Article
Pharmacology & Pharmacy
Yu Fang, Chung-Yu Chen, Hsien-Chung Yu, Pei-Chin Lin
Summary: This retrospective cohort study used Taiwan's National Health Insurance Research Database to evaluate the difference in incidence of neuropsychological disorders (NPDs) between chronic hepatitis C patients receiving interferon therapy and direct-acting antivirals (DAAs) therapy. The study found that patients receiving DAA therapy had a lower risk of NPDs compared to those receiving interferon therapy during the 6-month period after treatment completion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Szu-Wei Cheng, Jing-Xing Li, Daniel Tzu-Li Chen, Yu-Chuan Chien, Jane Pei-Chen Chang, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su
Summary: This study provided supportive evidence of the involvement of the kynurenine pathway in IFN-alpha-induced depression, with SNPs in this pathway being predictive of this disease.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Qutabuddin Khuhro, Hafeezullah Shaikh, Washdev, Shahkamal Hashmi
Summary: The objective of this study was to determine the frequency of depression in Hepatitis-C patients and its association with viral clearance. The results showed that patients with chronic Hepatitis-C commonly suffer from depression, regardless of their PCR test results.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Bijia Song, Jun-Chao Zhu
Summary: Sleep is crucial for health and longevity, with disturbances potentially leading to various physical and psychological disorders. Ketamine, originally used as an antidepressant, has shown new potential applications in treating sleep disturbances and circadian rhythm disorders, in addition to its well-known anesthetic and analgesic properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Yung-Ju Yeh, Ching-Ping Tseng, Sheng-Da Hsu, His -Yuan Huang, Michael M. C. Lai, Hsien-Da Huang, Ju-Chien Cheng
Summary: MicroRNA let-7b is induced by HCV infection and directly targets the HCV genome to regulate HCV replication. Through targeting negative regulators of IFN signaling, let-7b enhances IFN expression and signaling to limit HCV replication in the early stage of infection. This study sheds new insight into the role of let-7b in combating HCV infection and understanding the initial defense mechanisms against RNA viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yadong Wang, Yangyang Hu, Xing Zhang, Yue Luo, Luyuan Ma, Jingjing Lu, Qianfei Liang, Chengjun Xu, Caiyan Zhao, Calvin Q. Pan
Summary: This study investigated the relationship between IP-10 and treatment response in patients with CHC treated with direct-acting antiviral agents. The results showed that IP-10 levels decreased gradually during the treatment and baseline IP-10 level and the decline at 12 weeks were independent predictors of SVR.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pediatrics
Evelyne Baroud, Nivedita Chaudhary, Anna M. Georgiopoulos
Summary: This study retrospectively analyzed the neuropsychiatric symptoms in patients who initiated ETI therapy. It found that 16 out of 148 patients developed new or worsened neuropsychiatric symptoms probably related to ETI, including cognitive impairment, insomnia, depression, and anxiety. Treatment strategies such as pharmacologic interventions, psychotherapy, and dose reduction/discontinuation of ETI resulted in significant improvement. The study highlights the importance of assessing and evaluating neuropsychiatric symptoms, and calls for larger studies to characterize the prevalence, course, and risk factors of adverse events related to CFTR modulators.
PEDIATRIC PULMONOLOGY
(2023)
Review
Behavioral Sciences
Hartej Gill, Barjot Gill, Nelson B. Rodrigues, Orly Lipsitz, Joshua Daniel Rosenblat, Sabine El-Halabi, Flora Nasri, Rodrigo B. Mansur, Yena Lee, Roger S. McIntyre
Summary: Research suggests that intravenous ketamine may have positive effects on cognition in TRD patients, including improvements in working memory and visual learning memory, although symptoms in anxious TRD participants may show more significant improvement.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Daniela Stadler, Martin Kaechele, Alisha N. Jones, Julia Hess, Christian Urban, Jessica Schneider, Yuchen Xia, Andreas Oswald, Firat Nebioglu, Romina Bester, Felix Lasitschka, Marc Ringelhan, Chunkyu Ko, Wen-Min Chou, Arie Geerlof, Maarten A. van de Klundert, Jochen M. Wettengel, Peter Schirmacher, Mathias Heikenwaelder, Sabrina Schreiner, Ralf Bartenschlager, Andreas Pichlmair, Michael Sattler, Kristian Unger, Ulrike Protzer
Summary: The study demonstrates that ISG20 is a nuclear protein induced by both type I and II interferons with nuclease activity, which works with APOBEC3A to degrade HBV cccDNA. ISG20 is localized in the nucleoli of interferon-stimulated hepatocytes and is expressed in acute, self-limiting hepatitis B but not in chronic infection.
Review
Gastroenterology & Hepatology
Lisa Sandmann, Heiner Wedemeyer
Summary: Interferon-alfa has been the main treatment for hepatitis D virus (HDV) infection, but only a portion of patients benefit from it. Successful interferon treatment is associated with improved long-term clinical outcomes. Although alternative treatments are being developed, pegylated interferon-alfa still plays an important role. There is a need for better biomarkers to select patients who are likely to benefit from interferon-based treatments.
LIVER INTERNATIONAL
(2023)
Article
Psychiatry
Raymond W. C. Au, Helen N. W. Sezto, Vera W. M. Lam, Y. T. Wan, L. T. Poon, P. F. Pang, Jackson K. K. Wong
Summary: Individuals with schizophrenia or depression often experience deficits in prospective memory (PM) which can significantly impact their daily functioning. A study was conducted to investigate the effects of a Chinese version of Cognitive Compensatory Training (CCT-C-PM) on PM performance in these populations. Results showed that CCT-C-PM improved PM, especially event-based PM, suggesting it as a viable training method for enhancing PM abilities in individuals with these mental health conditions. Further research is needed to clarify the effects on time-based PM.
PSYCHIATRY RESEARCH
(2021)
Review
Endocrinology & Metabolism
Anne-Sophie C. A. M. Koning, Merel van der Meulen, Daphne Schaap, Djaina D. Satoer, Christiaan H. Vinkers, Elisabeth F. C. van Rossum, Wouter R. van Furth, Alberto M. Pereira, Onno C. Meijer, Olaf M. Dekkers
Summary: The proportion of neuropsychiatric adverse effects in patients using synthetic glucocorticoids is high, with depression and mania being the most significant associations. Awareness of possible psychiatric side effects is essential when starting glucocorticoid treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Virology
Mariya Farooq, Mahd Rauf, Fatima Tahir, Sobia Manzoor
Summary: The study compared the effects of DAAs and PEG IFN-alpha therapy on the expression of immunomodulatory genes in individuals with hepatitis C. The findings showed that patients receiving either treatment had increased expression of TGF-β, potentially leading to fibrosis. DAAs nonresponders exhibited elevated expression of TNF-α, SOCS-3, and IL-10, suggesting future risks of insulin resistance and steatosis. Interferon relapsers had high expression of collagen, indicating susceptibility to developing cirrhosis.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Matteo Nazzareno Barbaglia, James Michael Harris, Artem Smirnov, Michela Emma Burlone, Cristina Rigamonti, Mario Pirisi, Rosalba Minisini, Andrea Magri
Summary: 17β-estradiol induces an interferon-mediated antiviral state in hepatocytes, pre-activating immune response signaling to control and suppress viral spread.
Article
Gastroenterology & Hepatology
Gulce Sari, Claudia E. Mulders, Jingting Zhu, Gertine W. van Oord, Zongdi Feng, Jolanda J. C. Kreeft-Voermans, Andre Boonstra, Thomas Vanwolleghem
Summary: PegIFN lambda is well tolerated in mice and leads to clearance of a persistent HEV infection in liver-humanized mice. The study found that human liver cells express the IFN lambda receptor and are responsive to pegIFN lambda. Dose escalation studies showed that a dose of 0.3 mg/kg pegIFN lambda treatment resulted in complete clearance of HEV antigen and HEV RNA from the liver in 8 out of 9 liver-humanized mice, demonstrating the potential efficacy of pegIFN lambda in treating chronic HEV infections.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monte-Rubio, Merce Boada, Agustin Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Duezel, Octavio Rodriguez Gomez, Tammie Benzinger, Alison Goate, Celeste M. Karch, Anne M. Fagan, Eric McDade, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Marc Suarez-Calvet, Christian Haass, Brian A. Gordon, Yen Ying Lim, Colin L. Masters, Daniel Janowitz, Cihan Catak, Steffen Wolfsgruber, Michael Wagner, Esther Milz, Sonia Moreno-Grau, Stefan Teipel, Michel J. Grothe, Ingo Kilimann, Martin Rossor, Nick Fox, Christoph Laske, Jasmeer Chhatwal, Peter Falkai, Robert Perneczky, Jae-Hong Lee, Annika Spottke, Henning Boecker, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Peter Nestor, Oliver Peters, Manuel Fuentes, Felix Menne, Josef Priller, Eike J. Spruth, Christiana Franke, Anja Schneider, Christine Westerteicher, Oliver Speck, Jens Wiltfang, Claudia Bartels, Miguel angel Araque Caballero, Coraline Metzger, Daniel Bittner, Stephen Salloway, Adrian Danek, Jason Hassenstab, Igor Yakushev, Peter R. Schofield, John C. Morris, Randall J. Bateman, Michael Ewers
Summary: The BDNFVal66Met mutation in Alzheimer's disease is associated with a greater impact on cognitive impairment, particularly through a decrease in hippocampal-medial-frontal connectivity. This finding was consistent across ADAD patients and elderly individuals with sporadically occurring Aβ, and was linked to lower global cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Linda A. Antonucci, Giulio Pergola, Alessandro Pigoni, Dominic Dwyer, Lana Kambeitz-Ilankovic, Nora Penzel, Raffaella Romano, Barbara Gelao, Silvia Torretta, Antonio Rampino, Maria Trojano, Grazia Caforio, Peter Falkai, Giuseppe Blasi, Nikolaos Koutsouleris, Alessandro Bertolino
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychiatry
Elias Wagner, William G. Honer, Iris E. Sommer, Sanne Koops, Daniel M. Blumberger, Zafiris J. Daskalakis, Jozarni J. Dlabac-De Lange, Leonie Bais, Henderikus Knegtering, Andre Aleman, Tomas Novak, Monika Klirova, Christina Slotema, Jerome Brunelin, Emmanuel Poulet, Milenko Kujovic, Joachim Cordes, Thomas Wobrock, Dan Siskind, Peter Falkai, Thomas Schneider-Axmann, Alkomiet Hasan
Summary: The study found that rTMS did not show a beneficial effect over sham treatment for patients treated with clozapine, but there may be a possible beneficial effect for improving persistent auditory hallucinations.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
F. Kamp, L. Hager, L. Proebstl, A. Schreiber, M. Riebschlaeger, S. Neumann, M. Straif, M. Schacht-Jablonowsky, P. Falkai, O. Pogarell, K. Manz, M. Soyka, G. Koller
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda AdIi, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Bernhard T. Baune
Summary: The study found a significant association between polygenic susceptibility to major depression and response to lithium treatment in patients with bipolar disorder. Patients with a lower polygenic load for depression were more likely to respond well to lithium. This highlights the genetic contribution to lithium response in bipolar disorder and supports the concept of a lithium-responsive biotype.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Reinhard Steinberg, Peter Falkai
Summary: In 1886, King Ludwig II of Bavaria was diagnosed with paranoia by Bernhard von Gudden and three other expert psychiatrists, leading to his removal from power. The psychiatrists based their diagnosis on sworn eyewitness accounts, general knowledge about Ludwig's behavior, and his extravagance, unusual beliefs, and hallucinations. Despite not evaluating Ludwig in detail, the experts' diagnosis was considered correct in the context of the psychiatric knowledge and societal philosophy of the time.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Isabel Maurus, Alkomiet Hasan, Andrea Schmitt, Astrid Roeh, Daniel Keeser, Berend Malchow, Thomas Schneider-Axmann, Martin Hellmich, Sabine Schmied, Moritz Lembeck, Katriona Keller-Varady, Irina Papazova, Dusan Hirjak, Cristina E. Topor, Henrik Walter, Sebastian Mohnke, Bob O. Vogel, Wolfgang Woelwer, Frank Schneider, Karsten Henkel, Andreas Meyer-Lindenberg, Peter Falkai
Summary: Patients with schizophrenia often have negative symptoms and cognitive deficits, leading to poor outcomes. Aerobic endurance training is believed to have positive effects on various aspects of patients' health. This study aims to investigate the benefits of endurance training on the mental and physical health of patients with schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Psychiatry
Daniel Martins-de-Souza, Paul C. Guest, Guilherme Reis-de-Oliveira, Andrea Schmitt, Peter Falkai, Christoph W. Turck
Summary: The study characterized the myelin proteome in schizophrenia patients and healthy controls, identifying new proteins associated with myelin. Changes in levels of proteins related to glial cell differentiation, metabolism/energy, synaptic vesicle function and neurodegeneration were observed between the two groups. The findings suggest disruptions in synaptic activity in schizophrenia, with implications for potential drug targets in psychiatric and neurodegenerative disorders.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Victoria Kramer, Irina Papazova, Andreas Thoma, Miriam Kunz, Peter Falkai, Thomas Schneider-Axmann, Anke Hierundar, Elias Wagner, Alkomiet Hasan
Summary: Healthcare workers face significant challenges during the COVID-19 pandemic, with nurses experiencing higher levels of subjective burden and stress compared to doctors and other hospital staff. Doctors and nurses are more likely to test positive for COVID-19, especially when working in a COVID-19 environment where they also experience higher levels of subjective burden and stress. German healthcare workers generally showed high levels of agreement with the measures implemented by hospitals during the pandemic.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Substance Abuse
Daniela Reichl, Niklas Enewoldsen, Kiona K. Weisel, Sebastian Saur, Lukas Fuhrmann, Catharina Lang, Matthias Berking, Mathias Zink, Andreas Ahnert, Peter Falkai, Thomas Kraus, Thomas Hillemacher, Felix-N Muller, Stephan Lins, Dominikus Bonsch, Linda Kerkemeyer, Sabine Steins-Loeber
Summary: There is evidence that craving mediates the relationship between Impulsive Personality Traits (IPTs) and relapse during the treatment of an Alcohol Use Disorder (AUD). Lower emotion regulation competencies were found to mediate the relationship between attentional as well as non-planning IPTs and craving. These findings contribute to a deeper understanding of the underlying processes and may inform tailored interventions for AUD treatment.
SUBSTANCE USE & MISUSE
(2022)
Article
Cell Biology
Florian J. Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V. Glaser, Michael C. Wehr, Michael J. Ziller, Andrea Schmitt, Peter Falkai, Moritz J. Rossner
Summary: Compared with SOX10 alone, the combination of SON increases the number of induced oligodendrocytes (iOLs) and enhances their complexity and myelin-marker gene expression levels. RNA velocity analysis shows that SOX10 generates OPCs that are apparently more immature than those generated by SON, with distinct molecular properties.
Article
Hospitality, Leisure, Sport & Tourism
A. Lassner, I Papazova, B. Pross, J. Scherr, J. Schoenfeld, M. Halle, B. Haller, P. Falkai, A. Hasan, A. Roeh
Summary: Endurance sports carry a higher risk of exercise addiction compared to other physical activities. This study evaluated the risk of exercise addiction among amateur marathon runners and investigated its relationship with fitness measures, affect, and general level of functioning.
INTERNATIONAL JOURNAL OF SPORT AND EXERCISE PSYCHOLOGY
(2022)
Article
Cell Biology
Andrea Schmitt, Laura Tatsch, Alisa Vollhardt, Thomas Schneider-Axmann, Florian J. Raabe, Lukas Roell, Helmut Heinsen, Patrick R. Hof, Peter Falkai, Christoph Schmitz
Summary: This study utilized stereology to investigate the numbers and densities of different cell types in the brains of individuals with schizophrenia. The results indicated a reduction in oligodendrocytes in the CA4 region in schizophrenia patients, which was absent in the control group.
Editorial Material
Neurosciences
David Popovic, Peter Falkai
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Andrea Fiorillo, Antonio Ventriglio, Gaia Sampogna, Peter Falkai
INTERNATIONAL REVIEW OF PSYCHIATRY
(2022)