Article
Medicine, General & Internal
Fuat H. Saner, Alexandra Frey, Bjoern-Ole Stueben, Dieter P. Hoyer, Katharina Willuweit, Martina Daniel, Jassin Rashidi-Alavieh, Jurgen W. Treckmann, Hartmut H. Schmidt
Summary: In this retrospective study of 82 patients who underwent liver transplantation for primary sclerosing cholangitis (PSC), the authors assessed morbidity, survival rates, PSC recurrence, and the impact of donor characteristics in long-term follow-up. The study showed that PSC patients had excellent 10-year survival rates and a lower lab-MELD score was associated with longer survival. Donor characteristics did not affect patient survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Shekhar Singh Jadaun, Rohit Mehtani, Ana Hasnain, Sushant Bhatia, Vikash Moond, Mukesh Kumar, Vikash Kuhad, Shweta Singh, Shaleen Agarwal, Subhash Gupta, Sanjiv Saigal
Summary: This retrospective study analyzed the outcomes of living donor liver transplant (LDLT) in primary sclerosing cholangitis (PSC) at a tertiary liver transplant center in north India. The study found that LDLT in PSC can achieve good long-term outcomes, but there is a risk of PSC recurrence in approximately one-fifth of patients.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Nidhi Jalan-Sakrikar, Abid Anwar, Usman Yaqoob, Can Gan, Anthony B. Lagnado, Alexander Q. Wixom, Diana Jurk, Robert C. Huebert
Summary: This study investigated the mechanistic relationship between telomere damage and biliary fibrosis in primary sclerosing cholangitis (PSC). The results showed telomere attrition and reduced telomerase reverse transcriptase (TERT) expression in patients with PSC. Cellular models demonstrated that telomere dysfunction can lead to senescence and fibrosis, which can be rescued by modulating TERT levels.
Article
Medicine, General & Internal
Esli Medina-Morales, Mohamed Ismail, Romelia Barba Bernal, Yazan Abboud, Leandro Sierra, Daniela Goyes, Ana Marenco-Flores, Behnam Saberi, Vilas Patwardhan, Alan Bonder
Summary: This study compares the outcomes of living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT) in patients with primary biliary cholangitis (PBC). The results show that LDLT has superior patient survival compared to DDLT, and there is no significant difference in graft survival between the two methods. The study also identifies predictors of poor post-transplant outcomes in PBC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Mark R. Pedersen, Garrett Greenan, Sumant Arora, Arvind R. Murali, Marlyn J. Mayo
Summary: UDCA after LT reduces the odds of BC and bile stones and sludge in all-comer LT recipients and reduces or delays the incidence of rPBC in patients transplanted for PBC. UDCA use after LT could be considered in all LT recipients to reduce the odds of BC and may be particularly beneficial for patients transplanted for PBC by reducing the incidence of rPBC.
LIVER TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Eric F. Martin
Summary: The number of liver transplantation for primary biliary cholangitis (PBC) has decreased over the years, but it remains an important and curative option for progressive PBC patients. Recent studies from the Global PBC Study Group have provided valuable insights into the changes in PBC before and after liver transplantation.
CLINICS IN LIVER DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Ji-Won Park, Jung-Hee Kim, Sung-Eun Kim, Jang Han Jung, Myoung-Kuk Jang, Sang-Hoon Park, Myung-Seok Lee, Hyoung-Su Kim, Ki Tae Suk, Dong Joon Kim
Summary: Cholangiopathies are various biliary diseases that affect the biliary epithelium and can lead to cholestasis and liver cirrhosis. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the most important progressive cholangiopathies in adults, with research focusing on genetic risk, epigenetic changes, dysregulated mucosal immunity, and altered biliary epithelial cell function. Understanding the molecular pathogenesis of these diseases can help clinicians prevent and treat them more effectively.
Article
Gastroenterology & Hepatology
Roopa H. Nanjundappa, Urs Christen, Channakeshava S. Umeshappa
Summary: Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are two major autoimmune liver diseases. PBC primarily affects intrahepatic small bile duct epithelial cells in women, while PSC mainly affects medium and big bile duct epithelial cells in men. Cholangiocarcinoma (CCA) is a malignancy arising from cholangiocytes and is more prevalent in PSC patients than in PBC patients. Understanding the immune surveillance mechanisms that differentiate between PBC and PSC patients is crucial for developing effective therapies and early diagnosis of CCA.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Roopa H. Nanjundappa, Urs Christen, Channakeshava S. Umeshappa
Summary: Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are two significant autoimmune liver diseases. PBC primarily affects small bile duct epithelial cells in women, while PSC predominantly affects medium and large intrahepatic and extrahepatic bile duct epithelial cells in men. Cholangiocarcinoma (CCA) is a malignancy arising from cholangiocytes and its incidence is increasing worldwide. Although PBC patients rarely develop CCA compared to PSC patients, understanding the differences in immune surveillance mechanisms is crucial for effective diagnosis and treatment.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Fernanda Onofrio, Katina Zheng, Cherry Xu, Shiyi Chen, Wei Xu, Mary Vyas, Katie Bingham, Keyur Patel, Leslie Lilly, Mark Cattral, Nazia Selzner, Elmar Jaeckel, Cynthia Tsien, Aliya Gulamhusein, Gideon M. Hirschfield, Mamatha Bhat
Summary: This study retrospectively analyzed the clinical trajectory of patients with primary sclerosing cholangitis (PSC) referred for liver transplantation assessment. The results showed that most patients were able to undergo transplantation through living donor transplantation, indicating that the conventional MELD-Na scoring system may not adequately address the disease burden of PSC patients.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Fernanda Onofrio, Katina Zheng, Cherry Xu, Shiyi Chen, Wei Xu, Mary Vyas, Katie Bingham, Keyur Patel, Leslie Lilly, Mark Cattral, Nazia Selzner, Elmar Jaeckel, Cynthia Tsien, Aliya Gulamhusein, Gideon M. Hirschfield, Mamatha Bhat
Summary: This retrospective cohort study examined the clinical trajectory of primary sclerosing cholangitis (PSC) patients referred for liver transplantation (LT) at a transplant center. The findings showed that most PSC patients were listed and transplanted, primarily through living donor transplantation. The study supports the concern that the current MELD-Na allocation system does not adequately address the needs of PSC patients.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Raanan Greenman, Michal Segal-Salto, Neta Barashi, Ophir Hay, Avi Katav, Omer Levi, Ilan Vaknin, Revital Aricha, Sarit Aharoni, Tom Snir, Inbal Mishalian, Devorah Olam, Johnny Amer, Ahmad Salhab, Rifaat Safadi, Yaakov Maor, Palak Trivedi, Christopher J. Weston, Francesca Saffioti, Andrew Hall, Massimo Pinzani, Douglas Thorburn, Amnon Peled, Adi Mor
Summary: CCL24 is involved in fibrosis and inflammation in liver and its inhibition can reduce liver injury. This study found that blocking CCL24 improves inflammation, fibrosis, and cholestasis in PSC, and reduces proliferation and senescence of cholangiocytes.
Article
Surgery
Nobuhisa Akamatsu, Kiyoshi Hasegawa, Hiroto Egawa, Hideki Ohdan, Atsushi Yoshizawa, Norihiro Kokudo, Susumu Tazuma, Atsushi Tanaka, Hajime Takikawa
Summary: The study investigated risk factors for PSC recurrence post liver transplantation, identifying donor age, cyclosporine use, type of immunosuppressive agent, postoperative biliary complications, and active intestinal bowel disease as significant factors. Donor age >=45 years and mono or no immunosuppressive agent 1-year post LT were independently associated with higher risk of recurrence in the final multivariate Cox regression model. These findings were consistent in sub-analysis of ABO-identical/compatible adult living donor LT cases.
TRANSPLANT INTERNATIONAL
(2021)
Article
Surgery
Thijmen Visseren, Nicole Stephanie Erler, Wojciech Grzegorz Polak, Rene Adam, Vincent Karam, Florian Wolfgang Rudolf Vondran, Bo-Goran Ericzon, Douglas Thorburn, Jan Nicolaas Maria IJzermans, Andreas Paul, Frans van der Heide, Pavel Taimr, Petr Nemec, Jacques Pirenne, Renato Romagnoli, Herold Johnny Metselaar, Sarwa Darwish Murad
Summary: Recurrence of PSC after liver transplantation has a significant negative impact on both graft and patient survival, leading to a higher number of re-transplants and a 33% decrease in 10-year graft survival.
TRANSPLANT INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Johannes R. Hov, Tom H. Karlsen
Summary: This Review explores the links between Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), and the mechanisms related to the gut-liver axis. It is found that the gut microbiota in people with PSC differs from that of healthy individuals, but the specific microbial factors that differentiate PSC from IBD without PSC are poorly understood. The potential existence of a specific unknown factor related to the gut-liver axis as a cause of PSC is postulated.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Atsushi Yoshizawa, Noriyo Yamashiki, Yoshihide Ueda, Toshimi Kaido, Hideaki Okajima, Hiroyuki Marusawa, Tsutomu Chiba, Shinji Uemoto
HEPATOLOGY RESEARCH
(2016)
Article
Immunology
Yusuke Okamura, Shintaro Yagi, Toshiya Sato, Koichiro Hata, Fri Ogawa, Atsushi Yoshizawa, Naoko Kamo, Noriyo Yamashiki, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
Article
Surgery
Toyonari Kubota, Koichiro Hata, Takashi Sozu, Yoshihide Ueda, Hirofumi Hirao, Yusuke Okamura, Ichiro Tamaki, Junichi Yoshikawa, Jiro Kusakabe, Hirokazu Tanaka, Shoichi Kageyama, Takayuki Anazawa, Atsushi Yoshizawa, Shintaro Yagi, Noriyo Yamashiki, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
Article
Endocrinology & Metabolism
Kiyoshi Hayasaka, Chikahiko Numakura, Mitsunori Yamakawa, Tetsuo Mitsui, Hisayoshi Watanabe, Hiroaki Haga, Masahide Yazaki, Hiromasa Ohira, Yasuo Ochiai, Toshiyuki Tahara, Tamio Nakahara, Noriyo Yamashiki, Takahiro Nakayama, Takashi Kon, Hiroshi Mitsubuchi, Hiroshi Yoshida
JOURNAL OF INHERITED METABOLIC DISEASE
(2018)
Article
Pediatrics
Noriyo Yamashiki, Atsushi Yoshizawa, Yoshihide Ueda, Toshimi Kaido, Hideaki Okajima, Hiroyuki Marusawa, Hiroshi Seno, Shinji Uemoto
PEDIATRIC TRANSPLANTATION
(2018)
Article
Multidisciplinary Sciences
Nao Nishida, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Kaname Kojima, Yosuke Kawai, Kazuko Ueno, Hitomi Nakamura, Noriyo Yamashiki, Tomohiro Tanaka, Sumito Tamura, Akira Mori, Shintaro Yagi, Yuji Soejima, Tomoharu Yoshizumi, Mitsuhisa Takatsuki, Atsushi Tanaka, Kenichi Harada, Shinji Shimoda, Atsumasa Komori, Susumu Eguchi, Yoshihiko Maehara, Shinji Uemoto, Norihiro Kokudo, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
SCIENTIFIC REPORTS
(2018)
Review
Biotechnology & Applied Microbiology
Piyapon Utako, Thapanakul Emyoo, Thunyarat Anothaisintawee, Noriyo Yamashiki, Ammarin Thakkinstian, Abhasnee Sobhonslidsuk
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Gastroenterology & Hepatology
Takamasa Ohki, Ryosuke Tateishi, Masaaki Akahane, Shintaro Mikami, Masaya Sato, Koji Uchino, Toru Arano, Kenichiro Enooku, Yuji Kondo, Noriyo Yamashiki, Tadashi Goto, Shuichiro Shiina, Haruhiko Yoshida, Yutaka Matsuyama, Masao Omata, Kuni Ohtomo, Kazuhiko Koike
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2013)
Article
Gastroenterology & Hepatology
Junichi Togashi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Sumihito Tamura, Noriyo Yamashiki, Junichi Kaneko, Yoshihiro Sakamoto, Taku Aoki, Kiyoshi Hasegawa, Norihiro Kokudo
HEPATOLOGY RESEARCH
(2013)
Article
Gastroenterology & Hepatology
Tomohiro Tanaka, Yasuhiko Sugawara, Sumihito Tamura, Junichi Kaneko, Yutaka Takazawa, Taku Aoki, Kiyoshi Hasegawa, Yoshihiro Sakamoto, Noriyo Yamashiki, Norihiro Kokudo
HEPATOLOGY RESEARCH
(2014)
Article
Gastroenterology & Hepatology
Tomohiro Tanaka, Noriyo Yamashiki, Yasuhiko Sugawara, Sumihito Tamura, Minoru Nakamura, Junichi Kaneko, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo
HEPATOLOGY RESEARCH
(2014)
Article
Multidisciplinary Sciences
Naoto Fujiwara, Ryosuke Tateishi, Masaaki Akahane, Masataka Taguri, Tatsuya Minami, Shintaro Mikami, Masaya Sato, Kouji Uchino, Kenichiro Enooku, Yuji Kondo, Yoshinari Asaoka, Noriyo Yamashiki, Tadashi Goto, Shuichiro Shiina, Haruhiko Yoshida, Kuni Ohtomo, Kazuhiko Koike
Article
Multidisciplinary Sciences
Nobuhiro Harada, Sumihito Tamura, Yasuhiko Sugawara, Junichi Togashi, Takeaki Ishizawa, Junichi Kaneko, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Tomohiro Tanaka, Noriyo Yamashiki, Norihiro Kokudo
Article
Immunology
Junichi Kaneko, Yasuhiko Sugawara, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Noriyo Yamashiki, Norihiro Kokudo
Article
Gastroenterology & Hepatology
Noriyo Yamashiki, Hironori Haga, Yoshihide Ueda, Takashi Ito, Shintaro Yagi, Naoko Kamo, Koichiro Hata, Akira Mori, Toshimi Kaido, Hideaki Okajima, Shinji Uemoto
HEPATOLOGY RESEARCH
(2020)