marshall, Jean-Frederic Colombel, Walter Reinisch
Summary: This post hoc analysis suggests that infliximab and ustekinumab have similar efficacy and speed of onset in biologic-naive patients with CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Chenglin Ye, Sizhe Zhu, Jingping Yuan
Summary: This study analyzed the gene expression profiles of patients with Crohn's disease (CD) and identified two gene subtypes: immune and metabolic. The immune subtype was associated with leukocyte migration and cytokine interactions, while the metabolic subtype was associated with metabolic pathways. The combination of interleukin 1 beta, interleukin 6, and Toll-like receptor 4 effectively distinguished between these two gene subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yizhong Wang, Xuefeng Gao, Xinyue Zhang, Fangfei Xiao, Hui Hu, Xiaolu Li, Fang Dong, Mingming Sun, Yongmei Xiao, Ting Ge, Dan Li, Guangjun Yu, Zhanju Liu, Ting Zhang
Summary: The study revealed that pediatric CD patients have gut microbial dysbiosis and altered metabolism after IFX therapy, which is related to treatment outcomes. The effects of IFX treatment may be mediated by enriching bacteria taxa that produce SCFAs and BSH, thereby inhibiting inflammation and restoring bile acid metabolism. Some fecal bacteria and metabolites may serve as predictors of IFX therapy outcomes for pediatric CD patients.
Article
Biochemistry & Molecular Biology
Yiyoung Kwon, Eun-Sil Kim, Yoon-Zi Kim, Yon-Ho Choe, Mi-Jin Kim
Summary: This study aims to measure the concentration of cytokines produced during the inflammation process to investigate if there are any differences in response to treatment of pediatric Crohn's disease and to determine if the initial tumor necrosis factor-alpha (TNF-alpha) level affected the trough concentration of infliximab (IFX).
Article
Pharmacology & Pharmacy
Shuyan Li, Yan Ma, Hongling Sun, Zijun Ni, Shurong Hu, Yan Chen, Meijuan Lan
Summary: This study investigated the adherence to Infliximab (IFX) among Chinese Crohn's disease patients and evaluated the association between medication belief and adherence. The results showed that medication concerns may be a predictive factor of adherence, and by enhancing knowledge and relieving concerns, patients' adherence to IFX can be increased.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Wuli Tang, Gang Xie, Junlin Li, Wei Tan, Rongqi Yi, Ling Yang, Lingqin Zhang, Jiaxing Deng, Yue Zhang, Kang Li
Summary: This study investigated the relationship between body composition parameters and disease severity in Crohn's disease (CD) patients treated with infliximab (IFX). The results showed significant differences in subcutaneous adiposity index (SAI), visceral adiposity index (VAI), and skeletal muscle mass index (SMI) among patients with different disease activity statuses. SMI was identified as a reliable indicator of disease activity status.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Laura H. Bukkems, Krisztina B. Gecse, Geert R. D'Haens, Ron A. A. Mathot
Summary: The study characterized the pharmacokinetics of subcutaneous CT-P13 through population PK modeling, identifying body weight, presence of anti-drug antibodies, and serum albumin concentration as clinically relevant covariates affecting drug clearance. Simulated drug exposure demonstrated differences between routes of administration in patients of varying body weights.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)