Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 15, Issue 11, Pages 1339-1345Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.15.1339
Keywords
Chito-oligosaccharides; Diabetes mellitus; Apoptosis; Antioxidant ability; Pancreastic islet cells; Streptozotocin
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Funding
- National Scientific Research fund of China [(2008JK007)]
- National Key Research and Development Program of China [2006BAD06A14]
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AIM: To investigate the antioxidant activity of chitooligosaccharides (COSs) on pancreatic islet cells in diabetic rats induced by streptozotocin. METHODS: The antioxidant effect of COSs on pancreatic islet cells was detected under optical microscopy and with colorimetric assay and gel electrophoresis. The activities of glutathione peroxidase and superoxide dismutase, total antioxidant capacity and content of malondialdehyde in serum and tissue slices of pancreas were examined after 60 d to determine the effect of COSs in streptozotocin-induced diabetes in rats. RESULTS: COSs can prohibit the apoptosis of pancreatic islet cells. All concentrations of COSs can improve the capability of total antioxidant capacity and activity of superoxide dismutase and decrease the content of malondialdehyde drastically. Morphological investigation in the pancreas showed that COSs have resulted in the reduction of islets, loss of pancreatic cells, and nuclear pyknosis of pancreatic cells. CONCLUSION: COSs possess various biological activities and can be used in the treatment of diabetes mellitus.
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