Article
Multidisciplinary Sciences
Pradeep Kumar, Yunshan Liu, Yang Shen, Jacquelyn J. Maher, Francesca Cingolani, Mark J. Czaja
Summary: It has been discovered that FGF23, which is originally associated with renal disease, is also linked to hepatic and cardiac diseases. The liver is found to produce FGF23 in response to injury and it may have proinflammatory effects on hepatocytes and other organs.
Article
Anatomy & Morphology
Jiao Li, Yang Lv, Haoyu Wang, Yang Liu, Junxu Ren, Haiping Wang
Summary: By using lentivirus-mediated FGF-2 gene transfection, the differentiation of rat BMSCs into cardiomyocyte-like cells was enhanced, with higher expression levels of cardiac differentiation markers, and specific features observed in the nucleus and cytoplasm.
Article
Biochemistry & Molecular Biology
Roberto Gramignoli, Aarati R. Ranade, Raman Venkataramanan, Stephen C. Strom
Summary: Pro-inflammatory cytokines can affect liver cell functions, particularly ammonia and drug metabolism, but do not necessarily indicate rejection or loss of cell graft.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Jianqing Yu, George G. Chen, Paul B. S. Lai
Summary: Hepatocellular carcinoma is a major cause of cancer mortality worldwide, with current treatments showing unsatisfactory outcomes. The HGF/c-Met axis is considered crucial in regulating liver diseases and promoting HCC, and inhibiting this pathway may lead to the development of new and effective treatments for HCC.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Cell & Tissue Engineering
Ping Wang, Yan Cui, Jing Wang, Donghua Liu, Yue Tian, Kai Liu, Xue Wang, Lin Liu, Yu He, Yufeng Pei, Li Li, Liying Sun, Zhijun Zhu, Dehua Chang, Jidong Jia, Hong You
Summary: This study compared the therapeutic effects of mesenchymal stem cells (MSCs) and N-acetylcysteine (NAC) on acetaminophen (APAP)-induced liver failure and explored the underlying mechanism. The results showed that MSCs had comparable therapeutic effects to NAC, but had slightly different effects on hepatocyte necrosis and cell infiltration, and attenuated hepatocyte necrosis by secreting hepatocyte growth factor (HGF). These findings provide a theoretical basis for the clinical application of MSCs in treating APAP liver failure.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Lucas Eduardo Botelho de Souza, Fernanda Ursoli Ferreira, Carolina Hassibe Thome, Heloisa Brand, Maristela Delgado Orellana, Vitor Marcel Faca, Aparecida Maria Fontes, Dimas Tadeu Covas
Summary: Melanoma cells have the capability to activate an EMT-like program and acquire metastatic traits through distinct pathways induced by MSCs' secretome, both in mouse and human cells.
Article
Biochemistry & Molecular Biology
Athanassios Fragoulis, Julia Schenkel, Nicole Schroeder, Elisa Fabiana Brandt, Mathias Weiand, Tabita Neu, Pierluigi Ramadori, Tim Caspers, Sebastian Kant, Thomas Pufe, Antje Mohs, Christian Trautwein, Thomas Longerich, Konrad Ludwig Streetz, Christoph Jan Wruck
Summary: The Nrf2 signaling pathway plays a dual role in cancer, both preventing initiation and being involved in various types of cancer. In this study, sustained Nrf2 activation was found to induce proliferation and dedifferentiation of hepatic progenitor cells, transforming them into metastatic cancer cells similar to hepatoblastoma. The upregulation and activation of beta-catenin were identified as the underlying mechanism for this malignant transformation. These findings highlight the importance of the Nrf2-beta-catenin axis in promoting proliferation of hepatic stem cells and triggering tumorigenesis.
Article
Cardiac & Cardiovascular Systems
Rani Singh, Barbara Vidal, Juan Ascanio, Naresh Singh Redhu, Jorge Ruiz de Somocurcio, Adnan Majid, Paul A. VanderLaan, Sidhu P. Gangadharan
Summary: Significant changes in gene expression are observed in the tracheal walls of patients with tracheobronchomalacia (TBM) and tracheal stenosis (TS) compared with control subjects.
ANNALS OF THORACIC SURGERY
(2022)
Article
Geriatrics & Gerontology
Adeline Dolly, Sarah A. Potgens, Morgane M. Thibaut, Audrey M. Neyrinck, Gabriela S. de Castro, Chloe Galbert, Camille Lefevre, Elisabeth Wyart, Silvio P. Gomes, Daniela C. Goncalves, Nicolas Lanthier, Pamela Baldin, Joshua R. Huot, Andrea Bonetto, Marilia Seelaender, Nathalie M. Delzenne, Harry Sokol, Laure B. Bindels
Summary: This study explores the potential role of the aryl hydrocarbon receptor (AHR) in cancer cachexia and finds that impaired AHR signaling contributes to hepatic inflammatory and metabolic disorders, exacerbating cachectic features. These findings provide innovative therapeutic strategies for cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Immunology
Alvaro Tamayo-Velasco, Maria Jesus Penarrubia Ponce, Francisco Javier alvarez, Hugo Gonzalo-Benito, Ignacio de la Fuente, Sonia Perez-Gonzalez, Lucia Rico, Maria Teresa Jimenez Garcia, Alba Sanchez Rodriguez, Milagros Hijas Villaizan, Marta Martin-Fernandez, Carlos Duenas, Esther Gomez-Sanchez, Maria Heredia-Rodriguez, Oscar Gorgojo-Galindo, Itziar Fernandez, Lourdes del Rio, Irene Carnicero-Frutos, Maria Fe Munoz-Moreno, Eduardo Tamayo, David Bernardo, Pedro Martinez-Paz
Summary: Research on COVID-19 patients has shown that individuals with blood type O have a lower risk of requiring mechanical ventilation or facing mortality, and they tend to have higher initial cytokine levels which decrease over time. On the other hand, A/B/AB blood group patients maintain stable cytokine levels. Hepatocyte growth factor has been identified as a significant biomarker for predicting intubation or mortality risk, particularly in non-O blood group patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Wang, Jiahui Ni, Aiyu Wang, Run Zhang, Linjie Wang
Summary: This study found that VEGFA regulates glycolipid metabolism in Schizothorax prenanti through AMPK alpha, contributing to a better understanding of the functions of VEGFA in fish glycolipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Aveline Filliol, Yoshinobu Saito, Ajay Nair, Dianne H. Dapito, Le-Xing Yu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Silvia Affo, Naoto Fujiwara, Hua Su, Qiuyan Sun, Thomas M. Savage, John R. Wilson-Kanamori, Jorge M. Caviglia, LiKang Chin, Dongning Chen, Xiaobo Wang, Stefano Caruso, Jin Ku Kang, Amit Dipak Amin, Sebastian Wallace, Ross Dobie, Deqi Yin, Oscar M. Rodriguez-Fiallos, Chuan Yin, Adam Mehal, Benjamin Izar, Richard A. Friedman, Rebecca G. Wells, Utpal B. Pajvani, Yujin Hoshida, Helen E. Remotti, Nicholas Arpaia, Jessica Zucman-Rossi, Michael Karin, Neil C. Henderson, Ira Tabas, Robert F. Schwabe
Summary: The shift in HSC subpopulations during chronic liver disease is associated with a switch from HCC protection to promotion. Quiescent and cytokine-producing HSCs prevent hepatocyte death and HCC development, while activated myofibroblastic HSCs promote proliferation and tumor development through increased stiffness and TAZ and discoidin domain receptor 1 activation.
Article
Biochemistry & Molecular Biology
Tatjana Seitz, Nora John, Judith Sommer, Peter Dietrich, Wolfgang E. Thasler, Arndt Hartmann, Katja Evert, Sven A. Lang, Anja Bosserhoff, Claus Hellerbrand
Summary: Hepatic metastasis is a critical factor for cancer-related mortality. It has been found that fibroblast growth factor 9 (FGF9) released by hepatic stellate cells (HSCs) promotes the proliferation of uveal melanoma (UM) cells, indicating FGF9 as a potential therapeutic target for hepatic metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Audiology & Speech-Language Pathology
Xueyan Li, Haizhou Wang, Wen Xu
Summary: This study investigated the effects of adipose-derived mesenchymal stem cells (ADSCs), secreted hepatocyte growth factor (HGF), and basic fibroblast growth factor (bFGF) on the fibroblast phenotype after vocal fold injury. The results showed that ADSCs and secreted HGF and bFGF can revert the fibroblast phenotype caused by vocal fold injury. HGF has a more significant effect on collagen secretion and the transformation of fibroblasts into myofibroblasts, while bFGF is more effective in upregulating hyaluronan synthase 1 (HAS1).
Article
Biochemical Research Methods
Seokhun Lee, Seunggyu Kim, Jessie S. Jeon
Summary: In this study, an enhanced outer blood-retinal barrier (oBRB) model was proposed, with fully vascularized choriocapillaris endothelium (CCE) and an in vivo analogous distance between the retinal pigment epithelium (RPE) and CCE. The model, constructed using physiological intercellular distance, can mimic the pathogenesis of wet age-related macular degeneration (AMD) and facilitate AMD research.