Article
Surgery
Amelia J. Hessheimer, Ana Magdalena Vargas-Martinez, Marta Trapero-Bertran, Miquel Navasa, Constantino Fondevila
Summary: This study evaluated the cost-effectiveness and utility of posttransplant hepatocellular carcinoma (HCC) surveillance compared to standard follow-up. Although surveillance slightly improves survival and quality of life, it also increases costs and does not appear to be cost-effective in this setting.
Review
Radiology, Nuclear Medicine & Medical Imaging
Dong Hwan Kim, Joon-Il Choi
Summary: The article describes the current status of US-based surveillance for HCC and summarizes the supporting evidence, while also discussing alternative surveillance imaging modalities that are currently being studied.
Article
Medicine, General & Internal
John T. Schousboe, Brian L. Sprague, Linn Abraham, Ellen S. O'Meara, Tracy Onega, Shailesh Advani, Louise M. Henderson, Karen J. Wernli, Dongyu Zhang, Diana L. Miglioretti, Dejana Braithwaite, Karla Kerlikowske
Summary: The study found that extending screening mammography to age 80 may have benefits for some women, but the absolute reduction in death rates is small for women with comorbidities. Therefore, women over 75 should weigh the risks and benefits when considering screening mammography.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
John T. Schousboe, Brian L. Sprague, Linn Abraham, Ellen S. O'Meara, Tracy Onega, Shailesh Advani, Louise M. Henderson, Karen J. Wernli, Dongyu Zhang, Diana L. Miglioretti, Dejana Braithwaite, Karla Kerlikowske
Summary: Extending mammography screening to age 80 appears to be cost-effective in certain scenarios, but the absolute number of deaths averted is small, especially for women with comorbidities. Women considering screening beyond age 75 should carefully weigh the potential harms of overdiagnosis against the potential benefits of averting breast cancer death.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Heejin Bae, Sang Ah Lee, Jong Won Choi, Shin Hye Hwang, Sumi Park, Mi-Suk Park
Summary: This study found that in a national HCC surveillance program, a surveillance interval of 6 months increased the chance of receiving curative therapy. As the surveillance interval extended, the likelihood of receiving treatment decreased, with a corresponding increase in all-cause mortality rates.
YONSEI MEDICAL JOURNAL
(2021)
Article
Economics
Hannah E. Carter, Gary P. Jeffrey, Grant A. Ramm, Louisa G. Gordon
Summary: The study found that risk-stratified screening and all-inclusive screening for HCC in Australia are more cost-effective compared to no formal screening, with all-inclusive screening being the most likely cost-effective option at a WTP threshold of A$50,000 per QALY. Risk-stratified screening using a serum biomarker test may be cost-effective at lower WTP thresholds, such as between A$25,000 and A$35,000 per QALY.
Article
Medicine, General & Internal
Ruyi Xia, Hongmei Zeng, Wenjun Liu, Li Xie, Mingwang Shen, Peng Li, He Li, Wenqiang Wei, Wanqing Chen, Guihua Zhuang
Summary: The study found that endoscopic screening for esophageal and gastric cancers every 2 years may be the most cost-effective strategy in high-risk areas of China, leading to increased quality-adjusted life-years and reduced incidence and mortality of the cancers.
Article
Multidisciplinary Sciences
Jin Shi, Yazhe Guan, Di Liang, Daojuan Li, Yutong He, Yunjiang Liu
Summary: This study evaluated the implementation of a Cancer Screening Program in Urban Hebei and modeled the cost-effectiveness of a risk-based breast Cancer Screening Program. The results showed that annual ultrasound screening was the most cost-effective strategy for breast cancer screening. Combined ultrasound and mammography screening also had a higher positive detection rate. The study found that high-risk population-based breast cancer screening by ultrasound annually was the most cost-effective strategy in Urban Hebei Province.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Wu, Julius Chapiro, Ajay Malhotra
Summary: Through cost-effectiveness evaluation of different tumor imaging response criteria in hepatocellular carcinoma patients, the study demonstrates qEASL to be the most cost-effective assessment criterion, leading to substantial cost savings compared to RECIST and mRECIST.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Review
Medicine, General & Internal
Zeno Sparchez, Rares Craciun, Cosmin Caraiani, Adelina Horhat, Iuliana Nenu, Bogdan Procopet, Mihaela Sparchez, Horia Stefanescu, Tudor Mocan
Summary: Hepatocellular carcinoma is a prime screening target with biannual ultrasound surveillance being the current global standard of care, but cases still slip through this safety net. Addressing its drawbacks, improving techniques, and enhancing accuracy are crucial challenges that need to be overcome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Kevin K. W. Chu, Albert C. Y. Chan, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Kenneth S. H. Chok, Tan To Cheung, Chung Mau Lo
Summary: The study identified predictive factors for PET-detected HCC metastasis, including AFP >= 400 ng/mL and bilobar disease. PET-CT altered treatment strategies for some patients, leading to cost savings in treatment. The use of PET-CT in patients with specific factors was recommended for cost-effective preoperative HCC staging.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Editorial Material
Oncology
Jacopo Giuliani, Beatrice Mantoan, Andrea Bonetti
Summary: The study evaluated the cost-effectiveness of lenvatinib and the combination of atezolizumab plus bevacizumab in first-line treatment for advanced hepatocellular carcinoma, with lenvatinib shown to be a cost-effective option.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2022)
Review
Economics
Anh Le Tuan Nguyen, Hoa Thi Thu Nguyen, Kwang Chien Yee, Andrew J. Palmer, Christopher Leigh Blizzard, Barbara de Graaff
Summary: This review examined 43 studies on the cost-effectiveness of HCC screenings, with most studies concluding that biannual ultrasound plus alpha fetoprotein was the most cost-effective strategy. However, the studies exhibited significant heterogeneity and limitations in quality, requiring caution in interpretation. Future modeling studies should consider factors such as central adiposity impact on ultrasound accuracy, real-world utilization rates, and projections of increasing HCC incidence.
Article
Gastroenterology & Hepatology
Jonggi Choi, Nabihah Tayob, Young-Suk Lim
Summary: This study evaluated the performance of the parametric empirical Bayes (PEB) longitudinal AFP screening algorithm in patients with hepatitis B compared to AFP surveillance with a fixed threshold. The results showed that the PEB algorithm improved the accuracy of hepatocellular carcinoma (HCC) screening in patients with hepatitis B compared to AFP alone, without additional cost or inconvenience to patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Chi-Leung Chiang, Sik-Kwan Chan, Shing-Fung Lee, Horace Cheuk-Wai Choi
Summary: Research shows that atezolizumab-bevacizumab may be cost-effective in treating patients with unresectable hepatocellular carcinoma, depending on factors such as long-term clinical benefits, price reductions, duration of therapy, and dosage optimization. The long-term effectiveness, price reduction, duration of therapy, and dosage optimization are critical determinants of the cost-effectiveness of atezolizumab-bevacizumab in patient treatment.
Article
Gastroenterology & Hepatology
Alessandro Vitale, Gianluca Svegliati-Baroni, Alessio Ortolani, Monica Cucco, Giulio Dalla Riva, Edoardo G. Giannini, Fabio Piscaglia, Gianludovico Rapaccini, Mariella Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo Sacco, Giuseppe Cabibbo, Fabio Marra, Andrea Mega, Filomena Morisco, Antonio Gasbarrini, Francesco Giuseppe Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Filippo Oliveri, Filippo Pelizzaro, Rafael Ramirez Morales, Umberto Cillo, Franco Trevisani, Luca Miele, Giulio Marchesini, Fabio Farinati
Summary: This study compared patients with MAFLD and non-MAFLD who had hepatocellular carcinoma (HCC) in Italy. It found that the proportion of MAFLD in HCC patients was increasing over time and is expected to surpass non-MAFLD in the future. Despite a later cancer stage at diagnosis, MAFLD HCC patients had a lower risk of HCC-related death, suggesting reduced cancer aggressiveness.
Letter
Gastroenterology & Hepatology
Cecilia Binda, Antonio Bocchino, Alessandro Cucchetti
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Medicine, General & Internal
Quirino Lai, Nicoletta De Matthaeis, Michele Finotti, Giovanni Galati, Giuseppe Marrone, Fabio Melandro, Filomena Morisco, Daniele Nicolini, Riccardo Pravisani, Edoardo G. Giannini
Summary: This study evaluates the impact of antiplatelet therapy on the incidence and mortality of hepatocellular carcinoma. The results suggest that antiplatelet therapy is associated with a reduced risk of HCC incidence and post-treatment mortality.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Gastroenterology & Hepatology
Stefano Kayali, Andrea Pasta, Maria Corina Plaz Torres, Ariel Jaffe, Mario Strazzabosco, Simona Marenco, Edoardo G. Giannini
Summary: This systematic review with pooled analysis assessed the safety and efficacy of immune checkpoint inhibitor (ICI) therapy in liver transplant recipients. The results showed that ICI treatment in these patients is associated with a risk of graft rejection and mortality, but some patients had disease control and longer overall survival. More prospective studies are needed to provide accurate data on the safety and efficacy of ICI treatment in this population.
LIVER INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Carlo Sposito, Alessandro Cucchetti, Vincenzo Mazzaferro
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Rodolfo Sacco, Daryl Ramai, Raffaella Tortora, Giovan Giuseppe di Costanzo, Michela Emma Burlone, Mario Pirisi, Piera Federico, Bruno Daniele, Marianna Silletta, Paolo Gallo, Caterina Cocuzza, Maurizio Russello, Giuseppe Cabibbo, Gabriele Rancatore, Silvia Cesario, Gianluca Masi, Luca Marzi, Andrea Mega, Alessandro Granito, Giulia Pieri, Edoardo G. G. Giannini, Rosa Paolillo, Gennaro Gadaleta-Caldarola, Vincenzo Dadduzio, Guido Giordano, Luca Giacomelli, Simonetta Papa, Matteo Renzulli, Marcello Maida, Michele Ghidini, Mauro Borzio, Antonio Facciorusso
Summary: Hepatocellular carcinoma is the fifth most common cancer worldwide. Lenvatinib has proven to be an effective option for treating advanced diseases. Our study showed that patients with nonviral etiologies have longer survival than those with viral etiology, which is important for clinical decision-making.
Review
Gastroenterology & Hepatology
Andrea Pasta, Francesco Calabrese, Sara Labanca, Simona Marenco, Giulia Pieri, Maria Corina Plaz Torres, Nicolas M. Intagliata, Stephen H. Caldwell, Edoardo G. Giannini
Summary: This study aimed to assess the safety and efficacy of venous thromboembolism (VTE) prophylaxis in patients with cirrhosis. The results suggested that the current evidence is insufficient to advise for or against the use of VTE prophylaxis, mainly due to lack of quality and homogeneity of available data. However, the prophylaxis does not appear to be associated with a significant bleeding risk.
LIVER INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Edoardo G. Giannini, Giacomo Borgonovo, Simona Marenco, Manuela Cesaretti
LIVER TRANSPLANTATION
(2023)
Letter
Hematology
Andrea Pasta, Francesco Calabrese, Edoardo G. Giannini
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Gastroenterology & Hepatology
Alessandro Cucchetti, Philip Johnson, Gabriele Capurso, Stefano Crippa, Carlo Alberto Pacilio, Carlo Fabbri, Massimo Falconi, Giorgio Ercolani
Summary: The aim of this study was to explore the correlation between incidence and mortality of pancreatic cancer and healthcare indicators in 36 European countries. The results showed that both incidence and mortality were increasing, and they were strongly positively correlated. Higher health expenditure, availability of beds and medical technology, as well as the number of practicing doctors were related to higher incidence. On the other hand, lower mortality was associated with indicators such as outpatient curative care expenditure, the number of pet scanners, and radiation therapy equipment. The study highlights the impact of healthcare environment on pancreatic cancer incidence and mortality.
Article
Oncology
Simone Caprioli, Giorgio-Gregory Giordano, Alessia Pennacchi, Valentina Campagnari, Andrea Iandelli, Giampiero Parrinello, Cristina Conforti, Riccardo Gili, Edoardo Giannini, Elisa Marabotto, Stefano Kayali, Bernardo Bianchi, Giorgio Peretti, Giuseppe Cittadini, Filippo Marchi
Summary: This study evaluates the potential of high-frequency intraoral ultrasonography (IOUS) in predicting histological risk factors in oral cavity squamous cell carcinoma (OSCC). The results show excellent agreement between ultrasonographic and pathological measurements of depth of invasion (DOI), and a significant association between ultrasonographic morphology and adverse histopathological factors. IOUS demonstrates high sensitivity and specificity in predicting Brandwein-Gensler score.
Editorial Material
Oncology
Stefano Kayali, Elisa Marabotto, Edoardo Giannini
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
Article
Rheumatology
Ylenia Marten Canavesio, Andrea Pasta, Francesco Calabrese, Elisa Alessandri, Maurizio Cutolo, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vincenzo Savarino, Edoardo Giovanni Giannini, Patrizia Zentilin, Giorgia Bodini, Manuele Furnari, Edoardo Savarino, Elisa Marabotto
Summary: This study aims to evaluate the association and prognostic implication between motor esophageal disorders and pulmonary involvement in SSc patients. The study found that the severity of motor esophageal disorders is positively correlated with the severity of pulmonary disease.
RHEUMATOLOGY INTERNATIONAL
(2023)
Letter
Medicine, General & Internal
Edoardo G. Giannini, Tommaso Testa, Federica Grillo, Luca Mastracci, Serena Arrigo, Piero Cai, Sabrina Paolino, Martina Burlando, Livia Pisciotta, Elena Formisano, Giuseppe Cittadini, Francesco Copello, Sabrina Tuo, Giorgia Bodini
Summary: The establishment of an interdisciplinary IBD center is associated with improved healthcare utilization, including a decrease in hospitalizations per patient/year, a decrease in length of hospitalization, and an increase in patients on biologics.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
