Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 14, Issue 11, Pages 1720-1733Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.14.1720
Keywords
tumor suppressor; hepatocellular carcinoma; deregulation; liver; carcinogenesis
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A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma. (c) 2008 WJG. All rights reserved.
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