Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 14, Issue 15, Pages 2394-2400Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.14.2394
Keywords
hepatocellular carcinoma; radiotherapy; treatment response; survival
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AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METHODS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage M and IV-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate I mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, alpha-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m >= 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%. (c) 2008 WJG. All rights reserved.
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