Review
Oncology
Caitlin T. Demarest, Andrew C. Chang
Summary: Esophagectomy is the main treatment for resectable esophageal cancer, with chemotherapy and chemoradiation as essential adjunct therapies. The optimal perioperative therapy remains controversial. Three landmark trials have established chemotherapy and chemoradiotherapy as standard care, with ongoing research aiming to clarify the roles of different regimens in esophageal cancer treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
I. L. Defize, S. van der Horst, M. Bulbul, N. Haj Mohammad, S. Mook, G. J. Meijer, L. A. A. Brosens, J. P. Ruurda, R. van Hillegersberg
Summary: In patients with cT4b esophageal cancer treated with dCRT followed by a salvage RAMIE, a radical resection rate of 92% was achieved, with acceptable complications and promising survival rates. These results demonstrate the feasibility of a curative surgical treatment for patients with initially irresectable esophageal cancer but underscore the importance of proper preoperative patient selection.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Wenjie Ni, Shufei Yu, Zefen Xiao, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Shugeng Gao, Yousheng Mao, Qi Xue, Kelin Sun, Xiangyang Liu, Dekang Fang, Jian Li, Dali Wang, Jun Zhao, Yushun Gao
Summary: The study demonstrated that postoperative radiotherapy/postoperative concurrent chemoradiotherapy (PORT/POCRT) could significantly improve disease-free survival and overall survival in patients with stage IIB-III esophageal squamous cell carcinoma.
Article
Cardiac & Cardiovascular Systems
Nicolas Zhou, Wayne L. Hofstetter
Summary: Variability in the definition of salvage esophagectomy can influence the interpretation of outcomes between trimodality therapy and bimodality therapy. Future studies should consistently define treatment groups.
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. H. Kauppila, Fredrik Mattsson, Mats Lindblad, Magnus Nilsson, Pernilla Lagergren, Ioannis Rouvelas, Jesper Lagergren, FINEGO Grp
Summary: This study suggests that minimally invasive esophagectomy (MIE) is associated with higher 5-year survival compared to open esophagectomy (OE) in patients with esophageal cancer, especially total MIE.
Article
Multidisciplinary Sciences
Guojun Chen, Zhitong Chen, Zejun Wang, Richard Obenchain, Di Wen, Hongjun Li, Richard E. Wirz, Zhen Gu
Summary: The cold atmospheric plasma (CAP) post-surgical treatment effectively induces immunogenic cell death in residual tumor cells and evokes T cell-mediated immune responses to combat them, contributing to tumor growth inhibition and prolonged survival in cancer models.
Article
Oncology
S. Senan, M. Ozguroglu, D. Daniel, A. Villegas, D. Vicente, S. Murakami, R. Hui, C. Faivre-Finn, L. Paz-Ares, Y. L. Wu, H. Mann, P. A. Dennis, S. J. Antonia
Summary: Durvalumab improves progression-free survival and overall survival in patients with or without stage IIIA-N2 non-small-cell lung cancer (NSCLC). Further research is needed to determine the optimal treatment approach for patients who are deemed operable.
Article
Surgery
Yusuke Fujii, Hiroyuki Daiko, Kentaro Kubo, Kyohei Kanematsu, Daichi Utsunomiya, Daisuke Kurita, Koshiro Ishiyama, Junya Oguma
Summary: Despite advances in diagnostic imaging modalities, the preoperative diagnosis of T4 esophageal cancer remains difficult and the prognosis is poor. The study retrospectively reviewed the prognosis of surgical T4b esophageal cancer.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Amit Katz, Yehonatan Nevo, Jose Luis Ramirez Garcia Luna, Sonia Anchouche, James Tankel, Natasha Caminsky, Carmen Mueller, Jonathan Spicer, Jonathan Cools-Lartigue, Lorenzo Ferri
Summary: This study aimed to determine the long-term quality of life after esophagectomy. The analysis of a high-volume center's esophagectomy database found that patients' health-related quality of life gradually improved after surgery and did not differ from the general population.
ANNALS OF THORACIC SURGERY
(2023)
Article
Surgery
Takashi Sakamoto, Michimasa Fujiogi, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
Summary: By comparing the surgical outcomes of MIE and OE for esophageal cancer, it was found that MIE had lower incidences of in-hospital mortality, morbidities, such as surgical site infection and anastomotic leakage, and a shorter postoperative length of stay; however, it also had higher incidences of vocal cord dysfunction and prolonged intubation period after esophagectomy.
Review
Oncology
M. Usman Ahmad, Christopher Javadi, George A. Poultsides
Summary: Neoadjuvant and/or perioperative therapy has emerged as a treatment tool to improve patient selection and locoregional control for resectable proximal gastric, gastroesophageal junction, and distal esophageal cancer. Treatment recommendations differ based on histologic type and tumor location. Neoadjuvant chemoradiation with concurrent taxane- or fluoropyrimidine-based chemotherapy has shown efficacy for both adenocarcinoma and squamous cell carcinoma of the distal esophagus and gastroesophageal junction.
Article
Oncology
Junichi Sano, Satoru Matsuda, Hirofumi Kawakubo, Ryo Takemura, Jun Okui, Tomoyuki Irino, Kazumasa Fukuda, Rieko Nakamura, Yuko Kitagawa
Summary: The postoperative hypercoagulable state (PHS) has been found to be a negative prognostic factor in patients with esophageal cancer, affecting their overall survival and recurrence-free survival. The possibility of improving oncological outcomes through early postoperative intervention with anticoagulants should be explored in clinical trials.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marianne C. Kalff, Isolde Vesseur, Wietse J. Eshuis, David J. Heineman, Freek Daams, Donald L. van der Peet, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
Summary: This study evaluated the clinicopathologic predictors of textbook outcome in esophageal cancer surgery and found that achieving textbook outcome was associated with better overall and disease-free survival. The study highlighted the correlation between textbook outcome and long-term survival, emphasizing the importance of pursuing textbook outcome.
ANNALS OF THORACIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Yu-Xiang Sun, Tian-Yu Zhu, Guo-Jun Wang, Bu-Lang Gao, Rui-Xin Li, Jing-Tao Wang
Summary: The feasibility of using the mesangium or membrane anatomy theory to guide thoracolaparoscopic radical esophagectomy for esophageal cancer was explored. The mesoesophageal group showed significant advantages in terms of surgical duration, blood loss, lymph node harvest, complications, and postoperative recovery.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Huiling Wang, Yufei Xu, Fengli Zuo, Junzhi Liu, Jiqiao Yang
Summary: This article provides a systematic summary and analysis of immunotherapy-based combination therapies for esophageal cancer (EC), highlighting the clinical advantages and various treatment options, particularly the use of PD-1 monoclonal antibodies.
FRONTIERS IN IMMUNOLOGY
(2022)