Article
Gastroenterology & Hepatology
Sandra Baile-Maxia, Carolina Mangas-Sanjuan, Uri Ladabaum, Cesare Hassan, Matthew D. Rutter, Michael Bretthauer, Licia Medina-Prado, Noelia Sala-Miquel, Oscar Murcia Pomares, Pedro Zapater, Rodrigo Jover
Summary: This study aimed to assess the association between HRA characteristics and the outcomes of CRC or AAs surveillance. The study found that adenomas larger than 20mm, high-grade dysplasia (HGD), and adenomas with villous component were associated with higher risk of metachronous CRC. However, multiplicity of adenomas did not seem to be significantly associated with higher CRC risk in the near term.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Yan Gong, Yansong Zheng, Rilige Wu, Miao Liu, Hong Li, Qiang Zeng
Summary: This study retrospectively determined and compared the detection rate of adenomas, advanced adenomas (AAs), and colorectal cancers (CRCs) in an average-risk Chinese population of different ages and genders. The results showed a high detection rate of adenomas, AAs, and CRCs, which were associated with gender and age.
CHINESE MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Michael B. Wallace, Prateek Sharma, Pradeep Bhandari, James East, Giulio Antonelli, Roberto Lorenzetti, Micheal Vieth, Ilaria Speranza, Marco Spadaccini, Madhav Desai, Frank J. Lukens, Genci Babameto, Daisy Batista, Davinder Singh, William Palmer, Francisco Ramirez, Rebecca Palmer, Tisha Lunsford, Kevin Ruff, Elizabeth Bird-Liebermann, Victor Ciofoaia, Sophie Arndtz, David Cangemi, Kirsty Puddick, Gregory Derfus, Amitpal S. Johal, Mohammed Barawi, Luigi Longo, Luigi Moro, Alessandro Repici, Cesare Hassan
Summary: This study demonstrates that the use of artificial intelligence can significantly reduce the miss rate of colorectal neoplasia, especially for small and subtle lesions. This is of great importance in improving the prevention of colorectal cancer.
Article
Oncology
Yingshuang Zhu, Yanqin Huang, Yeting Hu, Yimin Fang, Xiangxing Kong, Qian Xiao, Jinjie He, Yunfeng Zhu, Qilong Li, Jinhuan Yang, Qi Dong, Mingjuan Jin, Meilin Wang, Kun Chen, Shu Zheng, Kefeng Ding
Summary: This study found that individuals with high-risk adenomas (at least one advanced adenoma or >= 3 nonadvanced adenomas) have an increased risk of subsequent CRC in the Chinese population, while those with 1 to 2 nonadvanced adenomas do not show significantly increased risk of CRC. These results provide valuable evidence for the current surveillance guidelines in China.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Surgery
Joceline V. Vu, Kyle H. Sheetz, Ana C. De Roo, Tadd Hiatt, Samantha Hendren
Summary: A study found that there is substantial variation in the rate of colectomy for benign polyps in the United States, suggesting potential overuse of surgery for benign polyps in some regions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Marco Spadaccini, Michael J. Bourke, Roberta Maselli, Marhieu Pioche, Pradeep Bhandari, Jeremie Jacques, Amyn Haji, Dennis Yang, Eduardo Albeniz, Michal Filip Kaminski, Helmut Messmann, Alberto Herreros de Tejada, Sandro Sferrazza, Boris Pekarek, Jerome Rivory, Sophie Geyl, Shraddha Gulati, Peter Draganov, Neal Shahidi, Ejaz Hossain, Carola Fleischmann, Edoardo Vespa, Andrea Iannone, Asma Alkandari, Cesare Hassan, Alessandro Repici
Summary: For patients with high-risk submucosa-invasive T1 colorectal cancer, follow-up only may be a reasonable choice after endoscopic submucosal dissection (ESD).
Article
Oncology
Liang Wang, Dong Hang, Xiaosheng He, Chun-Han Lo, Kana Wu, Andrew T. Chan, Shuji Ogino, Edward L. Giovannucci, Mingyang Song
Summary: The study indicates that erythrocyte PUFAs in a typical American diet are unlikely to have a substantial influence on the risk of colorectal cancer precursors. However, certain PUFAs may be associated with different types of colorectal polyp risks. Further confirmation is needed for subgroup associations.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Surgery
Roupen Djinbachian, Marie-Lyssa Lafontaine, Talia Dufault, Edgard Medawar, Michel Boivin, Mickael Bouin, Daniel von Renteln
Summary: This study aimed to evaluate the rate of synchronous advanced neoplasia (S-AN) and synchronous CRC (S-CRC) in colonoscopies where serrated lesions (SL) were detected. The study included 1262 patients with 1649 SLs. The results showed that patients with SLs are at high-risk of S-AN and S-CRC, with SSPs >= 10 mm and SSP dysplasia being high-risk factors for S-AN.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
Joseph C. Anderson, Douglas K. Rex, Todd A. Mackenzie, William Hisey, Christina M. Robinson, Lynn F. Butterly
Summary: In this study, New Hampshire Colonoscopy Registry data were used to analyze the association between postcolonoscopy colorectal cancer (PCCRC) and sessile serrated detection rates (SSLDRs). The results showed that endoscopists with higher SSLDRs had lower risks of PCCRC, indicating that SSLDR is a clinically relevant quality measure.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Joshua Demb, Lin Liu, Caitlin C. Murphy, Chyke A. Doubeni, Maria Elena Martinez, Samir Gupta
Summary: The incidence of young-onset colorectal cancer (YCRC) is increasing, and there may be an association between iron-deficiency anaemia (IDA), haematochezia, and YCRC in US Veterans aged 18-49. By comparing individuals with IDA or haematochezia to those without, the cumulative incidence and risk of YCRC can be assessed.
Article
Gastroenterology & Hepatology
Uri Ladabaum, John Shepard, Ajitha Mannalithara
Summary: The study analyzed colonoscopy volumes and lesion detection rates before and after the endorsement of colorectal cancer (CRC) screening at 45-49 years of age. It found that lowering the screening initiation age had a modest effect on colonoscopy volume without compromising screening yield, and the detection rates for lesions in the 45-49 age group were similar to those in older age groups. Further national monitoring is needed to fully assess the impact of this change in screening guidelines.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Surgery
Hyun Jung, Ja In Lee, Cheal Wung Huh, Min Jae Kim, Young Noon Youn, Yeong Hyeon Choi, Byung-Wook Kim
Summary: This study investigated the association between withdrawal time (WT) and adenoma detection rate (ADR) in surveillance colonoscopy after colorectal cancer (CRC) surgery, revealing the importance of sufficient WT for increasing ADR. Slow colonoscopists showed significantly higher ADR than fast colonoscopists, emphasizing the impact of WT on ADR.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, General & Internal
Xuechen Chen, Hengjing Li, Marko Mandic, Michael Hoffmeister, Hermann Brenner
Summary: This study explores the association between body mass index (BMI), polygenic risk, and colorectal cancer (CRC), finding that excess weight is associated with CRC regardless of genetic risk, and having a BMI within the reference range may offset the increased genetic risk for CRC.
Article
Gastroenterology & Hepatology
Maanek Sehgal, Uri Ladabaum, Alka Mithal, Harminder Singh, Manisha Desai, Gurkirpal Singh
Summary: This study found that undergoing colonoscopy at ages 45-49 or 50-54 years was associated with substantial decreases in subsequent colorectal cancer incidence.
Letter
Gastroenterology & Hepatology
Henriette C. Jodal, Magnus Loberg
Summary: This article is linked to papers by Jodal et al. To view these articles, please visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Leonardo Frazzoni, Liboria Laterza, Marina La Marca, Rocco Maurizio Zagari, Franco Radaelli, Cesare Hassan, Alessandro Repici, Antonio Facciorusso, Paraskevas Gkolfakis, Cristiano Spada, Konstantinos Triantafyllou, Franco Bazzoli, Mario Dinis-Ribeiro, Lorenzo Fuccio
Summary: This study assessed the diagnostic performance of alarm features (rectal bleeding, anemia, change in bowel habit, and weight loss) for colorectal cancer (CRC) diagnosis through a systematic review and meta-analysis. The results showed variable accuracy for each alarm feature, and rectal bleeding and anemia were identified as the most practical features for selecting patients for colonoscopy.
Letter
Gastroenterology & Hepatology
Cesare Hassan, Prateek Sharma, Yuichi Mori, Michael Bretthauer, Douglas K. Rex, A. L. E. S. S. A. N. D. R. O. Combo Study Grp, Alessandro Repici
Article
Gastroenterology & Hepatology
Mohamed Abdelrahim, Masahiro Saiko, Naoto Maeda, Ejaz Hossain, Asma Alkandari, Sharmila Subramaniam, Adolfo Parra-Blanco, Andres Sanchez-Yague, Emmanuel Coron, Alessandro Repici, Pradeep Bhandari
Summary: This study aimed to develop and validate a computer-aided detection system for Barrett's neoplasia and compare its performance with that of general endoscopists. The results showed that the CAD system had a higher sensitivity in detecting Barrett's neoplasia compared to the endoscopists.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Cesare Hassan, Daniele Piovani, Marco Spadaccini, Tommaso Parigi, Kareem Khalaf, Antonio Facciorusso, Alessandro Fugazza, Thomas Roesch, Michael Bretthauer, Yuichi Mori, Prateek Sharma, Douglas K. Rex, Stefanos Bonovas, Alessandro Repici
Summary: This study conducted a systematic review and meta-analysis of the control groups in randomized controlled trials (RCTs) using high-definition white-light endoscopy to investigate the variability of adenoma detection rate (ADR). The results showed a high level of variability in ADR among different studies. Fecal immunochemical testing-based colonoscopy studies were found to have an impact on ADR, while primary colonoscopy screening was similar to other indications. Standardization of variables related to clinical, methodologic, and technical parameters is necessary to achieve generalizability and reproducibility.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Leonardo Da Rio, Marco Spadaccini, Tommaso Lorenzo Parigi, Roberto Gabbiadini, Arianna Dal Buono, Anita Busacca, Roberta Maselli, Alessandro Fugazza, Matteo Colombo, Silvia Carrara, Gianluca Franchellucci, Ludovico Alfarone, Antonio Facciorusso, Cesare Hassan, Alessandro Repici, Alessandro Armuzzi
Summary: Inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, pose a growing burden on healthcare systems worldwide. Artificial intelligence has emerged as an essential tool in the diagnosis, treatment, and surveillance of these diseases, as well as in data collection and analysis. This review discusses the recent evidence and potential future developments in the use of artificial intelligence in inflammatory bowel diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Manuel Zorzi, Giulio Antonelli, Claudio Barbiellini Amidei, Jessica Battagello, Bastianello Germana, Flavio Valiante, Stefano Benvenuti, Alberto Tringali, Francesco Bortoluzzi, Erica Cervellin, Davide K. Giacomin, Tamara Meggiato, Erik Rosa-Rizzotto, Diego Fregonese, Manuela Dinca, Gianluca Baldassarre, Paola Scalon, Maurizio Pantalena, Luisa Milan, Gianmarco Bulighin, Daniele Di Piramo, Maurizio Azzurro, Armando Gabbrielli, Alessandro Repici, Douglas Rex, Massimo Rugge, Cesare Hassan
Summary: In a FIT-based screening program, there is an inverse association between ADR and the risk of PCCRC, highlighting the importance of monitoring colonoscopy quality. Increasing endoscopists' ADR can significantly reduce the risk of PCCRC.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Benedetto Mangiavillano, Alberto Larghi, Jorge Vargas-Madrigal, Antonio Facciorusso, Francesco Di Matteo, Stefano Francesco Crino, Khanh Do-Cong Pham, Jong Hoo Moon, Francesco Auriemma, Lorenzo Camellini, Danilo Paduano, Serena Stigliano, Federica Calabrese, Andrew Ofosu, Abed Al-Lehibi, Alessandro Repici
Summary: This study evaluated the safety, technical, and clinical effectiveness of EUS-GE using a newly available EC-LAMS for the treatment of malignant and benign gastric outlet obstruction (GOO). The results showed that EUS-GE was successfully performed in all patients, with a mean procedural time of 35 minutes and a clinical success rate of 68%. Improvements in GOOSS score and resumption of oral diet were observed in all patients. No procedure-related adverse events occurred, and no stent dysfunctions were observed during follow-up.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Yuichi Mori, James E. East, Cesare Hassan, Natalie Halvorsen, Tyler M. Berzin, Michael Byrne, Daniel von Renteln, David G. Hewett, Alessandro Repici, Mohan Ramchandani, Maryam Al Khatry, Shin-ei Kudo, Pu Wang, Honggang Yu, Yutaka Saito, Masashi Misawa, Sravanthi Parasa, Carolina Ogawa Matsubayashi, Haruhiko Ogata, Hisao Tajiri, Nonthalee Pausawasdi, Evelien Dekker, Omer F. Ahmad, Prateek Sharma, Douglas K. Rex
Summary: The number of AI tools for colonoscopy is increasing, but their implementation is facing challenges due to lack of clinical evidence and cost-effectiveness, lack of guidelines, uncertain indications, and implementation costs. The World Endoscopy Organization (WEO) has provided its position statement to address these issues and guide practitioners. The statement includes recommendations for the use of computer-aided detection (CADe) and computer-aided diagnosis (CADx), and emphasizes the need for cost-effectiveness research to understand the benefits of AI implementation.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Mathilde Simonnot, Pierre H. Deprez, Mathieu Pioche, Eliane Albuisson, Timothee Wallenhorst, Fabrice Caillol, Stephane Koch, Emmanuel Coron, Isabelle Archambeaud, Jeremie Jacques, Paul Basile, Ludovic Caillo, Thibault Degand, Vincent Lepilliez, Philippe Grandval, Adrian Culetto, Geoffroy Vanbiervliet, Marine Camus Duboc, Olivier Gronier, Carina Leal, Jeremie Albouys, Jean-Baptiste Chevaux, Maximilien Barret, Marion Schaefer
Summary: The study aimed to evaluate the safety and efficacy of endoscopic resection for early esophageal neoplasia in patients with cirrhosis or portal hypertension. The results showed that endoscopic resection was effective and safe for these patients, and the choice of resection technique should be made in expert centers following European Society of Gastrointestinal Endoscopy guidelines.
Article
Nutrition & Dietetics
Giulia Rizzo, Samuel Elias Pineda Chavez, Elisa Vandenkoornhuyse, Cindy Lorena Cardenas Rincon, Valeria Cento, Valentina Garlatti, Marek Wozny, Giusy Sammarco, Alessia Di Claudio, Lisa Meanti, Sudharshan Elangovan, Andrea Romano, Giulia Roda, Laura Loy, Arianna Dal Buono, Roberto Gabbiadini, Sara Lovisa, Roberto Rusconi, Alessandro Repici, Alessandro Armuzzi, Stefania Vetrano
Summary: This study found that pomegranate extract has beneficial effects in promoting the recovery phase of colitis and the complete restoration of the intestinal barrier. It also affects pathogen biofilm formation and promotes mucosal regeneration through the regulation of the crosstalk between epithelial and stromal cells.
Review
Medicine, General & Internal
Virginia Solitano, Arianna Dal Buono, Roberto Gabbiadini, Marek Wozny, Alessandro Repici, Antonino Spinelli, Stefania Vetrano, Alessandro Armuzzi
Summary: Fibro-stenosing Crohn's disease (CD) is a common disease presentation that leads to impaired quality of life and often requires endoscopic treatments or surgery. Currently, there are no existing imaging techniques that can accurately quantify the amount of fibrosis within a stricture, and managing patients is challenging, requiring a multidisciplinary team.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Kareem Khalaf, Maria Terrin, Manol Jovani, Tommy Rizkala, Marco Spadaccini, Katarzyna M. Pawlak, Matteo Colombo, Marta Andreozzi, Alessandro Fugazza, Antonio Facciorusso, Fabio Grizzi, Cesare Hassan, Alessandro Repici, Silvia Carrara
Summary: Endoscopic Ultrasound (EUS) is widely used for diagnosing bilio-pancreatic and gastrointestinal (GI) tract diseases, as well as evaluating subepithelial lesions and sampling lymph nodes and solid masses. Artificial Intelligence (AI) algorithms can aid in lesion detection and characterization in EUS by analyzing images and identifying suspicious areas, leading to faster and more accurate diagnoses. Deep learning techniques, such as convolutional neural networks (CNNs), have shown potential in tumor identification and subepithelial lesion evaluation by extracting important features from EUS images. AI integration in EUS has the potential to improve diagnostic accuracy, patient outcomes, and reduce non-diagnostic biopsies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Marco Spadaccini, Davide Massimi, Yuichi Mori, Ludovico Alfarone, Alessandro Fugazza, Roberta Maselli, Prateek Sharma, Antonio Facciorusso, Cesare Hassan, Alessandro Repici
Summary: Colorectal cancer is the third most common cancer worldwide, with the highest incidence in high-income countries. A well-designed endoscopic screening program can significantly reduce colorectal cancer incidence and mortality. Artificial intelligence (AI) applications in endoscopy, specifically machine and deep learning, have the potential to automatically extract specific features from endoscopic images/videos, assisting endoscopists in various aspects of their practice. This review aims to summarize the current knowledge on AI-aided endoscopy and its potential role in colorectal cancer prevention.
Review
Cardiac & Cardiovascular Systems
Roberto Gabbiadini, Arianna Dal Buono, Elisabetta Mastrorocco, Virginia Solitano, Alessandro Repici, Antonino Spinelli, Gianluigi Condorelli, Alessandro Armuzzi
Summary: Atherosclerotic cardiovascular disease and stroke contribute significantly to global morbidity and mortality. Chronic inflammation, in addition to traditional risk factors, plays a crucial role in the progression of atherosclerosis and the occurrence of arterial thromboembolic events. Recent studies have shown an increased risk of atherosclerotic disease in patients with inflammatory bowel diseases (IBD), particularly during disease flares. Therefore, IBD treatment may be important in reducing the risk of arterial thromboembolic events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biology
Marco Spadaccini, Ludovico Alfarone, Viveksandeep Thoguluva Chandrasekar, Roberta Maselli, Antonio Capogreco, Gianluca Franchellucci, Davide Massimi, Alessandro Fugazza, Matteo Colombo, Silvia Carrara, Antonio Facciorusso, Pradeep Bhandari, Prateek Sharma, Cesare Hassan, Alessandro Repici
Summary: Over the last two decades, endoscopic eradication therapy has become the preferred treatment strategy for patients with Barrett's oesophagus-related dysplasia and early oesophageal adenocarcinoma. Radiofrequency ablation is the first-line option due to its proven effectiveness and safety, although it is expensive and not universally applicable. Cryotherapy techniques and hybrid argon plasma coagulation have shown promising results as potential alternatives to radiofrequency ablation. This review aims to provide a practical guide for the different ablative options for Barrett's oesophagus.