An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer
Authors
Keywords
Universal Pattern, Epigenetic Enzyme, DNAm Level, Promoter CGIs, Causal Network Modeling
Journal
GENOME BIOLOGY
Volume 16, Issue 1, Pages -
Publisher
Springer Nature
Online
2015-07-13
DOI
10.1186/s13059-015-0699-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/β-catenin pathway
- (2015) Hey-Yon Kim et al. FASEB JOURNAL
- Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma
- (2015) Irfan A Asangani et al. Oncotarget
- A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control
- (2014) Yinming Jiao et al. BIOINFORMATICS
- UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma
- (2014) Raksha Mudbhary et al. CANCER CELL
- Integrated Genomic Characterization of Papillary Thyroid Carcinoma
- (2014) Nishant Agrawal et al. CELL
- Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming
- (2014) Xiao Hu et al. Cell Stem Cell
- Targeting histone methyltransferase EZH2 as cancer treatment
- (2014) Y. Kondo JOURNAL OF BIOCHEMISTRY
- New and emerging HDAC inhibitors for cancer treatment
- (2014) Alison C. West et al. JOURNAL OF CLINICAL INVESTIGATION
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- CBX7 Modulates the Expression of Genes Critical for Cancer Progression
- (2014) Pierlorenzo Pallante et al. PLoS One
- EZH2 as a potential target in cancer therapy
- (2014) Michael T McCabe et al. Epigenomics
- Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors
- (2014) Winston Timp et al. Genome Medicine
- Dissecting the expression landscape of RNA-binding proteins in human cancers
- (2014) Bobak Kechavarzi et al. GENOME BIOLOGY
- CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation
- (2014) F. Forzati et al. Biology Open
- Overexpression of multiple myeloma SET domain (MMSET) is associated with advanced tumor aggressiveness and poor prognosis in serous ovarian carcinoma
- (2013) Shanshan Yang et al. BIOMARKERS
- Genomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers
- (2013) Adam L Cohen et al. BMC Medical Genomics
- Interplay between the Cancer Genome and Epigenome
- (2013) Hui Shen et al. CELL
- Unraveling Tumor Suppressor Networks with In Vivo RNAi
- (2013) Christian J. Braun et al. Cell Stem Cell
- Histone Lysine-Specific Methyltransferases and Demethylases in Carcinogenesis: New Targets for Cancer Therapy and Prevention
- (2013) Xuejiao Tian et al. CURRENT CANCER DRUG TARGETS
- Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinomaviaTRAIL-induced apoptotic pathway regulation
- (2013) Kanako Shinjo et al. INTERNATIONAL JOURNAL OF CANCER
- Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies
- (2013) J A Oyer et al. LEUKEMIA
- Integrated genomic characterization of endometrial carcinoma
- (2013) Gad Getz et al. NATURE
- Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
- (2013) Christoph Plass et al. NATURE REVIEWS GENETICS
- Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes
- (2013) Nathan D. VanderKraats et al. NUCLEIC ACIDS RESEARCH
- UHRF1 Promotes Cell Growth and Metastasis Through Repression of p16ink4a in Colorectal Cancer
- (2012) Feng Wang et al. ANNALS OF SURGICAL ONCOLOGY
- A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
- (2012) Andrew E. Teschendorff et al. BIOINFORMATICS
- Tumor suppressor activity of CBX7 in lung carcinogenesis
- (2012) Floriana Forzati et al. CELL CYCLE
- Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies
- (2012) Andrew E Jaffe et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- CBX7 is a tumor suppressor in mice and humans
- (2012) Floriana Forzati et al. JOURNAL OF CLINICAL INVESTIGATION
- TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group
- (2012) Verena I. Gaidzik et al. JOURNAL OF CLINICAL ONCOLOGY
- Overexpression of MMSET in endometrial cancer: A clinicopathologic study
- (2012) Min Xiao et al. JOURNAL OF SURGICAL ONCOLOGY
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Dissecting the genomic complexity underlying medulloblastoma
- (2012) David T. W. Jones et al. NATURE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
- (2012) Akihiro Fujimoto et al. NATURE GENETICS
- UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression
- (2012) L Sabatino et al. ONCOGENE
- The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein
- (2012) D Guan et al. ONCOGENE
- The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression
- (2012) F Babbio et al. ONCOGENE
- Overexpression of MMSET is Correlation with Poor Prognosis in Hepatocellular Carcinoma
- (2012) Peng Zhou et al. PATHOLOGY & ONCOLOGY RESEARCH
- Linking epithelial-to-mesenchymal-transition and epigenetic modifications
- (2012) Sonja C. Stadler et al. SEMINARS IN CANCER BIOLOGY
- Correction: The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's Cancer
- (2012) Joanna Zhuang et al. PLoS Genetics
- Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies
- (2011) Andrew E. Teschendorff et al. BIOINFORMATICS
- Inhibition Effect of siRNA-Downregulated UHRF1 on Breast Cancer Growth
- (2011) Feng Yan et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma
- (2011) H. R. Hudlebusch et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors
- (2011) H. R. Hudlebusch et al. CLINICAL CANCER RESEARCH
- Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
- (2011) Juan Sandoval et al. Epigenetics
- CpG islands and the regulation of transcription
- (2011) A. M. Deaton et al. GENES & DEVELOPMENT
- Increased methylation variation in epigenetic domains across cancer types
- (2011) Kasper Daniel Hansen et al. NATURE GENETICS
- Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
- (2011) Yaoting Gui et al. NATURE GENETICS
- Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
- (2011) Benjamin P Berman et al. NATURE GENETICS
- Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
- (2011) Xiao-Jing Yan et al. NATURE GENETICS
- Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
- (2011) K Kim et al. ONCOGENE
- UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer
- (2010) Alexandros Daskalos et al. CANCER
- Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
- (2010) Houtan Noushmehr et al. CANCER CELL
- Discovery and characterization of chromatin states for systematic annotation of the human genome
- (2010) Jason Ernst et al. NATURE BIOTECHNOLOGY
- Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis
- (2009) Motoko Unoki et al. BIOCHEMICAL PHARMACOLOGY
- UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer
- (2009) M Unoki et al. BRITISH JOURNAL OF CANCER
- An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer
- (2009) Andrew E. Teschendorff et al. PLoS One
- Loss of the CBX7 Gene Expression Correlates with a Highly Malignant Phenotype in Thyroid Cancer
- (2008) P. Pallante et al. CANCER RESEARCH
- Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
- (2008) S. Varambally et al. SCIENCE
- The methylome: approaches for global DNA methylation profiling
- (2008) Stephan Beck et al. TRENDS IN GENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started