Article
Gastroenterology & Hepatology
Pierre Nahon, Christophe Aube, Lucile Moga, Julia Chalaye, Boris Guiu, Alain Luciani, Agnes Rode, Maxime Ronot, Olivier Seror, Michael Soussan, Olivier Sutter, Marc Bourliere, Christophe Bureau, Victor de Ledinghen, Nathalie Ganne-Carrie
Summary: Hepatocellular carcinoma (HCC) is the most common malignant liver tumor that develops on a background of cirrhosis, and histological confirmation is not mandatory in many cases due to typical radiological patterns described by contrast-enhanced imaging. Liver biopsy may be essential in atypical presentations or to exclude other rare malignant tumors developed in the absence of cirrhosis.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Marc Monachese, Gautam Mankaney, Faris El-Khider, Carol Rouphael, Rocio Lopez, Carol A. Burke
Summary: Patients with small proximal and distal HPs are at increased risk of metachronous SSLs, underscoring the importance of considering these findings in surveillance recommendations and future studies with larger cohorts.
GASTROINTESTINAL ENDOSCOPY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Kathryn R. Taylor, Michelle Monje
Summary: This research has further revealed the interaction mechanism between neural circuits and glioblastoma, highlighting the importance of neuron-to-glioma synaptic communication in glioma invasion.
Article
Oncology
Yeonu Choi, Jonghoon Kim, Hyunjin Park, Hong Kwan Kim, Jhingook Kim, Ji Yun Jeong, Joong Hyun Ahn, Ho Yun Lee
Summary: Prognostic considerations for non-predominant histologic patterns are necessary because most lung adenocarcinomas have a mixed histologic pattern, with the second most predominant pattern being able to stratify patients according to prognosis. Imaging parameters like non-contrast CT value and SUVmax can help predict non-predominant but high-grade histologic patterns.
Article
Obstetrics & Gynecology
Manasawee Srisuttayasathien, Tarinee Manchana
Summary: This study evaluated the adherence to follow-up and regression rate of CIN 1 in women over a 24-month period. Results showed that nearly 40% of women were lost to follow-up at 24 months, highlighting the importance of adherence to follow-up for all women.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Gastroenterology & Hepatology
Edouard Bardou-Jacquet, Houda Hamdi-Roze, Anita Paisant, Marie Decraecker, Marc Bourliere, Nathalie Ganne-Carrie, Victor de Ledinghen, Christophe Bureau
Summary: Increased serum ferritin is a common reason for referral, requiring thorough evaluation to avoid unnecessary exploration and inaccurate diagnosis. Factors and tools relevant to this situation must be known by clinicians. Magnetic resonance imaging is a reference method for accurately determining liver iron content.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Urology & Nephrology
Morgan Roupret, Paolo Gontero, Stuart R. C. McCracken, Tim Dudderidge, Jacqueline Stockley, Ashleigh Kennedy, Oscar Rodriguez, Caroline Sieverink, Felicien Vanie, Marco Allasia, J. Alfred Witjes, Marc Colombel, Fabrizio Longo, Emanuele Montanari, Joan Palou, Richard J. Sylvester
Summary: The noninvasive ADXBLADDER urine test shows a high negative predictive value and has the potential to reduce unnecessary cystoscopies for patients with low-grade bladder cancer.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Urology & Nephrology
J. Alfred Witjes
Summary: Patients with non-muscle invasive bladder cancer (NMIBC) face challenges in frequent and suboptimal follow-up, with low levels of evidence and limitations in current tools. Urinary markers may offer a promising solution, potentially reducing patient burden and healthcare costs in the future.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Alessandra Mangia, Annarita Valeria Piazzolla, Maria Maddalena Squillante, Giovanna Cocomazzi, Vanna Maria Valori, Massimiliano Copetti, Paola Parente, Vito Attino, Maria Guido
Summary: Non-alcoholic fatty liver disease (NAFLD) can progress to severe liver fibrosis and cirrhosis. The presence of portal inflammation, high triglycerides levels, advanced fibrosis at baseline, and the duration of follow-up are predictors of disease progression in NAFLD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Dominique Thabut, Delphine Weil, Charlotte Bouzbib, Marika Rudler, Christophe Cassinotto, Laurent Castera, Thomas Serste, Frederic Oberti, Nathalie Ganne-Carrie, Victor de Ledinghen, Marc Bourliere, Christophe Bureau
Summary: Compensated advanced chronic liver disease (cACLD) refers to the advanced fibrosis/cirrhosis in asymptomatic patients who are at risk of developing clinically significant portal hypertension (CSPH). cACLD patients have a high risk of liver-related morbidity and mortality. LSM value or clinical/biological/radiological signs can strongly suggest the presence of cACLD. Favorable Baveno VI criteria can avoid endoscopic screening.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jerome Dumortier, Camille Besch, Lucile Moga, Audrey Coilly, Filomena Conti, Christophe Corpechot, Arnaud Del Bello, Francois Faitot, Claire Francoz, Marie-Noelle Hilleret, Pauline Houssel-Debry, Caroline Jezequel, Laurence Lavayssiere, Martine Neau-Cransac, Domitille Erard-Poinsot, Victor de Ledinghen, Marc Bourliere, Christophe Bureau, Nathalie Ganne-Carrie
Summary: Liver transplantation encompasses a wide range of diseases, with diagnosis mainly relying on MELD score and alpha-fetoprotein score for hepatocellular carcinoma. Radiological methods are used for post-transplantation complication diagnosis, while liver biopsy remains the gold standard for evaluating graft lesions.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Sara Lemoinne, Alexandra Heurgue, Charlotte Bouzbib, Bertrand Hanslik, Jerome Gournay, Eric Nguyen-Khac, Christophe Bureau, Victor de Ledinghen, Nathalie Ganne-Carrie, Marc Bourliere
Summary: Autoimmune hepatitis (AIH) is a liver disease characterized by necro-inflammatory lesions of hepatocytes, specific autoantibodies, and response to corticosteroid treatment. The diagnosis is based on a combination of clinical, biological, immunological, and histological findings, after excluding other causes of liver disease. Non-invasive tests can be used at different steps in the management of AIH for diagnosis and follow-up.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Lauren Hernandez-Buelvas, Milena Camargo, Ricardo Sanchez, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo
Summary: The study found a high distribution of TV among Colombian women and its coexistence with human papillomavirus (HPV) and other risk factors influenced parasite infection dynamics.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Nermin Koc, Ayse Deniz Erturk Coskun
Summary: This study evaluated the clinical course of patients with focal gland crowdings in endometrial polyps through repeat biopsies and found that the loss/decrease of PAX2 and altered epithelial cytological features in the initial biopsy can indicate a premalignant course.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Francesco Pierconti, Maurizio Martini, Tonia Cenci, Vincenzo Fiorentino, Luca Di Gianfrancesco, Mauro Ragonese, Riccardo Bientinesi, Ernesto Rossi, Luigi M. Larocca, Marco Racioppi, Pier Francesco Bassi
Summary: In the early follow-up of NMIBC, the EpiCheck test has the potential to replace urinary cytology.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Gastroenterology & Hepatology
Olga P. Nyssen, Dino Vaira, Angeles Perez Aisa, Luis Rodrigo, Manuel Castro-Fernandez, Laimas Jonaitis, Bojan Tepes, Liudmila Vologzhanina, Maria Caldas, Angel Lanas, Alfredo J. Lucendo, Luis Bujanda, Juan Ortuno, Jesus Barrio, Jose M. Huguet, Irina Voynovan, Jorge Perez Lasala, Aiman Silkanovna Sarsenbaeva, Luis Fernandez-Salazar, Javier Molina-Infante, Natasa Brglez Jurecic, Miguel Areia, Antonio Gasbarrini, Juozas Kupcinskas, Dmitry Bordin, Ricardo Marcos-Pinto, Frode Lerang, Marcis Leja, Gyorgy M. Buzas, Yaron Niv, Theodore Rokkas, Perminder Phull, Sinead Smith, Oleg Shvets, Marino Venerito, Vladimir Milivojevic, Ilkay Simsek, Vincent Lamy, Peter Bytzer, Lyudmila Boyanova, Lumir Kunovsky, Christoph Beglinger, Michael Doulberis, Wojciech Marlicz, Adrian Goldis, Ante Tonkic, Lisette Capelle, Ignasi Puig, Francis Megraud, Colm O' Morain, Javier P. Gisbert
Summary: The study evaluated the effectiveness and safety of second-line empiric treatment for H pylori infection by European gastroenterologists. For patients who failed previous eradication treatment attempts, treatment regimens including quinolone triple therapies and levofloxacin-bismuth quadruple therapy showed optimal eradication rates.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
A. Hernandez-Camba, L. Arranz, I Vera, D. Carpio, M. Calafat, A. J. Lucendo, C. Taxonera, S. Marin, M. J. Garcia, G. Suris Marin, E. Sanchez Rodriguez, A. Y. Carbajo, M. L. De Castro, M. Iborra, A. Martin-Cardona, I Rodriguez-Lago, D. Busquets, F. Bertoletti, M. Sierra Ausin, C. Tardillo, J. Huguet Malaves, L. Bujanda, A. Castano, E. Domenech, L. Ramos
Summary: This study evaluated the use of MMF in IBD and found that it has some effectiveness and good safety in treating IBD patients.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Sabela Carballal, Ariadna Sanchez, Leticia Moreira, Jesus Eduardo Cuellar-Monterrubio, Julio Bernuy, Maria Daca, Oswaldo Ortiz, Teresa Ocana, Liseth Rivero-Sanchez, Gerhard Jung, Anna Serradesanferm, Angels Pozo, Jaume Grau, Isabel Tora, Diana Zaffalon, Antoni Castells, Maria Pellise, Francesc Balaguer
Summary: The prevalence of having >= 10 adenomas in a FIT-based CRC screening program was 2.2%. Only a small percentage of patients with >= 20 adenomas had inherited syndromes. The rate of post-colonoscopy CRC was low and the risk of advanced neoplasia decreased throughout follow-up.
Article
Gastroenterology & Hepatology
Paula Arratibel, Ines Gil-Lasa, Julyssa Cobian, Arantzazu Izagirre-Arostegi, Teresa Arzallus, Ane Etxart, Cristina Sarasqueta, Leire Zubiaurre, Luis Bujanda
Summary: This retrospective study analyzed the clinical data of patients with esophageal foreign body impactions and found that eosinophilic esophagitis (EE) was closely related to factors such as age, history of respiratory diseases, endoscopic findings, and medication use. The study also pointed out a low mortality rate among patients, and deaths were associated with impactions.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Medicine, General & Internal
Olga P. Nyssen, Dino Vaira, Ilaria Maria Saracino, Giulia Fiorini, Maria Caldas, Luis Bujanda, Rinaldo Pellicano, Alma Keco-Huerga, Manuel Pabon-Carrasco, Elida Oblitas Susanibar, Alfredo Di Leo, Giuseppe Losurdo, Angeles Perez-Aisa, Antonio Gasbarrini, Doron Boltin, Sinead Smith, Perminder Phull, Theodore Rokkas, Dominique Lamarque, Anna Cano-Catala, Ignasi Puig, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: Rifabutin-containing therapy is an effective and safe strategy for Helicobacter pylori eradication, especially after first-line treatment failure or multiple treatment failures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Luis G. Guijarro, David Cano-Martinez, M. Val Toledo-Lobo, Lidia Ruiz-Llorente, Maria Chaparro, Ivan Guerra, Marisa Iborra, Jose Luis Cabriada, Luis Bujanda, Carlos Taxonera, Valle Garcia-Sanchez, Ignacio Marin-Jimenez, Manuel Barreiro-de Acosta, Isabel Vera, Maria Dolores Martin-Arranz, Francisco Mesonero, Laura Sempere, Fernando Gomollon, Joaquin Hinojosa, Sofia Zoullas, Jorge Monserrat, Cesar Menor-Salvan, Melchor Alvarez-Mon, Javier P. Gisbert, Miguel A. Ortega, Borja Hernandez-Breijo
Summary: This study found that levels of serum AIF-1 decrease in Crohn's disease (CD) patients after treatment with anti-TNFs. The study also revealed that active CD patients have higher levels of serum AIF-1 compared to inactive CD patients. The combination of serum AIF-1 and CRP levels improves the predictive ability for classifying CD patients by their severity.
Article
Gastroenterology & Hepatology
Kota Nakamura, Goretti Hernandez, Geeta G. Sharma, Yuma Wada, Jasjit K. Banwait, Natalia Gonzalez, Jose Perea, Francesc Balaguer, Hiroyuki Takamaru, Yutaka Saito, Yuji Toiyama, Yasuhiro Kodera, C. Richard Boland, Luis Bujanda, Enrique Quintero, Ajay Goel
Summary: A circulating miRNA signature has been developed as a potential noninvasive diagnostic tool for early-onset colorectal cancer (EOCRC), with high accuracy and clinical application potential.
Article
Medicine, General & Internal
Luis Fernandez-Salazar, Ana Campillo, Luis Rodrigo, Angeles Perez-Aisa, Jesus M. Gonzalez-Santiago, Xavier Segarra Ortega, Maja Denkovski, Natasa Brglez Jurecic, Luis Bujanda, Blas Jose Gomez Rodriguez, Juan Ortuno, Sotirios Georgopoulos, Laimas Jonaitis, Ignasi Puig, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert
Summary: This study evaluated the decisions and outcomes of H. pylori management by European gastroenterologists through an international multicenter observational registry. The findings suggest that high-dose dual therapy (HDDT) is not a good option for first-line or rescue treatment of H. pylori in Europe, even with the addition of bismuth.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yasuyuki Okada, Fuduan Peng, Jose Perea, Luis Corchete, Luis Bujanda, Wei Li, Ajay Goel
Summary: A novel methylation signature risk-scoring model was developed to reliably identify patients with synchronous colorectal cancer (SyCRC), which has the potential to improve the diagnosis and management of colorectal cancer (CRC) patients.
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Antonio Giordano, Gherzon Casanova, Miriam Escapa, Gloria Fernandez-Esparrach, Angels Gines, Oriol Sendino, Isis K. Araujo, Andres Cardenas, Henry Cordova, Julia Martinez-Ocon, Graciela Martinez-Palli, Francesc Balaguer, Josep Llach, Elena Ricart, Begona Gonzalez-Suarez
Summary: Motorized Spiral Enteroscopy (MSE) is an effective and safe examination method for patients with prior major abdominal surgery. Although longer procedure times were observed in these patients, the diagnostic yield was similar. Patients with gastrointestinal surgery showed a lower depth of insertion compared to those with other abdominal surgeries.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Genetics & Heredity
Yasmin Soares de Lima, Coral Arnau-Collell, Jenifer Munoz, Cristina Herrera-Pariente, Leticia Moreira, Teresa Ocana, Marcos Diaz-Gay, Sebastia Franch-Exposito, Miriam Cuatrecasas, Sabela Carballal, Anael Lopez-Novo, Lorena Moreno, Guerau Fernandez, Aranzazu Diaz de Bustamante, Sophia Peters, Anna K. Sommer, Isabel Spier, Iris B. A. W. te Paske, Yasmijn J. van Herwaarden, Antoni Castells, Luis Bujanda, Gabriel Capella, Verena Steinke-Lange, Khalid Mahmood, JiHoon Eric Joo, Julie Arnold, Susan Parry, Finlay A. Macrae, Ingrid M. Winship, Christophe Rosty, Joaquin Cubiella, Daniel Rodriguez-Alcalde, Elke Holinski-Feder, Richarda de Voer, Daniel D. Buchanan, Stefan Aretz, Clara Ruiz-Ponte, Laura Valle, Francesc Balaguer, Laia Bonjoch, Sergi Castellvi-Bel
Summary: Rare germline variants in the WNK2 gene were identified through functional evaluation of a candidate gene and replication in additional SPS cohorts. These variants may affect protein function in the MAPK pathway, thereby increasing the risk for SPS.
JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Biochemistry & Molecular Biology
Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, Joan Maurel, Ajay Goel
Article
Gastroenterology & Hepatology
Francisco J. Caballero-Camino, Pedro M. Rodrigues, Fredrik Wangsell, Alona Agirre-Lizaso, Paula Olaizola, Laura Izquierdo-Sanchez, Maria J. Perugorria, Luis Bujanda, Bo Angelin, Sara Straniero, Anna Walleback, Ingemar Starke, Per-Goran Gillberg, Ellen Strangberg, Britta Bonn, Jan P. Mattsson, Martin R. Madsen, Henrik H. Hansen, Erik Lindstrom, Peter Akerblad, Jesus M. Banales
Summary: The ASBT inhibitor A3907 improves cholestatic liver diseases by clearing circulating bile acids and protecting liver function. A3907 targets ASBT in the intestine, liver, and kidney, leading to improved bilirubin and liver injury markers. A3907 is well tolerated in healthy individuals, supporting further clinical development.
Article
Gastroenterology & Hepatology
Joel Flores-Arriaga, Maria C. Aso, Arantzazu Izagirre, Ami D. Sperber, Olafur S. Palsson, Shrikant I. Bangdiwala, Angel Lanas, Luis Bujanda, Beatriz Lobo, Carmen Alonso-Cotoner, Alex Sanchez-Pla, Javier Santos
Summary: The study used data from the Rome Foundation Global Epidemiology Study to assess the prevalence and burden of gut-brain disorders in Spain. The survey, completed by 2072 participants, revealed that 43.6% of respondents met diagnostic criteria for at least one disorder, with functional constipation being the most prevalent. The study highlights the need for specialized training and future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Surgery
Maria Daca-Alvarez, Marc Marti, Antonino Spinelli, Noel F. F. C. de Miranda, Claire Palles, Alfredo Vivas, Andrew Lachtford, Kevin Monahan, Marek Szczepkowski, Wieslaw Tarnowski, Silviu-Tiberiu Makkai-Popa, Rosario Vidal, Irene Lopez, Elena Hurtado, Fernando Jimenez, Marta Jimenez-Toscano, Edurne Alvaro, Gonzalo Sanz, Araceli Ballestero, Sirio Melone, Lorena Brandariz, Isabel Prieto, Damian Garcia-Olmo, Teresa Ocana, Rebeca Moreira, Lorena Moreno, Sabela Carballal, Leticia Moreira, Maria Pellise, Rogelio Gonzalez-Sarmiento, Andreana N. Holowatyj, Jose Perea, Francesc Balaguer
Summary: This study aimed to explore the impact of family history on preventing early-onset colorectal cancer, finding that the proportion of preventable cases varied based on different guidelines. Early colonoscopy could significantly decrease the incidence of familial early-onset colorectal cancer.
BRITISH JOURNAL OF SURGERY
(2022)