Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 14, Issue 48, Pages 7280-7288Publisher
W J G PRESS
DOI: 10.3748/wjg.14.7280
Keywords
Microscopic colitis; Collagenous colitis; Lymphocytic colitis; Chronic diarrhea; Budesonide
Categories
Funding
- Swedish Society of Medicine (Bengt lhre Foundation) [16898-2005, 18293-2006, 21142-2008]
- Orebro County Research Committee
- Orebro University Hospital Research Foundation
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Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscopic examination. The annual incidence of each disorder is 4-6/100000 inhabitants, with a peak incidence in 60-70-year-old individuals and a noticeable female predominance for collagenous colitis. The etiology is unknown. Chronic diarrhea, abdominal pain, weight loss, fatigue and fecal incontinence are common symptoms, which impair the health-related quality of life of the patient. There is an association with other autoimmune disorders such as celiac disease, diabetes mellitus, thyroid disorders and arthritis. Budesonide is the best-documented short-term treatment, but the optimal long-term strategy needs further study. The long-term prognosis is good and the risk of complications including colonic cancer is low. (c) 2008 The WJG Press. All rights reserved.
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