Review
Biochemistry & Molecular Biology
Pooja Mittal, Sujata Singh, Rajesh Sinha, Anju Shrivastava, Archana Singh, Indrakant Kumar Singh
Summary: MCL-1 plays a crucial role in cancer cells and its overexpression is associated with drug resistance. Advancements in selective MCL-1 inhibitors offer new therapeutic strategies for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Hyun-Ju Yu, Ji-Ae Shin, Su-Jung Choi, Sung-Dae Cho
Summary: Podophyllotoxin (PPT) inhibits the growth of human oral squamous cell carcinoma (OSCC) cells and induces apoptosis by lowering mitochondrial membrane potential and reducing Mcl-1 protein expression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Virology
Areayi Haiyilati, Linyi Zhou, Jiaxin Li, Wei Li, Li Gao, Hong Cao, Yongqiang Wang, Xiaoqi Li, Shijun J. Zheng
Summary: This study found that gga-miR-30c-5p enhances FAdV-4-induced apoptosis by directly targeting the Mcl-1 protein, facilitating viral replication in host cells.
Article
Biochemistry & Molecular Biology
Marlen Michalski, Magdalena Bauer, Franziska Walz, Deniz Tuemen, Philipp Heumann, Petra Stoeckert, Manuela Gunckel, Claudia Kunst, Arne Kandulski, Stephan Schmid, Martina Mueller, Karsten Guelow
Summary: Despite recent advances in therapy, hepatocellular carcinoma (HCC) prognosis remains poor. This study presents the potential of combining BH3-mimetics as a new treatment option for HCC. BH3-mimetics inhibit anti-apoptotic proteins, triggering the intrinsic apoptosis pathway. The combination of two BH3-mimetic inhibitors showed enhanced efficacy in inducing the apoptosis pathway in HCC cell lines, suggesting the potential of this approach as a new therapeutic option for HCC.
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Manal Alfwuaires, Hany Elsawy, Azza Sedky
Summary: This study suggests that ACN can inhibit the activation of STAT3 and suppress the expression of genes associated with HCC, making it a promising therapeutic compound for the treatment of HCC and other cancers.
Article
Oncology
Shi-Zhe Zhang, Xiao-Dong Zhu, Long-Hai Feng, Xiao-Long Li, Xue-Feng Liu, Hui-Chuan Sun, Zhao-You Tang
Summary: The study revealed that high expression of PCSK9 in hepatocellular carcinoma (HCC) is associated with microvascular invasion and large tumor size, leading to poor overall survival and disease-free survival in patients. Experimental findings demonstrated that PCSK9 promotes HCC growth by inhibiting cell apoptosis, with FASN-mediated anti-apoptosis playing a significant role in this process.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Immunology
Shinan Li, Fujie Li, Xinying Liu, Xiaoxu Zhu, Wanlin Gao, Xiaokun Shen
Summary: In this study, Pam3CSK4 injection was found to attenuate tumor growth, decrease MDSCs, and restore T cell function; Pam3CSK4 promoted MDSC polarization by targeting Runx1, while a Runx1 inhibitor reversed this effect; TLR2 and Runx1 play critical roles in regulating the differentiation and function of MDSCs, potentially through the ferroptosis pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenliang Tan, Kelin Zhang, Xinming Chen, Lei Yang, Sicong Zhu, Yingcheng Wei, Zhiqin Xie, Yajin Chen, Changzhen Shang
Summary: This study revealed that Lenvatinib can induce apoptosis in HCC cells by increasing reactive oxygen species levels, with GPX2 identified as a crucial target for Lenvatinib against HCC. It was found that GPX2 was highly expressed in tumor tissues and correlated with poor overall survival in HCC patients. Furthermore, Lenvatinib was shown to inhibit GPX2 expression in HCC cells by preventing the nuclear translocation of β-catenin. These findings suggest that GPX2 may play an important role in Lenvatinib-induced HCC cell apoptosis and can serve as a biomarker for guiding Lenvatinib therapy in HCC patients.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yinglan Jin, Jinghua Wang, Mingming Zhao, Jingyi Lin, Luojia Hong
Summary: In this study, it was found that inhibition of MEIS1 activity promoted apoptosis, inhibited cell proliferation, and enhanced the anticancer effect of drugs in acute myeloid leukemia cells. This suggests that inhibition of MEIS1 may be a potential strategy for the treatment of AML.
Article
Biochemistry & Molecular Biology
Fan Feng, Lianhong Pan, Jiaqin Wu, Lanqing Li, Haiying Xu, Li Yang, Kang Xu, Chunli Wang
Summary: Cepharanthine (CEP), extracted from Stephania cepharantha Hayata, has shown potential in treating hepatocellular carcinoma (HCC) by inhibiting cell migration, proliferation, and inducing apoptosis. Through RNA-seq and GC-MS, CEP was found to affect metabolism-associated pathways and down-regulate metabolites, leading to significant antitumor effects in both in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Luhao Li, Suxin Li, Haohao Wang, Lin Li, Peiju Wang, Dongqi Shen, Xiaowei Dang
Summary: The study revealed that GSG2 is overexpressed in HCC tissues, and knockdown of GSG2 can inhibit the progression of HCC, promote cell apoptosis, and potentially participate in the oncogenesis of HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Chendi Xie, Hui Zhou, Dongmei Qin, Huijian Zheng, Yuanfang Tang, Wenjuan Li, Jie Zhou, Long Liu, Xinxin Yu, Hongpeng Duan, Yong Zhou, Zhifeng Li, Zhihong Fang, Yiming Luo, Bing Z. Carter, Bing Xu, Jie Zha
Summary: This study found that the combination of Bcl-2 inhibitor venetoclax and PPARa agonist chiglitazar can effectively eliminate LSCs of acute myeloid leukemia (AML) without damaging normal cells. This combination therapy also significantly inhibits AML progression in mouse models.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang
Summary: The study demonstrated that ginkgetin has an anti-tumor effect on human hepatocellular carcinoma cell lines by inducing apoptosis through affecting the balance between cell proliferation and apoptosis.
Article
Biochemistry & Molecular Biology
Yusha Xiao, Kang Yang, Pengpeng Liu, Dong Ma, Ping Lei, Quanyan Liu
Summary: The study showed that DNASE1L3 could inhibit the progression of HCC by inducing cell apoptosis and weakening glycolysis, suggesting its potential as a prognostic biomarker and therapeutic target for HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Qi Xie, Fengxu Fan, Wei Wei, Yang Liu, Zhongwei Xu, Linhui Zhai, Yingzi Qi, Bingyu Ye, Yao Zhang, Sumit Basu, Zhihu Zhao, Junzhu Wu, Ping Xu
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Yin Xu, Fei-qun Zheng, Qun-wei Zhang, Yang Liu, Hai-feng Duan, Chun-ping Cui, Bin Wu, Yi-de Qin
CHINESE JOURNAL OF CANCER RESEARCH
(2009)
Article
Oncology
Bu-Dong Zhu, Xiao-Li Li, Yong Liu, Jing Chang, Yang Liu, Dong-Dong Zhang, Qiang Wang, Jun Ren, Chun-Ping Cui
CLINICAL & EXPERIMENTAL METASTASIS
(2010)
Review
Biotechnology & Applied Microbiology
Yang Liu, Dong-An Wang
EXPERT OPINION ON BIOLOGICAL THERAPY
(2015)
Article
Gastroenterology & Hepatology
Chun-Ping Cui, Da-Jin Zhang, Bing-Xing Shi, Shao-Jun Du, Dan-Li Wu, Ping Wei, Gen-Shen Zhong, Zi-Kuan Guo, Yang Liu, Li-Sheng Wang, Chu-Tse Wu
Article
Biochemistry & Molecular Biology
Yang Liu, Xiao-Li Li, Dong-Dong Zhang, Qiang Wang, Yong Liu, Dong-Mei Liu, Chu-Tse Wu, Chun-Ping Cui
MOLECULAR BIOTECHNOLOGY
(2011)
Article
Materials Science, Biomaterials
Yang Liu, Timothy Thatt Yang Tan, Shaojun Yuan, Cleo Choong
JOURNAL OF MATERIALS CHEMISTRY B
(2013)
Article
Materials Science, Biomaterials
Gordon Minru Xiong, Shaojun Yuan, Chek Kun Tan, Jun Kit Wang, Yang Liu, Timothy Thatt Yang Tan, Nguan Soon Tan, Cleo Choong
JOURNAL OF MATERIALS CHEMISTRY B
(2014)
Article
Chemistry, Analytical
Megha Mehta, Yang Liu, Mark Waterland, Geoff Holmes
Summary: This study utilized Raman spectroscopy to analyze the growth of bacteria on sheepskin, identifying universal biochemical signatures of bacterial growth through multivariate analysis methods. The findings demonstrate the potential of Raman spectroscopy for monitoring bacterial growth on animal skin.
ANALYTICAL LETTERS
(2021)
Article
Engineering, Biomedical
Yi Zhang, Wenkai Zhang, Tim Snow, Ying Ju, Yang Liu, Andrew J. Smith, Sujay Prabakar
Summary: This study investigated the changes in structure and stability of ABPs during crosslinking using GA or EDC at different concentrations through synchrotron small-angle X-ray scattering and thermal and colorimetric methods. The findings reveal that telopeptidyl-helical linkages are preferred at low crosslinker concentrations, while excess crosslinking leads to structural changes and plateauing of stabilities.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Yi Zhang, Megha Mehta, Bradley W. Mansel, Hon Wei Ng, Yang Liu, Geoff Holmes, Eric C. Le Ru, Sujay Prabakar
Article
Biochemistry & Molecular Biology
Yang Liu, Manoj N. Krishnan, Kyle K. L. Phua