Review
Clinical Neurology
Kelly G. Gwathmey, Kelsey Satkowiak
Summary: Rheumatological diseases can cause damage to connective tissue and the peripheral nervous system, leading to peripheral neuropathies and overlap myositis. These conditions have diverse presentations and require prompt recognition and treatment.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Nathan A. Shlobin, Nader S. Dahdaleh
Summary: Rheumatoid arthritis is a progressive autoimmune inflammatory disease with a high rate of cervical spine involvement. Early diagnosis and treatment of cervical spine involvement is crucial, with surgical management indicated for patients with symptoms of biomechanical instability or neurological deficits.
NEUROSURGICAL REVIEW
(2021)
Review
Biochemistry & Molecular Biology
Jessica Maiuolo, Carolina Muscoli, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Sara Paone, Sara Ilari, Rocco Mollace, Ernesto Palma, Vincenzo Mollace
Summary: Rheumatoid arthritis is a chronic autoimmune disease that affects joints, but can also result in extra-articular manifestations such as nerve disorders. Research on the pathophysiological basis of microvascular disease associated with RA is ongoing.
Article
Immunology
Siyuan Fan, Jiuliang Zhao, Bo Hou, Mange Liu, Jingwen Niu, Yan Zhou, Chenhui Mao, Haitao Ren, Feng Feng, Mengtao Li, Xiaofeng Zeng, Yicheng Zhu, Hongzhi Guan
Summary: The clinical and neuroimaging characteristics of rheumatoid meningitis (RM) in Chinese patients were analyzed retrospectively. Among 933 patients with rheumatoid arthritis (RA), six patients were identified with RM. Headache, hyperacute focal neurological deficits, and seizures were the most common symptoms. Meninges were affected in all patients and cerebral parenchyma in one patient. The lesions were generally located in the frontoparietal region. Immunotherapy, including tocilizumab, showed good response in most patients. RM in Chinese patients share similar characteristics and respond well to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Mateusz Kotecki, Robert Gasik, Piotr Gluszko, Iwona Sudol-Szopinska
Summary: This study retrospectively analyzed radiological lesions in the cervical spine of 240 patients with RA and found that 75% of patients had cervical spine involvement, with anterior atlanto-axial subluxation and subaxial subluxation being the most common findings. Cervical spine involvement was associated with longer disease duration, rheumatoid factor positivity, and elevated inflammatory markers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Environmental Sciences
May Bin-Jumah, Abdel-Fattah M. Abdel-Fattah, Essa M. Saied, Hesham R. El-Seedi, Mohamed M. Abdel-Daim
Summary: Acrylamide is a harmful chemical compound found in cooked food, particularly fried and baked items, which has toxic effects on the nervous system and other body systems, including carcinogenic effects. Research has shown that acrylamide has direct toxic effects on nerve cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Clinical Neurology
Michael W. Fields, Nathan J. Lee, Daniel Y. Hong, Ashok Para, Venkat Boddapati, Justin Mathew, Jun S. Kim, Joseph Lombardi, Ronald A. Lehman, K. Daniel Riew
Summary: The study utilized the National Readmission Database to determine complication and 90-day readmission rates for RA patients undergoing cervical spine fusion. The results showed that readmission rates were high and commonly due to postoperative infections. Potential modifiable factors to improve outcomes include minimizing intraoperative blood loss, postoperative DVT prophylaxis, and patient discharge disposition.
Review
Biochemistry & Molecular Biology
Josko Mitrovic, Stela Hrkac, Josip Tecer, Majda Golob, Anja Ljilja Posavec, Helena Kolar Mitrovic, Lovorka Grgurevic
Summary: Rheumatoid arthritis (RA) is a prevalent autoimmune inflammatory chronic disease that primarily affects the joints but can also have extraarticular manifestations (EAMs) that impact various organs and increase the risk of cardiovascular disease (CVD), the leading cause of death in RA patients. Despite known risk factors, there is still limited understanding of the pathophysiology of EAMs. Better understanding the connections between joint and extra-joint manifestations could lead to improved treatments and patient care.
Review
Immunology
Fabiana Assunta Figus, Matteo Piga, Irene Azzolin, Rebecca McConnell, Annamaria Iagnocco
Summary: Synovitis is the primary manifestation of rheumatoid arthritis (RA), but many extra-articular manifestations and comorbidities are likely due to the chronic, complex nature of the disease. Cardiovascular disease is the leading cause of death in RA patients, with increased risks of myocardial infarction and CV mortality. Other common causes of death in RA patients include respiratory disease and neurological issues, with evidence linking systemic inflammation to Alzheimer's disease and vascular dementia. In order to reduce morbidity and mortality, physicians must actively manage RA disease activity and monitor for potential risk factors and associated conditions.
AUTOIMMUNITY REVIEWS
(2021)
Review
Orthopedics
Mostafa Ellatif, Ban Sharif, David Baxter, Asif Saifuddin
Summary: This article reviews the current role of imaging in the rheumatoid spine, with a focus on radiographs and MRI.
SKELETAL RADIOLOGY
(2022)
Article
Clinical Neurology
Nara Miriam Michaelson, Ashwin Malhotra, Zehui Wang, Linda Heier, Kurenai Tanji, Scott Wolfe, Alka Gupta, Daniel MacGowan
Summary: This study investigates the peripheral neurologic complications in patients with COVID-19 and highlights the presence of nerve system damage in some patients. The study found that 14 out of 25 patients had peripheral neurological complications, while the other 11 patients did not have such complications. Peripheral neurological complications often exhibit multiple types concurrently.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Andreas Thimm, Alexander Carpinteiro, Sara Oubari, Maria Papathanasiou, Peter Luedike, Lukas Kessler, Christoph Rischpler, Tobias Blau, Hans Christian Reinhardt, Tienush Rassaf, Hartmut Schmidt, Christoph Kleinschnitz, Tim Hagenacker
Summary: Neurological involvement is common in systemic AL amyloidosis, particularly in the peripheral nervous system. Male sex and cardiac involvement are independent predictors of peripheral neuropathy. Peripheral neuropathy has no impact on survival.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Rheumatology
Motasem Alkhayyat, Mohannad Abou Saleh, Mehnaj Kaur Grewal, Mohammad Abureesh, Emad Mansoor, C. Roberto Simons-Linares, Abby Abelson, Prabhleen Chahal
Summary: A study using a large database found that patients with rheumatoid arthritis (RA) are at a modestly increased risk of developing acute pancreatitis and chronic pancreatitis; further research is needed to better understand this association and the impact of RA medications on pancreatic diseases.
Review
Virology
Brittany Bodnar, Kena Patel, Wenzhe Ho, Jin Jun Luo, Wenhui Hu
Summary: Research indicates that Neuro-SARS2 may worsen the severity and mortality of COVID-19. Understanding the neuropathogenesis and cellular mechanisms of Neuro-SARS2 is crucial for developing effective strategies. While progress has been made, there is still much to learn about the neuroinvasive routes of the virus and the mechanisms underlying disease progression.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Rheumatology
In-Woon Baek, Young Bin Joo, Kyung-Su Park, Ki-Jo Kim
Summary: The study found that the prevalence of cervical spine instability is high in rheumatoid arthritis patients, and it is closely related to AUCP and biologic DMARD therapies.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Mirkamal Tolend, Thitiporn Junhasavasdikul, Randy Q. Cron, Emilio J. Inarejos Clemente, Thekla von Kalle, Christian J. Kellenberger, Bernd Koos, Elka Miller, Marion A. van Rossum, Rotraud K. Saurenmann, Lynn Spiegel, Jennifer Stimec, Marinka Twilt, Nikolay Tzaribachev, Shelly Abramowicz, Simone Appenzeller, Linda Z. Arvidsson, Saurabh Guleria, Jacob L. Jaremko, Eva Kirkhus, Tore A. Larheim, Arthur B. Meyers, Jyoti Panwar, Cory M. Resnick, Susan C. Shelmerdine, Brian M. Feldman, Andrea S. Doria
Summary: A DCE survey was used to determine the relative importance weights of items and grades of the JAMRIS-TMJ, showing high convergent validity with an unrestricted, holistic vignette ranking method.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Ivan Foeldvari, Jens Klotsche, Ozgur Kasapcopur, Amra Adrovic, Maria Teresa Terreri, Ana Paula Sakamoto, Valda Stanevicha, Flavio Sztajnbok, Jordi Anton, Brian Feldman, Ekaterina Alexeeva, Maria Katsicas, Vanessa Smith, Tadej Avcin, Edoardo Marrani, Mikhail Kostik, Thomas Lehman, Walter-Alberto Sifuentes-Giraldo, Natalia Vasquez-Canizares, Simone Appenzeller, Mahesh Janarthanan, Monika Moll, Dana Nemcova, Anjali Patwardhan, Maria Jose Santos, Sujata Sawhney, Dieneke Schonenberg-Meinema, Cristina Battagliotti, Lillemor Berntson, Blanca Bica, Jurgen Brunner, Patricia Costa-Reis, Despina Eleftheriou, Liora Harel, Gerd Horneff, Daniela Kaiser, Tilmann Kallinich, Dragana Lazarevic, Kirsten Minden, Susan Nielsen, Farzana Nuruzzaman, Yosef Uziel, Nicola Helmus, Kathryn S. Torok
Summary: This study evaluated the baseline clinical characteristics of juvenile SSc patients and found significant differences in disease severity and organ involvement between juvenile dcSSc and lcSSlc patients. Additionally, patients with overlap features had a higher frequency of interstitial lung disease.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Nathalie E. Chalhoub, Scott E. Wenderfer, Deborah M. Levy, Kelly Rouster-Stevens, Amita Aggarwal, Sonia Savani, Natasha M. Ruth, Thaschawee Arkachaisri, Tingting Qiu, Angela Merritt, Karen Onel, Beatrice Goilav, Raju P. Khubchandani, Jianghong Deng, Adriana R. Fonseca, Stacy P. Ardoin, Coziana Ciurtin, Ozgur Kasapcopur, Marija Jelusic, Adam M. Huber, Seza Ozen, Marisa S. Klein-Gitelman, Simone Appenzeller, Andre Cavalcanti, Lampros Fotis, Sern Chin Lim, Rodrigo M. Silva, Julia Ramirez-Miramontes, Natalie L. Rosenwasser, Claudia Saad-Magalhaes, Dieneke Schonenberg-Meinema, Christiaan Scott, Clovis A. Silva, Sandra Enciso, Maria T. Terreri, Alfonso-Ragnar Torres-Jimenez, Maria Trachana, Sulaiman M. Al-Mayouf, Prasad Devarajan, Bin Huang, Hermine Brunner
Summary: This study aimed to develop a standardized steroid dosing regimen for physicians treating childhood-onset systemic lupus erythematosus complicated by lupus nephritis. By evaluating patient course and various parameters, a consensus-based dosing regimen was developed and validated.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alison Jhisel Mansmith Calle, Celso Massahiro Ogawa, Jaqueline Serra Martins, Fernanda Cardoso Santos, Sergio Lucio Pereira de Castro Lopes, Ana Carla Raphaelli Nahas-Scocate, Bengt Hasseus, Simone Appenzeller, Andre Luiz Ferreira Costa
Summary: The aim of this study was to investigate TMJ components in patients with JIA compared to a control group using MRI measurements. The study found lower measurement values for IAE, HAE, and CEA in JIA patients, indicating differences in these indices compared to controls.
Article
Rheumatology
Ivan Foeldvari, Jens Klotsche, Bernd Hinrichs, Nicola Helmus, Ozgur Kasapcopur, Amra Adrovic, Flavio Sztajnbok, Maria Teresa Terreri, Jordi Anton, Vanessa Smith, Maria Katsicas, Mikhail Kostik, Natalia Vasquez-Canizares, Tadej Avcin, Brian Feldman, Mahesh Janarthanan, Maria Jose Santos, Sujata Sawhney, Dieneke Schonenberg-Meinema, Walter-Alberto Sifuentes-Giraldo, Ekaterina Alexeeva, Simone Appenzeller, Cristina Battagliotti, Lillemor Berntson, Blanca Bica, Patricia Costa-Reis, Despina Eleftheriou, Tilmann Kallinich, Thomas Lehman, Edoardo Marrani, Kirsten Minden, Susan Nielsen, Farzana Nuruzzaman, Anjali Patwardhan, Raju Khubchandani, Valda Stanevicha, Yosef Uziel, Kathryn S. Torok
Summary: This study utilized data from an international juvenile SSc cohort to evaluate the effectiveness of pulmonary screening with FVC and DLco in detecting ILD compared to HRCT. The results showed that the performance of PFTs, especially FVC, was limited in detecting ILD in juvenile SSc patients, missing around 60% of children with ILD changes on HRCT. DLco had higher sensitivity but lower specificity than FVC in detecting potential abnormalities on HRCT. These findings support the use of HRCT in tandem with PFTs for ILD screening in juvenile SSc.
ARTHRITIS CARE & RESEARCH
(2022)
Editorial Material
Otorhinolaryngology
Samuel de Oliveira Andrade, Simone Appenzeller
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Rheumatology
Ana Paula Rosa dos Santos, Camila de Oliveira Vaz, Bidossessi Wilfried Hounkpe, Bruna Cardoso Jacintho, Jose Diogo Oliveira, Gabriela Lisiane Tripiquia Vechiatto Mesquita, Irene Pereira dos Santos, Joyce Annichino-Bizzacchi, Simone Appenzeller, Bruna de Moraes Mazetto Fonseca, Fernanda Andrade Orsi
Summary: This study found an association between plasmacytoid dendritic cells and interferon (IFN)-I with thrombotic antiphospholipid syndrome (APS), providing a new mechanism for the pathophysiology of APS.
Correction
Rheumatology
Fabiola Reis Oliveira, Valeria Valim, Sandra Gofnet Pasoto, Marilena Leal Mesquita Silvestre Fernandes, Maria Lucia Lemos Lopes, Sonia Cristina de Magalhaes Souza Fialho, Aysa Cesar Pinheiro, Laura Caldas dos Santos, Simone Appenzeller, Tania Fidelix, Sandra Lucia Euzebio Ribeiro, Danielle Christinne Soares Egypto de Brito, Tatiana Liborio, Maria Carmen Lopes Ferreira Silva Santos, Leandro Tanure, Juliana DAgostino Gennari, Vinicius Tassoni Civile, Ana Carolina Pereira Nunes Pinto, Cesar Ramos Rocha-Filho, Samira Tatiyama Miyamoto, Lissiane Karine Noronha Guedes, Alisson Pugliesi, Virginia Fernandes Moca Trevisani
ADVANCES IN RHEUMATOLOGY
(2022)
Article
Neuroimaging
Milena K. Farche, Natalia O. Fachinetti, Luciana R. P. da Silva, Larissa A. Matos, Simone Appenzeller, Fernando Cendes, Fabiano Reis
Summary: This study evaluated the usefulness of proton magnetic resonance spectroscopy (H-1-MRS) in distinguishing primary from secondary brain tumors. The results showed that secondary tumors had higher NAA/Cr and Cho/Cr ratios, with a good correlation between NAA/Cr and Cho/Cr. By constructing a logistic regression model, the nature of the tumor could be reasonably predicted.
NEURORADIOLOGY JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ana Lucia Franco Ricardo, Gabriel Araujo da Silva, Celso Massahiro Ogawa, Amanda D. Nussi, Catharina Simione De Rosa, Jaqueline Serra Martins, Sergio Lucio Pereira de Castro Lopes, Simone Appenzeller, Paulo Henrique Braz-Silva, Andre Luiz Ferreira Costa
Summary: This study evaluated the feasibility of using texture analysis (TA) based on magnetic resonance imaging (MRI) to identify patients with juvenile idiopathic arthritis (JIA) likely to progress to temporomandibular joint damage. The results showed significant differences in texture parameters of the condyle between the JIA group and the control group, and a progressive loss of uniformity in grayscale pixels of MRI with increasing age in the JIA group.
Proceedings Paper
Computer Science, Interdisciplinary Applications
William Javier Herrera, Simone Appenzeller, Fabiano Reis, Danilo Rodrigues Pereira, Mariana Pinheiro Bento, Leticia Rittner
Summary: In this study, a convolutional neural network (CNN) is proposed for quality control of corpus callosum (CC) segmentations. The method was validated using magnetic resonance imaging (MRI) data and achieved high accuracy on the test set. Furthermore, the approach demonstrated good generalization capability to data from different domains.
MEDICAL IMAGING 2022: IMAGE PROCESSING
(2022)
Review
Pediatrics
Simone Appenzeller, Danilo Rodrigues Pereira, Paulo Rogerio Julio, Fabiano Reis, Leticia Rittner, Roberto Marini
Summary: Neuropsychiatric manifestations are common in childhood-onset systemic lupus erythematosus (SLE) and are difficult to diagnose. Most patients experience these manifestations within the first two years of the disease, with 30-70% of them having multiple events during the course of the disease. These symptoms have significant impact on disability and mortality, but only a few biomarkers have been validated for diagnosis, treatment monitoring, and prognosis.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Immunology
Karina de Oliveira Pelicari, Mariana Postal, Nailu Angelica Sinicato, Ana Carolina Londe, Paula Teixeira Fernandes, Roberto Marini, Lilian Tereza Lavras Costallat, Simone Appenzeller
Summary: This study aimed to compare the levels of Th1 (IL-12) and Th2 (IL-6 and IL-10) cytokines among cSLE, aSLE, and healthy controls over a two-year period. The results showed that cSLE patients had significantly higher levels of IL-12 compared to healthy controls, while aSLE patients had significantly higher levels of IL-6 compared to healthy controls.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)
Review
Health Care Sciences & Services
Luciana Paim-Marques, Rodrigo Joel de Oliveira, Simone Appenzeller
Summary: Fabry disease is a rare genetic disorder caused by a gene variant that leads to a deficiency in the enzyme alpha-galactosidase A. This deficiency causes the accumulation of a specific lipid in various organs, resulting in a wide range of clinical manifestations and potentially life-threatening complications such as cardiac arrhythmia, kidney failure, and stroke. This review provides an overview of the clinical features and current multidisciplinary management approaches for Fabry disease patients.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Article
Rheumatology
Renan Bazuco Frittoli, Danilo Rodrigues Pereira, Aline Tamires Lapa, Mariana Postal, Nailu Angelica Sinicato, Paula Teixeira Fernandes, Fernando Cendes, Gabriela Castellano, Leticia Rittner, Roberto Marini, Timothy B. Niewold, Simone Appenzeller
Summary: This study found that childhood-onset SLE patients have axonal dysfunction, which is associated with IFN-gamma levels and depressive symptoms. Increased CHO ratios are related to cognitive impairment, while mI/Cr ratios are correlated with cumulative glucocorticoids dosage.
