Article
Biotechnology & Applied Microbiology
Jingjing Hu, Ke Chen, Fangfang Hong, Guosheng Gao, Xiaoyu Dai, Hua Yin
Summary: METTL3 modifies SOCS3 mRNA with m6A to promote the stemness and tumorigenicity of LCSCs.
CANCER GENE THERAPY
(2023)
Review
Oncology
Xingning Lai, Yiling Guo, Miaomiao Chen, Yuxuan Wei, Wanting Yi, Yubo Shi, Lixia Xiong
Summary: Cav1 plays dual roles in stem cell biology, with both inhibitory and promoting effects on stem cell self-renewal, differentiation, proliferation, migration, and tumorigenicity. Targeting the Cav1-stem cell axis may provide new approaches for tissue repair and overcoming cancer drug resistance.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Cell Biology
Alejandro Ordaz-Ramos, Olivia Tellez-Jimenez, Karla Vazquez-Santillan
Summary: Breast cancer stem cells (BCSCs) are a specific subpopulation of cells capable of self-renewal and differentiation into diverse tumor cells. The involvement of cancer stem cells in treatment resistance and cancer recurrence is well established. Specific signaling pathways, such as Wnt/beta-catenin, NF-kappa B, Notch, Hedgehog, TGF-beta, and Hippo, play crucial roles in regulating the self-renewal ability of cancer stem cells. Targeting these signaling pathways holds promise as a therapeutic strategy for combating breast cancer aggressiveness. This review discusses the main signaling pathways involved in maintaining the self-renewal ability of BCSCs and highlights current strategies to disrupt stemness-related signaling molecules.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Gulab Sher, Tariq Masoodi, Kalyani Patil, Sabah Akhtar, Shilpa Kuttikrishnan, Aamir Ahmad, Shahab Uddin
Summary: Since the introduction of the cancer stem cell paradigm, significant progress has been made in understanding the role of cancer stem cells (CSCs) in tumor biology, including metastasis and drug resistance. The transcription factor FOXM1 has emerged as a key regulator of CSCs, involved in their formation, maintenance, and functionality. This review summarizes the evidence for the mechanisms by which FOXM1 promotes stemness in different types of cancers and highlights its prognostic importance.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Shixin Liao, Kaili Wang, Lulu Zhang, Gaoli Shi, Zhiwei Wang, Zhenzhen Chen, Pingping Zhu, Qiankun He
Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, and reliable markers for early detection are lacking. This study identified PRC1 and RACGAP1 as reliable markers for early HCC detection and demonstrated their crucial roles in HCC therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Seisuke Tanigawa, Mitsugu Fujita, Chiami Moyama, Shota Ando, Hiromi Ii, Yasushi Kojima, Teruaki Fujishita, Masahiro Aoki, Hayato Takeuchi, Takumi Yamanaka, Yoshinobu Takahashi, Naoya Hashimoto, Susumu Nakata
Summary: Recent research has identified Gli2 as a key player in glioblastoma, affecting the Hedgehog and Wnt pathways and contributing to the maintenance of GSCs, suggesting it as a potential therapeutic target for glioblastoma treatment.
CANCER GENE THERAPY
(2021)
Review
Oncology
Tong Niu, Weiwei Zhang, Wei Xiao
Summary: Breast cancer stem cells (BCSCs) play critical roles in modulating breast tumor behaviors and drug resistance, while miRNAs in breast cancer exhibit multifaceted roles as suppressors or oncogenes in regulating cancer progression. The review highlights the importance of miRNAs in regulating key signaling pathways that are essential for BCSC maintenance.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
S. S. Hoepner, Ana Raykova, R. Radpour, M. A. Amrein, D. Koller, G. M. Baerlocher, C. Riether, A. F. Ochsenbein
Summary: The study demonstrates that LIGHT and its receptor LT beta R promote quiescence and self-renewal of HSCs, while LT beta R deficiency contributes to survival in a mouse leukemia model.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Qian Feng, Nan Cui, Shan Li, Jing Cao, Qian Chen, Haiyan Wang
Summary: SOX9 is correlated with poor prognosis of cervical cancer and its overexpression enhances stem cell properties and promotes tumorigenicity. SOX9 regulates the self-renewal and tumorigenicity of cervical cancer through the Wnt/beta-catenin pathway by directly activating FZD10 and MYC and inhibiting DKK1.
Article
Cell Biology
Xiaomin Du, Siyu Wu, Yudong Wei, Xiuwei Yu, Fanglin Ma, Yuanxin Zhai, Donghui Yang, Mengfei Zhang, Wenqing Liu, Haijing Zhu, Jiang Wu, Mingzhi Liao, Na Li, Chunling Bai, Guangpeng Li, Jinlian Hua
Summary: The study identified a subset of spermatogonial stem cells in dairy goats with high PAX7 expression, indicating that PAX7 can maintain the self-renewal of these cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Miaoling Tang, Meisongzhu Yang, Geyan Wu, Shuang Mo, Xingui Wu, Shuxia Zhang, Ruyuan Yu, Yameng Hu, Yingru Xu, Ziwen Li, Xinyi Liao, Jun Li, Libing Song
Summary: In liver cancer cells, the upregulation of MFF mediated by the TBX19/PRMT1 complex promotes mitochondrial fission and tumor-initiating capacity, indicating that PRMT1 may be a viable therapeutic target in liver cancer.
Review
Cell & Tissue Engineering
Cong Zhao, Wen Xie, Hecheng Zhu, Ming Zhao, Weidong Liu, Zhaoping Wu, Lei Wang, Bin Zhu, Shasha Li, Yao Zhou, Xingjun Jiang, Qiang Xu, Caiping Ren
Summary: Stem cells are unique cells with the ability to self-renew and differentiate into various functional cells. Recent studies have revealed the crucial roles of long non-coding RNAs (lncRNAs) and RNA-binding proteins (RBPs) in the self-renewal and differentiation of stem cells. This review summarizes the functions of lncRNAs and their RBPs in determining the fate of stem cells, focusing on their involvement in epigenetic regulation, signaling pathway regulation, splicing, mRNA stability, and subcellular localization. Understanding the regulatory mechanisms of lncRNAs and RBPs will contribute to the development of clinical regenerative medicine.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Karolin Walter, Eva Rodriguez-Aznar, Monica S. Ventura Ferreira, Pierre-Olivier Frappart, Tabea Dittrich, Kanishka Tiwary, Sabine Meessen, Laura Lerma, Nora Daiss, Lucas-Alexander Schulte, Zeynab Najafova, Frank Arnold, Valentyn Usachov, Ninel Azoitei, Mert Erkan, Andre Lechel, Tim H. Brummendorf, Thomas Seufferlein, Alexander Kleger, Enrique Tabares, Cagatay Gunes, Steven A. Johnsen, Fabian Beier, Bruno Sainz Jr, Patrick C. Hermann
Summary: This study demonstrates the critical role of telomerase regulation in maintaining stemness in pancreatic CSCs and examines the effects of telomerase inhibition as a potential treatment option for pancreatic cancer. This may significantly enhance our understanding of PDAC tumor biology and potentially lead to improved treatment for pancreatic cancer patients.
Article
Biotechnology & Applied Microbiology
Lifa Li, Jingxiao Zhang, Hong Peng, Xianhong Jiang, Zuoliang Liu, Hongpeng Tian, Songlin Hou, Xingjiang Xie, Qiang Peng, Tong Zhou
Summary: This study investigates the role of miR-92a in colorectal cancer (CRC). It is found that miR-92a functions as an oncogene by directly binding and repressing SOCS3, resulting in the regulation of stemness and proliferation of CRC cells.
Article
Cell & Tissue Engineering
Haiqing Luo, Chih-Yu Chen, Xiangyong Li, Xin Zhang, Chien-Wen Su, Yinghua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing X. Kang
Summary: Aberrant lipid metabolism is recognized as a new hallmark of malignancy, and targeting specific enzymes involved in fatty acid metabolism can limit self-renewal and growth of breast cancer stem cells. Omega-3 fatty acids are effective in suppressing lipogenic enzymes and reducing tumor load in BCSC-derived tumors.
Article
Gastroenterology & Hepatology
A. Hernandez-Camba, L. Arranz, I Vera, D. Carpio, M. Calafat, A. J. Lucendo, C. Taxonera, S. Marin, M. J. Garcia, G. Suris Marin, E. Sanchez Rodriguez, A. Y. Carbajo, M. L. De Castro, M. Iborra, A. Martin-Cardona, I Rodriguez-Lago, D. Busquets, F. Bertoletti, M. Sierra Ausin, C. Tardillo, J. Huguet Malaves, L. Bujanda, A. Castano, E. Domenech, L. Ramos
Summary: This study evaluated the use of MMF in IBD and found that it has some effectiveness and good safety in treating IBD patients.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Sabela Carballal, Ariadna Sanchez, Leticia Moreira, Jesus Eduardo Cuellar-Monterrubio, Julio Bernuy, Maria Daca, Oswaldo Ortiz, Teresa Ocana, Liseth Rivero-Sanchez, Gerhard Jung, Anna Serradesanferm, Angels Pozo, Jaume Grau, Isabel Tora, Diana Zaffalon, Antoni Castells, Maria Pellise, Francesc Balaguer
Summary: The prevalence of having >= 10 adenomas in a FIT-based CRC screening program was 2.2%. Only a small percentage of patients with >= 20 adenomas had inherited syndromes. The rate of post-colonoscopy CRC was low and the risk of advanced neoplasia decreased throughout follow-up.
Article
Gastroenterology & Hepatology
Paula Arratibel, Ines Gil-Lasa, Julyssa Cobian, Arantzazu Izagirre-Arostegi, Teresa Arzallus, Ane Etxart, Cristina Sarasqueta, Leire Zubiaurre, Luis Bujanda
Summary: This retrospective study analyzed the clinical data of patients with esophageal foreign body impactions and found that eosinophilic esophagitis (EE) was closely related to factors such as age, history of respiratory diseases, endoscopic findings, and medication use. The study also pointed out a low mortality rate among patients, and deaths were associated with impactions.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Review
Gastroenterology & Hepatology
Marta Herreros-Villanueva, Luis Bujanda, Lourdes Ruiz-Rebollo, Rosana Torremocha, Ricardo Ramos, Ruben Martin, Maria Consuelo Artigas
Summary: This study aimed to evaluate the clinical significance of Next Generation Sequencing (NGS) results from plasma samples of pancreatic cancer patients. The experimental results showed the detection of pathogenic mutations in genes such as KRAS, BRCA2, FLT3, and HNF1A. However, the clinical utility of NGS liquid biopsy in pancreatic cancer patients still needs to be improved.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Biochemistry & Molecular Biology
Luis G. Guijarro, David Cano-Martinez, M. Val Toledo-Lobo, Lidia Ruiz-Llorente, Maria Chaparro, Ivan Guerra, Marisa Iborra, Jose Luis Cabriada, Luis Bujanda, Carlos Taxonera, Valle Garcia-Sanchez, Ignacio Marin-Jimenez, Manuel Barreiro-de Acosta, Isabel Vera, Maria Dolores Martin-Arranz, Francisco Mesonero, Laura Sempere, Fernando Gomollon, Joaquin Hinojosa, Sofia Zoullas, Jorge Monserrat, Cesar Menor-Salvan, Melchor Alvarez-Mon, Javier P. Gisbert, Miguel A. Ortega, Borja Hernandez-Breijo
Summary: This study found that levels of serum AIF-1 decrease in Crohn's disease (CD) patients after treatment with anti-TNFs. The study also revealed that active CD patients have higher levels of serum AIF-1 compared to inactive CD patients. The combination of serum AIF-1 and CRP levels improves the predictive ability for classifying CD patients by their severity.
Article
Gastroenterology & Hepatology
Kota Nakamura, Goretti Hernandez, Geeta G. Sharma, Yuma Wada, Jasjit K. Banwait, Natalia Gonzalez, Jose Perea, Francesc Balaguer, Hiroyuki Takamaru, Yutaka Saito, Yuji Toiyama, Yasuhiro Kodera, C. Richard Boland, Luis Bujanda, Enrique Quintero, Ajay Goel
Summary: A circulating miRNA signature has been developed as a potential noninvasive diagnostic tool for early-onset colorectal cancer (EOCRC), with high accuracy and clinical application potential.
Article
Medicine, General & Internal
Luis Fernandez-Salazar, Ana Campillo, Luis Rodrigo, Angeles Perez-Aisa, Jesus M. Gonzalez-Santiago, Xavier Segarra Ortega, Maja Denkovski, Natasa Brglez Jurecic, Luis Bujanda, Blas Jose Gomez Rodriguez, Juan Ortuno, Sotirios Georgopoulos, Laimas Jonaitis, Ignasi Puig, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: This study evaluated the decisions and outcomes of H. pylori management by European gastroenterologists through an international multicenter observational registry. The findings suggest that high-dose dual therapy (HDDT) is not a good option for first-line or rescue treatment of H. pylori in Europe, even with the addition of bismuth.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yasuyuki Okada, Fuduan Peng, Jose Perea, Luis Corchete, Luis Bujanda, Wei Li, Ajay Goel
Summary: A novel methylation signature risk-scoring model was developed to reliably identify patients with synchronous colorectal cancer (SyCRC), which has the potential to improve the diagnosis and management of colorectal cancer (CRC) patients.
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Antonio Giordano, Gherzon Casanova, Miriam Escapa, Gloria Fernandez-Esparrach, Angels Gines, Oriol Sendino, Isis K. Araujo, Andres Cardenas, Henry Cordova, Julia Martinez-Ocon, Graciela Martinez-Palli, Francesc Balaguer, Josep Llach, Elena Ricart, Begona Gonzalez-Suarez
Summary: Motorized Spiral Enteroscopy (MSE) is an effective and safe examination method for patients with prior major abdominal surgery. Although longer procedure times were observed in these patients, the diagnostic yield was similar. Patients with gastrointestinal surgery showed a lower depth of insertion compared to those with other abdominal surgeries.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Genetics & Heredity
Yasmin Soares de Lima, Coral Arnau-Collell, Jenifer Munoz, Cristina Herrera-Pariente, Leticia Moreira, Teresa Ocana, Marcos Diaz-Gay, Sebastia Franch-Exposito, Miriam Cuatrecasas, Sabela Carballal, Anael Lopez-Novo, Lorena Moreno, Guerau Fernandez, Aranzazu Diaz de Bustamante, Sophia Peters, Anna K. Sommer, Isabel Spier, Iris B. A. W. te Paske, Yasmijn J. van Herwaarden, Antoni Castells, Luis Bujanda, Gabriel Capella, Verena Steinke-Lange, Khalid Mahmood, JiHoon Eric Joo, Julie Arnold, Susan Parry, Finlay A. Macrae, Ingrid M. Winship, Christophe Rosty, Joaquin Cubiella, Daniel Rodriguez-Alcalde, Elke Holinski-Feder, Richarda de Voer, Daniel D. Buchanan, Stefan Aretz, Clara Ruiz-Ponte, Laura Valle, Francesc Balaguer, Laia Bonjoch, Sergi Castellvi-Bel
Summary: Rare germline variants in the WNK2 gene were identified through functional evaluation of a candidate gene and replication in additional SPS cohorts. These variants may affect protein function in the MAPK pathway, thereby increasing the risk for SPS.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Oncology
Loretta De Chiara, Leticia Barcia-Castro, Maria Gallardo-Gomez, Maria Paez de la Cadena, Vicenta S. Martinez-Zorzano, Francisco J. Rodriguez-Berrocal, Luis Bujanda, Ane Etxart, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Joaquin Cubiella, Oscar J. Cordero
Summary: Fecal hemoglobin immunodetection (FIT) in combination with endoscopy has been implemented to reduce mortality from colorectal cancer (CRC), but there is room for improvement in terms of participation rates. The blood biomarkers sCD26 and DPP4 activity show potential in reducing false positives and have statistically significant differences related to age and sex.
Letter
Biochemistry & Molecular Biology
Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, Joan Maurel, Ajay Goel
Article
Gastroenterology & Hepatology
Francisco J. Caballero-Camino, Pedro M. Rodrigues, Fredrik Wangsell, Alona Agirre-Lizaso, Paula Olaizola, Laura Izquierdo-Sanchez, Maria J. Perugorria, Luis Bujanda, Bo Angelin, Sara Straniero, Anna Walleback, Ingemar Starke, Per-Goran Gillberg, Ellen Strangberg, Britta Bonn, Jan P. Mattsson, Martin R. Madsen, Henrik H. Hansen, Erik Lindstrom, Peter Akerblad, Jesus M. Banales
Summary: The ASBT inhibitor A3907 improves cholestatic liver diseases by clearing circulating bile acids and protecting liver function. A3907 targets ASBT in the intestine, liver, and kidney, leading to improved bilirubin and liver injury markers. A3907 is well tolerated in healthy individuals, supporting further clinical development.
Article
Gastroenterology & Hepatology
Joel Flores-Arriaga, Maria C. Aso, Arantzazu Izagirre, Ami D. Sperber, Olafur S. Palsson, Shrikant I. Bangdiwala, Angel Lanas, Luis Bujanda, Beatriz Lobo, Carmen Alonso-Cotoner, Alex Sanchez-Pla, Javier Santos
Summary: The study used data from the Rome Foundation Global Epidemiology Study to assess the prevalence and burden of gut-brain disorders in Spain. The survey, completed by 2072 participants, revealed that 43.6% of respondents met diagnostic criteria for at least one disorder, with functional constipation being the most prevalent. The study highlights the need for specialized training and future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Surgery
Maria Daca-Alvarez, Marc Marti, Antonino Spinelli, Noel F. F. C. de Miranda, Claire Palles, Alfredo Vivas, Andrew Lachtford, Kevin Monahan, Marek Szczepkowski, Wieslaw Tarnowski, Silviu-Tiberiu Makkai-Popa, Rosario Vidal, Irene Lopez, Elena Hurtado, Fernando Jimenez, Marta Jimenez-Toscano, Edurne Alvaro, Gonzalo Sanz, Araceli Ballestero, Sirio Melone, Lorena Brandariz, Isabel Prieto, Damian Garcia-Olmo, Teresa Ocana, Rebeca Moreira, Lorena Moreno, Sabela Carballal, Leticia Moreira, Maria Pellise, Rogelio Gonzalez-Sarmiento, Andreana N. Holowatyj, Jose Perea, Francesc Balaguer
Summary: This study aimed to explore the impact of family history on preventing early-onset colorectal cancer, finding that the proportion of preventable cases varied based on different guidelines. Early colonoscopy could significantly decrease the incidence of familial early-onset colorectal cancer.
BRITISH JOURNAL OF SURGERY
(2022)
