Targeting zinc homeostasis to combat Aspergillus fumigatus infections

Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

(2014) Maamoun Fatfat et al.   BMC CANCER

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

(2014) Jan Rybniker et al.   Cell Host & Microbe

Zinc Acquisition: A Key Aspect in Aspergillus fumigatus Virulence

(2014) Jorge Amich et al.   MYCOPATHOLOGIA

Quinone-Amino Acid Conjugates Targeting Leishmania Amino Acid Transporters

(2014) Federica Prati et al.   PLoS One

The ZrfC alkaline zinc transporter is required forAspergillus fumigatusvirulence and its growth in the presence of the Zn/Mn-chelating protein calprotectin

(2013) Jorge Amich et al.   CELLULAR MICROBIOLOGY

A proteomic view of the response of Paracoccidioides yeast cells to zinc deprivation

(2013) Ana Flávia Alves Parente et al.   Fungal Biology

Granulocyte Macrophage-Colony Stimulating Factor Induced Zn Sequestration Enhances Macrophage Superoxide and Limits Intracellular Pathogen Survival

(2013) Kavitha Subramanian Vignesh et al.   IMMUNITY

Concerns About Reliability in the Trial to Assess Chelation Therapy (TACT)

(2013) Steven E. Nissen   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum

(2013) Sixto M. Leal et al.   PLoS Pathogens

The taste of heavy metals: Gene regulation by MTF-1

(2012) Viola Günther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis

(2012) A. L.S. Santos et al.   CURRENT MEDICINAL CHEMISTRY

Novel Polypyridyl chelators deplete cellular zinc and destabilize the X-linked inhibitor of apoptosis protein (XIAP) prior to induction of apoptosis in human prostate and breast cancer cells

(2012) Jian Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Zap1 Regulates Zinc Homeostasis and Modulates Virulence in Cryptococcus gattii

(2012) Rafael de Oliveira Schneider et al.   PLoS One

A Nonredundant Role for Plasmacytoid Dendritic Cells in Host Defense against the Human Fungal Pathogen Aspergillus fumigatus

(2011) Zaida G. Ramirez-Ortiz et al.   Cell Host & Microbe

Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages

(2011) Hélène Botella et al.   Cell Host & Microbe

Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa

(2011) Ksenija Slavic et al.   MALARIA JOURNAL

The oxidative stress of zinc deficiency

(2011) David J. Eide   Metallomics

Safety issues of iron chelation therapy in patients with normal range iron stores including thalassaemia, neurodegenerative, renal and infectious diseases

(2010) G J Kontoghiorghes et al.   Expert Opinion On Drug Safety

NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus

(2010) Allison McCormick et al.   MICROBES AND INFECTION

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Antifungal Activities of Natural and Synthetic Iron Chelators Alone and in Combination with Azole and Polyene Antibiotics against Aspergillus fumigatus

(2009) K. A. Zarember et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aspergillus fumigatus Survival in Alkaline and Extreme Zinc-Limiting Environments Relies on the Induction of a Zinc Homeostasis System Encoded by thezrfCandaspf2Genes

(2009) Jorge Amich et al.   EUKARYOTIC CELL

The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis

(2009) A. S. Ibrahim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Zinc Deficiency Affects DNA Damage, Oxidative Stress, Antioxidant Defenses, and DNA Repair in Rats

(2009) Yang Song et al.   JOURNAL OF NUTRITION

A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis

(2009) M. Huesca et al.   MOLECULAR CANCER THERAPEUTICS

Biofilm Matrix Regulation by Candida albicans Zap1

(2009) Clarissa J. Nobile et al.   PLOS BIOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Metal ions in biological catalysis: from enzyme databases to general principles

(2008) Claudia Andreini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE