Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 18, Issue 48, Pages 7357-7361Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v18.i48.7357
Keywords
Gastric cancer; Pepsinogens; Helicobacter pylori; Gastric atrophy; Screening
Categories
Funding
- National Natural Science Foundation of China [30972476, 81072369]
Ask authors/readers for more resources
AIM: To investigate screening makers for gastric cancer, we assessed the association between gastric cancer and serum pepsinogens (PGs). METHODS: The subjects comprised 450 patients with gastric cancer, 111 individuals with gastric atrophy, and 961 healthy controls. Serum anti-Helicobacter pylori (H. pylon) immunoglobulin G (IgG), PG I and PG II were detected by enzyme-linked immunosorbent assay. Gastric atrophy and gastric cancer were diagnosed by endoscopy and histopathological examinations. Odds ratios and 95%CIs were calculated using multivariate logistic regression. RESULTS: Rates of H. pylori infection remained high in Northeastern China. Rates of H. pylori IgG positivity were greater in the gastric cancer and gastric atrophy groups compared to the control group (69.1% and 75.7% vs 49.7%, P < 0.001). Higher levels of PG II (15.9 mu g/L and 13.9 mu g/L vs 11.5 mu g/L, P < 0.001) and lower PG I / PG II ratio (5.4 and 4.6 vs 8.4, P < 0.001) were found in patients with gastric cancer or gastric atrophy compared to healthy controls, whereas no correlation was found between the plasma PG I concentration and risk of gastric cancer (P = 0.537). In addition, multivariate logistic analysis indicated that H. pylori infection and atrophic gastritis were independent risk factors for gastric cancer. Lower plasma PG I /PG H ratio was associated with higher risks of atrophy and gastric cancer. Furthermore, plasma PG II level significantly correlated with H. pylori-infected gastric cancer. CONCLUSION: Serum PG II concentration and PG I /PG 11 ratio are potential biomarkers for H. pylori-infected gastric disease. PG 11 is independently associated with risk of gastric cancer. (C) 2012 Baishideng. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available