Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 16, Issue 8, Pages 997-1002Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v16.i8.997
Keywords
Pancreatic neoplasms; Adenocarcinoma; Portal vein; Superior mesenteric vein; Pancreaticoduodenectomy; Chemotherapy
Categories
Ask authors/readers for more resources
Aim: To establish the prognosis and feasibility of en-bloc vascular resection of stage U pancreatic adenocarcinoma of the head and uncinate process. METHODS: We retrospectively analyzed 87 patients with stage 11 pancreatic adenocarcinoma, who were subjected to pancreaticoduodenectomy (PD) and pylorus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital, Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV), respectively. RESULTS: The overall 1- and 3-year survival rates of patients undergoing PD/PPPD with and without vascular resection were 50.0% and 16.7%, and 44.4% and 12.2%, respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%, and 40.0% and 2.7%, respectively. In multivariate analysis, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors that influenced survival. CONCLUSION: In stage 11 adenocarcinoma of the pancreatic head and uncinate process, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors, and en-bloc vascular resection is a feasible option in carefully selected patients. (C) 2010 Baishideng. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available