Article
Medicine, Research & Experimental
Joeke L. Nollet, Per Cajander, Lara F. Ferris, Jordache Ramjith, Taher Omari, Johanna Savilampi
Summary: The study aimed to investigate the effects of bolus volume and viscosity on pharyngeal swallow using circumferential pressure sensor technology and found that larger volumes increased intrabolus pressure and all upper esophageal sphincter metrics, while thicker viscosity decreased UES relaxation time and flow timing metrics. The use of this technology provides consistent results with previous reports, offering insights into aberrant pharyngo-esophageal motor responses over time.
Article
Gastroenterology & Hepatology
Boram Cha, Kyungmin Choi, Kee Wook Jung, Hwa Jung Kim, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Segyeong Joo
Summary: This study compared two diagnostic tools for non-obstructive dysphagia (NOD) and found that the volume of inverted impedance (VII) ratio is more reliable than the esophageal impedance integral (EII) ratio.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Wenjun Kou, Katharine P. Rooney, Alexandra J. Baumann, Erica Donnan, Joseph R. Triggs, Ezra N. Teitelbaum, Amy Holmstrom, Eric Hungness, Sajiv Sethi, Peter J. Kahrilas, John E. Pandolfino
Summary: Using FLIP panometry and machine learning, a model was developed to predict and classify achalasia subtypes on HRM. The model can differentiate type III achalasia from non-spastic achalasia, with potential for clinical application.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Mate Csucska, Takahiro Masuda, Ross M. Bremner, Sumeet K. Mittal
Summary: The study aimed to compare preperistaltic distal esophageal pressure in patients with EGJOO with and without dysphagia. Patients with severe dysphagia had significantly higher median preperistaltic pressures in the distal esophagus, which showed better sensitivity and specificity for dysphagia than integral relaxation pressure. Inclusion of preperistaltic pressure in the diagnostic criteria for EGJOO may enhance the clinical relevance of manometric classification.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Jacqueline E. Prescott, Alexandra J. Baumann, Jacob M. Schauer, Amanda Krause, Erica N. Donnan, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: FLIP panometry accurately identifies clinically relevant esophagogastric junction obstruction as defined by the Chicago Classification version 4.0 in patients evaluated for esophageal motor disorders. It is a valuable tool for assessing esophageal motility.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, General & Internal
Amir Mari, Rami Sweis
Summary: Dysphagia can range from benign inconvenience to serious morbidity, requiring a detailed clinical assessment to identify underlying diseases. Treatment should be tailored according to the dysmotility phenotype and patient characteristics.
Article
Gastroenterology & Hepatology
Anand S. Jain, Chaitanya Allamneni, Meredith Kline, Raj Dalsania, Marie Godiers, Steven Keilin, Shanthi Srinivasan, Ravinder Mittal
Summary: This study examined the relationship between distensibility index (DI) and integrated relaxation pressure (IRP), and their correlations with dysphagia symptoms in patients with achalasia and esophagogastric junction outflow obstruction (EGJOO). The study found that DI is not correlated with HRM EGJ measurements and has the strongest effect on dysphagia severity.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Albert J. Bredenoord, Arash Babaei, Dustin Carlson, Taher Omari, Jun Akiyama, Rena Yadlapati, John E. Pandolfino, Joel Richter, Ronnie Fass
Summary: EGJOO is defined as an elevated IRP and IBP during wet swallows and persistently elevated IRP in the upright position according to CCv4. A conclusive diagnosis requires a manometric diagnosis of EGJOO and associated symptoms supported by additional investigations, with history and endoscopic evaluation being crucial for excluding secondary causes. Proposed changes in CC4.0 aim to improve specificity of diagnosis and reduce clinically irrelevant diagnoses.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Margaret J. Zhou, Afrin Kamal, Daniel E. Freedberg, David Markowitz, John O. Clarke, Daniela Jodorkovsky
Summary: An analysis of patients diagnosed with achalasia revealed a significant increase in the prevalence of type II achalasia and a decrease in type I cases. However, there were no apparent correlations between age or gender and these differences. The findings suggest that advancements in diagnostic techniques and increased awareness of the disease may be contributing factors to the changing epidemiology.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Christina Shehata, Nirmala Gonsalves, Ikuo Hirano, Stephanie Peterson, Jacqueline Prescott, Domenico A. Farina, Jacob M. Schauer, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: This study evaluated the characteristics of secondary peristalsis in patients with EoE and found that abnormal esophageal contractions were associated with disease severity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Daniel Cisternas, Arvind Rengarajan, Ingrid Marin, Luiz Abrahao, Albis Hani, Ana M. Lequizamo, Jose M. Remes-Troche, Julio Perez de la Serna, Antonio Ruiz de Leon, Frank Zerbib, Jordi Serra, C. Prakash Gyawali
Summary: In healthy asymptomatic subjects, breaks in peristaltic integrity predict abnormal bolus clearance better than DCI or IRP.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, General & Internal
Faiz Tuma, Jafar Aljazeeri, Zhamak Khorgami, Leena Khaitan
Summary: This study reviewed esophageal function testing results over a 12-month period and found that the most likely levels of impaired bolus transit in the esophagus were 15 and 20 cm above the gastroesophageal junction (GEJ). Common symptoms among the study sample included dysphagia, chest pain, and regurgitation. The study suggests that focusing on the levels of impaired bolus transit identified in the esophagus may be important for future research on the pathophysiology of esophageal dysmotility.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Medicine, General & Internal
Ryusei Nishi, Haruka Amitani, Kazumasa Hamada, Takamasa Fukumoto, Ryuichi Kato, Takako Yamamoto, Yuuki Fuku, Kenichiro Sagiyama, Akihiro Asakawa
Summary: Idiopathic achalasia is a rare esophageal disorder characterized by progressive dysphagia and high lower esophageal sphincter pressure. This case report highlights the importance of considering achalasia when patients present with persistent symptoms, even if initially excluded. Medication is not a definitive treatment, and surgical intervention may be necessary for recovery. The psychosomatic approach can also be beneficial in managing symptoms.
Article
Physiology
Eden Koo, John O. Clarke, Boli Yang, Pankaj J. Pasricha, Nina Zhang
Summary: This study aimed to quantify the characteristics of acid reflux episodes in patients with extraesophageal GERD symptoms, hiatal hernia, and erosive esophagitis using multichannel intraluminal impedance pH (MII-pH), and investigate the correlation between impedance parameters and high resolution esophageal manometry (HREM). The findings showed that patients with extraesophageal GERD symptoms had an increased average height of reflux, while patients with hiatal hernia had a longer total reflux duration. The average composite reflux index was significantly different in all three subgroups. Impedance metrics were weakly correlated with lower esophageal sphincter rest pressure and distal contractile integral.
PHYSIOLOGICAL REPORTS
(2022)
