Article
Pharmacology & Pharmacy
Amira Abugomaa, Mohamed Elbadawy, Yusuke Ishihara, Haru Yamamoto, Masahiro Kaneda, Hideyuki Yamawaki, Yuta Shinohara, Tatsuya Usui, Kazuaki Sasaki
Summary: Despite its disadvantages, chemotherapy is commonly used for bladder cancer treatment. Developing natural supplements that target cancer stem cells (CSCs) is necessary. Chaga mushrooms are known for their health-promoting and anti-cancer properties. In this study, the anti-tumor potentials of Chaga mushroom extract against dog bladder cancer organoids (DBCO) were examined.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Yoshie Tsujiya, Motohiro Yamamori, Ai Hasegawa, Yurie Yamamoto, Masakazu Yashiro, Noboru Okamura
Summary: The study revealed that TEL has a significant inhibitory effect on SGC cells, inducing apoptosis, autophagy, and G(0)/G(1) cell cycle arrest.
ANTICANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Zhijie Cao, Ning Kon, Yajing Liu, Wenbin Xu, Jia Wen, Han Yao, Mi Zhang, Zhen Wu, Xiaojun Yan, Wei-Guo Zhu, Wei Gu, Donglai Wang
Summary: The study revealed that PD-1 in cancer cells is a direct target of the tumor suppressor p53, with its transcription being influenced by acetylation of p53. Acetylated p53 enhances PD-1 transcription, facilitating activation of cancer cell-intrinsic PD-1 and inhibiting tumor growth.
Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Rui Han, Yu-Qi Gao, Ding Li, Xia Yin, Jin-Ming Gao
Summary: Chaga mushroom, known as Inonotus obliquus, has been used as a food and traditional herb in Russia, China, and Japan, showing anti-inflammatory and anticancer activities. Chemical investigations revealed that Inonotusols I and L, two lanostane-type triterpenoids isolated from Chaga, exhibited potent inhibitory effects on nitric oxide (NO) production without significant cytotoxicity. Molecular docking studies confirmed their interaction with inducible nitric oxide synthase (iNOS) protein, indicating their potential anti-inflammatory effects in BV-2 microglial cells. These findings support the potential use of Inonotus obliquus for food and medicinal purposes.
Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Forestry
Jari Miina, Rainer Peltola, Pyry Veteli, Riikka Linnakoski, Marta Cortina Escribano, Juho Haveri-Heikkila, Pirjo Mattila, Pertti Marnila, Juha-Matti Pihlava, Jarkko Hellstrom, Tytti Sarjala, Niko Silvan, Mikko Kurttila, Henri Vanhanen
Summary: This study examined the success rate of inoculating I. obliquus fungus on birch trees under different conditions, finding that factors such as sunny location, mineral soil, small tree diameter, and early inoculation in the thermal growing season were key to success. Despite successful inoculation, the formation of conks was found to be a slow process.
FOREST ECOLOGY AND MANAGEMENT
(2021)
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Haini Wang, Junli Zuo
Summary: Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. Result showed that shikonin inhibited the NSCLC H1299 cell proliferation in a dose-dependent manner. Moreover, shikonin fits well with survivin by molecular docking. Shikonin also inhibited the mRNA expression and protein level of survivin in H1299 cells. Shikonin arrested H1299 cell cycle at the G0/G1 phase by regulating CDK/cyclin family members. In addition, shikonin regulated the expression of X-linked inhibitor of apoptosis- (XIAP-) mediated caspases 3 and 9, thus leading to the damage of mitochondrial membrane potential and induction of H1299 cell apoptosis. Overall, shikonin inhibited H1299 cell growth by inducing apoptosis and blocking the cell cycle. The underlying mechanism involves targeting survivin, which subsequently regulates the protein expression of XIAP/caspase 3/9, CDK2/4, and cyclin E/D1. Thus, shikonin, a survivin inhibitor, is a promising therapeutic strategy in NSCLC treatment.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Cell Biology
Liliana Torres-Lopez, Miguel Olivas-Aguirre, Kathya Villatoro-Gomez, Oxana Dobrovinskaya
Summary: G-1 can induce cytotoxicity, cell cycle arrest, reduced viability, and apoptosis in acute T-cell lymphoblastic leukemia cell lines. The rise of intracellular Ca2+ and destabilization of microtubules are important factors in the cytotoxic effects of G-1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae-Goo Kim, Wooki Kim, Ki-Young Kim
Summary: Hepatic cancer is the third leading cause of cancer-related death globally, with increasing incidence. Traditional herbal medicine Alpinia japonica (AJ) demonstrated anticancer activity against hepatic cancer cells. AJ extract inhibited cell viability, induced apoptosis, and arrested cell cycle progression in HepG2 cells. Activation of JNK and ERK1/2 pathways played a role in AJ extract-induced cell death and apoptosis. AJ extract has potential as a therapeutic agent for hepatic cancer.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Taewook Kang, Honggang Huang, Thomas Mandrup-Poulsen, Martin R. Larsen
Summary: Pro-inflammatory cytokines promote iron-import in pancreatic beta-cells through upregulation of divalent metal transporter-1 (DMT1), leading to cell death. Silencing of DMT1 protects against apoptosis in diabetes animal models by reversing IL-1 beta-induced phosphosites levels and inactivating autophagic flux, potentially improving beta-cell functions. This study sheds light on the signal transduction pathways involved in protecting beta-cells against inflammation-induced cell death after DMT1 silencing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Jinghua Hao, Xiaoli Wang, Yanhua Shi, Lingjun Li, Jinxin Chu, Junjie Li, Weiping Lin, Tao Yu, Dianhai Hou
Summary: This study provides a comprehensive analysis of the Inonotus obliquus fungus, including its genome, transcriptome, proteome, and metabolome. The results reveal the potential medicinal and antioxidant properties of the fungus, as well as differential metabolic changes between seed and fermentation culture. The study also establishes a link between transcription levels and expression levels of key genes involved in metabolism.
Article
Immunology
Perry Ayn Mayson A. Maza, Ji-Hyun Lee, Yong-Su Kim, Gyu-Min Sun, Youn-Joo Sung, Ludmila P. Ponomarenko, Valentine A. Stonik, Minsook Ryu, Jong-Young Kwak
Summary: The study found that Inotodiol can promote the maturation of dendritic cells (DCs) and induce T cell activation. Additionally, Inotodiol-treated DCs enhance T cell proliferation and IL-2 secretion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Mo Yang, Dong Hu, Zhengying Cui, Hongxuan Li, Chaoxin Man, Yujun Jiang
Summary: In this study, it was found that Inonotus obliquus polysaccharide (IOP) has lipid-lowering effects both in vivo and in vitro, reducing fat deposition and lowering lipid levels in the blood.
Article
Oncology
Yi Wu, Heming Cui, Yuying Zhang, Ping Yu, Yuangeng Li, Dan Wu, Yan Xue, Wenwen Fu
Summary: Inonotus obliquus extract exerts cardioprotective effects against myocardial ischemia/reperfusion injury through activating antioxidant enzymes and suppressing endoplasmic reticulum stress-induced apoptosis.
MOLECULAR MEDICINE REPORTS
(2021)
