Article
Multidisciplinary Sciences
Shanshan Luo, Rujing Lin, Xiwen Liao, Daimou Li, Yuzhou Qin
Summary: This study assessed the clinical significance and molecular mechanisms of CDH genes in gastric cancer, identifying CDH2, CDH6, CDH7, and CDH10 as significantly associated with poor prognosis in GC. A prognostic signature based on CDH2 and CDH6 genes was constructed, and their potential functional mechanisms and drug interactions were explored.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ji-Hoon Kim, Kwang-Won Lee, Dong-Gi Ahn, Kyu-Young Oh, Hye-Jung Yoon
Summary: The study reveals that L1 cell adhesion molecule (L1CAM) expression is associated with the aggressive characteristics and poor prognosis of oral squamous cell carcinoma (OSCC), suggesting its potential as a prognostic marker and therapeutic target in OSCC.
Article
Anatomy & Morphology
Xiangwen Zhang, Jiaming Xue, Huiliang Yang, Tingting Zhou, Guo Zu
Summary: TNFAIP6 plays an important role in the prognosis of gastric cancer patients, with higher expression levels associated with tumor invasion depth, lymph node metastasis, TNM stage, and poorer overall survival. Knockdown of TNFAIP6 inhibited proliferation, invasion, and metastasis of gastric cancer cells in vitro.
Article
Pathology
Christina M. Gutierrez, Bradley C. Carthon, Shreyas Joshi, Adeboye O. Osunkoya
Summary: Primary urothelial carcinoma of the ureter is a relatively rare type of urinary tract tumor, often found in association with other urinary tract tumors. Our understanding of this type of cancer is limited due to the lack of comprehensive studies, highlighting the need for further research to explore its clinical characteristics.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Fengxiang Zhang, Huaxian Chen, Dandong Luo, Zhizhong Xiong, Xianzhe Li, Shi Yin, Longyang Jin, Shi Chen, Junsheng Peng, Lei Lian
Summary: Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with poorer prognosis in gastric cancer (GC). This study aimed to investigate their prognostic value in curative resected GC patients. The incidence of LVI/PNI was significantly higher in GC patients compared to colorectal cancer patients (50.54% vs. 21.91%, p < 0.001). LVI/PNI was closely associated with disease progression and served as an independent risk factor for lymph node metastasis and overall survival in GC.
Article
Medicine, General & Internal
Zefeng Li, Hu Ren, Xiaojie Zhang, Chongyuan Sun, He Fei, Zheng Li, Chunguang Guo, Susheng Shi, Yingtai Chen, Dongbing Zhao
Summary: This study compared the characteristics and survival outcomes between patients with gastric large-cell neuroendocrine carcinoma (GLNEC) and gastric small-cell neuroendocrine carcinoma (GSNEC), and concluded that there was no significant statistical difference in prognosis between the two types despite their different cell morphologies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Weizhu Zhao, Yanfei Jia, Guangyu Sun, Haiying Yang, Luguang Liu, Xianlin Qu, Jishuang Ding, Hang Yu, Botao Xu, Siwei Zhao, Ligang Xing, Jie Chai
Summary: Gastric signet ring cell carcinoma (GSRC) is a distinct subtype of gastric cancer with poor prognosis, but there is a lack of in-depth and systematic study on GSRC. In this study, single-cell RNA sequencing was performed on GC samples, revealing the presence of signet ring cell carcinoma (SRCC) cells. These SRCC cells showed upregulation of genes involved in cancer-related and immune response signaling pathways. They also demonstrated lower cell adhesion, higher immune evasion capabilities, and an immunosuppressive microenvironment, which may contribute to the relatively poor prognosis of GSRC. Overall, GSRC exhibits unique cytological characteristics and a distinct immune microenvironment, which could be beneficial for accurate diagnosis and treatment.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
An Wang, Yulong Tan, Shaohua Wang, Xiaofeng Chen
Summary: Lymphatic invasion and vascular invasion are associated with the prognosis of patients with oesophageal squamous cell carcinoma, but their prognostic roles remain controversial. A meta-analysis found that both lymphatic invasion and vascular invasion are associated with worse overall survival, and lymphatic invasion is a more significant indicator for predicting worse recurrence-free survival.
Review
Pharmacology & Pharmacy
Umer Ejaz, Fahad Akhtar, Jinbing Xue, Xinyu Wan, Tong Zhang, Shuying He
Summary: Low molecular weight heparin, derived from commercial-grade heparin, has potential anti-tumor and anti-metastatic effects in addition to its anticoagulant activity. Studies suggest that it may inhibit tumor metastasis by influencing cell adhesion molecules.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pathology
Seokhwi Kim, Won Jung Bae, Ji Mi Ahn, Jin-Hyung Heo, Kyoung-Mee Kim, Kyeong Woon Choi, Chang Ohk Sung, Dakeun Lee
Summary: The study identified unique miRNA expression profiles that can predict metastasis in intramucosal carcinomas (IMCs), with most miRNAs showing stepwise increased or decreased expression. A machine-learning algorithm could distinguish metastatic IMC from nonmetastatic IMC, and gene ontology and pathway analysis revealed enrichment of key signaling pathways. Furthermore, immunohistochemical staining indicated differential expression of pathway components between metastatic and nonmetastatic IMC.
Article
Multidisciplinary Sciences
Hongwei You, Shengsen Chen, Shi Wang
Summary: This study aimed to develop a nomogram to predict lymph node involvement in early gastric signet ring cell carcinoma (SRCC) and evaluate its clinical usefulness. Data from 183 patients with early gastric SRCC who underwent radical gastrectomy with lymph node dissection were retrospectively collected and analyzed. Multiple predictors of lymph node metastasis were identified, and a nomogram was established. The nomogram showed good discrimination and calibration, and demonstrated good clinical performance.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Briana E. Heinly, Christa N. Grant
Summary: Neuroblastoma is a biologically heterogeneous tumor derived from neural crest cells, and its treatment remains challenging. The expression of cell adhesion molecules in neuroblastoma is closely associated with clinical prognosis, and targeted therapies against cell adhesion molecules may represent an innovative treatment strategy in the future.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fang Liu, Xin-Ting Zhu, Yi Li, Chen-jing Wang, Jia-li Fu, Jing Hui, Yi Xiao, Liu Liu, Rong Yan, Xiao-Fei Li, Yun Liu
Summary: The study demonstrated that Magnesium demethylcantharidate (MDC) has inhibitory effects on the invasion and metastasis of hepatocellular carcinoma (HCC) cells, through activating the transcription factor FOXO1. The combination of MDC and sorafenib showed significant enhancement in inhibiting HCC cell invasion and metastasis compared to single drug treatment, indicating that MDC could be a potential therapeutic candidate against the invasion and metastasis of HCC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Tuo Deng, Zihao He, Xiaolu Duan, Di Gu, Chao Cai, Wenqi Wu, Yongda Liu, Guohua Zeng
Summary: STAM1 expression is lower in ccRCC compared with normal renal tissues, and is associated with shorter overall survival in patients. In vitro experiments show that STAM1 inhibits cell viability, invasion, and migration in ccRCC cell lines. Further research is needed to understand the mechanisms of STAM1 in modulating ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Aaron M. Praiss, Douglas Allison, Basile Tessier-Cloutier, Jessica Flynn, Alexia Iasonos, Lien Hoang, Andrei Patrichi, Cristina Terinte, Anna Pesci, Claudia Mateoiu, Ricardo R. Lastra, Lucian Puscasiu, Takako Kiyokawa, Rouba Ali-Fehmi, Mira Kheil, Esther Oliva, Kyle M. Devins, Nadeem R. Abu-Rustum, Robert A. Soslow, Simona Stolnicu
Summary: This study evaluated the clinicopathologic parameters of patients with cervical squamous cell carcinoma who received initial surgical management and assessed their relation to survival outcomes. The extent of lymphovascular invasion was found to be related to survival outcomes.
GYNECOLOGIC ONCOLOGY
(2023)