Article
Immunology
Zoltan Szittner, Arthur E. H. Bentlage, A. Robin Temming, David E. Schmidt, Remco Visser, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, C. Ellen van der Schoot, Gestur Vidarsson
Summary: The core fucosylation in anti-HPA-1a IgG greatly influences its binding to leukocyte IgG-Fc receptors IIIa/b. A cellular surface plasmon resonance imaging technique was developed to quantify the biological activity of IgG antibodies targeting cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Obstetrics & Gynecology
James B. Bussel, Emilie L. Vander Haar, Richard L. Berkowitz
Summary: Advances in managing fetal and neonatal alloimmune thrombocytopenia may include screening all antepartum patients, noninvasively testing fetal human platelet antigen 1 genotype, developing a prophylactic product equivalent to Rh immune globulin, and creating neonatal Fc receptor inhibitors as potential therapies.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Thijs W. de Vos, Masja de Haas, Dick Oepkes, Ratna N. G. B. Tan, C. Ellen van der Schoot, Sylke J. Steggerda, Linda S. de Vries, Enrico Lopriore, Jeanine M. M. van Klink
Summary: This study aimed to evaluate the long-term neurodevelopmental outcomes in children with fetal and neonatal alloimmune thrombocytopenia who were treated with antenatal intravenous immunoglobulin. The results showed that the risk of neurodevelopmental impairment in these children is comparable to that reported in the general population.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Hematology
Assaf Barg, Lilach Bonstein
Summary: This review discusses the advances in the field of fetal and neonatal alloimmune thrombocytopenia (FNAIT), including new methods for prenatal diagnosis and treatment. Topics explored include noninvasive prenatal testing, novel therapeutic options developed through the use of mouse models, and research on the biological characteristics of alloantibodies and their association with the risk of fetal bleeding.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Rheumatology
Elena Aranda Escano, Mikel Prieto Calvo, Arkaitz Perfecto Valero, Guillermo Ruiz Irastorza, Mikel Gastaca Mateo, Andres Valdivieso Lopez
Summary: Transplantation-mediated alloimmune thrombocytopenia (TMAT) is a rare complication in recipients of organs from donors with immune thrombocytopenia (ITP). Severe and refractory cases may require early retransplantation for successful treatment.
Article
Veterinary Sciences
L. Chantillon, B. Devriendt, B. De Jonge, J. Oostvogels, J. Coppens, M. L. Pas, J. Bokma, B. Pardon
Summary: This study reports on three calves from two different farms that were diagnosed with immune-mediated pancytopenia, which is clinically indistinguishable from BNP.
BMC VETERINARY RESEARCH
(2022)
Article
Medicine, General & Internal
Jing Fu, Ruojin Yao, Wenjing Yong
Summary: This study reported a case of prenatal diagnosis and treatment of FAIT. The patient presented with severe fetal anemia and thrombocytopenia at 32 weeks of gestational age. Following treatment with dexamethasone, the newborn's platelet count gradually increased to a normal level.
Article
Cell Biology
Rebecca Carter, Anna-Kaisa Niemi
Summary: Noonan syndrome is a genetic disorder with distinctive physical features and often involves bleeding disorders. This case report presents a neonate with intracranial hemorrhage and severe thrombocytopenia, found to have both NAIT and a de novo heterozygous pathogenic variant in PTPN11, consistent with Noonan syndrome.
Article
Hematology
Kristine Matusiak, Christopher J. Patriquin, Stacy Deniz, Nancy Dzaja, James W. Smith, Grace Wang, Ishac Nazy, John G. Kelton, Donald M. Arnold
Summary: This study investigated clinical and laboratory predictors of severe FNAIT and found that maternal antibodies to HPA were the only independent predictor of severe FNAIT in subsequent pregnancies. However, one infant had a severe FNAIT recurrence without maternal antibodies, highlighting the need for improved prevention and treatment strategies.
Article
Obstetrics & Gynecology
Paola Quaresima, Federica Visconti, Fabiana Interlandi, Luigi Puccio, Patrizia Caroleo, Giuseppina Amendola, Michele Morelli, Roberta Venturella, Costantino Di Carlo
Summary: Post-diagnosis counselling for women diagnosed with gestational diabetes mellitus has been shown to significantly improve their awareness of the risks related to foetal-maternal outcomes. Most women who received counselling demonstrated a secondary level of education and a higher mean level of awareness compared to those who did not receive counselling.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Hematology
Zachary A. Colvin, Jennifer Schiller, Shirng-Wern Tsaih, Ruchika Sharma, Rachael F. Grace, Jennifer J. McIntosh, Brian R. Curtis
Summary: This study examined whether suspected cases of fetal and neonatal alloimmune thrombocytopenia (FNAIT) without maternal human platelet antigens (HPA) antibodies had different human leukocyte antigen (HLA) antibody strength and specificity compared to controls. The results showed that FNAIT cases had significantly higher HLA antibody strength and broader HLA antibody specificity compared to matched controls.
Article
Biochemistry & Molecular Biology
Thijs W. de Vos, Dian Winkelhorst, Hans J. Baelde, Kyra L. Dijkstra, Rianne D. M. van Bergen, Lotte E. van der Meeren, Peter G. J. Nikkels, Leendert Porcelijn, C. Ellen van der Schoot, Gestur Vidarsson, Michael Eikmans, Rick Kapur, Carin van der Keur, Leendert A. Trouw, Dick Oepkes, Enrico Lopriore, Marie-Louise P. van der Hoorn, Manon Bos, Masja de Haas
Summary: This study found that untreated FNAIT cases showed more C4d deposition in the placenta, which may impact placental function and fetal growth. Histopathological examination revealed a certain proportion of placental delayed maturation in these cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Hematology
Julia Alm, Yalin Duong, Sandra Wienzek-Lischka, Nina Cooper, Sentot Santoso, Ulrich J. Sachs, Volker Kiefel, Gregor Bein
Summary: Most cases of FNAIT are caused by maternal anti-HPA-1a antibodies, while anti-HPA-5b antibodies are the second most common antibodies. However, there is no evidence supporting the idea that anti-HPA-5b antibodies cause severe thrombocytopenia or bleeding complications.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
David Boehm, Sandra Wienzek-Lischka, Nina Cooper, Heike Berghoefer, Katja Mueller, Behnaz Bayat, Gregor Bein, Ulrich J. Sachs
Summary: In fetal/neonatal alloimmune thrombocytopenia (FNAIT), maternal alloantibodies against paternal human platelet antigens (HPA) lead to platelet destruction through the placenta. The extent of thrombocytopenia varies, and inflammation may play a role. In this study, inflammatory markers were measured in serum samples from neonates with low platelet counts, and it was found that systemic inflammation did not contribute significantly to thrombocytopenia in FNAIT. However, the antiangiogenic enzyme sFlt-1 released by the placenta correlated with platelet count in FNAIT cases, suggesting that placental inflammation may modulate disease severity.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Nursing
Tonya Norton, Desi Newberry, Amy Jnah
Summary: NAIT is a rare platelet disorder caused by maternal alloimmunization to paternally inherited HPAs, resulting in low platelet levels and intracranial hemorrhage in newborns. Despite promising results from universal screening tools, none have been incorporated into practice and prophylactic treatment remains unavailable.
ADVANCES IN NEONATAL CARE
(2021)
