Article
Medicine, General & Internal
Nabil Gastli, Margaux Allain, Dominique Lamarque, Vered Abitbol, Annick Billoet, Gislene Collobert, Romain Coriat, Benoit Terris, Nicolas Kalach, Josette Raymond
Summary: This study highlights the low sensitivity of conventional culture and histology which may lead to false negative diagnosis if used alone. H. pylori quantification associated with cagA genotyping in routine workflow are essential for a sensitive and reliable diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Microbiology
Claudia Sousa, Rute Ferreira, Silvio B. Santos, Nuno F. Azevedo, Luis D. R. Melo
Summary: This article reviews the current available diagnostic methods for Helicobacter pylori, including invasive and non-invasive methods, and discusses the advantages, limitations, and recent advances for each method. The research on the development of new diagnostic methods is also discussed.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Nesrin Gareayaghi, Bekir Kocazeybek
Summary: Reports suggest an increasing prevalence of clarithromycin resistance in children. This study investigated primary clarithromycin resistance in Helicobacter pylori strains isolated from symptomatic and asymptomatic children. It found a significant difference in point mutations between age groups and symptoms, indicating the potential impact of clarithromycin-resistant H. pylori strains on gastrointestinal symptoms in children.
Review
Medical Laboratory Technology
Salika Mehreen Shakir, Faiz Ahmed Shakir, Marc Roger Couturier
Summary: This review provides a summary of the prevalence and microbiology of H. pylori, as well as current diagnostic methods and clinical management strategies. The advantages of molecular methods for diagnosis and predicting drug resistance are discussed. The gold standard for detecting resistance patterns is culture-based diagnostics followed by antimicrobial susceptibility testing.
CLINICAL CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Michiel C. Mommersteeg, Stella A. V. Nieuwenburg, Leonieke M. M. Wolters, Buddy H. C. M. Roovers, Hanneke A. J. van Vuuren, Auke P. Verhaar, Marco J. Bruno, Ernst J. Kuipers, Maikel P. Peppelenbosch, Manon C. W. Spaander, Gwenny M. Fuhler
Summary: This study investigates the feasibility of using non-invasive stool tests to verify successful Helicobacter pylori (H. pylori) eradication and determine clarithromycin resistance. The results indicate that H. pylori antigen testing on fecal immunochemical test (FIT) stool samples has similar accuracy as testing on dry stool samples.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Infectious Diseases
Julie Nguyen, Kallirroi Kotilea, Patrick Bontems, Veronique Yvette Miendje Deyi
Summary: In the context of epidemiology, the manifestation of Helicobacter pylori (H. pylori) infection varies between children and adults. The prevalence of H. pylori infection is decreasing globally, including in many developing countries. However, pediatric H. pylori infection and its consequences remain a concern in some areas. Most infected children do not show symptoms, and there is no evidence supporting the link between H. pylori and functional disorders like recurrent abdominal pain. The pathophysiology of H. pylori infection depends on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. Various gastritis phenotypes can develop, potentially leading to different gastroduodenal pathologies. The diagnosis of H. pylori infection in children requires upper gastrointestinal endoscopy with mucosal biopsy samples for histology and culture, or at least Polymerase Chain Reaction (PCR). Eradication treatment should be given when necessary and compliance is expected, with treatment choice based on antimicrobial susceptibility. Vigilant surveillance of resistance patterns and strategic antibiotic management are crucial for combating multidrug resistance.
Article
Medicine, General & Internal
Natalia Garcia-Morales, Angeles Perez-Aisa, Giulia Fiorini, Bojan Tepes, Manuel Castro-Fernandez, Alfredo Lucendo, Irina Voynovan, Luis Bujanda, Ana Garre, Luis Rodrigo, Samuel Jesus Martinez Dominguez, Maja Denkovski, Jose M. Huguet Malaves, Laimas Jonaitis, Renate Bumane, Oleg Zaytsev, Pilar Mata Romero, Jesus Barrio, Luis Fernandez-Salazar, Aiman Silkanovna Sarsenbaeva, Inmaculada Ortiz Polo, Sergey Alekseenko, Ilaria Maria Saracino, Dino Vaira, Alma Keco-Huerga, Dmitry Bordin, Antonio Gasbarrini, Frode Lerang, Theodore Rokkas, Juozas Kupcinskas, Marcis Leja, Gulustan Babayeva, Ricardo Marcos Pinto, Ante Tonkic, Sinead Smith, Perminder Phull, Gyorgy Buzas, Halis Simsek, Doron Boltin, Oleksiy Gridnyev, Marino Venerito, Vladimir Milivojevic, Nuria Tora, Anna Cano-Catala, Leticia Moreira, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert, Ignasi Puig
Summary: This study evaluates the tests used for diagnosing Helicobacter pylori infection in Europe, including initial diagnosis and confirmation of eradication. The results show a great heterogeneity in the tests used among different countries, indicating a need to further explore the reasons for the lack of adherence to clinical guidelines.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Dmitry S. Bordin, Irina N. Voynovan, Dmitrii N. Andreev, Igor Maev
Summary: This article reviews the various methods available for detecting Helicobacter pylori, including both invasive and non-invasive diagnostic tests, highlights the advancements and new developments in endoscopic examination techniques, and discusses the advantages and limitations of different diagnostic methods and their applications.
Article
Infectious Diseases
Magnus Halland, Rashidul Haque, Jost Langhorst, James H. Boone, William A. Petri
Summary: The study evaluated the performance of two novel enzyme immunoassays in detecting H. pylori antigen in stool, showing high sensitivity and specificity for diagnosing H. pylori infection. Comparing to a composite reference method, the H. PYLORI QUIK CHEK (TM) and H. PYLORI CHEK (TM) assays demonstrated excellent clinical performance.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Veronica Martinez-Santos, Manuel Hernandez Catalan, Luis Octavio Ojeda Salazar, Octavio Andrei Orozco Gomez, Sandra Ines Lorenzo, Rayver Santos Gomez, Norma S. Romero-Castro, Roxana Reyes Rios, Dinorah Nashely Martinez Carrillo, Gloria Fernandez-Tilapa
Summary: In asymptomatic children from Guerrero, Mexico, there was a high prevalence of H. pylori infection, with the highest proportion detected through stool antigen testing.
Article
Gastroenterology & Hepatology
Enming Qiu, Shaoqin Jin, Zhuo Xiao, Qianyun Chen, Qiaohui Wang, Huayong Liu, Chanfang Xie, Chong Chen, Zhou Li, Shuai Han
Summary: The study established a rapid, simple, and inexpensive noninvasive method based on CRISPR-Cas12a technology for detecting Helicobacter pylori in stool specimens. The method demonstrated high sensitivity and specificity, with the ability to distinguish H. pylori from other pathogens, making it a promising supplemental test in clinical practice. Further evaluation against gold standard tests is necessary to assess its sensitivity and specificity.
Article
Infectious Diseases
Salma Burayzat, Mohammad Al-Tamimi, Mohammad Barqawi, Mustafa Sabri Massadi, Jumanah Abu-Raideh, Hadeel Albalawi, Ashraf I. Khasawneh, Nisreen Himsawi, Maha Barber
Summary: This study investigated the molecular mechanisms of H. pylori antimicrobial resistance among Jordanian children. The results showed that resistance to Clarithromycin and Metronidazole was prevalent, and RT-PCR was a valuable alternative to culture for determining antimicrobial susceptibility.
Article
Medicine, General & Internal
Elena Resina, Maria G. Donday, Samuel J. Martinez-Dominguez, Emilio Jose Laserna-Mendieta, Angel Lanas, Alfredo J. Lucendo, Marta Sanchez-Luengo, Noelia Alcaide, Luis Fernandez-Salazar, Luisa De La Pena-Negro, Luis Bujanda, Marta Gomez-Ruiz De Arbulo, Javier Alcedo, Angeles Perez-Aisa, Raul Rodriguez, Sandra Hermida, Yanire Brenes, Olga P. Nyssen, Javier P. Gisbert
Summary: This study assessed the accuracy of a new SAT, the LIAISON(R) Meridian H. pylori SA, compared to the gold standard UBT. The results showed that the new SAT had good accuracy for the diagnosis of H. pylori infection, and PCR testing further improved its accuracy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Shamshul Ansari, Yoshio Yamaoka
Summary: Despite the decrease in H. pylori infection rates, gastric cancer morbidity and mortality rates remain high, fueled by antimicrobial resistance and treatment failure. Accurate diagnosis is crucial for effective treatment and eradication of infections. This article provides a comprehensive description of available diagnostic methods, aiding clinicians and researchers in selecting appropriate approaches and emphasizing the importance of clinical settings, patient factors, and clinical factors in diagnosis and evaluating eradication efficacy.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Review
Medicine, Research & Experimental
Yi-Chia Lee, Maria Pina Dore, David Y. Graham
Summary: The past 5 years have witnessed significant changes in the testing and treatment of Helicobacter pylori infection. Peptic ulcer has transitioned from a chronic disease to an acute condition, and countries with high incidence of gastric cancer have started implementing population-wide screening and treatment. A proactive approach to testing and treatment, including outreach to family members and high-risk populations, is now recommended. The rise in antimicrobial resistance has led to a decline in treatment success, necessitating a reconsideration of treatment guidelines and adherence to principles of antibiotic usage and antimicrobial stewardship.
ANNUAL REVIEW OF MEDICINE
(2022)
Article
Plant Sciences
Tahereh Falsafi, Parisa Moradi, Mohaddese Mahboubi, Ebrahim Rahimi, Hassan Momtaz, Behzhad Hamedi
Article
Medicine, General & Internal
Tahereh Falsafi, Afsaneh Khani, Fatemeh Mahjoub, Ezat Asgarani, Nazli Sotoudeh
TURKISH JOURNAL OF MEDICAL SCIENCES
(2015)
Article
Microbiology
Tahereh Falsafi, Azadeh Ehsani, Bahareh Attaran, Vahid Niknam
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2016)
Article
Biotechnology & Applied Microbiology
Tahereh Falsafi, Monir Ebrahimi, Ezat Asgarani, Vahid Mirtorabi
ANNALS OF MICROBIOLOGY
(2009)
Article
Immunology
T. Falsafi, A. Ehsani, V. Niknam
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2009)
Article
Microbiology
Mona Anoushiravani, Tahereh Falsafi, Vahid Niknam
JOURNAL OF MEDICAL MICROBIOLOGY
(2009)
Article
Microbiology
Tahereh Falsafi, Paria Lavasani, Ilnaz Basardeh, Sadegh Massarrat, Zahra Landarani
JUNDISHAPUR JOURNAL OF MICROBIOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Mohaddese Mahboubi, Tahereh Falsafi, Majid Sadeghizadeh
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2014)
Article
Medicine, Research & Experimental
Hengameh Soudi, Tahereh Falsafi, Sara Gharavi, Mohaddeseh Mahboubi
GALEN MEDICAL JOURNAL
(2020)
Article
Gastroenterology & Hepatology
Bahareh Attaran, Tahereh Falsafi, Ali N. Moghaddam
SAUDI JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Pediatrics
Tahereh Falsafi, Nazli Sotoudeh, Mohammad-Mehdi Feizabadi, Fatemeh Mahjoub
IRANIAN JOURNAL OF PEDIATRICS
(2014)
Article
Microbiology
Zahra Landarani, Tahereh Falsafi, Mohaddese Mahboubi, Behzad Lameh-rad
IRANIAN JOURNAL OF MICROBIOLOGY
(2014)
Review
Microbiology
Tahereh Falsafi, Mohaddese Mahboubi
IRANIAN JOURNAL OF MICROBIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Tahereh Falsafi, Nargess Valizadeh, Mehri Najafi, Azadeh Ehsani, Afsaneh Khani, Zahra Landarani, Zahra Falahi
CANADIAN JOURNAL OF MICROBIOLOGY
(2007)