Article
Surgery
Wei-Feng Li, Yi-Hao Yen, Yueh-Wei Liu, Chih-Chi Wang, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng, Jing-Houng Wang, Sheng-Nan Lu
Summary: This study aimed to predict early recurrence of hepatocellular carcinoma after liver resection by assessing preoperative image tumor characteristics and alpha-fetoprotein levels. The study identified AFP level, tumor size, vascular invasion, and multiple tumors as predictive factors for early recurrence. A simple diagnostic model was developed to successfully predict early recurrence.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Wencui Li, Lizhu Han, Bohan Xiao, Xubin Li, Zhaoxiang Ye
Summary: This study aimed to identify the independent risk factors for AFP-NHCC and construct an individual prediction nomogram of early recurrence. The researchers found several independent predictors for early recurrence of AFP-NHCC and developed an effective nomogram. This nomogram could assist physicians in making more accurate personalized treatment decisions for AFP-NHCC patients.
Article
Oncology
Lei Liang, Ming-Da Wang, Yao-Ming Zhang, Wan-Guang Zhang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Timothy M. Pawlik, Dong-Sheng Huang, Tian Yang
Summary: This study investigated long-term recurrence and survival after hepatectomy for high-AFP HCC, finding that postoperative incomplete biomarker response was the strongest risk factor for predicting poor overall survival and recurrence-free survival in these patients.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Oncology
Yu Sun, Yiqi Xiong, Qi Wang, Wenying Qiao, Honghai Zhang, Yonghong Zhang
Summary: This study developed and validated a nomogram for patients with dynamic changes in AFP, which showed good predictive power for predicting the outcomes of these patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yuxin Liang, Zilong Zhang, Deyuan Zhong, Chunyou Lai, Zonglin Dai, Haibo Zou, Tianhang Feng, Jin Shang, Ying Shi, Xiaolun Huang
Summary: This study aimed to evaluate the prognostic value of the Inflammation-Immunity-Nutrition Score (IINS) in HCC patients undergoing radical surgery. The results showed that IINS could be a powerful clinical prognostic indicator for predicting overall survival and progression-free survival in these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chengkai Yang, Huaxiang Wang, Jianyong Liu, Fang Yang, Lizhi Lv, Yi Jiang, Qiucheng Cai
Summary: The study aimed to investigate the role of the AFP ratio before and after curative resection in the prognosis of HCC patients and develop a nomogram to predict RFS. The results showed that the AFP ratio was a reliable biomarker for tumor recurrence, and the AFP ratio-based nomogram accurately predicted tumor recurrence in HCC patients after curative resection.
FRONTIERS IN ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Hira Hanif, Mukarram Jamat Ali, Ammu T. Susheela, Iman Waheed Khan, Maria Alejandra Luna-Cuadros, Muzammil Muhammad Khan, Daryl Tan-Yeung Lau
Summary: Alpha-fetoprotein (AFP) is a tumor marker for hepatocellular carcinoma (HCC), but its utility is limited. However, combining AFP with other novel biomarkers can improve its accuracy. Additionally, increased AFP levels may be associated with liver diseases and other non-hepatic disorders.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Ke Ye, Qinqiao Fan, Mingming Yuan, Dong Wang, Liang Xiao, Guo Long, Rongrong Chen, Tongdi Fang, Zengbo Li, Ledu Zhou
Summary: This study investigated the application of ctDNA sequencing in the postoperative period of hepatocellular carcinoma. The results showed that postoperative ctDNA was an independent prognostic predictor of disease-free survival and overall survival in liver cancer patients, and combining it with AFP improved prediction performance. Postoperative ctDNA sequencing has great prognostic value in patients with liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Takashi Tanaka, Kazuhide Takata, Takashi Miyayama, Kumiko Shibata, Hiromi Fukuda, Ryo Yamauchi, Atsushi Fukunaga, Keiji Yokoyama, Satoshi Shakado, Shotaro Sakisaka, Fumihito Hirai
Summary: Percutaneous radiofrequency ablation (RFA) is an effective treatment for small hepatocellular carcinoma (HCC) with a diameter <= 3.0 cm. However, for HCC with a diameter > 3.0 cm, the treatment outcomes are influenced by prognostic factors such as distant tumor recurrence, Child-Pugh class, and pre-ablation des-gamma-carboxy prothrombin (DCP) levels.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Dirk Andreas Ridder, Arndt Weinmann, Mario Schindeldecker, Lana Louisa Urbansky, Kristina Berndt, Tiemo Sven Gerber, Hauke Lang, Johannes Lotz, Karl J. Lackner, Wilfried Roth, Beate Katharina Straub
Summary: AFP is a commonly used biomarker for HCC, with its serum concentration moderately correlated to in situ expression. High AFP levels in serum and tissue are associated with poor prognosis, vascular invasion, higher tumor grade, and specific tumor subtype. Serum AFP concentration is a stronger prognostic predictor independent of tissue AFP immunostaining.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Lan-Qing Yao, Zhong-Qi Fan, Ming-Da Wang, Yong-Kang Diao, Ting-Hao Chen, Yong-Yi Zeng, Zhong Chen, Xian-Ming Wang, Ya-Hao Zhou, Jie Li, Xin-Ping Fan, Ying-Jian Liang, Chao Li, Feng Shen, Guo-Yue Lv, Tian Yang
Summary: This study demonstrated the important prognostic value of preoperative AFP levels among patients undergoing resection for early-stage HCC. Incorporating AFP into the prognostic estimation of the BCLC algorithm can help guide individualized risk stratification and identify the necessity for neoadjuvant/adjuvant treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Andrew X. Zhu, Richard S. Finn, Yoon-Koo Kang, Chia-Jui Yen, Peter R. Galle, Josep M. Llovet, Eric Assenat, Giovanni Brandi, Kenta Motomura, Izumi Ohno, Bruno Daniele, Arndt Vogel, Tatsuya Yamashita, Chih-Hung Hsu, Guido Gerken, John Bilbruck, Yanzhi Hsu, Kun Liang, Ryan C. Widau, Chunxiao Wang, Paolo Abada, Masatoshi Kudo
Summary: Baseline AFP is an important prognostic factor and predictive biomarker for the survival benefit of ramucirumab, with AFP response showing a significant association with longer patient survival.
BRITISH JOURNAL OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Ruoyu Liu, Yi Li, Anqi Wu, Mingzhu Kong, Weijia Ding, Zeyang Hu, Lin Chen, Weihua Cai, Feng Wang
Summary: Plasma circular RNA hsa_circ_0005397 is upregulated in HCC patients and closely correlated with tumor size and TNM staging. Its combination with other biomarkers can improve diagnostic sensitivity for HCC, predict recurrence or metastasis, and is associated with shorter overall survival in HCC patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Quirino Lai, Andre Viveiros, Samuele Iesari, Alessandro Vitale, Gianluca Mennini, Simona Onali, Maria Hoppe-Lotichius, Marco Colasanti, Tommaso M. Manzia, Federico Mocchegiani, Gabriele Spoletini, Salvatore Agnes, Marco Vivarelli, Giuseppe Tisone, Giuseppe M. Ettorre, Jens Mittler, Emmanuel Tsochatzis, Massimo Rossi, Umberto Cillo, Benedikt Schaefer, Jan P. Lerut
Summary: This study aimed to identify risk factors for long-term survival after liver transplantation for hepatocellular cancer (HCC). The results showed that a significant number of patients experienced HCC recurrence after transplantation, but liver transplantation still yields better long-term survival rates compared to other oncologic treatments. The study also found that the era of transplantation affects patients' survival rates, with more recent cases showing improved survival rates.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Nada El-domiaty, Faouzi Saliba, Eric Vibert, Vincent Karam, Rodolphe Sobesky, Wafaa Ibrahim, Gabriella Pittau, Oriana Ciacio, Chady Salloum, Khaled Amer, Maysaa A. Saeed, Jihan A. Shawky, Antonio Sa Cunha, Olivier Rosmorduc, Daniel Cherqui, Rene Adam, Didier Samuel
Summary: The study found that recurrence of hepatocellular carcinoma (HCC) has a significant impact on short- and medium-term outcomes after liver transplantation, with significantly lower survival rates among patients with early recurrence compared to those with late recurrence. Factors such as alcoholic cirrhosis, bilobar tumor at the time of LT, and tumor size in the explant have been identified as independent predictors of early recurrence.
Article
Medicine, Research & Experimental
Chun-Jung Cho, Cheng-Ping Yu, Chia-Lun Wu, Jar-Yi Ho, Ching-Wei Yang, Dah-Shyong Yu
Summary: The study demonstrated that capsaicin has the strongest synergistic cytotoxic effect with gemcitabine on T24-GCB cells, while quercetin, curcumin, and resveratrol have additive effects. Different phytochemicals have varying mechanisms when combined with gemcitabine for the treatment of bladder cancer.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Tai-Han Lin, Hong-Wei Gao, Guo-Shiou Liao, Jyh-Cherng Yu, Ming-Shen Dai, Jar-Yi Ho, Cheng-Ping Yu
Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death of women worldwide. This retrospective study aimed to propose better prognostic cut-off levels for ER and PgR, and found that patients with PgR expression <= 50% or an Allred score <= 5 exhibited a poor prognosis, needing more attention during follow-up.
Article
Environmental Sciences
Mohammad Radwanur Talukder, Cordia Chu, Shannon Rutherford, Cunrui Huang, Dung Phung
Summary: Vietnam is one of the most vulnerable countries in Southeast Asia to climate change, with the northern sub-tropical region lacking research on temperature-health effects, making specific health system preparedness challenging. This study found a significant effect of high temperature on hospitalizations on the same day, particularly for infectious and respiratory diseases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Rina Suryani Oktari, Febi Dwirahmadi, Connie Cai Ru Gan, Kristin Darundiyah, Pratomo Cahyo Nugroho, Arif Wibowo, Cordia Chu
Summary: In recent years, Indonesia has faced severe climate-related disasters with uneven impacts on the population, particularly the poor and vulnerable groups. This study aims to examine the existing measures and policies addressing climate-related disasters and health impacts among vulnerable groups in Indonesia. Through a scoping review, the study identifies action areas, content, and potential gaps in the Health Emergency and Disaster Risk Management framework. The study also proposes strategies and recommendations to support health adaptation actions in facing climate-related disasters in Indonesia.
Article
Oncology
Cheng-Shuo Huang, Chen-Hua Tsai, Cheng-Ping Yu, Ying-Si Wu, Ming-Fong Yee, Jar-Yi Ho, Dah-Shyong Yu
Summary: This study demonstrates that LINC02470 plays a crucial role in promoting TGF-beta-induced EMT through the miR-143-3p/SMAD3 axis, thus aggravating bladder cancer progression. The findings suggest that LINC02470 could be a potential prognostic marker for bladder cancer.
Editorial Material
Medicine, General & Internal
Sotiris Vardoulakis, Veronica Matthews, Ross S. Bailie, Wenbiao Hu, Luis Salvador-Carulla, Alexandra L. Barratt, Cordia Chu
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Review
Environmental Sciences
Yingying Jiang, Haijun Guo, Weiwei Zhang, Connie C. R. Gan, Fan Mao, Maigeng Zhou, Hai Phung, Dung Phung, Jianqun Dong, Cordia Chu
Summary: This review evaluates the existing control and prevention policies for NCDs in China and highlights the government's determination and commitment towards addressing these diseases and promoting public health. Although significant efforts have been made, there is a need for further action in terms of policy transformation and evaluation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Biology
Ting Li, Tetsuya Asakawa, Hui Liu, Cordia Chu, Hongzhou Lu
Summary: COVID-19 has led to a decrease in attention towards influenza, but influenza is still present and recent epidemics have occurred in China and Australia. There may be interactions between COVID-19 and influenza, and measures against COVID-19 could reduce the population's adaptive immunity against influenza. Insufficient immunity may lead to a future influenza pandemic, and co-infection with COVID-19 and influenza is a potential issue to be addressed.
Article
Public, Environmental & Occupational Health
Nu Quy Linh Tran, Son Nghiem, Cordia Chu, Mai Anh Luong, Thi Tu Ho, Dung Phung
Summary: Hot weather poses a significant occupational health risk for rice farmers in Vietnam, with those having chronic diseases such as hypertension and cardiovascular diseases being at higher risk of heat-related illnesses. Changing the working schedule, reducing working hours, and staying well-hydrated can help reduce the risk of heat-related illnesses.
JOURNAL OF AGROMEDICINE
(2023)
Article
Medicine, General & Internal
Chuanxi Li, Zhendong Wang, Yu Yan, Yinan Qu, Liangyu Hou, Yijie Li, Cordia Chu, Alistair Woodward, Tamara Schikowski, Paulo Hilario Nascimento Saldiva, Qiyong Liu, Qi Zhao, Wei Ma
Summary: This study quantified the association between hydrological conditions and dengue fever incidence in China and explored the modification role of city development in this association. Results showed that both extreme wet and dry conditions were associated with increased dengue fever risk, with different dimensions of city development playing various modification roles. These findings are important for developing climate change adaptation strategies and public health interventions against dengue fever.
Article
Public, Environmental & Occupational Health
Shasha Yuan, Ting Li, Cordia Chu, Xiaowan Wang, Lei Liu
Summary: This study estimated the treatment cost and specific cost components for COVID-19 inpatients in Shenzhen, China from 2020 to 2021. The results showed differences in treatment cost among different clinical classifications and admission stages, highlighting the importance of informing the financial burden on the health insurance fund and government, emphasizing the rational use of lab tests and western medicine in the treatment guidelines, and designing suitable treatment and control policies for convalescent cases.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Public, Environmental & Occupational Health
Mahan Mohammadi, Hamid Jafari, Manal Etemadi, Yohani Dalugoda, Heba Mohtady Ali, Hai Phung, Alireza Ahmadvand, Febi Dwirahmadi, Paul Barnes, Cordia Chu
Summary: Forcibly displaced populations, especially long-settled ones, face various health problems, with noncommunicable diseases and mental health issues being prominent. This scoping review examined the prevalence of these disorders and their correlates among displaced populations worldwide. The study revealed that noncommunicable diseases have the highest prevalence among the studied populations, followed by communicable diseases. Forced displaced migrants experience a triple burden of communicable and noncommunicable diseases, making it crucial for health-related research and policy to consider the linkages between disasters, health problems, and forced migration in the era of climate change-induced displacements.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Article
Public, Environmental & Occupational Health
Yingying Jiang, Tingling Xu, Wenlan Dong, Cordia Chu, Maigeng Zhou
Summary: The number of deaths and disease burdens caused by high sugar-sweetened beverages intake in China has significantly increased over the past three decades. The burden of disease due to high intake of sugary beverages varies widely from province to province. Attention should be paid to the issue of excessive intake of high sugar-sweetened beverages in the Chinese population, and comprehensive measures should be taken in China's sugar control work.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Yuqi Bai, Yutong Zhang, Olena Zotova, Helen Pineo, Jose Siri, Lu Liang, Xiangyu Luo, Mei-Po Kwan, John Ji, Xiaopeng Jiang, Cordia Chu, Na Cong, Vivian Lin, William Summerskill, Yong Luo, Hongjun Yu, Tinghai Wu, Changhong Yang, Jing Li, Yixiong Xiao, Jingbo Zhou, Dejing Dou, Hui Xiong, Lee Ligang Zhang, Lan Wang, Shu Tao, Bojie Fu, Yong Zhang, Bing Xu, Jun Yang, Peng Gong
Summary: China's National Healthy Cities pilot program and related urban health governmental initiatives have raised awareness of health among local governments and the public. However, the Healthy Cities initiative in China is at a crucial juncture due to overlapping efforts, changing public health priorities, and partial adoption of the World Health Organization's approach. Aligning the initiative with national and global agendas will require integrating governance frameworks and best practices to improve population health systematically.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Medicine, General & Internal
Chien-Peng Huang, Ming-Shen Dai, Chien-Chang Kao, Wen-Chiuan Tsai, Cheng-Ping Yu
Summary: Oncocytic adrenal cortical neoplasms, including oncocytoma, oncocytic neoplasms of uncertain malignant potential, and oncocytic adrenal cortical carcinomas, are rare cases. We present a case of oncocytic adrenal cortical carcinoma with scalp metastasis, which is the first reported case of its kind. Our case highlights the limitations of the current diagnostic algorithm and emphasizes the importance of two parameters (PHH3 and Ki-67) in determining the malignant potential of oncocytic adrenal cortical neoplasms.
MEDICINA-LITHUANIA
(2022)