Review
Chemistry, Medicinal
Ines Ben Ghezala, Maeva Charkaoui, Christophe Michiels, Marc Bardou, Maxime Luu
Summary: Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and Ulcerative Colitis (UC), are chronic disorders with an unclear pathogenesis. While tumor necrosis factor (TNF)-alpha inhibitors and other compounds have significantly improved the clinical management of IBDs, approximately one third of patients still have insufficient efficacy. Therefore, orally administered Small Molecules Drugs (SMDs) are being developed to address these issues.
Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Review
Nutrition & Dietetics
Claudia Infantino, Roberta Francavilla, Adriana Vella, Sabrina Cenni, Nicola Principi, Caterina Strisciuglio, Susanna Esposito
Summary: Vitamin D plays a crucial role in calcium homeostasis and bone health, and it may also modulate the immune system to affect the development of autoimmune diseases such as celiac disease and inflammatory bowel diseases. Research suggests that vitamin D could be involved in the pathogenesis and treatment of these conditions.
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Antigony Mitselou, Vasileios Grammeniatis, Anna Varouktsi, Stamatis S. Papadatos, Antonios Klaroudas, Konstantinos Katsanos, Vasiliki Galani
Summary: The expression of adhesion molecules was found to be lower in patients with inflammatory bowel disease (IBD) compared to those with irritable bowel syndrome (IBS), while it was higher in IBS patients compared to the control group. This suggests that adhesion molecule expression levels differ between patients with inflammatory bowel disease and irritable bowel syndrome.
ADVANCED BIOMEDICAL RESEARCH
(2021)
Review
Medicine, General & Internal
Daniel C. Baumgart, Catherine Le Berre
Summary: This review discusses newer biologic and small-molecule therapies for inflammatory bowel disease, emphasizing the importance of achieving clinical and endoscopic remission as well as more precise molecular targeting of inflammatory cascades.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Paul T. Williams
Summary: This study investigates whether the heritabilities of inflammatory biomarkers linked to cardiovascular disease are quantile-dependent. The results show that the heritabilities of certain biomarkers are indeed dependent on the percentiles of their distributions, which may contribute to genetic modulations of related diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biology
Cameron D. Haydinger, Liam M. Ashander, Alwin Chun Rong Tan, Justine R. Smith
Summary: Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein that plays important roles in the immune system and is involved in various diseases. It mediates cellular adhesive interactions and is upregulated in inflammation. This review provides a comprehensive summary of the structure and regulation of ICAM1 gene and the ICAM-1 protein, discusses its functions in the immune system and diseases, and explores current therapeutics and future advancements.
Article
Neurosciences
Jonathan D. Drake, Alison B. Chambers, Brian R. Ott, Lori A. Daiello
Summary: The study found that plasma-based vascular biomarkers, particularly VCAM-1 and ICAM-1, were associated with Alzheimer's disease (AD) and clinical impairment. VCAM-1 was linked with clinical dementia rating sum-of-boxes (CDR-SB) scores, with the APOE epsilon 4 genotype modifying this relationship. Additionally, combining VCAM-1 and cerebrospinal fluid (CSF) biomarkers showed independent associations with AD-related clinical impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Nutrition & Dietetics
Dominika Glabska, Aleksandra Kolota, Katarzyna Lachowicz, Dominika Skolmowska, Malgorzata Stachon, Dominika Guzek
Summary: Inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) are associated with decreased quality of life and mental health problems. Vitamin D supplementation is considered to be effective in improving mental health in affected individuals. Studies have shown a positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, but further research is needed for confirmation.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Badr Al-Bawardy, Raina Shivashankar, Deborah D. Proctor
Summary: This review discusses novel therapeutic targets for inflammatory bowel diseases, including selective JAK inhibitors, anti-interleukin drugs, leukocyte migration inhibitors, and other small molecules currently in development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nurul Sulimai, Jason Brown, David Lominadze
Summary: Traumatic brain injury (TBI) is linked to inflammation and compromised blood-brain barrier, which can lead to neurodegeneration. Inflammation causes an increase in fibrinogen (Fg) levels in the blood, and this protein can extravasate into the brain parenchyma and interact with neurons. This interaction results in the upregulation of pro-inflammatory cytokines, oxidative damage, and cell death. The transcription factor NF-kappa B is involved in this process. This mechanism may play a role in vascular cognitive impairment during neuroinflammatory diseases.
Article
Rheumatology
Yuan Wang, Yan Wang, Xiaoxia Jia, Zongwei Wang, Xin Li, Lin Mu, Baoyu Zhang
Summary: The study aimed to investigate the alteration of high-density lipoprotein (HDL) function in gout patients. Results showed that the anti-inflammatory activities of HDLs were impaired in gout patients, indicating potential implications for gout management.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Jae-Young Park, Hyo-Min Park, Seonhwa Kim, Kyeong-Bae Jeon, Chae-Min Lim, Jin Tae Hong, Do-Young Yoon
Summary: IL-32 theta A94V, a mutant isoform, can inhibit monocyte-endothelial adhesion by binding to integrins aVb3 and aVb6, thus reducing the early step of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Runting Li, Fa Lin, Yu Chen, Junlin Lu, Heze Han, Li Ma, Yahui Zhao, Debin Yan, Ruinan Li, Jun Yang, Shihao He, Zhipeng Li, Haibin Zhang, Kexin Yuan, Ke Wang, Qiang Hao, Xun Ye, Hao Wang, Hongliang Li, Linlin Zhang, Guangzhi Shi, Jianxin Zhou, Yang Zhao, Yukun Zhang, Youxiang Li, Shuo Wang, Xiaolin Chen, Yuanli Zhao
Summary: This study aimed to establish a scoring model based on early brain injury indicators to predict the functional outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) at 90 days. The model, named TAPS, showed good discrimination and calibration in both the derivation and validation cohorts, and proved to be an easy handle tool for clinicians to predict the 90-day outcomes and identify patients at risk for poor prognosis.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Siqi Jin, Qingli Zhu, Li Huo, Ou Wang, Xiaoping Xing, Quan Liao, Li Ma, Jianchu Li, Yuxin Jiang, He Liu
Summary: The study aimed to evaluate the value of second-look ultrasound (US) for preoperative localization in patients with primary hyperparathyroidism with negative or discordant imaging results. The sensitivity, positive predictive value, and accuracy of second-look US were found to be 92.1%, 95.1%, and 88.1%, respectively. Overall, second-look US is a promising method for preoperative localization, especially for patients with negative or discordant imaging findings.
ENDOCRINE PRACTICE
(2023)
Editorial Material
Clinical Neurology
Zongze Li, Li Ma, Yuanli Zhao, Chunde Li
Article
Gastroenterology & Hepatology
Jin-Lei Wang, Xiang Li, Jia-Ru Fan, Jia-Ping Yan, Ze-Mao Gong, Yue Zhao, Dong-Mei Wang, Li Ma, Na Ma, Diao-Mei Guo, Lian-Sheng Ma
Summary: This study conducted a statistical analysis of seven journals published by Baishideng Publishing Group to determine the importance of editorial and publication process integrity in improving the academic influence and impact factor of academic journals. The results indicate that enhancing integrity has a positive impact on the academic influence and impact factor of academic journals.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Hui Zhang, Yi Hu, Yan Wang, Xia Song, Ying Hu, Li Ma, Xinjie Yang, Kun Li, Na Qin, Jinghui Wang, Jialin Lv, Xi Li, Xinyong Zhang, Quan Zhang, Yuhua Wu, Guangyin Yao, Shucai Zhang
Summary: This study assessed the performances of droplet digital polymerase chain reaction (ddPCR) and next-generation sequencing (NGS) in detecting EGFR T790M mutation in the plasma samples of NSCLC patients. The results showed that ddPCR had a high sensitivity and specificity in detecting EGFR T790M mutation. Furthermore, a higher EGFR T790M abundance was associated with a better response to third-generation EGFR-TKIs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Analytical
Zhengyin Yan, Li Ma, Julie Huang, Pasquale Carione, Jane R. Kenny, Cornelis E. C. A. Hop, Matthew Wright
Summary: Determination of drug binding kinetics in plasma is challenging, and this study introduces a new parameter called dynamic free fraction to describe drug-protein binding kinetics. The dynamic free fraction can be determined by coupling the drug binding assay with a reporter enzyme and high-resolution mass spectrometry. This methodology bypasses the challenges in existing methods and allows assessment of the impact of protein binding kinetics on drug properties.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Li Ma, Juan Ma, Xin Sun, Honggang Liu
Summary: T cells play a crucial role in the cell-mediated antitumour response. Bispecific antibodies (Bi-Abs) have shown promise in recruiting T cells for killing tumours. This study demonstrates the expression of CD155 in a wide range of human haematologic tumours and highlights the effectiveness of the bispecific antibody anti-CD3 x anti-CD155 in activating T cells to target malignant haematologic cells. The results show that CD155Bi-Ab-armed T cells exhibit enhanced cytotoxicity and increased secretion of cell-killing mediators and T-cell-derived cytokines, indicating that CD155 could be a novel target for immunotherapy against haematologic malignancies.
INVESTIGATIONAL NEW DRUGS
(2023)
Article
Surgery
Yu Chen, Heze Han, Hengwei Jin, Xiangyu Meng, Li Ma, Ruinan Li, Zhipeng Li, Debin Yan, Haibin Zhang, Kexin Yuan, Ke Wang, Yang Zhao, Yukun Zhang, Weitao Jin, Runting Li, Fa Lin, Qiang Hao, Hao Wang, Xun Ye, Shuai Kang, Dezhi Gao, Jun Pu, Zhiyong Shi, Xiaofeng Chao, Zhengfeng Lin, Junlin Lu, Jiangan Li, Shibin Sun, Ali Liu, Xiaolin Chen, Youxiang Li, Yuanli Zhao, Shuo Wang
Summary: This study compared the long-term outcome of hemorrhagic stroke or death in patients with conservative management or stand-alone embolization for AVM. The results showed that embolization did not prevent long-term hemorrhagic stroke or death compared with conservative management in the overall cohort, as well as in the unruptured and ruptured AVM subgroups. Stratified analysis suggested that target embolization might be beneficial for unruptured AVMs, while curative embolization improved the outcomes of ruptured AVMs. The long-term neurological status was similar between the two strategies.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Xiaoyong Xiang, Peng Chen, Fengming Lan, Li Ma, Jing Jin, Ye Zhang
Summary: This study retrospectively analyzed the clinical data of 206 patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). The findings showed that adding PD-1 inhibitor to induction chemotherapy significantly improved short-term efficacy without intolerable adverse effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Yu Chen, Heze Han, Xiangyu Meng, Hengwei Jin, Dezhi Gao, Li Ma, Ruinan Li, Zhipeng Li, Debin Yan, Haibin Zhang, Kexin Yuan, Ke Wang, Yukun Zhang, Yang Zhao, Weitao Jin, Runting Li, Fa Lin, Xiaofeng Chao, Zhengfeng Lin, Qiang Hao, Hao Wang, Xun Ye, Shuai Kang, Youxiang Li, Shibin Sun, Ali Liu, Shuo Wang, Yuanli Zhao, Xiaolin Chen
Summary: In this study, a scoring system was developed and validated to predict the rupture risk of AVMs, performing well in different cohorts. Patients can be stratified based on the scoring system to avoid unnecessary interventions according to their rupture risk.
Article
Chemistry, Analytical
Qin Sun, Li Ma, Fernando Ferreira, Chelsea Brown, Brian Reid, Min Zhao
Summary: The uptake of oxygen by cells and tissues is an important indicator of metabolic demand, microenvironment changes, and pathophysiology. Using a non-invasive optical fiber oxygen sensor, researchers have revealed a spatiotemporal profile of oxygen uptake at the ocular surface of rodents and non-human primates. The results showed a distinct oxygen uptake gradient in mice, with a higher influx at the limbus and conjunctiva regions compared to the center of the cornea. The findings provide valuable insights for comparative studies and understanding the response of the cornea and other tissues to various insults or environmental changes.
Article
Cell & Tissue Engineering
Gibran Ali, Mo Zhang, Jianjun Chang, Runzhen Zhao, Yang Jin, Jiwang Zhang, Hong-Long Ji
Summary: This study finds that elevated levels of PAI-1 are present in both lung edema fluid and the circulating system in patients with acute lung injury. The study also reveals that PAI-1 inhibits the self-renewal of alveolar epithelial cells (AT2), thereby affecting the regeneration of alveolar epithelium. Through the investigation of a humanized mouse line carrying Serpine1 gene mutants, it is found that Serpine1 gene mutations lead to a decrease in the number of AT2 cells and a delay in the formation of injured epithelium.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Yu Chen, Pingting Chen, Ruinan Li, Heze Han, Zhipeng Li, Li Ma, Debin Yan, Haibin Zhang, Fa Lin, Runting Li, Xiangyu Meng, Hengwei Jin, Youxiang Li, Xun Ye, Shuai Kang, Hao Wang, Xiaolin Chen, Yuanli Zhao
Summary: In this study, quantitative digital subtraction angiography (QDSA) was used to explore the hemorrhagic quantitative hemodynamic indicators of brain arteriovenous malformation (AVM) nidus. The results showed that a higher stasis index and slower transnidal relative velocity (TRV) were significantly correlated with AVM rupture and could be used as effective indicators to predict future hemorrhage risk.
JOURNAL OF NEUROSURGERY
(2023)
Article
Health Care Sciences & Services
Luying Gao, Jianchu Li, Yang Gu, Li Ma, Wen Xu, Xixi Tao, Ruojiao Wang, Rui Zhang, Yixuan Zhang, Hongyan Wang, Yuxin Jiang
Summary: With the growing demand for breast screening, ultrasound departments in China are facing tremendous challenges. The utilization rate of BI-RADS templates and per capita GDP are positively associated with the diagnostic accuracy of breast cancer ultrasound.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Oncology
Ran Chen, Li Ma, Chang Jiang, Shucai Zhang
Summary: This study found that CCL4 is highly expressed in NSCLC patients and is closely associated with immune cell infiltration, CD8+T cell survival, and mutant genes associated with lung cancer treatment. Therefore, CCL4 may be a potential target for immunotherapy in NSCLC patients.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
