Article
Clinical Neurology
Eun Hye Jeong, Mun Kyung Sunwoo, Jae Yong Lee, Sun-Ku Han, Sung Wook Hyung, Yoo Sung Song
Summary: This study estimated the asymmetry of specific binding ratio (SBR) of I-123 FP-CIT SPECT images during 4-years of follow up in Parkinson's disease (PD) patients. The results showed that the second method of calculating the asymmetry index revealed a more significant decrease over the 4-year follow up period. Furthermore, the baseline asymmetry index was significantly correlated with the non-dominant putamen SBRs and could be used to predict and evaluate the natural course of PD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Cecilia Boccalini, Giulia Carli, Andrea Pilotto, Alessandro Padovani, Daniela Perani
Summary: This study investigated the impact of gender differences on clinical features, dopaminergic dysfunction, and connectivity in patients with Parkinson's disease across different clinical subtypes. Results showed that males and females with idiopathic PD exhibit distinct vulnerabilities and disease expressions, particularly in cognitive function, anxiety symptoms, and dopaminergic binding patterns in different brain regions.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Hiroshi Mitoma, Hitoshi Aizawa
Summary: The results of this study showed that I-123-FP-CIT-SPECT findings were significantly associated with motor severity and gait severity in drug-naive patients with Parkinson's disease (PD), particularly the mean specific binding ratios of the striatum and anterior putamen.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Computer Science, Artificial Intelligence
Diego Castillo-Barnes, Carmen Jimenez-Mesa, Francisco J. Martinez-Murcia, Diego Salas-Gonzalez, Javier Ramirez, Juan M. Gorriz
Summary: Spatial normalization allows quantitative comparison of brain scans and the quantification of bias introduced by nonlinear transformations is important for studying neurological disorders. Nonlinear transformations can alter diagnosis outcomes and introduce artificial information.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. Dotinga, J. D. van Dijk, B. N. Vendel, C. H. Slump, A. T. Portman, J. A. van Dalen
Summary: The study aimed to develop and validate a machine learning-based approach for interpreting I-123 FP-CIT SPECT scans to discriminate Parkinson's disease. The results showed that the method was generalizable in two centers and accurately differentiated PD from non-PD, with performance comparable to that of nuclear medicine physicians.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Biology
Maria Silvia De Feo, Viviana Frantellizzi, Nicoletta Locuratolo, Arianna Di Rocco, Alessio Farcomeni, Caterina Pauletti, Andrea Marongiu, Julia Lazri, Susanna Nuvoli, Francesco Fattapposta, Giuseppe De Vincentis, Angela Spanu
Summary: This multicenter retrospective study aimed to assess the diagnostic accuracy of 123I-FP-CIT (DAT-SPECT), 123I-MIBG (mIBG-scintigraphy), or a combination of both exams in de novo Parkinson's disease patients. The results showed that mIBG-scintigraphy has higher diagnostic accuracy in de novo Parkinson's disease patients compared to DAT-SPECT. Therefore, the combined use of both exams does not appear to be mandatory in the early phase of Parkinson's disease.
Review
Clinical Neurology
Balestrino Roberta, Barone Paolo, Filippi Massimo, Erro Roberto
Summary: Although the diagnosis of Parkinson's disease relies on clinical presentation, the use of imaging techniques, particularly DAT imaging, can aid in differential diagnosis. Structural lesions and certain medications may alter the results of DAT imaging, and unexpected findings such as SWEDD or SWIDD should be considered.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Mahmood Nazari, Andreas Kluge, Ivayla Apostolova, Susanne Klutmann, Sharok Kimiaei, Michael Schroeder, Ralph Buchert
Summary: This study utilized explainable artificial intelligence to identify extrastriatal brain regions that could assist in the interpretation of dopamine transporter SPECT in parkinsonian syndromes. The study found that besides the striatum, other brain regions like insula, amygdala, and prefrontal cortex also played a significant role in differentiating neurodegenerative and non-neurodegenerative parkinsonian syndromes.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Lars Frings, Franziska Henninger, Martin Treppner, Goran Koeber, Martin Boeker, Philipp T. Meyer
Summary: DAT SPECT, commonly used in dementia diagnostics, has been found to provide valuable prognostic information. Patients with nigrostriatal degeneration (NSD) detected by DAT SPECT have a significantly higher mortality risk compared to those without NSD, with lower striatal DAT binding associated with increased mortality risk.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Caterina Pauletti, Daniela Mannarelli, Nicoletta Locuratolo, Andrea Maffucci, Antonio Curra, Lucio Marinelli, Francesco Fattapposta
Summary: The study evaluated central serotonergic activity in PD patients, showing significant differences between patients and healthy controls, but did not demonstrate an association between serotonergic central transmission deficit and fatigue.
NEUROSCIENCE LETTERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuliya Piatkova, Pierre Payoux, Caroline Boursier, Manon Bordonne, Veronique Roch, Pierre-Yves Marie, Gabriela Hossu, Laetitia Imbert, Antoine Verger
Summary: This study compared I-123-FP-CIT SPECT imaging obtained from a 360 degrees CZT camera with different focus configurations to that from a conventional Anger camera. The results showed that the 360 degrees CZT camera provided higher image quality, shorter acquisition times, and fewer discordant cases compared to the conventional camera, possibly due to its higher spatial resolution.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Vera Flasbeck, Julia Hirsch, Frank Petrak, Juris J. Meier, Stephan Herpertz, Soren Gatermann, Georg Juckel
Summary: The role of gut-brain axis functioning is gaining attention in research on major depressive disorders, and this study explores the relationship between microbiota composition and central serotonergic activity. The findings suggest that gut microbiota composition may play an important role in regulating central serotonergic activity in the brain.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
KyungAh Chun, EunJung Kong, IhnHo Cho
Summary: This study demonstrates a strong correlation between regional brain uptake ratios (URs) in perfusion FP-CIT PET and ECD SPECT images in patients with Parkinson's symptoms, especially in dopamine poor regions. The findings suggest that a single tracer dual phase N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane test may aid in the differential diagnosis of parkinsonian disorders. Further large-scale, longitudinal studies are needed to investigate the changes in correlations between perfusion F-18-FP-CIT PET/CT and Tc-99m-ECD SPECT over time in diseases with parkinsonian patterns.
Article
Clinical Neurology
Seok Jong Chung, Su Hong Kim, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Phil Hyu Lee, Yong Jeong, Young H. Sohn
Summary: The study investigates the association between the cingulate island sign (CIS) ratio and early dementia conversion in patients with Parkinson's disease (PD). The results suggest that inverse CIS, rather than CIS, is relevant to the risk of early dementia conversion in PD patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychiatry
Ivan Milenkovic, Lucie Bartova, Konstantinos Papageorgiou, Siegfried Kasper, Tatjana Traub-Weidinger, Dietmar Winkler
Summary: Diagnosing parkinsonian syndromes in patients with severe depression can be challenging due to overlapping clinical phenomena. [I-123]FP-CIT-SPECT is a useful method for detecting degenerative parkinsonian disorders but drugs may influence the results. Consultation with a movement disorder specialist prior to dopamine transporter imaging is recommended.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Rebecca Overmeyer, Julia Berghaeuser, Raoul Dieterich, Max Wolff, Thomas Goschke, Tanja Endrass
Summary: Higher amplitudes of the error-related negativity (ERN) were found to be related to fewer self-control failures (SCFs) in daily life, suggesting that lower error-related activity may lead to lower recruitment of interventive self-control in daily life.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Psychiatry
Malin K. Hildebrandt, Raoul Dieterich, Tanja Endrass
Summary: The study found that sensation seeking and impulsivity-related traits can predict the degree of substance use, while urgency may be specifically linked to substance-related problems, highlighting their importance in substance use disorders.
Article
Psychology, Biological
Raoul Dieterich, Verena Wullhorst, Julia Berghaeuser, Rebecca Overmeyer, Tanja Endrass
Summary: The study found that high binge-watchers showed less differentiation between gains and losses at the neural level and recruited less brain activity during inhibition and stopping processes. This indicates a potentially problematic interaction between outcome processing and inhibitory functions in binge-watchers.
Article
Clinical Neurology
Sandra Paul, Norbert Kathmann, Bjorn Elsner, Benedikt Reuter, Sven Barnow, Daniela Simon, Tanja Endrass, Julia Klawohn
Summary: This study investigated whether the late positive potential (LPP), a neural marker of attention and stimulus processing, could predict the response to cognitive-behavioral therapy (CBT) in patients with obsessive-compulsive disorder (OCD). The results showed that higher LPP responses to negative stimuli were predictive of lower self-reported OCD symptoms after completion of CBT. The findings suggest that patients with increased emotional reactivity may benefit more from CBT, possibly through reduced avoidance of anxiety-provoking stimuli. The LPP shows promise as a prognostic marker for CBT response in OCD, but further research is needed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Annika C. Konrad, Katharina Foerster, Marcel Kurtz, Tanja Endrass, Emanuel Jauk, Philipp Kanske
Summary: This study found that physical distancing measures during the coronavirus pandemic can lead to increased psychological distress, especially in individuals with pre-existing mental disorders. Factors such as low social resources, empathic disconnection, and perceived social isolation were found to contribute to higher levels of distress in this population. These findings provide valuable information for targeted social interventions to prevent an increase in incidence of mental disorders during physical distancing measures.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Sascha Froelich, Marlon Esmeyer, Tanja Endrass, Michael N. Smolka, Stefan J. Kiebel
Summary: Human behavior often consists of repeated action sequences that become automatic or habitual through extensive repetition. However, we are also required to react flexibly and in a goal-directed manner in response to events in our environment. In this study, we developed a novel behavioral paradigm to investigate how implicitly learned action sequences interfere with goal-directed control.
FRONTIERS IN NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Tanja Endrass, Franziska Weiss
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Malin K. Hildebrandt, Kristina Schwarz, Raoul Dieterich, Tanja Endrass
Summary: The study found that hypoactivation in the right inferior frontal gyrus during inhibition is specifically related to substance-related problems in individuals with SUDs. Interestingly, increased activity in the same region may serve as a resilience factor in substance use without SUDs. Future research should differentiate between processes linked to the degree of substance use and substance-related problems to better understand why some substance users develop SUDs while others do not.
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Psychology, Biological
M. K. Hildebrandt, R. Dieterich, J. Veredjo-Roman, T. Endrass
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Meeting Abstract
Psychology, Biological
V. Wuellhorst, R. Overmeyer, R. Dieterich, T. Endrass
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Meeting Abstract
Psychology, Biological
R. Dieterich, T. Endrass
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Psychology, Biological
Kerstin Dueck, Rebecca Overmeyer, Holger Mohr, Tanja Endrass
Summary: This study examined the influence and interaction of impulsivity and compulsivity on behavioral performance and neural inhibition effects. The results showed no significant relationship between the self-report measures and behavioral or neural inhibition effects, except for a linear effect of the lack of premeditation subscale on behavioral performance.
Article
Biochemistry & Molecular Biology
Solvej Nickel, Tanja Endrass, Raoul Dieterich
Summary: Craving, induced by substance-related cues, plays a crucial role in continued substance use and relapse. Regulation of craving (ROC) is essential for successful treatment, and engaging with the risks of drug use (reappraisal) may be more beneficial than avoiding craving triggers (distraction). However, these effects do not seem to be mediated by lasting changes in cue-related motivated attention (LPP).
Review
Neurosciences
Nuria Donamayor, Claudia Ebrahimi, Viktoria A. Arndt, Franziska Weiss, Florian Schlagenhauf, Tanja Endrass
Summary: This article provides an overview of the mechanisms underlying goal-directed and habitual behavior in individuals with substance use disorders and summarizes the current state of research on this topic. The evidence regarding alterations in addiction and substance use is mixed and requires further investigation. Increased habitual responding is observed in more severely affected groups, while reduced model-based behavior is mainly observed in alcohol use disorder.
NEUROPSYCHOBIOLOGY
(2022)
Article
Psychology, Clinical
Raoul Dieterich, Tanja Endrass
Summary: This article discusses how neuroimaging research can reveal the neural predictors of relapse in substance use disorders and how interventions can modify these markers. The study found that brain activity related to drug value and automatized use behaviors can predict relapse. Established and emerging interventions can help treat substance use disorders by modifying brain activity associated with drug value. However, executive deficits in addiction may affect the effectiveness of interventions targeting control-related brain areas.
ZEITSCHRIFT FUR KLINISCHE PSYCHOLOGIE UND PSYCHOTHERAPIE
(2022)
