Article
Multidisciplinary Sciences
Aura M. Rodriguez, Daniel A. Urrea, Carlos F. Prada
Summary: Helicobacter pylori is a pathogenic bacteria that causes diseases in the human stomach, with high genetic diversity among strains observed in different geographic lineages. Analysis of virulence factor genetic variability in H. pylori strains can provide key information in understanding their pathogenic behavior.
Review
Cell Biology
Jacek Baj, Alicja Forma, Monika Sitarz, Piero Portincasa, Gabriella Garruti, Danuta Krasowska, Ryszard Maciejewski
Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Fernanda Gonzalez, Paula Diaz, Alejandra Sandoval-Borquez, Daniela Herrera, Andrew F. G. Quest
Summary: Extracellular vesicles are important in host-pathogen interactions, playing a role in modulating inflammatory responses and promoting disease development. Both EVs from cells infected with H. pylori and H. pylori-OMVs are involved in the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Hang Gong, Hui-Mei Xu, De-Kui Zhang
Summary: As an established carcinogen, H. pylori is a major cause of inflammatory diseases and gastric cancer. Elderly individuals have a high prevalence of H. pylori infection, which can lead to adverse clinical outcomes. Existing guidelines and expert consensus often overlook the management of H. pylori infection in the elderly population. This review provides a brief overview of H. pylori in the elderly, including detection techniques, treatment considerations, and the importance of eradication for reducing gastric cancer risk.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Cell Biology
Jose Jessurun
Summary: This article focuses on the various aspects of infection that challenge the universality of medical implications through the application of evolutionary science to medicine. It discusses the divergent epidemiological and clinical outcomes observed in different populations, as well as the potential beneficial aspects of the infection. The article also reviews Correa's seminal contributions to the understanding of gastric cancer and postinflammatory tumors, along with the renewed interest in intestinal metaplasia and its clinical implications.
Article
Multidisciplinary Sciences
Rumiko Suzuki, Naruya Saitou, Osamu Matsuari, Seiji Shiota, Takashi Matsumoto, Junko Akada, Nagisa Kinjo, Fukunori Kinjo, Kuniko Teruya, Makiko Shimoji, Akino Shiroma, Mototsugu Kato, Kazuhito Satou, Takashi Hirano, Masahiro Asaka, Kirill Kryukov, Yoshan Moodley, Yoshio Yamaoka
Summary: Helicobacter pylori, a virulence bacterium, can be used as a marker for tracing human migration. This study identified indigenous H. pylori strains hspOkinawa and hpRyukyu in Okinawa, Japan and revealed their origin and divergence patterns.
Review
Infectious Diseases
Julie Nguyen, Kallirroi Kotilea, Patrick Bontems, Veronique Yvette Miendje Deyi
Summary: In the context of epidemiology, the manifestation of Helicobacter pylori (H. pylori) infection varies between children and adults. The prevalence of H. pylori infection is decreasing globally, including in many developing countries. However, pediatric H. pylori infection and its consequences remain a concern in some areas. Most infected children do not show symptoms, and there is no evidence supporting the link between H. pylori and functional disorders like recurrent abdominal pain. The pathophysiology of H. pylori infection depends on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. Various gastritis phenotypes can develop, potentially leading to different gastroduodenal pathologies. The diagnosis of H. pylori infection in children requires upper gastrointestinal endoscopy with mucosal biopsy samples for histology and culture, or at least Polymerase Chain Reaction (PCR). Eradication treatment should be given when necessary and compliance is expected, with treatment choice based on antimicrobial susceptibility. Vigilant surveillance of resistance patterns and strategic antibiotic management are crucial for combating multidrug resistance.
Review
Microbiology
Alejandro Tejada-Arranz, Hilde De Reuse
Summary: Helicobacter pylori is a Gram-negative bacterial pathogen that colonizes the stomach of about half of the human population worldwide, causing chronic gastritis and other serious diseases. It has evolved efficient adaptive strategies for gene expression control through transcriptional and post-transcriptional regulation.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Alain P. Gobert, Keith T. Wilson
Summary: Gastric cancer is the fifth most common cancer and the fourth most common cause of cancer-related death worldwide. The key factor in the development of gastric inflammation and disease progression is Helicobacter pylori infection, although only a small percentage of infected individuals develop gastric adenocarcinoma.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pediatrics
Changzheng Yuan, Davies Adeloye, Tzu Tsun Luk, Liyan Huang, Yusa He, Yunhan Xu, Xinxin Ye, Qian Yi, Peige Song, Igor Rudan
Summary: The global prevalence of Helicobacter pylori infection in children is high and influenced by factors such as diagnostic method, economic status, and age. In low-income and middle-income countries, the prevalence of H pylori infection is higher compared to high-income countries. Additionally, paediatric H pylori infection is significantly associated with family economic status, number of siblings, room sharing, lack of access to sewage system, maternal or sibling infection, drinking untreated water, and older age.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Roghayeh Mohammadzadeh, Shaho Menbari, Abbas Pishdadian, Hadi Farsiani
Summary: Helicobacter pylori, a worldwide spread bacterium, co-evolves with humans and is responsible for intra-gastric and extra-gastric diseases. Through the production of virulence factors and immune evasion strategies, H. pylori becomes a prominent pathogenic bacterium. Understanding these factors can help predict infection severity and aid in the development of an effective vaccine.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2023)
Review
Microbiology
Lu Han, Xu Shu, Jian Wang
Summary: This review summarizes the oxidative stress response triggered by Helicobacter pylori (HP) in the gastric mucosa and the subsequent signaling pathways. The findings are expected to help in the formulation of new targeted drugs for preventing the occurrence of early gastric cancer and its progression to middle and advanced cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Michael J. Maroney, Stefano Ciurli
Summary: Helicobacter pylori, a human pathogen causing peptic ulcers and classified as a Class I carcinogen, relies on nickel-urease and hydrogenase enzymes for survival and virulence. Nickel plays a crucial role in virulence, and proteins involved in nickel trafficking may be potential antibiotic targets.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sungil Jang, Lori M. Hansen, Hanfu Su, Jay Solnick, Jeong-Heon Cha
Summary: This study found that the number of cagA copies in Helicobacter pylori is higher in mice with less intense immune response and lower in mice with more intense immune response. Additionally, cagY recombination is also associated with H. pylori virulence.
Article
Neurosciences
Lin Ma, Wei Mao, Erhe Xu, Yanning Cai, Chaodong Wang, Jagadish K. Chhetri, Piu Chan
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2020)
Letter
Geriatrics & Gerontology
Jagadish K. Chhetri, Chao Han, Xiaojuan Dan, Lina Ma, Piu Chan
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Article
Neurosciences
Wei Zhang, Wei Mao, Erhe Xu, Jagadish K. Chhetri, Piu Chan
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2020)
Article
Clinical Neurology
Meijie Chen, Jie Chen, Xitong Xu, Fangwei Qiao, Xue Wang, Shaozhen Ji, Zhuqin Gu, Jagadish K. Chhetri, Piu Chan
FRONTIERS IN NEUROLOGY
(2020)
Article
Geriatrics & Gerontology
H. Liu, N. Shang, J. K. Chhetri, L. Liu, W. Guo, P. Li, Shubin Guo, Lina Ma
JOURNAL OF NUTRITION HEALTH & AGING
(2020)
Editorial Material
Geriatrics & Gerontology
Jagadish K. Chhetri, P. Chan, H. Arai, S. Chul Park, P. Sriyani Gunaratne, S. Setiati, P. Assantachai
JOURNAL OF NUTRITION HEALTH & AGING
(2020)
Article
Critical Care Medicine
Fang-Yan Liu, Xue-Lian Sun, Yong Zhang, Lin Ge, Jing Wang, Xiao Liang, Jun-Fen Li, Chang-Liang Wang, Zheng-Tao Xing, Jagadish K. Chhetri, Peng Sun, Piu Chan
CRITICAL CARE MEDICINE
(2020)
Article
Geriatrics & Gerontology
Jing Zhao, Jagadish K. Chhetri, Shaozhen Ji, Lina Ma, Xiaojuan Dan, Piu Chan
Editorial Material
Geriatrics & Gerontology
Jagadish K. Chhetri, Lina Ma, Jean Woo, Piu Chan
Article
Peripheral Vascular Disease
Lina Ma, Jagadish K. Chhetri, Pan Liu, Tong Ji, Li Zhang, Zhe Tang
JOURNAL OF HYPERTENSION
(2020)
Article
Geriatrics & Gerontology
Lina Ma, Y. Zhang, P. Liu, S. Li, Y. Li, T. Ji, L. Zhang, J. K. Chhetri, Y. Li
Summary: The study found that elevated NT-proBNP levels were associated with decreased intrinsic capacity in older persons, and it was the only independent risk factor for decreased intrinsic capacity among multiple covariates.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Neurosciences
Ma Lin, Tao-Mian Mi, Qian Jia, Chao Han, Jagadish K. Chhetri, Piu Chan
Summary: This study objectively evaluated the gait characteristics of Parkinson's disease (PD) fallers using wearable sensors and found that increased gait variability is a significant feature of PD fallers. Gait variability is more sensitive to detect high-risk fallers than spatiotemporal parameters.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Lina Ma, Jagadish K. Chhetri, Li Zhang, Fei Sun, Yun Li, Zhe Tang
Summary: The study investigated the prevalence and factors associated with intrinsic capacity (IC) decline among community-dwelling older adults in China. They found that IC decline was significantly associated with risks of frailty, disability, falls, fractures, and immobility.
Article
Medicine, General & Internal
Lina Ma, Jagadish K. Chhetri, Yaxin Zhang, Pan Liu, Yumeng Chen, Yun Li, Piu Chan
FRONTIERS IN MEDICINE
(2020)
Article
Geriatrics & Gerontology
J. K. Chhetri, L. Ma, Z. Zheng, F. -Y. Liu, J. Zhao, Z. -Q. Gu, P. Chan
Summary: The study found no significant association between ApoE genotype and frailty, but fatigue in older adults is the only component of frailty phenotype influenced by ApoE genotype.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)