Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 22, Pages 2708-2713Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.2708
Keywords
Colorectal cancer; Submucosal invasion; Lymph node metastasis; Endoscopic mucosal resection
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AIM: To clarify the clinicopathological characteristics of small and large early invasive colorectal cancers (EICRCs), and to determine whether malignancy grade depends on size. METHODS: A total of 583 consecutive EI-CRCS treated by endoscopic mucosal resection or surgery at the National Cancer Center Hospital between 1980 and 2004 were enrolled in this study. Lesions were classified into two groups based on size: small (<= 10 mm) and large (> 10 mm). Clinicopathological features, incidence of lymph node metastasis (LNM) and risk factors for LNM, such as depth of invasion, lymphovascular invasion (LVI) and poorly differentiated adenocarcinoma (PDA) were analyzed in all resected specimens. RESULTS: There were 120 (21%) small and 463 (79%) large lesions. Histopathological analysis of the small lesion group revealed submucosal deep cancer (sm: >= 1000 mu m) in 90 (75%) cases, LVI in 26 (22%) cases, and PDA in 12 (10%) cases. Similarly, the large lesion group exhibited submucosal deep cancer in 380 (82%) cases, LVI in 125 (27%) cases, and PDA in 79 (17%) cases. The rate of LNM was 11.2% and 12.1% in the small and large lesion groups, respectively. CONCLUSION: Small EI-CRC demonstrated the same aggressiveness and malignant potential as large cancer. (C) 2009 The WJG Press and Baishideng. All rights reserved.
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