Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 16, Issue 45, Pages 5669-5681Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v16.i45.5669
Keywords
Barrett's esophagus; Esophageal adenocarcinoma; Esophageal dysplasia; Prognosis
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Funding
- Medical Research Council [MC_U105365007] Funding Source: researchfish
- MRC [MC_U105365007] Funding Source: UKRI
- Medical Research Council [MC_U105365007] Funding Source: Medline
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Barrett's esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett's esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett's esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett's esophagus and EA and to discuss what is required to move the field forward towards clinical application. (C) 2010 Baishideng. All rights reserved.
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