Article
Biochemistry & Molecular Biology
Heather R. Ferguson Bennit, Amber Gonda, Janviere Kabagwira, Laura Oppegard, David Chi, Jenniffer Licero Campbell, Marino De Leon, Nathan R. Wall
Summary: Cancer cell exosomes containing Survivin protein weaken the immune response of NK cells, but direct treatment with exosomes did not significantly alter NK cell functionality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Christian Binder, Felix Sellberg, Filip Cvetkovski, Stefan Berg, Erik Berglund, David Berglund
Summary: The study showed that siplizumab increased NK cell activation by binding to Fc gamma RIIIA, suggesting potential application in inhibiting NK cell activation. However, the inhibitory effects of CD2 blockade on natural cytotoxicity and antibody-dependent cytotoxicity remain unclear.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Adil Ijaz, Femke Broere, Victor P. M. G. Rutten, Christine A. Jansen, Edwin J. A. Veldhuizen
Summary: This study confirms the presence of perforin and granzyme A in chicken NK cells and their release upon degranulation. This provides a new tool to study the activity of cytotoxic lymphocytes in chickens.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Immunology
Josefine Ruder, Jordan Rex, Simon Obahor, Maria Jose Docampo, Antonia M. S. Mueller, Urs Schanz, Ilijas Jelcic, Roland Martin
Summary: It was found that after autologous hematopoietic stem cell transplantation, the relative frequency and absolute numbers of CD56(bright) NK cells in patients with multiple sclerosis increased, while all studied innate-like T cell populations decreased.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yorleny Vicioso, Derek P. Wong, Nand K. Roy, Nayanika Das, Keman Zhang, Parameswaran Ramakrishnan, Reshmi Parameswaran
Summary: Germline deficiency of NF-kappa B c-Rel leads to a marked decrease in cytotoxic function of NK cells, which is regulated by c-Rel through controlling the expression of perforin and granzyme B. The study reveals a crucial role of c-Rel in the cytotoxic function of NK cells through transcriptional regulation of perforin and granzyme B expressions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mickey V. Patel, Zheng Shen, Marta Rodriguez-Garcia, Edward J. Usherwood, Laura J. Tafe, Charles R. Wira
Summary: Endometrial cancer suppresses host immune function by regulating the cytotoxic capacity of CD8+ T cells. CD103-CD8+ T cells are primarily responsible for killing of allogeneic target cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fernanda Scopelliti, Valentina Dimartino, Caterina Cattani, Andrea Cavani
Summary: This study found that TRPA1 channels are highly expressed in the CD56(dim)CD16(+) subpopulation of NK cells, and their activation can increase cell-mediated cytotoxicity against tumors while also regulating the survival of NK cells to limit excessive cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ziming Hu, Xiuxiu Xu, Haiming Wei
Summary: NK cells are essential components of innate immunity, playing a key role in defending against tumors and viral infections. They express a diverse range of receptors and exhibit phenotypic and functional diversity influenced by various factors such as developmental origins, tumors, and viral infections. Understanding NK cells in the tumor microenvironment is crucial for the development of NK cell immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Karoliina Tuomela, Debayan Mukherjee, Ashley R. Ambrose, Ashish Harikrishnan, Holly Mole, Adam Hurlstone, Bjorn Onfelt, Jamie Honeychurch, Daniel M. Davis
Summary: The study reveals that radiotherapy induces resistance in cancer cells by inhibiting perforin-induced calcium flux and lysis. This resistance also hampers NK cell-mediated clearance of cancer cells and chimeric antigen receptor T-cell cytotoxicity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Grace Lee, Sheela Karunanithi, Bruce Posner, Hanspeter Niederstrasser, Hong Cheng, Yuriy Federov, Shivaprasad Manjappa, Karam Musaitif, Huaiyu Wang, Zachary Jackson, David Wald
Summary: Our work led to the identification of a promising compound that potently increases NK cell-mediated killing of a variety of different cancer cells, but has no impact on the killing of normal cells. This compound demonstrates the utility of this screening assay.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Cell & Tissue Engineering
Hans Klingemann
Summary: The NK-92 cell line is a highly active blood natural killer (NK) cell that exhibits broader and greater cytotoxicity. It has significant implications in both research and clinical treatment, showing great potential in the treatment of cancer and infections.
Article
Chemistry, Multidisciplinary
Jeehun Park, Yerin Shin, Jung Min Kim, SoonHo Kweon, Ah Young Song, Yujin Baek, Jinho Kim, Duck Cho, Hun Sik Kim, Junsang Doh
Summary: NK cells are innate lymphoid cells that play a crucial role in immune surveillance and defense. Impaired NK cell functions could indicate a higher susceptibility to infection or tumor development. Developing a comprehensive test that measures both cytotoxicity and cytokine secretion simultaneously is important for accurately assessing NK cell activity.
Article
Immunology
Qi Li, Suna Cai, Mengjiao Li, Xiaojie Zhou, Gao Wu, Kang Kang, Jingli Yuan, Ruohan Wang, Huyan Ting, Wei Zhang
Summary: This study found that NK cells from lung cancer patients had significantly decreased colony formation and cytotoxicity, upregulated NKG2A expression, and downregulated CD226 expression, all of which were significantly correlated with lung cancer occurrence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Li Yanli, Ivan Diaz, Gerard Martin-Valls, Niklas Beyersdorf, Enric Mateu
Summary: This study investigated the role of cytotoxic lymphocytes in preventing transplacental infection of PRRSV-1 in vaccinated sows, and found that the health status of the piglets was associated with the immune response of these cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tomonori Iyoda, Satoru Yamasaki, Shogo Ueda, Kanako Shimizu, Shin-ichiro Fujii
Summary: Natural killer T (NKT) cells and natural killer (NK) cells play important roles in the innate immune response to tumors and microorganisms by producing inflammatory cytokines and chemokines. The status and function of these cells in the tumor microenvironment (TME) have been investigated. Bacteria producing NKT cell ligands have been found to have anti-tumor effects, while tumor-derived lipids or metabolites may suppress NKT and NK cells. The balance between inhibitory and activating receptor signals determines the status and function of NKT and NK cells.